Parameters of arterial stiffness in hypertensive patients with and without subclinical carotid atherosclerosis

Objective. To assess the relationship between arterial stiffness parameters in hypertensive patients with and without atherosclerotic lesions.Design and methods. We included 127 subjects who were divided into 3 groups: patients with hypertension (HTN) without atherosclerosis (n = 42); patients with HTN and subclinical atherosclerosis (SА) (n = 52) and control group which consisted of individuals without HTN, SA, or coronary artery disease (n = 33). All groups matched by age and gender. All subjects underwent following examinations: ultrasonography of extracranial segments of carotid arteries, 24-hour blood pressure monitoring with the assessment of arterial stiffness parameters.Results. In subjects with HTN compared to controls, pulse wave velocity in aorta (PWVao) was significantly higher (11,3 ± 1,5; 12,3 ± 1,8 vs 10,4 ± 1,3 m/s; p < 0,05), as well as pulse pressure (PP) (46,4 ± 9,8; 45,6 ± 10,6 vs 39,9 ± 6,5 mmHg; p < 0,05), central pulse pressure (PPао) (35,5 ± 8,5; 34,9 ± 8,5 vs 30,9 ± 5,4 mmHg; p < 0,05), and arterial stiffness index (ASI) (141 (127, 159); 139 (128,5, 160,5) vs 126 (118, 138) mmHg; p < 0,05). In subjects with HTN and SA, PWVao was significantly higher compared to other groups (p < 0,05). No significant difference in augmentation index was found (–32,5 (–45, –12); –22 (–36, –12); –37 (–50, –17); p = 0,25). Аmbulatory arterial stiffness index was higher in controls (0,5 ± 0,2) compared to HTN group (0,4 ± 0,2; p = 0,05), while HTN and SA group did not differ significantly (0,5 ± 0,2; p = 0,3). PWVao above 11,15 m/s is associated with 4,3 (2,3–8,2) times higher rate of atherosclerosis plaque detection.Conclusions. In HTN patients, arterial stiffness is changed compared to healthy individuals. PWVao above 11,15 m/s is associated with 4,3 (2,3–8,2) times higher rate of atherosclerosis plaque detection. In patients with HTN and SA arterial stiffness is higher, which might have additional predictive value in risk stratification.

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Association of renal function with the ambulatory arterial stiffness index and pulse pressure in hypertensive patients

Hypertension Research ◽

10.1038/hr.2011.167 ◽

2011 ◽

Vol 35 (2) ◽

pp. 201-206 ◽

Cited By ~ 8

Author(s):

Yaqiong Wang ◽

Yarong Hu ◽

Yan Li ◽

Hua Li ◽

Shaoli Chu ◽

...

Keyword(s):

Renal Function ◽

Arterial Stiffness ◽

Pulse Pressure ◽

Stiffness Index ◽

Hypertensive Patients ◽

Arterial Stiffness Index

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AMBULATORY ARTERIAL STIFFNESS MONITORING IN PATIENTS WITH ASTHMA

The Russian Archives of Internal Medicine ◽

10.20514/2226-6704-2019-9-4-301-307 ◽

2019 ◽

Vol 9 (4) ◽

pp. 301-307

Author(s):

N. A. Karoli ◽

O. T. Zarmanbetova ◽

A. P. Rebrov

Keyword(s):

Arterial Stiffness ◽

Augmentation Index ◽

Target Organ Damage ◽

Vascular Wall ◽

Organ Damage ◽

Stiffness Index ◽

Control Group ◽

Target Organs ◽

Gender And Age ◽

Arterial Stiffness Index

Cardiovascular disease is one of the major causes of death throughout the world. Early detection of target organ damage is important for more successful prevention of cardiovascular diseases and improvement of patient outcomes. One of these target organs is the vascular wall, and its damage consists in loss of elastic properties and increase in stiffness. Many studies have shown that the increasing stiffness of the vascular wall is an independent predictor of cardiovascular risk. Objective: To evaluate parameters of the ambulatory arterial stiffness monitoring in patients with bronchial asthma. Materials and methods. The study enrolled 119 patients with asthma. The group of control included 30 practically healthy volunteers comparable by gender and age with the patients of the main group. Each patient underwent ambulatory blood pressure and arterial stiffness monitoring using BPLab MnSDP-2 device (Petr Telegin, Russia). Results: In patients with asthma higher values of augmentation index, arterial stiffness index and pulse wave velocity in the aorta in comparison with patients of the control group, as well as violation of the 24-hour profile of arterial stiffness were noted. Conclusion. Patients with asthma demonstrated significantly increased arterial stiffness in comparison with control group.

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THE PARTICULARITIES OF ABPM PARAMETERS IN HYPERTENSIVE PATIENTS WITH NON-DIALYSIS CKD

Romanian Medical Journal ◽

10.37897/rmj.2017.4.3 ◽

2017 ◽

Vol 64 (4) ◽

pp. 279-283

Author(s):

Alexandru Minca ◽

◽

Mihai Comsa ◽

Maria Mirabela Manea ◽

Maria Daniela Tanasescu ◽

...

