Histopathological and biochemical evaluations of the kidney inbroiler chickens under acute heat stress conditions.

Author(s):  
S.C. Huang ◽  
Y.F. Fu ◽  
Y.F. Lan ◽  
M.U. Rehman ◽  
Z.X. Tong

The purpose of the present study was to investigate the correlation between acute heat stress and relevant histopathology and biochemical parameters of kidney function. A total of 80 healthy Arbor Acer (AA) broiler chickens were randomly divided into two groups: CT (Control Temperature; 22±1°C) group and HT (High Temperature; 38±1°C) group. Histopathological images revealed alteration in kidney (renal tubular lumen dilation with tubular necrosis, especially after 10h of heat stress) of broiler chickens in HT group leading to disturbance of acid base balance. Blood urea nitrogen (BUN) and creatinine (CREA) as serum markers of renal dysfunction were elevated significantly (p less than 0.05) after 5h, and especially, after 10h of heat stress (p less than 0.01) as compared with CT group. These results indicated that the evaluation of morphological and functional parameters in kidney is required, in order to monitor broiler chickens exposed to heat stress.

2017 ◽  
Vol 57 (12) ◽  
pp. 2415
Author(s):  
J. J. Cottrell ◽  
F. Liu ◽  
S. Wan ◽  
U. A. Wijesiriwardana ◽  
K. DiGiacomo ◽  
...  

2000 ◽  
Vol 37 (2) ◽  
pp. 86-94 ◽  
Author(s):  
Hayford Y. TABIRI ◽  
Kan SATO ◽  
Kazuaki TAKAHASHI ◽  
Masaaki TOYOMIZU ◽  
Yukio AKIBA

1993 ◽  
Vol 72 (9) ◽  
pp. 1693-1704 ◽  
Author(s):  
B. RUÍZ-LÓPEZ ◽  
M. RANGEL-LUGO ◽  
R.E. AUSTIC

2014 ◽  
Vol 2014 ◽  
pp. 1-7 ◽  
Author(s):  
Motonobu Nakamura ◽  
Ayumi Shirai ◽  
Osamu Yamazaki ◽  
Nobuhiko Satoh ◽  
Masashi Suzuki ◽  
...  

Sodium-coupled bicarbonate absorption from renal proximal tubules (PTs) plays a pivotal role in the maintenance of systemic acid/base balance. Indeed, mutations in the Na+-HCO3-cotransporter NBCe1, which mediates a majority of bicarbonate exit from PTs, cause severe proximal renal tubular acidosis associated with ocular and other extrarenal abnormalities. Sodium transport in PTs also plays an important role in the regulation of blood pressure. For example, PT transport stimulation by insulin may be involved in the pathogenesis of hypertension associated with insulin resistance. Type 1 angiotensin (Ang) II receptors in PT are critical for blood pressure homeostasis. Paradoxically, the effects of Ang II on PT transport are known to be biphasic. Unlike in other species, however, Ang II is recently shown to dose-dependently stimulate human PT transport via nitric oxide/cGMP/ERK pathway, which may represent a novel therapeutic target in human hypertension. In this paper, we will review the physiological and pathophysiological roles of PT transport.


2010 ◽  
Vol 64 (5-6) ◽  
pp. 349-358
Author(s):  
Natalija Fratric ◽  
Ivan Vujanac ◽  
Horea Samanc ◽  
Danijela Kirovski ◽  
Dragan Gvozdic ◽  
...  

The work presents the results of investigations of the effect of moderate heat stress on the acidobasal status in high-yield dairy cows in early lactation. Improving performance in high-yield dairy cows increases their inclination toward metabolic disorders. The most likely to be affected is the acid-base balance, in particular when cows are exposed to heat stress. Investigations so far have shown that the taking of urine samples and their analysis is the best and fastest way to diagnose disorders in the acid-base balance. Investigations were carried out on 7 clinically healthy cows of the Holstein- Friesian breed in the phase of early lactation, 30 to 40 days (on days 30, 33 and 40 ) following calving during the summer period, during the month of July, when there were significant variations in daily and nightly temperatures. The cows were in the second and fourth lactation, the annual milk yield was 8000 L milk per cow. The average daily milk production in the early phase of lactation ranged from 35 to 40 L. The cows were fed mixed rations (TMR) twice daily. Lucerne hay in limited quantities was given to the cows prior to the mixed feed ration. The ration for this animal category was optimized on the grounds of the daily milk production. The balance of cations and anions in the feed ration stood at 95 mEq/kg DM. The results clearly demonstrate the cows' response to moderate heat stress through the defense parameters in urine (urine pH, NABE (net-acid-base-excretion), acids, bases, ammonium ion (NH4). The determination of the kidney NABE yields more correct data than the urine pH on acidotic conditions. The results of examinations of the urine pH do not show any digressions from physiological values and are approximately the same in all cows during the investigated periods. Normal NABE values are from 100-200 mmol/L. Burdening with acid products results in a NABE range from 0-100mmol/L, and metabolic acidosis results in NAB<0 mmol/L. NABE in the cows in this experiment revealed that the organism is burdened by acid metabolic products and it stood at 58.28?27.96 mmol/L on day 30, 69.28?29.89 mmol/L on day 33, and 60.60?26.88mmol/L on day 40. Consequently, it seems that NABE values are decreased in cases of acidosis due to stepped up H+ excretion and stepped up bicarbonate reabsorption.


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