The Prevalence of Celiac Disease-Specific Auto-Antibodies in Type 1 Diabetes in a Moroccan Population

Objective. We aimed to determine the prevalence of specific auto-antibodies to celiac disease (CD) in Moroccan type 1 diabetic (T1D) patients and compare the clinical and biological characteristics of seropositive and seronegative cases. Patients and Methods. A cross-sectional study was carried out on 276 T1D patients including 109 adults and 167 pediatric cases. The screening for CD was performed by an Elisa IgA anti-tissue transglutaminase antibody (tTGA) testing, combined with IgA quantification by nephelometry. Positive-IgA-tTGA cases were secondly tested for anti-endomysial antibodies (EMA) using an immunofluorescence technique, and the IgA deficiency cases were screened for IgG-tTGA. Patients with low positive tTGA titers underwent HLA-DQ2/DQ8 typing. Sociodemographic and clinical data of the patients were collected using a hetero-administered questionnaire. The comparison of clinical and biological data between seropositive and seronegative diabetics was done using independent T, Mann–Whitney U, chi-squared, and Fisher tests, which were considered significant if p value <0.05. Results. The prevalence of CD-specific auto-antibodies was estimated to be 9.1% (IC = 95%), with 25 positive cases in tTGA and EMA testing. Eight cases displayed low titers of IgA-tTGA, among which 4 were positive for HLA-DQ2, 1 for HLA-DQ8, and 1 for both DQ2 and DQ8. The other 2 cases had a biopsy-proven CD. Compared to seronegative patients, seropositive cases had a higher percentage of associated autoimmune disorders (16% vs. 2.4%, p=0.008), with a significant lower height Z-scores (median: −0.90 (−3.93 to 0.95) vs. −0.51 (−4.54 to 2.18), p=0.029) and a higher HbA1c level (median: 11.30% (7.31 to 16.00) vs. 9.30% (4.40 to17.31), p=0.022). Conclusion. The current study gave evidence of a high prevalence of CD specific auto-antibodies in T1D population. The co-existence of these two conditions was associated with a poor glycemic control, a lower height, and other autoimmune diseases. These findings may suggest the necessity of a systematic screening of CD in T1D patients.

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Psychosocial impairment in children with Celiac disease.

The Professional Medical Journal ◽

10.29309/tpmj/2021.28.10.6142 ◽

2021 ◽

Vol 28 (10) ◽

pp. 1484-1488

Author(s):

Erum Afzal ◽

Aslam Sheikh ◽

Ghazi Khan Khosa ◽

Komal Noor

Keyword(s):

Celiac Disease ◽

Tissue Transglutaminase ◽

Cross Sectional Study ◽

Depressive Illness ◽

Outcome Variable ◽

Cross Sectional ◽

Psychosocial Impairment ◽

Asking Questions ◽

Male Patients ◽

Disease Study

Objective: To determine the frequency of psychosocial impairment in patients with celiac disease. Study Design: Descriptive Cross Sectional study. Setting: Children Hospital Complex and Institute of Child Health, (CHICH) Multan. Period: August 2019 to August 2020. Material & Methods: A total number of 177 patients having age 4-16 years with diagnosis of CD were included in this study. In children with CD depressive illness were assessed by using Pediatric symptoms checklist (PSC) form and this PSC form was filled by asking questions from parents then filling of form by doctor. Outcome variable was calculated on the basis of Pediatric symptoms checklist (PSC), whether patient has psychosocial illness or not. Results: Mean age of patients was 8.91±3.50 years. Mean duration of celiac disease of patients was 4.27±2.00 months. There were 135 (76.27%) female patients and 42 (23.73%) male patients. Mean serum anti-tissue transglutaminase IgA (tTG-IgA) level of patients was 122.73±24.31 µg/ml. The socioeconomic status of 115 (64.97%) patients was poor, 31 (17.51%) was middle, 18 (10.17%) patient was upper middle and 13 (7.34%) patients was high. Psychosocial illness was present in 35 (19.77%) patients. Conclusion: Psychosocial illness was diagnosed in 19.77% children having CD. So the children with celiac disease should be monitored for symptoms of anxiety and depression and a thorough counselling of the children to reduce the risk of psychosocial illness.

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Prevalence of Celiac Disease in Omani Children with Type 1 Diabetes Mellitus: A Cross Sectional Study

Oman Medical Journal ◽

10.5001/omj.2013.73 ◽

2013 ◽

Vol 28 (4) ◽

pp. 260-263 ◽

Cited By ~ 4

Author(s):

Siham Al-Sinani ◽

Sharef Waadallah Sharef ◽

Saif Al-Yaarubi ◽

Ibrahim Al-Zakwani ◽

Khalid Al-Naamani ◽

...

