scholarly journals Association and prognostic significance of BRCA1/2-mutation status with neoantigen load, number of tumor-infiltrating lymphocytes and expression of PD-1/PD-L1 in high grade serous ovarian cancer

Oncotarget ◽  
2016 ◽  
Vol 7 (12) ◽  
pp. 13587-13598 ◽  
Author(s):  
Kyle C. Strickland ◽  
Brooke E. Howitt ◽  
Sachet A. Shukla ◽  
Scott Rodig ◽  
Lauren L. Ritterhouse ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Prognostic Significance ◽  
Tumor Infiltrating Lymphocytes ◽  
High Grade ◽  
Serous Ovarian Cancer ◽  
Mutation Status ◽  
Infiltrating Lymphocytes

scholarly journals Dose-Response Association of CD8+ Tumor-Infiltrating Lymphocytes and Survival Time in High-Grade Serous Ovarian Cancer

JAMA Oncology ◽  
2017 ◽  
Vol 3 (12) ◽  
pp. e173290 ◽  
Author(s):  
◽  
Ellen L. Goode ◽  
Matthew S. Block ◽  
Kimberly R. Kalli ◽  
Robert A. Vierkant ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Survival Time ◽  
Dose Response ◽  
Tumor Infiltrating Lymphocytes ◽  
High Grade ◽  
Serous Ovarian Cancer ◽  
Infiltrating Lymphocytes

scholarly journals Nomograms to Predict the Density of Tumor-Infiltrating Lymphocytes in Patients With High-Grade Serous Ovarian Cancer

2021 ◽  
Vol 11 ◽  
Author(s):  
Danian Dai ◽  
Lili Liu ◽  
He Huang ◽  
Shangqiu Chen ◽  
Bo Chen ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
T Cells ◽  
Menopausal Status ◽  
Tumor Infiltrating Lymphocytes ◽  
Roc Curves ◽  
Clinicopathological Characteristics ◽  
High Grade ◽  
Serous Ovarian Cancer ◽  
Ki 67 ◽  
Infiltrating Lymphocytes

BackgroundTumor-infiltrating lymphocytes (TILs) have important roles in predicting tumor therapeutic responses and progression, however, the method of evaluating TILs is complicated. We attempted to explore the association of TILs with clinicopathological characteristics and blood indicators, and to develop nomograms to predict the density of TILs in patients with high-grade serous ovarian cancer (HGSOC).MethodsThe clinical profiles of 197 consecutive postoperative HGSOC patients were retrospectively analyzed. Tumor tissues and matched normal fallopian tubes were immunostained for CD3+, CD8+, and CD4+ T cells on corresponding tissue microarrays and the numbers of TILs were counted using the NIH ImageJ software. The patients were classified into low- or high-density groups for each marker (CD3, CD4, CD8). The associations of the investigated TILs to clinicopathological characteristics and blood indicators were assessed and the related predictors for densities of TILs were used to develop nomograms; which were then further evaluated using the C-index, receiver operating characteristic (ROC) curves and calibration plots.ResultsMenopausal status, estrogen receptor (ER), Ki-67 index, white blood cell (WBC), platelets (PLT), lactate dehydrogenase (LDH), and carbohydrate antigen 153 (CA153) had significant association with densities of tumor-infiltrating CD3+, CD8+, or CD4+ T cells. The calibration curves of the CD3+ (C-index = 0.748), CD8+ (C-index = 0.683) and CD4+ TILs nomogram (C-index = 0.759) demonstrated excellent agreement between predictions and actual observations. ROC curves of internal validation indicated good discrimination for the CD8+ TILs nomogram [area under the curve (AUC) = 0.659, 95% CI 0.582–0.736] and encouraging performance for the CD3+ (AUC= 0.708, 95% CI 0.636–0.781) and CD4+ TILs nomogram (AUC = 0.730, 95% CI 0.659–0.801).ConclusionMenopausal status, ER, Ki-67 index, WBC, PLT, LDH, and CA153 could reflect the densities of T cells in the tumor microenvironment. Novel nomograms are conducive to monitor the immune status of patients with HGSOC and help doctors to formulate the appropriate treatment strategies.

scholarly journals Prognostic impact of tumor-infiltrating lymphocytes in high grade serous ovarian cancer: a systematic review and meta-analysis

2020 ◽  
Vol 12 ◽  
pp. 175883592096724
Author(s):  
Jiatao Hao ◽  
Hui Yu ◽  
Taohong Zhang ◽  
Ruifang An ◽  
Yan Xue
Keyword(s):  
Systematic Review ◽  
Ovarian Cancer ◽  
Multivariate Analysis ◽  
Meta Analysis ◽  
Tumor Infiltrating Lymphocytes ◽  
Extensive Literature ◽  
Prognostic Impact ◽  
High Grade ◽  
Serous Ovarian Cancer ◽  
Infiltrating Lymphocytes

