Causes of different goiter rates with the same iodine deficiency among the pastoral and agricultural populations of Tibet: A geographical comparison

Background The residents of both the agricultural and pastoral areas of Tibet share the same iodine deficiency and iodine nutrition, but the rate of thyroid goiter was significantly higher in the agricultural areas than in the pastoral areas. This project sought to determine why the populations in the iodine-deficient pastoral areas show a lower rate of thyroid goiter. Methods Food frequency questionnaires (FFQs) and 24 h history recalls were adopted to investigate the dietary patterns of the residents of the agricultural and pastoral areas. Meat and milk samples were collected to measure their inorganic iodine, total iodine and thyroid hormone contents using ICP-MS, AsIII-Ce4+ catalytic spectrophotometry and the Siemens’ chemiluminescence method, respectively. The intake of protein, and the microelements, selenium and iron, was calculated according to their content in the food. Results The per capita daily intake of meat, dairy, and cereal in the pastoral areas was 116.7, 216.7, and 433.3 g, respectively, which are significantly higher than those in the agricultural areas (50.0, 72.2, and 375.0 g, respectively) (p < 0.05). The content of thyroid hormone in dried beef and milk in the pastoral areas was 62.6 and 13.5 µg/kg, respectively, which was significantly higher than those in the agricultural areas (25.1 and 4.1 µg/kg, respectively) (p < 0.05). The daily intake of thyroid hormone, protein and microelements, selenium and iron from foods by the residents of the pastoral areas were 10.5 µg, 99.6 g, 30.0 µg and 15.8 mg respectively, which was significantly higher than those in the agricultural areas (1.79 µg, 56.5 g, 23.8 µg and 13.2 mg, respectively) (p < 0.05). Conclusions The significantly high intake of the food-borne thyroid hormone by the residents of the pastoral area could be the main reason the residents in the pastoral areas show a lower rate of thyroid goiter than those in the agricultural area. Moreover, the relatively high intake of protein and trace elements, selenium and iron by residents in the pastoral area could be another important factor for reducing the goiter rates.

Gambaran Pemeriksaan Ultrasonografi pada Pasien Struma di Bagian/SMF Radiologi RSUP DR. M. Djamil Periode Januari–Desember 2019

Background: A goiter is an enlargement of the thyroid gland caused by abnormalities of the thyroid gland in the form of malfunctioning or disorders of the structure of the gland and its morphology. According to WHO, the incidence of goiter is still quite high with iodine deficiency as the main cause. Objective: This study aims to determine the description of ultrasound examinations in goiter patients in Department of Radiology DR. M. Djamil January-December 2019 period. Method: This research was a retrospective descriptive study using cross sectional method using secondary data on 123 patients with thyroid goiter who meet the inclusion criteria in RSUP DR. M. Djamil Padang period January 2019-December 2019. The sampling method used a total sampling technique. Result: The results showed that 112 patients with thyroid goiter disorders met the inclusion criteria. The most clinical diagnosis results were goiter nodusa as many as 61 people (54.5%). The highest incidence was in the age range 41-50 years with 35 people (31.3%). The most gender was 88 women (78.6%). The results of ultrasonography in most goiter patients were diffuse in 43 people (38%).Conclusion: The conclusion of this study, it was found that the most age group of patients suffering from goitre were 41-50 years old, the majority of goiters occurred in the female compared to the male and the results of the most thyroid ultrasound images were diffuse goiter

CD73 expression in normal, hyperplastic, and neoplastic thyroid: a systematic evaluation revealing CD73 overexpression as a feature of papillary carcinomas

CD73 converts AMP to adenosine, an immunosuppressive metabolite that promotes tumorigenesis. This study presents a systematic evaluation of CD73 expression in benign, hyperplastic, and neoplastic thyroid. CD73 expression was assessed by immunohistochemistry in 142 thyroid samples. CD73 was expressed in normal thyroid (3/6) and goiter (5/6), with an apical pattern and mild intensity. Apical and mild CD73 expression was also present in oncocytic cell adenomas/carcinomas (9/10; 5/8) and in follicular adenomas/carcinomas (12/18; 23/27). In contrast, papillary thyroid carcinomas featured extensive and intense CD73 staining (49/50) (vs. normal thyroid/goiter, p < 0.001). Seven of nine anaplastic carcinomas were CD73-positive with heterogeneous extensiveness of staining. Medullary and poorly differentiated carcinomas were mostly CD73-negative (1/6; 2/2). These results were corroborated by NT5E mRNA profiling. Papillary carcinomas feature enhanced CD73 protein and mRNA expression with distinct and intense staining, more pronounced in the invasive fronts of the tumors.

Progress in the Pathogenesis, Diagnosis, and Treatment of TSH-Secreting Pituitary Neuroendocrine Tumor

TSH-secreting pituitary neuroendocrine tumor (PitNET) is one of the causes of central hyperthyroidism. The incidence of TSH PitNET is far lower than that of other PitNETs. The clinical manifestations of TSH PitNETs mainly include thyrotoxicosis or thyroid goiter, secretion disorders of other anterior pituitary hormones, and mass effect on the pituitary gland and its surrounding tissues. The application of high-sensitivity TSH detection methods contributes to the early diagnosis and timely treatment of TSH PitNETs. Improvements in magnetic resonance imaging (MRI) have advanced the noninvasive visualization of smaller PitNETs. Treatments for TSH PitNETs include surgery, drugs, and radiotherapy. This review focuses on the progress in pathogenesis, diagnosis, and treatment of TSH PitNETs to provide more information for the clinician.