Sero prevalence of anti-tissue transglutaminase in patients having sign symptoms of celiac disease: A cross sectional study from Peshawar, Pakistan

Abstract Background: Global prevalence of irritable bowel syndrome is high among medical students and health care professionals with significant morbidity. Similarly, the prevalence of celiac disease in irritable bowel syndrome is higher than the general population. These conditions impair quality of life and contribute to social-economic burden. In Tanzania, little is known about irritable bowel syndrome and celiac disease among medical students and health care professionals. Methods: A cross sectional study was conducted to MUHAS and Mloganzila Academic Medical Center (MAMC) staff and students who fulfilled the online shared Rome IV criteria of irritable bowel syndrome from August to November 2018. A structured questionnaire was used to collect socio-demographic data, anthropometric measurements and clinical manifestations. Blood samples for full blood picture, liver enzymes and Erythrocyte Sedimentation Rate were taken. Celiac disease was tested using anti-tissue transglutaminase antibody test. Qualitative and quantitative data were summarized using frequency distribution tables. Chi-square and fishers exact test were used to study comparison between groups. Logistic regression was used to study associations. Data was analyzed using SPSS version 20.0 and a P value of ≤0.05 was considered significant.Results: Out of 1,321 participants, 192 (14.5%) had irritable bowel syndrome in which 77 (40.1%) were males and 115 (59.9%) were females. Among the 192 participants with irritable bowel syndrome, 3 (1.6%) were positive for celiac disease, 2 (66.7%) were females and 1 (33.3%) was a male. Of the 3 patients with CD, 2 had elevated ALAT and 1 had anaemia. Age (AOR 2.53, 95% C.I 1.57-4.09), sex (AOR 1.67, 95% C.I 1.16-2.41), marital status (AOR 4.95 C.I 2.07-11.82), alcohol intake (AOR 2.47, 95% C.I 1.16-5.23), year of study (AOR 8.49, 95% C.I 5.71-12.64) and sleep duration (AOR 2.24, 95% C.I 1.23-4.06) were found to be independently associated with IBS. Conclusion: Prevalence of IBS and its associated factors in our study population was similar to findings from studies done elsewhere. Also, our study revealed a low prevalence of celiac disease among IBS participants.

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Celiac Disease in Children with Chronic Diarrhoea: A Cross-sectional Study

JOURNAL FOR CLINICAL AND DIAGNOSTIC RESEARCH ◽

10.7860/jcdr/2021/46825.14397 ◽

2021 ◽

Author(s):

YM Bhavika ◽

DG Prasanna Kumar ◽

HN Harish

Keyword(s):

Celiac Disease ◽

Tissue Transglutaminase ◽

Tertiary Care ◽

Cross Sectional Study ◽

Intestinal Biopsy ◽

Chronic Diarrhoea ◽

Sectional Study ◽

Tertiary Care Centre ◽

Serological Tests ◽

Cross Sectional

Introduction: Celiac disease is a chronic gastrointestinal disorder, very often underdiagnosed due to lack of awareness among the general practitioners. Aim: To study the prevalence of celiac disease among children with chronic diarrhoea. Materials and Methods: A cross-sectional study was conducted in which, 890 children between the age group of 1-18 years with history of chronic diarrhoea (loose stools or increased frequency for more than two weeks) were enrolled, between November 2015 and January 2018 in a tertiary care centre in India. The children were screened with serological tests for celiac disease and among those who were tested positive; the diagnosis was confirmed by intestinal biopsy. Results: Of the 890 patients with chronic diarrhoea, 252 (28.3%) were tested positive for anti-tissue Transglutaminase (tTG) antibodies with levels more than 10 times the upper normal limit. Among the 252 patients with positive serology, 144 patientshad intestinal biopsy findings suggestive of celiac disease (Marsh stage 3b and 3c) while the rest had normal or mild (marsh grade 1, 2 and 3a) histological changes. Conclusion: Celiac disease is one of the most important causes of chronic diarrhoea and hence should be actively looked for in children presenting with chronic diarrhoea.