Keyword(s):

Diabetes Mellitus ◽

Type 1 Diabetes ◽

Celiac Disease ◽

Type 1 Diabetes Mellitus ◽

Cross Sectional Study ◽

Sectional Study ◽

Cross Sectional

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Sero prevalence of anti-tissue transglutaminase in patients having sign symptoms of celiac disease: A cross sectional study from Peshawar, Pakistan

Pure and Applied Biology ◽

10.19045/bspab.2021.100029 ◽

2021 ◽

Vol 10 (1) ◽

Author(s):

Shehryar Ahmad

Keyword(s):

Celiac Disease ◽

Tissue Transglutaminase ◽

Cross Sectional Study ◽

Sectional Study ◽

Cross Sectional

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The Association between Treatment Modality, Lipid Profile, Metabolic Control in Children with Type 1 Diabetes and Celiac Disease—Data from the International Sweet Registry

Nutrients ◽

10.3390/nu13124473 ◽

2021 ◽

Vol 13 (12) ◽

pp. 4473

Author(s):

Monica Marino ◽

Alexander J. Eckert ◽

Shoshana Tell ◽

Nevena Krnic ◽

Grazyna Deja ◽

...

Keyword(s):

Type 1 Diabetes ◽

Celiac Disease ◽

Lipid Profile ◽

Metabolic Control ◽

Treatment Modality ◽

Cross Sectional Study ◽

Overweight And Obesity ◽

Diabetes Duration ◽

Cross Sectional

Background and Aims: A higher frequency of dyslipidemia is reported in children with type 1 diabetes (T1D) and celiac disease (CD). Recently, continuous subcutaneous insulin infusion (CSII) has been associated with better lipid profiles in patients with T1D. The aim of this study was to investigate the association between treatment modality and lipid profile, metabolic control, and body mass index (BMI)-SDS in children with both T1D and CD. Methods: Cross-sectional study in children registered in the international SWEET database in November 2020. Inclusion criteria were children (2–18 years) with T1D and CD with available data on treatment modality (CSII and injections therapy, IT), triglyceride, total cholesterol, HDL, LDL, dyslipidemia, HbA1c, and BMI-SDS. Overweight/obesity was defined as > +1 BMI-SDS for age. Data were analyzed by linear and logistical regression models with adjustment for age, gender, and diabetes duration. Results: In total 1009 children with T1D and CD (female 54%, CSII 54%, age 13.9 years ±3.6, diabetes duration 7.2 years ±4.1, HbA1c 7.9% ±1.4) were included. Significant differences between children treated with CSII vs. IT were respectively found; HDL 60.0 mg/dL vs. 57.8 mg/dL, LDL 89.4 mg/dL vs. 94.2 mg/dL, HbA1c 7.7 vs. 8.1%, BMI-SDS 0.4 vs. 0.6, overweight and obesity 17% vs. 26% (all p < 0.05). Conclusions: CSII is associated with higher HDL and lower LDL, HbA1c, BMI-SDS, and percentage of overweight and obesity compared with IT in this study. Further prospective studies are required to determine whether CSII improves lipid profile, metabolic control and normalize body weight in children with both T1D and CD.

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Prevalence Of Irritable Bowel Syndrome, Celiac Disease And Their Manifestations Among Muhimbili University Of Health And Allied Sciences Staff And Students: A Cross Sectional Study

10.21203/rs.3.rs-19611/v1 ◽

2020 ◽

Author(s):

Adam Miraj Gembe

Keyword(s):

Health Care ◽

Irritable Bowel Syndrome ◽

Celiac Disease ◽

Medical Students ◽

Health Care Professionals ◽

Tissue Transglutaminase ◽

Cross Sectional Study ◽

Sectional Study ◽

Cross Sectional ◽

Irritable Bowel

Abstract Background: Global prevalence of irritable bowel syndrome is high among medical students and health care professionals with significant morbidity. Similarly, the prevalence of celiac disease in irritable bowel syndrome is higher than the general population. These conditions impair quality of life and contribute to social-economic burden. In Tanzania, little is known about irritable bowel syndrome and celiac disease among medical students and health care professionals. Methods: A cross sectional study was conducted to MUHAS and Mloganzila Academic Medical Center (MAMC) staff and students who fulfilled the online shared Rome IV criteria of irritable bowel syndrome from August to November 2018. A structured questionnaire was used to collect socio-demographic data, anthropometric measurements and clinical manifestations. Blood samples for full blood picture, liver enzymes and Erythrocyte Sedimentation Rate were taken. Celiac disease was tested using anti-tissue transglutaminase antibody test. Qualitative and quantitative data were summarized using frequency distribution tables. Chi-square and fishers exact test were used to study comparison between groups. Logistic regression was used to study associations. Data was analyzed using SPSS version 20.0 and a P value of ≤0.05 was considered significant.Results: Out of 1,321 participants, 192 (14.5%) had irritable bowel syndrome in which 77 (40.1%) were males and 115 (59.9%) were females. Among the 192 participants with irritable bowel syndrome, 3 (1.6%) were positive for celiac disease, 2 (66.7%) were females and 1 (33.3%) was a male. Of the 3 patients with CD, 2 had elevated ALAT and 1 had anaemia. Age (AOR 2.53, 95% C.I 1.57-4.09), sex (AOR 1.67, 95% C.I 1.16-2.41), marital status (AOR 4.95 C.I 2.07-11.82), alcohol intake (AOR 2.47, 95% C.I 1.16-5.23), year of study (AOR 8.49, 95% C.I 5.71-12.64) and sleep duration (AOR 2.24, 95% C.I 1.23-4.06) were found to be independently associated with IBS. Conclusion: Prevalence of IBS and its associated factors in our study population was similar to findings from studies done elsewhere. Also, our study revealed a low prevalence of celiac disease among IBS participants.