Keyword(s):

Blood Pressure ◽

Kidney Disease ◽

Arterial Stiffness ◽

Blood Pressure Monitoring ◽

Target Organ Damage ◽

Organ Damage ◽

Stiffness Index ◽

Area Index ◽

Hypertensive Patients ◽

Arterial Stiffness Index

Chronic kidney disease (CKD) affects approximately two million people (in a population of 20 million) in Romania. Hypertension is often associated with CKD and both (hypertension and CKD) are risk factors for cardiovascular (CV) events. Ambulatory blood pressure monitoring (ABPM) is increasingly used all around the world for the diagnosis and monitoring of BP (blood pressure) because it is proven that the ABPM is superior to office BP measurements in evaluating patients with hypertension, with or without CKD. Reduced nocturnal BP fall (non-dipping or reverse-dipping patterns) is associated with target organ damage, especially kidney disease and the proportion of non-dippers and reverse-dippers patients increases progressively with the reduction of glomerular filtration rate (GFR). Another ABPM parameter, ambulatory arterial stiffness index (AASI), is an index which was recently proposed for the evaluation of arterial stiffness (a better tool than PP). It has prognostic value for cardiac death and stroke and several studies have showed that is negatively related to eGFR and is positively related to albuminuria. Hyperbaric area index (HBI) might be considered a novel sensitive marker [independent of patterns of NBPC (nocturnal BP change)] for the reduction of kidney function. These facts suggest that ABPM offers multiple useful data with impact, not only in future CV and renal outcomes assessment, but also in the treatment and management of hypertensive patients with CKD.

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Increased Ambulatory Arterial Stiffness Index and Pulse Pressure in Microalbuminuric Patients With Type 1 Diabetes

American Journal of Hypertension ◽

10.1038/ajh.2009.27 ◽

2009 ◽

Vol 22 (5) ◽

pp. 513-519 ◽

Cited By ~ 16

Author(s):

E. Laugesen ◽

K. W. Hansen ◽

S. T. Knudsen ◽

M. Erlandsen ◽

E. Ebbehoj ◽

...

Keyword(s):

Type 1 Diabetes ◽

Arterial Stiffness ◽

Pulse Pressure ◽

Stiffness Index ◽

Arterial Stiffness Index

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Ambulatory arterial stiffness index correlates with ambulatory pulse pressure but not dipping status in patients with grade 1/grade 2 essential hypertension

Journal of International Medical Research ◽

10.1177/0300060514548288 ◽

2014 ◽

Vol 42 (6) ◽

pp. 1323-1334 ◽

Cited By ~ 3

Author(s):

Tingli Qin ◽

Hong Jiang ◽

Yuan Jiao ◽

Yuannan Ke ◽

Ningling Sun ◽

...

Keyword(s):

Essential Hypertension ◽

Arterial Stiffness ◽

Pulse Pressure ◽

Stiffness Index ◽

Arterial Stiffness Index ◽

Ambulatory Pulse Pressure

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Effect of Aerobic Training on Cognitive Function and Arterial Stiffness in Sedentary Young Adults: A Pilot Randomized Controlled Trial

Physiology Journal ◽

10.1155/2013/847325 ◽

2013 ◽

Vol 2013 ◽

pp. 1-9 ◽

Cited By ~ 2

Author(s):

Samuel Asamoah ◽

Jason Siegler ◽

Dennis Chang ◽

Andrew Scholey ◽

Alan Yeung ◽

...

Keyword(s):

Young Adults ◽

Cognitive Function ◽

Arterial Stiffness ◽

Pulse Pressure ◽

Processing Speed ◽

Aerobic Training ◽

Augmentation Index ◽

Control Group ◽

Experimental Group ◽

Over Time

This study measured cognitive and vascular responses to aerobic training in sedentary young adults. Ten adults (6 women, 4 men; 18–29 years) were randomly assigned to an experimental or no-treatment control group. The experimental group engaged in a 6-week intervention, performed on exercise cycle and treadmill, 3x/week, 50 min/session; intensity was increased over time. Outcome measures included arterial stiffness (augmentation index, AIx, and pulse pressure), cardiorespiratory fitness (), and cognitive function (attention, processing speed, working memory, episodic memory, and executive function). Participants randomized to aerobic training improved processing speed versus control (, ES = 0.55). However, no group × time effects were noted in other domains of cognitive function. AIx was reduced by approximately 16% from before to after intervention in the experimental group; however, the improvement was not statistically significant versus control (, ES = 0.22). Pulse pressure did not change between groups over time (, ES = 0.0). increased by approximately 10% in the experimental group; however, the change was not significant between groups over time (, ES = 0.27). Vascular and cognitive adaptations to aerobic training may move in parallel. Robust trials simultaneously investigating a broad spectrum of aerobic training interventions and vascular and cognitive outcomes are warranted.

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