scholarly journals Clinical observation of metastatic thyroid disease in a patient with breast cancer

2018 ◽  
Vol 46 (4) ◽  
pp. 379-383
Author(s):  
E. V. Bondarenko ◽  
L. E. Gurevich ◽  
I. V. Kotova
Keyword(s):  
Breast Cancer ◽  
Thyroid Gland ◽  
Thyroid Disease ◽  
Progesterone Receptors ◽  
Needle Aspiration ◽  
Thyroid Tumors ◽  
Breast Cancer Metastases ◽  
Thyroid Goiter ◽  
Diagnostic Panel ◽  
The Right

Metastatic tumors of the thyroid gland (TG) are rare. Usually thyroid gland metastases originate from renal, lung, skin and gastrointestinal cancers. Breast cancer metastases are more rare and in various samples amount to 3 to 34% of all cases of the metastatic thyroid disease. We present a rare case of metastatic carcinomatosis into the thyroid goiter in a 63-year old female patient who has received combination therapy for breast cancer. In 2016, right-sided mastectomy was performed due to the right breast cancer (invasive carcinoma, non-specific type, Grade 2, with skin invasion) with subsequent four chemotherapy courses. A slowly growing nodule in the thyroid gland was first found in 2012; in 2017, fine needle aspiration biopsy was performed, which showed a follicular tumor that resulted in thyroidectomy. At the histological examination, against the background of thyroid goiter, multiple small lesions with advanced nuclear polymorphism were found, with doubtful diagnosis. To clarify the histogenesis of the tumor lesions, immunohistochemical assessment was performed. Its first phase included the markers of primary thyroid tumors (thyroglobulin, TTF-1), and the second one consisted of the breast cancer diagnostic panel (mammoglobin, GATA-3, estrogen and progesterone receptors). The results showed multiple small metastases of the invasive breast carcinoma of non-specific type into the thyroid goiter. Taking into account eventual problems of differential diagnosis and significant morphological polymorphism of thyroid tumors, we recommend extending of the immunohistochemistry panel in this patient category.

scholarly journals Thyroid gland metastasis from breast cancer: a case report

2020 ◽  
Vol 8 (1) ◽  
pp. 15-15
Author(s):  
Mehmet Sözen ◽  
Zeynep Cantürk ◽  
Berrin Çetinarslan ◽  
Alev Selek ◽  
Emre Gezer ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Case Report ◽  
Thyroid Gland ◽  
Cancer Metastasis ◽  
Cancer Staging ◽  
Breast Conserving Surgery ◽  
Needle Aspiration ◽  
Breast Cancer Staging ◽  
Positron Emission ◽  
Pet Ct

Primary cancer metastasis to thyroid gland is rare. The most common metastatic tumors of the thyroid gland are from lung, breast and renal cell carcinoma. In this case report, a patient with breast cancer metastasized to the thyroid gland is presented. A 38-year-old female patient was diagnosed with breast cancer, and positron emission tomography-computed tomography (PET-CT) imaging for breast cancer staging revealed fluoro-2deoxy-D-glucose (FDG) uptake in the thyroid nodule. Fine needle aspiration biopsy (FNAB) of the nodule revealed atypia of undetermined significance (Bethesda III). After neoadjuvant chemotherapy, simultaneous breast conserving surgery and total thyroidectomy were performed. Immunohistochemical staining of the pathological specimens revealed breast cancer that had metastasized to the thyroid gland. Immunohistochemical methods helped distinguishing primary thyroid cancer from metastasis. Also, nodules that showed activity involvement were detected randomly in PET-CT, and had to be evaluated in terms of malignancy.

scholarly journals Isolated Langerhans Cell Histiocytosis of the Thyroid in an Adult Female: One-Year Followup

2011 ◽  
Vol 2011 ◽  
pp. 1-4 ◽  
Author(s):  
Ramon Vilallonga ◽  
Andrea Ciudin ◽  
José Manuel Fort ◽  
Juan Antonio Baena ◽  
Oscar Gonzalez ◽  
...  
Keyword(s):  
Thyroid Gland ◽  
Langerhans Cell Histiocytosis ◽  
Immunohistochemical Analysis ◽  
Needle Aspiration ◽  
Langerhans Cell ◽  
Thyroid Mass ◽  
Histologic Evaluation ◽  
One Year ◽  
The Right ◽  
Surgery Department