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Short stature as a significant marker in celiac disease

International Journal of Contemporary Pediatrics ◽

10.18203/2349-3291.ijcp20193153 ◽

2019 ◽

Vol 6 (5) ◽

pp. 1855

Author(s):

Jasraj Bohra ◽

Virendra K. Gupta ◽

Ashok Gupta

Keyword(s):

Celiac Disease ◽

Short Stature ◽

Tissue Transglutaminase ◽

Gastrointestinal Symptoms ◽

Cross Sectional Study ◽

Anthropometric Measurement ◽

Clinical Feature ◽

Serum Samples ◽

Cross Sectional ◽

The Difference

Background: Celiac disease (CD) is a genetically determined gluten-sensitive enteropathy resulting in nutrient malabsorption, can have extra gastrointestinal tract (GIT) presentations, short stature may be the only presenting clinical feature, even in the absence of gastrointestinal symptoms. The aim and objective of this study was toMethods: This cross-sectional study was performed on 1000 children between ages 5 to 10 year of different schools, in Jaipur, district of Rajasthan. An anthropometric measurement (height, weight) was done for all children. Serum samples were analyze for IgA antibodies to human tissue transglutaminase (tTG) with lower detection limit of 1.0 U/ml and 15 U/ml. Positive samples for tTG antibodies were reanalyzed human endomysial autoantigens (EmA).Results: Out 1000 children screened, six were seropositive, of those four were females and two were males. The serological proportion of CD in this population was 1:166. These Six seropositive group tends to have lower height, weight than the seronegative group, but the difference was only significant for height (P=<0.01).Conclusions: Although gastrointestinal manifestations are important presentation of celiac disease, nevertheless short stature alone or in combination with other symptoms of celiac disease has been present.

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Examination of preterm babies for ROP referred to an eye department from an urban and semi-urban neonatal intensive care unit: implications for practice.

10.21203/rs.2.9416/v2 ◽

2019 ◽

Author(s):

Ramesh Venkatesh ◽

Prachi Abhishek Dave ◽

Prachi Gurav ◽

Manisha Agarwal ◽

Mamta Jajoo ◽

...

Keyword(s):

Neonatal Intensive Care ◽

Cross Sectional Study ◽

Urban Setting ◽

North India ◽

Cross Sectional ◽

Systematic Screening ◽

Factors Affecting ◽

Preterm Babies ◽

The Mean

Abstract Background: To study and analyse the factors affecting the proportion of retinopathy of prematurity (ROP) distribution between the urban and semi-urban regions in North India. Methods: Retrospective, observational, cross-sectional study. All babies referred for ROP examination by paediatricians or other general ophthalmologists between 2013 – 2016 were included in the study. Demographic, clinical and treatment related findings were recorded. Results: Five hundred and fifty-eight (467: urban & 91: semi urban) babies were examined for ROP. The mean birth weight in the urban and semi-urban setting was 1348.6 ± 395.21 gm and 1703.77 ± 401.76 gm respectively. The mean gestational age was 30.99 ± 2.93 weeks and 30.73 ± 2.08 weeks in the urban and semi-urban cohorts respectively. The average time for first ophthalmic examination following birth was 23.82 ± 13.69 (range: 3-77) days in the urban and 101.16 ± 238.26 (range: 13- 330) days in the semi-urban setting. 94% of the babies completed all screening examination visits. Any ROP was identified in 11.6% and 33.0% of the urban and semi-urban cohorts respectively; Type 1 was detected in 7.5% of urban babies and 23.1% of semi-urban babies Conclusion: Differences in the proportion of babies developing any ROP and Type 1 ROP between the semi-urban and urban groups is likely due to selection bias, as a high proportion of semi-urban babies did not attend for examination or failed to complete all the examinations necessary. This was particularly true for females. More needs to be done to increase access to regular, systematic screening of preterm babies within neonatal units.

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