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Evaluation of malnutrition status and clinical indications in children with celiac disease: a cross-sectional study

BMC Pediatrics ◽

10.1186/s12887-021-02621-3 ◽

2021 ◽

Vol 21 (1) ◽

Author(s):

Zahra Setavand ◽

Maryam Ekramzadeh ◽

Naser Honar

Keyword(s):

Celiac Disease ◽

Tissue Transglutaminase ◽

Cross Sectional Study ◽

World Health ◽

Sectional Study ◽

Anthropometric Indices ◽

Cross Sectional ◽

Clinical Indications ◽

Number Of Patients ◽

Skeletal Pain

Abstract Background Celiac Disease (CD) is an autoimmune systemic disorder triggered by gluten in genetically susceptible individuals, which can lead to chronic malabsorption. Considering the changes in the manifestations of CD, this study aimed to determine anthropometric indices and clinical indications in children with CD. Methods This cross-sectional study aimed to evaluate the children with CD who had referred to Imam Reza Celiac Clinic between 2016 and 2019. Totally, 361 children were eligible and their anti-tissue transglutaminase (TGA-IgA) level, weight, height, and Body Mass Index (BMI) were extracted from their records. The anthropometric indices were presented based on the criteria of the Center for Disease Control and Prevention (CDC) and World Health Organization (WHO). The prevalent symptoms were assessed, as well. Results Based on the CDC’s criteria, 18.3, 28.8, and 25.8% of the children had short stature, low body weight, and low BMI, respectively. These measures were obtained as 10, 22.4, and 13.9% according to the WHO’s categorization respectively. Furthermore, the most common symptoms among the children were abdominal pain (56.5%), skeletal pain (28%), constipation (27.4%), and anemia (23.8%). Conclusion To sum up, the results clearly indicated that growth failure and low height, weight, and BMI were prevalent among the children with CD. Moreover, in addition to gastrointestinal symptoms, a considerable number of patients had skeletal pain and anemia.

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Prevalence of COVID-19 in Italian Children With Celiac Disease: A Cross-Sectional Study

Clinical Gastroenterology and Hepatology ◽

10.1016/j.cgh.2020.11.035 ◽

2020 ◽

Author(s):

Elena Lionetti ◽

Andrea Fabbrizi ◽

Carlo Catassi

Keyword(s):

Celiac Disease ◽

Cross Sectional Study ◽

Sectional Study ◽

Cross Sectional ◽

Italian Children

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Psychosocial impairment in children with Celiac disease.

The Professional Medical Journal ◽

10.29309/tpmj/2021.28.10.6142 ◽

2021 ◽

Vol 28 (10) ◽

pp. 1484-1488

Author(s):

Erum Afzal ◽

Aslam Sheikh ◽

Ghazi Khan Khosa ◽

Komal Noor

Keyword(s):

Celiac Disease ◽

Tissue Transglutaminase ◽

Cross Sectional Study ◽

Depressive Illness ◽

Outcome Variable ◽

Cross Sectional ◽

Psychosocial Impairment ◽

Asking Questions ◽

Male Patients ◽

Disease Study

Objective: To determine the frequency of psychosocial impairment in patients with celiac disease. Study Design: Descriptive Cross Sectional study. Setting: Children Hospital Complex and Institute of Child Health, (CHICH) Multan. Period: August 2019 to August 2020. Material & Methods: A total number of 177 patients having age 4-16 years with diagnosis of CD were included in this study. In children with CD depressive illness were assessed by using Pediatric symptoms checklist (PSC) form and this PSC form was filled by asking questions from parents then filling of form by doctor. Outcome variable was calculated on the basis of Pediatric symptoms checklist (PSC), whether patient has psychosocial illness or not. Results: Mean age of patients was 8.91±3.50 years. Mean duration of celiac disease of patients was 4.27±2.00 months. There were 135 (76.27%) female patients and 42 (23.73%) male patients. Mean serum anti-tissue transglutaminase IgA (tTG-IgA) level of patients was 122.73±24.31 µg/ml. The socioeconomic status of 115 (64.97%) patients was poor, 31 (17.51%) was middle, 18 (10.17%) patient was upper middle and 13 (7.34%) patients was high. Psychosocial illness was present in 35 (19.77%) patients. Conclusion: Psychosocial illness was diagnosed in 19.77% children having CD. So the children with celiac disease should be monitored for symptoms of anxiety and depression and a thorough counselling of the children to reduce the risk of psychosocial illness.

