Pandu is a Pitta Pradhana Tridoshaja Vyadhi producing Pandutva or Pandu Varna in Mukha, Nayana, Asya and Mutra. Alpa Rakthata, Vaivarnaya, Agni Mandhya, Ojokshaya and Balahani are other symptoms. It affects people of all ages irrespective of sex. Haritaki Churna and Amalaki Churna are having Deepana, Pachana, Varnya, Tridosha Shamaka, Raktha Vardhaka, Rasayana and Ojovardhaka properties which helps in Samprapti Vighatana of Pandu Roga. This study is an attempt to clinically analyze the independent effect of Haritaki Churna and Amalaki Churna in Pandu Roga.This study is a single blind comparative clinical study conducted on 60 subjects divided randomly in two groups. They were reviewed at an interval of 15 days for 1 month. Haritaki Churna was given at a dose of 1.5g. twice a day with Madhu before food. Amalaki Churna was given at a dose of 1.5g. twice a day with Madhu before food. The Patients were assessed with severity of symptoms subjectively and objectively before and after treatment. Data from each group were statistically analyzed and compared. Both the group showed marked results but Amalaki Churna is slightly significant then the Haritaki Churna in the management of Pandu (IDA). The study shows that both Haritaki Churna and Amalaki Churna are effective in relieving the symptoms of Pandu Roga. Haritaki Churna was effective in subjective parameter like Pandutva, Arohanayasa, Shrama, Aruchi, Bhrama, Daurbalya, Hairfall, Bodyache, Glossitis, Hb%, RBC, and Sr.Ferritin. Amalaki Churna was effective in conditions like Pandutva, Arohanayasa, Aruchi, Shrama, Karna Ksweda, Daurbalya, Hairfall, Bodyache, Hb% PCV, Sr.Iron and TIBC.