THE STATE OF THIOLDISULPHIDE SYSTEM OF PATIENTS WITH CHRONIC DISEASES OF UPPER RESPIRATORY TRACT WITH CONCOMITANT COELIAC DISEASE

2018 ◽  
Vol 93 (2) ◽  
pp. 53-57
Author(s):  
A. A. Karpov ◽  
◽  
L. S. Oreshko ◽  
A. N. Pashchinin ◽  
L. A. Belozerova ◽  
...  
Keyword(s):  
Respiratory Tract ◽  
Coeliac Disease ◽  
Chronic Diseases ◽  
The State ◽  
Upper Respiratory Tract ◽  
Upper Respiratory

scholarly journals Immunodiagnostics, immunotherapy and immunoprophylaxis in the department of otolaryngology. Message 1. Optimal indicators of systemic immunity in assessing the clinical and laboratory status of patients with inflammatory diseases of the upper respiratory tract (analytical generalization)

2020 ◽  
pp. 4-11
Author(s):  
Oleg Melnikov ◽  
Diana Zabolotna ◽  
Dmitry Zabolotny
Keyword(s):  
Respiratory Tract ◽  
Blood Cells ◽  
Inflammatory Diseases ◽  
Diagnostic Value ◽  
The State ◽  
Immunological Methods ◽  
Integrated Analysis ◽  
Upper Respiratory Tract ◽  
Systemic Immunity ◽  
Upper Respiratory

Introduction: It is considered proven that the state of the immune system determines the development and course of many pathological processes, which are based on inflammation. At the same time, taking into account current trends in assessing the immunological status, conditional variants of deviation from the norm, a decrease in the number of cells from the average statistical norm of the region and control parameters in the performing laboratory by 1.5 or 2 times were adopted, since deviations are within 30-60 % are borderline and quite easily compensated by the body. The aim of the work was to conduct an integrated analysis of data to determine the state of systemic immunity in inflammatory diseases of the upper respiratory tract (URT) to select the optimal informa-tional indicators. Materials and methods: Immunological methods were used to examine 260 people with inflammatory pa-thology of the upper respiratory tract, of which 82 had chronic tonsillitis, 76 with chronic rhinitis, 70 with chronic pharyngitis and 32 people made up a control group of healthy donors. The age of the subjects ranged from 16 to 60 years, the duration of the disease from 1 year to 5 years, female patients predominated (≈60%). Examinations were conducted in the clinical remission stage. When assessing systemic immunity, the number of T-lymphocytes (CD 3, 4, 8), B-lymphocytes (CD22), NK (CD56), monocytes (CD14), concentration of immunoglobulins of classes M, G, A, E, cytokines with regulatory properties, interferon-γ-IL4 were determined. Functional tests in assessing systemic immunity are presented by determining the cytolytic activity of blood mononuclear cells in relation to avian xenogenic red blood cells and the activity of phagocytic blood cells in relation to latex particles at the absorption stage. Statistical processing was performed using the angular transfor-mation method "φ" according to Fisher and the "one-sided" criterion "U" Wilcoxon. Results: Based on a wide range of immunological studies in patients with chronic diseases of the upper respiratory tract, it seems most appropriate to use the following laboratory tests to assess systemic immunity to determine the characteristic deviations in the immune status of patients: High diagnostic value: - decreased serum IgA concentration (<0.5 g/l); - low level of activity of ECC of blood (<20% for xenoerythrocytes); - increased level of interleukin-1β (> 25 pg/ml); Relative diagnostic value: - determination of the degree of dysimmunoglobulinemia in serum; - increased titers of antibodies to streptolysin-O, other microbial antigens; - increased serum IgM. Conclusion: The developed criteria and approaches in assessing systemic immunity in patients with in-flammatory diseases of the upper respiratory tract can be used to examine patients and assess the effectiveness of the treatment.

scholarly journals Immunodiagnostics, immunotherapy and immunoprophylaxis in the clinic of otolaryngology. Message 2. Indicators of local immunity in assessment of clinical and laboratory status of patients in inflammatory ENT diseases (Analytical summary)