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Evaluation of anti-COVID-19 measures taken by the parents of children with celiac disease: a cross-sectional study

Sao Paulo Medical Journal ◽

10.1590/1516-3180.2020.0644.10122020 ◽

2021 ◽

Author(s):

Ayşegül Bükülmez ◽

Melike Taşdelen Baş ◽

Esra Çiftci

Keyword(s):

Celiac Disease ◽

Cross Sectional Study ◽

Sectional Study ◽

Cross Sectional

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Prevalence of Celiac Disease in Omani Children with Type 1 Diabetes Mellitus: A Cross Sectional Study

Oman Medical Journal ◽

10.5001/omj.2013.73 ◽

2013 ◽

Vol 28 (4) ◽

pp. 260-263 ◽

Cited By ~ 4

Author(s):

Siham Al-Sinani ◽

Sharef Waadallah Sharef ◽

Saif Al-Yaarubi ◽

Ibrahim Al-Zakwani ◽

Khalid Al-Naamani ◽

...

Keyword(s):

Diabetes Mellitus ◽

Type 1 Diabetes ◽

Celiac Disease ◽

Type 1 Diabetes Mellitus ◽

Cross Sectional Study ◽

Sectional Study ◽

Cross Sectional

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The Prevalence of Celiac Disease-Specific Auto-Antibodies in Type 1 Diabetes in a Moroccan Population

International Journal of Endocrinology ◽

10.1155/2019/7895207 ◽

2019 ◽

Vol 2019 ◽

pp. 1-9

Author(s):

Ider Oujamaa ◽

Majda Sebbani ◽

Lahcen Elmoumou ◽

Aïcha Bourrahouate ◽

Rabiy El Qadiry ◽

...

Keyword(s):

Celiac Disease ◽

Tissue Transglutaminase ◽

Iga Deficiency ◽

Cross Sectional Study ◽

Biological Data ◽

Cross Sectional ◽

Systematic Screening ◽

Lower Height ◽

Hla Dq2

Objective. We aimed to determine the prevalence of specific auto-antibodies to celiac disease (CD) in Moroccan type 1 diabetic (T1D) patients and compare the clinical and biological characteristics of seropositive and seronegative cases. Patients and Methods. A cross-sectional study was carried out on 276 T1D patients including 109 adults and 167 pediatric cases. The screening for CD was performed by an Elisa IgA anti-tissue transglutaminase antibody (tTGA) testing, combined with IgA quantification by nephelometry. Positive-IgA-tTGA cases were secondly tested for anti-endomysial antibodies (EMA) using an immunofluorescence technique, and the IgA deficiency cases were screened for IgG-tTGA. Patients with low positive tTGA titers underwent HLA-DQ2/DQ8 typing. Sociodemographic and clinical data of the patients were collected using a hetero-administered questionnaire. The comparison of clinical and biological data between seropositive and seronegative diabetics was done using independent T, Mann–Whitney U, chi-squared, and Fisher tests, which were considered significant if p value <0.05. Results. The prevalence of CD-specific auto-antibodies was estimated to be 9.1% (IC = 95%), with 25 positive cases in tTGA and EMA testing. Eight cases displayed low titers of IgA-tTGA, among which 4 were positive for HLA-DQ2, 1 for HLA-DQ8, and 1 for both DQ2 and DQ8. The other 2 cases had a biopsy-proven CD. Compared to seronegative patients, seropositive cases had a higher percentage of associated autoimmune disorders (16% vs. 2.4%, p=0.008), with a significant lower height Z-scores (median: −0.90 (−3.93 to 0.95) vs. −0.51 (−4.54 to 2.18), p=0.029) and a higher HbA1c level (median: 11.30% (7.31 to 16.00) vs. 9.30% (4.40 to17.31), p=0.022). Conclusion. The current study gave evidence of a high prevalence of CD specific auto-antibodies in T1D population. The co-existence of these two conditions was associated with a poor glycemic control, a lower height, and other autoimmune diseases. These findings may suggest the necessity of a systematic screening of CD in T1D patients.

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