Thyroid gland involvement as the unique presentation of Langerhans cell histiocytosis is a rare phenomenon that can result in misdiagnosis. We report a case of Langerhans cell histiocytosis (LCH) presenting as a thyroid mass. It is a 52-year-old woman who presented an enlarged, diffusely firm, nontender, nonmobile, and not particularly nodular thyroid gland with mild compressive symptoms. Ultrasound and fine-needle aspiration showed a unique right node with benign signs. Patient was referred to our Ambulatory Surgery Department, where a hemithyroidectomy was performed. Histologic evaluation of the right thyroid gland revealed an involvement by LCH, confirmed by immunohistochemical analysis showing Langerhans cells that were positive for CD1a. LCH was a completely incidental occult finding apparent only after surgical resection and examination of the gland. Patient was evaluated, and no evidence of systemic affectation was found. LCH can rarely involve the thyroid gland in adults. Few cases have been reported in the literature. Most patients had evidence of LCH involving other anatomic sites.

Our Initial Experience of the Transaxillary Totally Endoscopic Approach for Hemithyroidectomy

2009 ◽  
Vol 141 (3) ◽  
pp. 335-339 ◽  
Author(s):  
Eugene H. Chang ◽  
Thom E. Lobe ◽  
Simon K. Wright
Keyword(s):  
Cohort Study ◽  
Thyroid Gland ◽  
Thyroid Disease ◽  
Young Patients ◽  
Needle Aspiration ◽  
Control Group ◽  
Benign Thyroid Disease ◽  
Initial Experience ◽  
Historic Cohort ◽  
Benign Thyroid

OBJECTIVE: To report our initial experience with the transaxillary totally endoscopic (TATE) approach to the thyroid gland. STUDY DESIGN: A historic cohort study of patients undergoing TATE procedures compared with open procedures for hemi-thyroidectomy with isthmusectomy. SETTING: Private-practice otolaryngology group. SUBJECT AND METHODS: Patients selected for benign thyroid disease confirmed by fine-needle aspiration and requiring hemithyroidectomy with isthmusectomy. A historic cohort study of 24 patients who underwent TATE procedures for hemithyroidectomy with isthmusectomy. Comparison of the first 10 TATE approaches to a control group of 10 consecutive open approaches by the senior author's group. RESULTS: All 24 TATE patients were successful without the need to convert to an open procedure. The TATE approach had longer operative times than the open group (142 vs 105), but these operative times decreased as the number of procedures increased (first five TATE = 170, last five TATE = 114, n = 24, average = 114). No patients had peri- or postoperative complications. CONCLUSIONS: The TATE approach to the thyroid gland is safe and effective. Operative time is longer but decreases with experience. The TATE approach is one option to treat young patients with unilateral benign thyroid disease who are seeking to avoid visible scars and limit morbidity.

scholarly journals Non-Hodgkin's Lymphoma in Thyroid Gland

2013 ◽  
Vol 14 (1) ◽  
pp. 83-84
Author(s):  
Md. Mahabubur Roshed ◽  
Sk. Manowar Ahsan ◽  
Kazi Abu Rashed
Keyword(s):  
Thyroid Gland ◽  
Fine Needle Aspiration ◽  
Rare Case ◽  
Large Mass ◽  
Needle Aspiration ◽  
Aspiration Cytology ◽  
Fine Needle ◽  
Right Lobe ◽  
Needle Aspiration Cytology ◽  
The Right

A rare case of primary non-Hodgkin’s Lymphoma in a 52-year-old female presented with a large mass in the right lobe of thyroid. The diagnosis was established by fine needle aspiration cytology (FNAC) followed by surgery andfinally confirmed by histopathology.DOI: http://dx.doi.org/10.3329/jom.v14i1.14584 J MEDICINE 2013; 14 : 83-84

scholarly journals Metastatic Renal Cell Cancer to Thyroid Diagnosed by Endoscopic Ultrasound Guided Fine Needle Aspiration Technique

