scholarly journals A novel small molecule STAT3 inhibitor, LY5, inhibits cell viability, colony formation, and migration of colon and liver cancer cells

Oncotarget ◽  
2016 ◽  
Vol 7 (11) ◽  
pp. 12917-12926 ◽  
Author(s):  
Chongqiang Zhao ◽  
Wenlong Wang ◽  
Wenying Yu ◽  
David Jou ◽  
Yina Wang ◽  
...  
Keyword(s):  
Liver Cancer ◽  
Cell Viability ◽  
Cancer Cells ◽  
Small Molecule ◽  
Colony Formation ◽  
Liver Cancer Cells ◽  
And Migration

Characterizing the differential physiological effects of adipocytokines visfatin and resistin in liver cancer cells

2019 ◽  
Vol 38 (2) ◽  
Author(s):  
Candace Miethe ◽  
Megan Zamora ◽  
Linda Torres ◽  
Kelsie G. Raign ◽  
Curissa J. Groll ◽  
...  
Keyword(s):  
Enzyme Activity ◽  
Liver Cancer ◽  
Cell Viability ◽  
Cancer Cells ◽  
Fatty Acid Synthase ◽  
Liver Tumors ◽  
Health Concern ◽  
Liver Cancer Cells ◽  
Erk Phosphorylation ◽  
Huh7 Cells

Abstract Background Obesity, a major public health concern, increases the risk of developing liver cancer which is the leading cause of cancer-related deaths worldwide. Obesity is associated with increased adiposity and macrophage infiltration both of which promote secretion of adipokines and cytokines in the tumor microenvironment. Specifically, visfatin and resistin have been detected at higher levels in the serum of obese individuals and liver tumors. However, the contribution of these adipocytokines in the progression of liver cancer remains unclear. Materials and methods The objective of this study was to characterize the effects of visfatin and resistin on HepG2, SNU-449 and HuH7 liver cancer cells. Cells exposed to visfatin and resistin were analyzed for fatty acid synthase protein, and phosphorylation of Akt and ERK tumorigenic signaling pathways, cell viability, lipogenesis, reactive oxygen species (ROS), matrix metallopeptidase 9 (MMP-9) enzyme activity and invasion. Results HepG2, SNU-449, and HuH7 liver cancer cells treated with visfatin and resistin increased cell viability, invasion, FASN protein, and Akt and ERK phosphorylation. Visfatin and resistin selectively increased ROS production in HepG2 and SNU-449 cells while there was no statistical difference in HuH7 cells. Visfatin and resistin stimulated lipogenesis in HepG2 cells while visfatin increased lipogenesis in SNU-449 cells, and visfatin nor resistin had an effect on lipogenesis in HuH7 cells. Lastly, visfatin and resistin increased MMP-9 enzyme activity in HepG2 and HuH-7 cells but only visfatin increased MMP-9 activity in SNU-449 cells. Conclusions Future studies are needed to determine if inhibition of ERK and Akt suppresses the visfatin and resistin-induced invasive liver cancer phenotype.

Nuclear expression of the ubiquitin ligase seven in absentia homolog (SIAH)-1 induces proliferation and migration of liver cancer cells

2011 ◽  
Vol 55 (5) ◽  
pp. 1049-1057 ◽  
Author(s):  
Antje Brauckhoff ◽  
Mona Malz ◽  
Darjus Tschaharganeh ◽  
Nisar Malek ◽  
Achim Weber ◽  
...  
Keyword(s):  
Liver Cancer ◽  
Cancer Cells ◽  
Ubiquitin Ligase ◽  
Liver Cancer Cells ◽  
Nuclear Expression ◽  
Seven In Absentia ◽  
And Migration ◽  
Proliferation And Migration

scholarly journals LDB2 inhibits proliferation and migration in liver cancer cells by abrogating HEY1 expression

Oncotarget ◽  
2017 ◽  
Vol 8 (55) ◽  
pp. 94440-94449 ◽  
Author(s):  
Hongyang Yu ◽  
Ruichun Jia ◽  
Ling Zhao ◽  
Shigang Song ◽  
Jing Gu ◽  
...  
Keyword(s):  
Liver Cancer ◽  
Cancer Cells ◽  
Liver Cancer Cells ◽  
And Migration ◽  
Proliferation And Migration

Overexpression of far upstream element binding proteins: A mechanism regulating proliferation and migration in liver cancer cells

Hepatology ◽  
2009 ◽  
Vol 50 (4) ◽  
pp. 1130-1139 ◽  
Author(s):  
Mona Malz ◽  
Achim Weber ◽  
Stephan Singer ◽  
Vera Riehmer ◽  
Michaela Bissinger ◽  
...  
Keyword(s):  
Liver Cancer ◽  
Cancer Cells ◽  
Binding Proteins ◽  
Liver Cancer Cells ◽  
Upstream Element ◽  
And Migration ◽  
Proliferation And Migration

scholarly journals Effects of propofol on the proliferation and migration of liver cancer cells

2021 ◽  
Vol 22 (1) ◽  
Author(s):  
Chan Li ◽  
Qingxia Fu ◽  
Jin Cai ◽  
Hongxia Mei ◽  
Wangning Shangguan
Keyword(s):  
Liver Cancer ◽  
Cancer Cells ◽  
Liver Cancer Cells ◽  
And Migration ◽  
Proliferation And Migration

scholarly journals Effect of lncRNA‑BC200 on proliferation and migration of liver cancer cells in�vitro and in�vivo

2019 ◽  
Author(s):  
Ni Tan ◽  
Bo Zhu ◽  
Hong Shu ◽  
Yi‑Feng Tao ◽  
Jun‑Rong Wu ◽  
...  
Keyword(s):  
Liver Cancer ◽  
Cancer Cells ◽  
Liver Cancer Cells ◽  
And Migration ◽  
Proliferation And Migration

scholarly journals Paeoniflorin inhibits cell viability and invasion of liver cancer cells via inhibition of Skp2

2020 ◽  
Author(s):  
Hong Liu ◽  
Lili Zang ◽  
Jun Zhao ◽  
Zhaolin Wang ◽  
Lingyun Li
Keyword(s):  
Liver Cancer ◽  
Cell Viability ◽  
Cancer Cells ◽  
Liver Cancer Cells
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