MDM2 and HIF1alpha expression levels in different histologic subtypes of malignant pleural mesothelioma: correlation with pathological and clinical data

62-year-old man with shortness of breath and an abnormal chest CT Axial 3D SPGR postgadolinium images (Figure 13.8.1) demonstrate diffuse thickening and enhancement of the left pleura, with a few minimally enhancing, focal right-sided pleural plaques. Malignant pleural mesothelioma Malignant pleural mesothelioma is a rare neoplasm that originates from the mesothelial cells lining the visceral and parietal pleura. The incidence of malignant pleural mesothelioma in the United States is 15 cases per million; there is a strong correlation with asbestos exposure. Malignant pleural mesothelioma is divided into 3 histologic subtypes: epithelial (55%-65%), sarcomatoid (10%-15%), and mixed (20%-35%). Patients with epithelial malignant pleural mesothelioma have the best prognosis, and among those with limited disease who undergo extrapleural pneumonectomy (removal of the pleura, lung, hemidiaphragm, and part of the pericardium), survival is longer (5-year survival, 39%) than among all patients (median survival, 8-18 months after diagnosis)....

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Evaluation of gene expression levels in the diagnosis of lung adenocarcinoma and malignant pleural mesothelioma

Turkish Journal of Thoracic and Cardiovascular Surgery ◽

10.5606/tgkdc.dergisi.2020.17279 ◽

2020 ◽

Vol 28 (1) ◽

pp. 188-196

Author(s):

Gökçen Ömeroğlu Şimşek

Keyword(s):

Gene Expression ◽

Lung Adenocarcinoma ◽

Malignant Pleural Mesothelioma ◽

Pleural Mesothelioma ◽

Expression Levels ◽

Gene Expression Levels

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Assessment of Glutathione Peroxidase-1 (GPX1) Gene Expression as a Specific Diagnostic and Prognostic Biomarker in Malignant Pleural Mesothelioma

Diagnostics ◽

10.3390/diagnostics11122285 ◽

2021 ◽

Vol 11 (12) ◽

pp. 2285

Author(s):

Amal F. Gharib ◽

Muhammad Alaa Eldeen ◽

Amany Salah Khalifa ◽

Wael H. Elsawy ◽

Emad Mohamed Eed ◽

...

Keyword(s):

Gene Expression ◽

Glutathione Peroxidase ◽

Malignant Pleural Mesothelioma ◽

Success Factors ◽

Malignant Tumors ◽

University Hospital ◽

Pleural Mesothelioma ◽

Mrna Levels ◽

Expression Levels ◽

Glutathione Peroxidase 1

Malignant pleural mesothelioma (MPM) is a malignant tumor of the mesothelial lining of the thorax. It has been related to frequent exposure to asbestos. Diagnosis of malignant pleural mesothelioma is considered a criticizing problem for clinicians. Early diagnosis and sufficient surgical excision of MPM are considered the cornerstone success factors for the management of early MPM. Glutathione peroxidase-1 (GPX1) is an intracellular protein found to be extensively distributed in all cells, and it belongs to the GPX group. In the current study, we included ninety-eight patients with MPM that underwent surgery at the Zagazig University Hospital in Egypt. We assessed GPX1 gene expression level as it was thought to be related to pathogenicity of cancer in a variety of malignant tumors. We observed a significant elevation in GPX1-mRNA levels in MPM relative to the nearby normal pleural tissues. It was found to be of important diagnostic specificity in the differentiation of MPM from normal tissues. Moreover, we studied the survival of patients in correlation to the GPX1 expression levels and we reported that median overall survival was about 16 months in patients with high GPX1 expression levels, while it was found to be about 40 months in low GPX1 levels.

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