2017 ◽  
Vol 2017 ◽  
pp. 1-4
Author(s):  
Yousef Abdel-Aziz ◽  
Tariq Hammad ◽  
Mohamad Nawras ◽  
Hayder Abdulwahid ◽  
Ali Nawras
Keyword(s):  
Thyroid Gland ◽  
Thyroid Nodule ◽  
Endoscopic Ultrasound ◽  
Fine Needle Aspiration ◽  
Renal Cell ◽  
Cell Cancer ◽  
Needle Aspiration ◽  
Fine Needle ◽  
History Of ◽  
The Right

Medical literature about the role of endoscopic ultrasound (EUS) in identifying thyroid lesions is limited. We present a case of secondary thyroid cancer from renal cell carcinoma (RCC) metastasis, diagnosed by thyroid EUS-fine needle aspiration (FNA) approach that was done for staging of esophageal adenocarcinoma, in a patient with 11-year history of complete right nephrectomy for RCC. An 81-year-old female patient underwent EUS for the evaluation of a newly discovered distal esophageal cancer. A hypoechoic, round, and well-demarcated mass that measured 26.9 mm × 21.9 mm was noticed in the right lobe thyroid gland. Therefore FNA was performed. The cytological results were consistent with metastatic RCC. In conclusion, EUS-FNA of thyroid nodule is a feasible and safe technique that can be used to evaluate any suspicious thyroid nodule. This case emphasizes the importance of carefully examining the thyroid gland during routine upper esophageal EUS examinations in the presence of history of nonthyroidal cancer.

scholarly journals Neglected Papillary Thyroid Carcinoma Seven Years after Initial Diagnosis

2013 ◽  
Vol 2013 ◽  
pp. 1-3 ◽  
Author(s):  
Eleftherios D. Spartalis ◽  
Theodore Karatzas ◽  
Petros Charalampoudis ◽  
Chrysovalantis Vergadis ◽  
Dimitrios Dimitroulis
Keyword(s):  
Papillary Thyroid Carcinoma ◽  
Thyroid Carcinoma ◽  
Needle Aspiration ◽  
Thyroid Tumor ◽  
Thyroid Tumors ◽  
Papillary Thyroid ◽  
Bleeding Management ◽  
Detection And Diagnosis ◽  
The Right ◽  
Early Detection And Diagnosis

Papillary thyroid carcinoma (PTC) is the most common epithelial thyroid tumor, accounting for more than 80% of all thyroid tumors. Recent advances in ultrasonographic screening and US-guided fine-needle aspiration biopsy (FNAB) have facilitated the early detection and diagnosis of papillary thyroid carcinomas. In exceptionally rare cases, papillary thyroid tumors may assume enormous dimensions due to recurrent disease or the patient's negligence of the problem. We report an extremely rare case of a 72-year-old woman presented with a neglected giant exophytic papillary thyroid carcinoma with hemorrhagic ulcers. Computed tomography showed a mass measured17×12 cm that caused a displacement of the trachea to the right side and reached the mediastinum. After bleeding management, patient was discharged. The patient was fully aware of her situation, but she denied any further therapeutic management.

scholarly journals Lateral differences of breast cancer proliferative activity (KI-67)

2016 ◽  
Vol 97 (4) ◽  
pp. 550-555
Author(s):  
A P Dmitrenko
Keyword(s):  
Breast Cancer ◽  
Proliferative Activity ◽  
Immunohistochemical Study ◽  
Progesterone Receptors ◽  
Ki 67 ◽  
Primary Tumors ◽  
Study Protocols ◽  
Tumor Lesion ◽  
Significant Difference ◽  
The Right

Aim. To determine lateral differences of breast cancer proliferative activity Ki-67.Methods. According to immunohistochemical study protocols analysis of material of 500 patients with breast cancer was conducted. In primary tumors estrogen and progesterone receptors expression, Ki-67, C-erbB-2 was studied.Results.Using two-way analysis of variance, it was found that Ki-67 index was significantly influenced by both side of the tumor lesion (p=0.009) and age of patients (p=0.0002). A higher Ki-67 corresponded to right-sided cancer localization. Statistically significant age differences of Ki-67 index are marked only in right-sided cancer (pConclusion. Statistically significant difference of Ki-67 index in right- and left-sided breast cancer was found, significantly higher Ki-67 was detected in the right-sided tumors, Ki-67 are present only in patients before 60 years.

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