A Randomized, Blinded, Placebo-Controlled Study Of BVP-01, A Proprietary Nutraceutical Formulation For The Treatment Of Canine Osteoarthritis

ABSTRACT The objective of this study was to provide preliminary data describing the safety and effect of cannabidiol (CBD) for symptom relief of canine osteoarthritis-associated pain in a clinical setting using objective outcome measures. Twenty-three client-owned dogs with naturally occurring osteoarthritis of appendicular joints completed this prospective, double-blinded, crossover, placebo-controlled study. Baseline data were acquired for 4 wk, followed by random allocation to either placebo or CBD treatment for 6 wk, followed by 6 wk with the opposite treatment. Outcome measures included objective gait analysis, activity counts (via accelerometry) and clinical metrology instruments. There were no differences noted between groups at any time point for any of the recorded outcome measures. Adverse events associated with CBD administration included elevation in liver enzymes (n = 14) and vomiting (n = 2).

Download Full-text

A randomized, double-blind, placebo-controlled study of daily cannabidiol for the treatment of canine osteoarthritis pain

Pain ◽

10.1097/j.pain.0000000000001896 ◽

2020 ◽

Vol 161 (9) ◽

pp. 2191-2202 ◽

Cited By ~ 4

Author(s):

Chris D. Verrico ◽

Shonda Wesson ◽

Vanaja Konduri ◽

Colby J. Hofferek ◽

Jonathan Vazquez-Perez ◽

...

Keyword(s):

Controlled Study ◽

Double Blind ◽

Double Blind Placebo ◽

Osteoarthritis Pain ◽

Canine Osteoarthritis

Download Full-text

Double-Blinded, Placebo Controlled Study Evaluating the Safety and Efficacy of Intravenous Allogeneic Adipose Stromal Cell Therapy for Canine Osteoarthritis

Veterinary and Comparative Orthopaedics and Traumatology ◽

10.1055/s-0038-1668221 ◽

2018 ◽

Vol 31 (S 02) ◽

pp. A1-A25

Author(s):

Kristina Kiefer ◽

Phillip Allen ◽

Michael Conzemius

Keyword(s):

Cell Therapy ◽

Stromal Cell ◽

Controlled Study ◽

Safety And Efficacy ◽

Double Blinded ◽

Adipose Stromal Cell ◽

Canine Osteoarthritis

Download Full-text

Application of a Simple Cold Stub to the Direct Observation of Frozen Hydrated Sand

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s0424820100071508 ◽

1973 ◽

Vol 31 ◽

pp. 212-213

Author(s):

John M. Wehrung ◽

Richard J. Harniman

Keyword(s):

United States ◽

Surface Water ◽

Direct Observation ◽

Controlled Study ◽

Clay Particles ◽

Organic Debris ◽

Rock Formations ◽

Water Tables ◽

Permeable Rock ◽

Natural Means

Water tables in aquifer regions of the southwest United States are dropping off at a rate which is greater than can be replaced by natural means. It is estimated that by 1985 wells will run dry in this region unless adequate artificial recharging can be accomplished. Recharging with surface water is limited by the plugging of permeable rock formations underground by clay particles and organic debris.A controlled study was initiated in which sand grains were used as the rock formation and water with known clay concentrations as the recharge media. The plugging mechanism was investigated by direct observation in the SEM of frozen hydrated sand samples from selected depths.

Download Full-text

Studies on Ultrastructure and Cytochemistry of Right Ventricular Endomyocardial Biopsy

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s0424820100158820 ◽

1990 ◽

Vol 48 (3) ◽

pp. 256-257

Author(s):

Xia Mingyu ◽

Ma Wengshu ◽

Wu Xiangh ◽

Chen Dong

Keyword(s):

Light Microscopy ◽

Right Ventricular ◽

Dilated Cardiomyopathy ◽

Endomyocardial Biopsy ◽

Heart Diseases ◽

Ultrastructural Localization ◽

Controlled Study ◽

Myocardial Biopsy ◽

Morphological Assessment ◽

Rheumatic Heart

This paper describes morphological and cytochemistry changes of endomyocardial biopsy in 94 patients. The samples of myoicardium were taken from 32 patients with dilated cardiomyopathy, and sdudied with light and electron microscop. The cytochemical studies in some of these patients were performed at histological and ultrastructure level. This paper also reported the result of myocardial biopsy in 33 patients with serious dysrythmia.The result of this controlled study indicates that morphological assessment in both cardiomyopathy and congenital or rheumatic heart diseases showed no special changes. In patients of dilated cardiomyopathy, the decreased activity of myosin ATPase was secondary to cardial failure. The change of succinate dehydrogenase (SDHase) was not significant with light microscopy. But ultrastructural localization of SDHase activity is valuable. Its activity was found to be localized in endomembrane and ridge of the mitochondria, the activity of this enzyme was decrease, normal, or increase. SDHase activity was more intense in cardial myocytes well-functioning, or ultrastructurally well preserved hearts.

Download Full-text

Morphometric analysis of peroxisomes in hepatocytes of alcohol-fed rats

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s0424820100157486 ◽

1989 ◽

Vol 47 ◽

pp. 1100-1101

Author(s):

D.C. Dominguez ◽

J.T. Ellzey

Keyword(s):

Caloric Intake ◽

Volume Density ◽

Controlled Study ◽

Control Group ◽

Numerical Density ◽

Cacodylate Buffer ◽

Paired Control ◽

Experimental Group ◽

Liver Peroxisomes ◽

Single Lesion

Peroxisomes which participate in 1ipid metabolism have been shown to be altered in several metabolic disorders and toxic conditions. In alcoholic liver disease, the single lesion most frequently found is lipid accumu1ation in hepatocytes. However, the mechanisms for this 1ipid accumu1ation are not clear. The occurrence of modifications of liver peroxisomes due to excess alcohol consumption has not been subjected to a controlled study. We utilized a combination of cytochemica1 and morphometrictechniques to study the size and number of liver peroxisomes in rats fed an alcohol-supplemented diet compared to those of matched-paired control animals.Male Sprague-Daw1ey rats (400-500 g) received a liquid diet. The experimental group (N = 5/group) was fed a diet containing 30% ethanol-derived calories (EDC) and the control group was fed an isocaloric diet to 30% EDC. A pair feeding procedure was employed to control for caloric intake. Small pieces of liver randomly selected, were fixed in 2.3% -glutaraldehyde in 0.1 M sodium cacodylate buffer, pH 7.2, incubated in a DAB medium and postfixed with. 2% aqueous osmium tetroxide. EM photographs were taken from sections of 3 tissue blocks from each sample (7,200X) with a Zeiss EM10-A (60 kV). With the use of a point counting method and a digital planimeter the volume density (Vv) and numerical density (Nv) were determined.

Download Full-text