Avaliação da função glomerular renal e ventilação pulmonar em coelhos submetidos ao pneumoperitôneo com di´óxido de carbono

Embora seja usual a realização de cirurgias vídeo-laparoscópicas, a ocorrência de lesões renais decorrentes destes procedimentos ainda não foi precisamente documentada na literatura médica. Todavia, é sabido que a elevação da pressão intra-abdominal por meio do pneumoperitônio cirúrgico pode ocasionar oligúria ou anúria em mamíferos. O objetivo deste trabalho é avaliar o impacto do pneumoperitônio na função glomerular renal, ventilação pulmonar e estresse oxidativo em um modelo experimental de coelhos machos, através da perfusão renal com 99mTc-DTPA (diethylene triamine pentaacetic acid, marcado com tecnécio), análise de volumes e gases respiratórios, bem como o status inflamatório e estresse oxidativo resultantes, através de marcadores específicos. Serão utilizados cinco coelhos machos Nova Zelândia saudáveis, previamente anestesiados e ventilados mecanicamente.

Measurement of the ratio of glomerular filtration rate to plasma volume from the technetium-99m diethylene triamine pentaacetic acid renogram: comparison with glomerular filtration rate in relation to extracellular fluid volume

European Journal of Nuclear Medicine ◽

10.1007/bf00176571 ◽

1994 ◽

Vol 21 (4) ◽

Author(s):

A.Michael Peters ◽

Helen Allison ◽

W.Yu. Ussov

Keyword(s):

Glomerular Filtration Rate ◽

Glomerular Filtration ◽

Plasma Volume ◽

Filtration Rate ◽

Extracellular Fluid ◽

Fluid Volume ◽

Extracellular Fluid Volume ◽

Technetium 99M ◽

Diethylene Triamine ◽

Exploitation of the size-exclusion effect of reversed-phase high performance liquid chromatography for the direct analysis of diethylene triamine pentaacetic acid in therapeutic monoclonal antibody formulations

Journal of Chromatography A ◽

10.1016/j.chroma.2016.05.087 ◽

2016 ◽

Vol 1455 ◽

pp. 140-146 ◽

Cited By ~ 2

Author(s):

Jason Z. Huang ◽

Karen Liao ◽

George Wang ◽

Thomas Haby ◽

Mark S. Bolgar

Keyword(s):

Monoclonal Antibody ◽

High Performance ◽

Direct Analysis ◽

Reversed Phase ◽

Size Exclusion ◽

Therapeutic Monoclonal Antibody ◽

Diethylene Triamine ◽

Size Exclusion Effect ◽

Exclusion Effect

Decorated Superparamagnetic Iron Oxide Nanoparticles with Monoclonal Antibody and Diethylene-Triamine-Pentaacetic Acid Labeled with Thechnetium-99m and Galium-68 for Breast Cancer Imaging

Pharmaceutical Research ◽

10.1007/s11095-017-2320-2 ◽

2018 ◽

Vol 35 (1) ◽

Cited By ~ 15

Author(s):

Marta de Souza Albernaz ◽

Sergio Hiroshi Toma ◽

Jeff Clanton ◽

Koiti Araki ◽

Ralph Santos-Oliveira

Keyword(s):

Breast Cancer ◽

Monoclonal Antibody ◽

Iron Oxide ◽

Iron Oxide Nanoparticles ◽

Superparamagnetic Iron Oxide ◽

Superparamagnetic Iron Oxide Nanoparticles ◽

Oxide Nanoparticles ◽

Breast Cancer Imaging ◽

Diethylene Triamine ◽

Relatively Selective Beta Irradiation of Lymphatic Structures in the Dog Using Y90-DTPA

Blood ◽

10.1182/blood.v23.3.321.321 ◽

1964 ◽

Vol 23 (3) ◽

pp. 321-336 ◽

Cited By ~ 3

Author(s):

H. S. WINCHELL ◽

MYRON POLLYCOVE ◽

A. C. ANDERSEN ◽

J. H. LAWRENCE

Keyword(s):

Clinical Course ◽

Severe Depression ◽

Large Mammals ◽

Diethylene Triamine ◽

Rejection Response ◽

Sublethal Doses ◽

Selective Irradiation ◽

Homologous Tissue ◽

Blood Elements

Abstract In an attempt to provide relatively selective irradiation of tissues responsible for the homograft rejection response and to minimize exposure of other radiosensitive tissues, we developed a technic using internally administered Yttrium-90 chelated with DTPA (diethylene triamine-pentaacetic acid). Dogs given sublethal doses of Y90-DTPA radiation had a benign clinical course, the only remarkable finding being a selective lymphopenia without depression of granulocytes, platelets, or reticulocytes. Dogs lethally irradiated with Y90-DTPA showed depression of all formed blood elements, and severe depression of lymphocytes was most prominent. As the homograft rejection response appears to be a function of lymphatic tissues, the results obtained suggest the use of this procedure to prepare large mammals for homologous tissue transplantation.

Concentration of Gadolinium-Diethylene Triamine Pentaacetic Acid in Human Kidney. Study on Proper Time for Dynamic Magnetic Resonance Imaging of the Human Kidney on Low and High Magnetic Fields.