2021 ◽  
pp. 4-11
Author(s):  
Oleg F. Melnikov ◽  
Dmitry I. Zabolotny ◽  
Diana D. Zabolotna ◽  
Alexander Yu. Bredun ◽  
Oksana G. Rylska ◽  
...  
Keyword(s):  
Respiratory Tract ◽  
Clinical Remission ◽  
Inflammatory Diseases ◽  
The State ◽  
Secretory Iga ◽  
Control Group ◽  
Special Role ◽  
Upper Respiratory Tract ◽  
Local Immunity ◽  
Upper Respiratory

Topicality: It is considered proven that the state of the immune system determines the development and course of many pathological processes, which are based on inflammation. At the same time, taking into account modern trends in assessing the immunological status, a mandatory component is to determine the state of local immunity in the upper respiratory tract. Aim: to conduct an integral analysis of data to determine the state of local immunity in inflammatory diseases of the upper respiratory tract (URT) to select the optimal necessary informative indicators. Materials and methods: A generalization of the data of immunological studies of 168 people with inflammatory pathology of the upper respiratory tract (VDS) was carried out, of whom 42 had chronic tonsillitis (CT), 36 – chronic rhinitis (HR – catarrhal form), 40 – chronic pharyngitis (CP), 28 – secretory mean otitis media (CO), 22 people made up the control group (C) of practically healthy donors. The age of the surveyed was from 14 to 60 years, the duration of the diseases was from 1 to 5 years, female patients predominated (~ 60%). The examination was carried out at the stage of clinical remission. The material for the research was mixed saliva, in which the content of immunolobulins and citrokines was investigated by the ELISA method: enzyme immunoassay, the following factors of immunity and inflammation in the CGS were determined: - secretory and monomeric form of immunoglobulin A (Hema Medica, RF); - immunoglobulins of classes G, M (Hema Medica, RF); - interleukins – 1β; 4; 8; 10 (Cytokine, RF); - interferons α and γ (Cytokine, RF); - pro- and defensins (Nucalt bioteknology, Netherlands); - macrophage inflammatory protein-Mip-1b (Assauro, USA); - salivary lysozyme (Diagnostik Nord, Germany). Statistical processing was carried out using the methods of Student’s t-criterion and angular transformation “φ” according to Fisher. Results: Integral of all methods for determining various types of immunity in diseases of the upper respiratory tract with a chronic course is the insufficiency of factors of both innate and acquired immunity, especially during the period of clinical remission of the disease. A special role in protective reactions belongs to the humoral component, in which the most stable indicator is the level of class A secretory immunoglobulin; it has been shown that almost all the studied components of the immune response had abnormalities in the presence of a chronic inflammatory process in the upper respiratory tract and they can be presented as a line the degree of decrease in the frequency of deviations: secretory IgA, IgG., pro-inflammatory cytokines (IL1β and IL-8), γ-interferon, lysozyme, defensin-β, Mip-1b. Conclusion: The developed criteria and approaches to assessing systemic immunity in patients with inflammatory diseases of the upper respiratory tract can be used in examining patients and assessing the effectiveness of therapy.

scholarly journals Elimination and irrigation therapy to optimize the state of the nasal microbiome in children

2021 ◽  
pp. 50-58
Author(s):  
Olga E. Chelpachenko ◽  
Elena I. Danilova ◽  
Irina N. Chainikova
Keyword(s):  
Young Children ◽  
Respiratory Tract ◽  
Nasal Cavity ◽  
Nasal Mucosa ◽  
Inflammatory Diseases ◽  
The State ◽  
Healthy Children ◽  
Upper Respiratory Tract ◽  
Upper Respiratory ◽  
Nasal Microbiota