Background: Tumor-infiltrating lymphocytes (TILs) are involved in the antitumor immune response. The association between prognosis in patients with TILs and high-grade serous ovarian cancer (HGSOC) remains obscure, with some studies reporting conflicting results. Methods: We conducted an extensive literature search of electronic databases and retrieved prognostic data of each selected subtype of TILs, including CD3+, CD4+, CD8+, CD103+, and PD-1+ TILs. The fixed-effects model was applied to derive the pooled hazard ratio (HR) and 95% confidence interval (CI) of these markers. Results: The systematic review process yielded 19 eligible studies comprising 6004 patients with HGSOC. We compared TIL-positive and TIL-negative patients, and the pooled HRs from the multivariate analysis revealed that intraepithelial CD8+ TILs were positively correlated with progression-free survival (PFS, HR 0.46, 95% CI 0.25–0.67) and overall survival (OS, HR 0.90, 95% CI 0.86–0.9); stromal CD8+ TILs were positively correlated with OS (HR 0.61, 95% CI 0.36–0.87). Furthermore, the pooled HRs from univariate analysis demonstrated that intraepithelial CD3+, CD4+, CD8+, and CD103+ TILs were positively associated with OS (HR 0.58, 95% CI 0.44–0.72; HR 0.37, 95% CI 0.16–0.59; HR 0.51, 95% CI 0.42–0.60, and HR 0.59, 95% CI 0.44–0.74, respectively); stromal CD4+ and CD8+ TILs were significantly associated with OS (HR 0.63, 95% CI 0.32–0.94 and HR 0.78, 95% CI 0.58–0.97, respectively). However, the pooled HR from the multivariate analysis revealed that PD-1+ TILs were not associated with the OS of patients with HGSOC (HR 0.97, 95% CI 0.90–1.04). Conclusion: This meta-analysis provided evidence of the association of CD3+, CD4+, CD8+, and CD103+ TILs with the survival benefits (OS and PFS) of patients with HGSOC.

scholarly journals Tumor-Infiltrating Lymphocytes Expressing the Tissue Resident Memory Marker CD103 Are Associated with Increased Survival in High-Grade Serous Ovarian Cancer

2013 ◽  
Vol 20 (2) ◽  
pp. 434-444 ◽  
Author(s):  
John R. Webb ◽  
Katy Milne ◽  
Peter Watson ◽  
Ronald J. deLeeuw ◽  
Brad H. Nelson
Keyword(s):  
Ovarian Cancer ◽  
Tumor Infiltrating Lymphocytes ◽  
High Grade ◽  
Serous Ovarian Cancer ◽  
Infiltrating Lymphocytes

scholarly journals Treatment Regimen, Surgical Outcome, and T-cell Differentiation Influence Prognostic Benefit of Tumor-Infiltrating Lymphocytes in High-Grade Serous Ovarian Cancer

2015 ◽  
Vol 22 (3) ◽  
pp. 714-724 ◽  
Author(s):  
Maartje C.A. Wouters ◽  
Fenne L. Komdeur ◽  
Hagma H. Workel ◽  
Harry G. Klip ◽  
Annechien Plat ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Cell Differentiation ◽  
T Cell ◽  
Treatment Regimen ◽  
Surgical Outcome ◽  
Tumor Infiltrating Lymphocytes ◽  
T Cell Differentiation ◽  
High Grade ◽  
Serous Ovarian Cancer ◽  
Infiltrating Lymphocytes

scholarly journals Tumor-infiltrating Lymphocytes Expression in Stage IIIc/IV of High-grade Serous Ovarian Cancer: Variation with Neoadjuvant Chemotherapy and Prognostic Value

Oncogen ◽  
2019 ◽  
Vol 2 (2) ◽  
Author(s):  
K Rojas ◽  
G Prado-Vazquez ◽  
C Barcena ◽  
L Trilla-Fuertes ◽  
A Gamez-Pozo ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Neoadjuvant Chemotherapy ◽  
Prognostic Value ◽  
Tumor Infiltrating Lymphocytes ◽  
High Grade ◽  
Serous Ovarian Cancer ◽  
Stage Iiic ◽  
Infiltrating Lymphocytes

CD3+ and CD8+ tumor-infiltrating lymphocytes (TILs) as markers of improved prognosis in high-grade serous ovarian cancer

2019 ◽  
Vol 154 ◽  
pp. 68
Author(s):  
R.M. Kahn ◽  
C. Matrai ◽  
A.S. Quinn ◽  
N. Talukdar ◽  
P. McIntire ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Tumor Infiltrating Lymphocytes ◽  
High Grade ◽  
Serous Ovarian Cancer ◽  
Infiltrating Lymphocytes

scholarly journals High-Grade Serous Ovarian Cancer: Associations between BRCA Mutation Status, CT Imaging Phenotypes, and Clinical Outcomes

Radiology ◽  
2017 ◽  
Vol 285 (2) ◽  
pp. 472-481 ◽  
Author(s):  
Stephanie Nougaret ◽  
Yulia Lakhman ◽  
Mithat Gönen ◽  
Debra A. Goldman ◽  
Maura Miccò ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Clinical Outcomes ◽  
Brca Mutation ◽  
Ct Imaging ◽  
High Grade ◽  
Serous Ovarian Cancer ◽  
Mutation Status
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