The Tohoku Journal of Experimental Medicine ◽

10.1620/tjem.171.119 ◽

1993 ◽

Vol 171 (2) ◽

pp. 119-128 ◽

Cited By ~ 5

Author(s):

MASAYUKI TAKEDA ◽

YASUSHI KATAYAMA ◽

TOSHIKI TSUTSUI ◽

TAKESHI KOMEYAMA ◽

TAKAKI MIZUSAWA ◽

...

Keyword(s):

Magnetic Resonance Imaging ◽

Magnetic Resonance ◽

Magnetic Fields ◽

Proper Time ◽

Human Kidney ◽

Dynamic Magnetic Resonance Imaging ◽

High Magnetic Fields ◽

Resonance Imaging ◽

Diethylene Triamine ◽

Improved diagnosis of well-differentiated hepatocellular carcinoma with gadolinium ethoxybenzyl diethylene triamine pentaacetic acid-enhanced magnetic resonance imaging and Sonazoid contrast-enhanced ultrasonography

Hepatology Research ◽

10.1111/j.1872-034x.2010.00697.x ◽

2010 ◽

Vol 40 (9) ◽

pp. 930-936 ◽

Cited By ~ 26

Author(s):

Natsuko Kawada ◽

Kazuyoshi Ohkawa ◽

Sachiko Tanaka ◽

Takashi Matsunaga ◽

Hiroyuki Uehara ◽

...

Keyword(s):

Magnetic Resonance Imaging ◽

Hepatocellular Carcinoma ◽

Magnetic Resonance ◽

Resonance Imaging ◽

Diethylene Triamine ◽

Contrast Enhanced ◽

Contrast Enhanced Ultrasonography ◽

Well Differentiated

Synthesis, Characterization, Thermodynamics Stability Constant, and Relaxation Properties of Neutral Gadolinium(III) Complex With Derivatives From Diethylene Triamine Pentaacetic Acid and m-hydroxybenzoyl Hydrazine

Synthesis and Reactivity in Inorganic Metal-Organic and Nano-Metal Chemistry ◽

10.1080/15533174.2012.750669 ◽

2013 ◽

Vol 43 (7) ◽

pp. 882-885

Author(s):

Ding-Wa Zhang ◽

Yin-Qiu Liu ◽

Ya-Jun Yang ◽

Fan Zhong

Keyword(s):

Stability Constant ◽

Relaxation Properties ◽

Diethylene Triamine ◽

A comparison between estimates of glomerular filtration rate using technetium-99m-diethylene-triamine-pentaacetic acid clearance and modification of diet in renal disease equation

Saudi Journal of Medicine and Medical Sciences ◽

10.4103/1658-631x.142504 ◽

2014 ◽

Vol 2 (3) ◽

pp. 157

Author(s):

Amrah Javaid ◽

Iqbal Munir ◽

MuhammadK Nawaz ◽

MuhammadH Qazi ◽

SaghirA Jaffri

Keyword(s):

Glomerular Filtration Rate ◽

Renal Disease ◽

Glomerular Filtration ◽

Filtration Rate ◽

Technetium 99M ◽

Diethylene Triamine ◽

Acid Clearance ◽

Colocalization of Gadolinium-Diethylene Triamine Pentaacetic Acid With High-Molecular-Weight Molecules After Intracerebral Convection-Enhanced Delivery in Humans

Neurosurgery ◽

10.1227/neu.0b013e3182181ba8 ◽

2011 ◽

Vol 69 (3) ◽

pp. 668-676 ◽

Cited By ~ 51

Author(s):

John H Sampson ◽

Martin Brady ◽

Raghu Raghavan ◽

Ankit I Mehta ◽

Allan H Friedman ◽

...

Keyword(s):

Therapeutic Agents ◽

Mri Contrast Agent ◽

Therapeutic Drug ◽

Convection Enhanced Delivery ◽

Mri Contrast ◽

Additional Information ◽

Diethylene Triamine ◽

Fluid Attenuated Inversion Recovery ◽

High Degree

Abstract BACKGROUND: Convection-enhanced delivery (CED) permits site-specific therapeutic drug delivery within interstitial spaces at increased dosages through circumvention of the blood-brain barrier. CED is currently limited by suboptimal methodologies for monitoring the delivery of therapeutic agents that would permit technical optimization and enhanced therapeutic efficacy. OBJECTIVE: To determine whether a readily available small-molecule MRI contrast agent, gadolinium-diethylene triamine pentaacetic acid (Gd-DTPA), could effectively track the distribution of larger therapeutic agents. METHODS: Gd-DTPA was coinfused with the larger molecular tracer, 124I-labeled human serum albumin (124I-HSA), during CED of an EGFRvIII-specific immunotoxin as part of treatment for a patient with glioblastoma. RESULTS: Infusion of both tracers was safe in this patient. Analysis of both Gd-DTPA and 124I-HSA during and after infusion revealed a high degree of anatomical and volumetric overlap. CONCLUSION: Gd-DTPA may be able to accurately demonstrate the anatomic and volumetric distribution of large molecules used for antitumor therapy with high resolution and in combination with fluid-attenuated inversion recovery (FLAIR) imaging, and provide additional information about leaks into cerebrospinal fluid spaces and resection cavities. Similar studies should be performed in additional patients to validate our findings and help refine the methodologies we used.