The article summarizes the results of the work of domestic and foreign researchers on the study of homeostasis of the nasal cavity, including the state of the microbiota of the nasal mucosa in healthy children and in inflammatory diseases of the upper respiratory tract. The normal microbiota of the nasal cavity is represented by corynebacteria (diphtheroids), neisseria, coagulasenegative staphylococci, alpha-hemolytic streptococci. From among the transient species, such species as Staphylococcus aureus, Escherihia coli, beta-hemolytic streptococci would be found in the specified biotope. The main attention is paid to the features of the nasal microbiota in newborns and young children (dependence of the nasal microbiota on the type of feeding, age and season). The role of hypercolonization by opportunistic microflora and its persistent potential (ability to biofilm formation, degradation of lysozyme, interferon) in the pathogenesis of inflammatory diseases of the upper respiratory tract is noted. The pathogenetic mechanisms providing multilevel protection of the organism from pathogens are considered. The expediency of using elimination-irrigation therapy as a hygienic means of sanitizing the nasal cavity in young children has been determined. The questions about the advantages of the use of isotonic solutions, their effectiveness for ensuring normal colonization resistance of the nasal mucosa are discussed. In conclusion, we must say that for hygienic care and sanitation purposes it is recommended only to rinse the nasal mucosa in newborns and infants using drops of isotonic saline solution and an aspirator to avoid aspiration and inflow of liquid into the cavity of Eustachian tube and middle ear, and also for the preventive purposes, as it allows to maintain homeostasis of the nasal mucosa and prevent the development of acute respiratory diseases.

scholarly journals ON THE ROLE OF COLLOID SILVER IN THE TREATMENT OF UPPER RESPIRATORY TRACT AND EAR DISORDERS

2017 ◽  
pp. 56-59
Author(s):  
N. E. BOIKOVA
Keyword(s):  
Respiratory Tract ◽  
Chronic Diseases ◽  
Broad Spectrum ◽  
High Resistance ◽  
Infectious Agents ◽  
Upper Respiratory Tract ◽  
Upper Respiratory ◽  
Anti Inflammatory ◽  
Colloid Silver

The high resistance of infectious agents to antibiotics that doctors currently face in therapy of acute and chronic diseases, especially in ENT-practice makes it possible for experts to search for alternative paths and to select drugs with a broad spectrum of action. These include colloid silver based drugs with proven microbicidal, virucidal and local protective and anti-inflammatory properties

Results of study of state of pharynx and larynx in aluminum production workers depending on length of service

2021 ◽  
Vol 19 (2) ◽  
pp. 32-36
Author(s):  
G. M. Beknazarova ◽  
◽  
F. Kh. Adylova ◽  
Keyword(s):  
Respiratory Tract ◽  
Mucous Membrane ◽  
Hydrogen Fluoride ◽  
The State ◽  
The Body ◽  
Working Environment ◽  
Aluminum Production ◽  
Upper Respiratory Tract ◽  
Length Of Service ◽  
Upper Respiratory

In the article, the author presented the results of a study of the state of the pharynx and larynx in workers of the aluminum production, depending on the length of service. The most toxic of the fluorine compounds is hydrogen fluoride, which, in addition to general toxic effects, has a local effect on the body, characterized by a predominant lesion of the mucous membrane of the upper respiratory tract. Almost all hydrogen fluoride inhaled with air is retained in the upper respiratory tract. This is one of the important reasons for the violation of the condition of the pharynx and larynx. Of the total number of workers examined, 578 workers showed changes in the state of the pharynx and in 125 the state of the larynx. All surveyed were divided depending on the duration of work experience. The huge number of those surveyed for certain age groups, which exceeds more than 100 people, gives grounds to consider the revealed results sufficiently reliable to determine the volume of the affected population in the studied contingent and allows, quite reasonably, to analyze the age and experience dynamics of the lesion. The materials obtained showed that the weakening of the protective functions of the epithelium of the nasal cavity makes the mucous membrane of the pharynx and larynx more sensitive to harmful factors of the working environment, prolonged exposure to harmful industrial factors, such as a significant concentration of dust and various chemical compounds cause deeper damage to the mucous membrane of the pharynx and larynx and damage the upper respiratory tract becomes descending.

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