scholarly journals Relatively Selective Beta Irradiation of Lymphatic Structures in the Dog Using Y90-DTPA

Blood ◽  
1964 ◽  
Vol 23 (3) ◽  
pp. 321-336 ◽  
Author(s):  
H. S. WINCHELL ◽  
MYRON POLLYCOVE ◽  
A. C. ANDERSEN ◽  
J. H. LAWRENCE
Keyword(s):  
Clinical Course ◽  
Severe Depression ◽  
Large Mammals ◽  
Diethylene Triamine ◽  
Rejection Response ◽  
Diethylene Triamine Pentaacetic Acid ◽  
Sublethal Doses ◽  
Selective Irradiation ◽  
Homologous Tissue ◽  
Blood Elements

Abstract In an attempt to provide relatively selective irradiation of tissues responsible for the homograft rejection response and to minimize exposure of other radiosensitive tissues, we developed a technic using internally administered Yttrium-90 chelated with DTPA (diethylene triamine-pentaacetic acid). Dogs given sublethal doses of Y90-DTPA radiation had a benign clinical course, the only remarkable finding being a selective lymphopenia without depression of granulocytes, platelets, or reticulocytes. Dogs lethally irradiated with Y90-DTPA showed depression of all formed blood elements, and severe depression of lymphocytes was most prominent. As the homograft rejection response appears to be a function of lymphatic tissues, the results obtained suggest the use of this procedure to prepare large mammals for homologous tissue transplantation.

scholarly journals Colocalization of Gadolinium-Diethylene Triamine Pentaacetic Acid With High-Molecular-Weight Molecules After Intracerebral Convection-Enhanced Delivery in Humans

Neurosurgery ◽  
2011 ◽  
Vol 69 (3) ◽  
pp. 668-676 ◽  
Author(s):  
John H Sampson ◽  
Martin Brady ◽  
Raghu Raghavan ◽  
Ankit I Mehta ◽  
Allan H Friedman ◽  
...  
Keyword(s):  
Therapeutic Agents ◽  
Mri Contrast Agent ◽  
Therapeutic Drug ◽  
Convection Enhanced Delivery ◽  
Mri Contrast ◽  
Additional Information ◽  
Diethylene Triamine ◽  
Fluid Attenuated Inversion Recovery ◽  
Diethylene Triamine Pentaacetic Acid ◽  
High Degree

Abstract BACKGROUND: Convection-enhanced delivery (CED) permits site-specific therapeutic drug delivery within interstitial spaces at increased dosages through circumvention of the blood-brain barrier. CED is currently limited by suboptimal methodologies for monitoring the delivery of therapeutic agents that would permit technical optimization and enhanced therapeutic efficacy. OBJECTIVE: To determine whether a readily available small-molecule MRI contrast agent, gadolinium-diethylene triamine pentaacetic acid (Gd-DTPA), could effectively track the distribution of larger therapeutic agents. METHODS: Gd-DTPA was coinfused with the larger molecular tracer, 124I-labeled human serum albumin (124I-HSA), during CED of an EGFRvIII-specific immunotoxin as part of treatment for a patient with glioblastoma. RESULTS: Infusion of both tracers was safe in this patient. Analysis of both Gd-DTPA and 124I-HSA during and after infusion revealed a high degree of anatomical and volumetric overlap. CONCLUSION: Gd-DTPA may be able to accurately demonstrate the anatomic and volumetric distribution of large molecules used for antitumor therapy with high resolution and in combination with fluid-attenuated inversion recovery (FLAIR) imaging, and provide additional information about leaks into cerebrospinal fluid spaces and resection cavities. Similar studies should be performed in additional patients to validate our findings and help refine the methodologies we used.

Possibility of Using 99mTc-Labeled Macro-Aggregates of Serum Albumin and Diethylene Triamine Pentaacetic Acid in the Assessment Lung Ventilation and Perfusion in Patients with Chronic Obstructive Pulmonary Disease and Coronary Artery Disease

2015 ◽  
Vol 1084 ◽  
pp. 430-433
Author(s):  
Nikolay G. Krivonogov ◽  
Tatjana S. Ageeva ◽  
Sergej P. Mishustin ◽  
Konstantin V. Zavadovsky ◽  
Viktor V. Saushkin ◽  
...  
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Serum Albumin ◽  
Pulmonary Disease ◽  
Chronic Obstructive ◽  
Obstructive Pulmonary Disease ◽  
Diethylene Triamine ◽  
Diethylene Triamine Pentaacetic Acid ◽  
Artery Disease

Basic scintigraphy data reflecting into lung microcirculation and ventilation were studied at 12 patients with chronic obstructive pulmonary disease (COPD) of I-II degree against the background of coronary artery disease (CAD). The bilateral increase in an apical-basal gradient of perfusion that signaled about redistribution of a pulmonary blood-groove in the top parts of lungs and development of pulmonary hypertension and also slowing-down of alveolar-capillary permeability (ACP) was revealed. The revealed violations indicate more expressed changes of pulmonary microcirculation and ventilation at patients with COPD in combination with CAD and promote timely pharmacotherapy correction of the specified combined disease. Pulmonary ventilation/perfusion scintigraphy with 99mТc-labeled macro-aggregates of serum albumin (MAA) and diethylene triamine pentaacetic acid (DTPA) acid have all necessary properties for receiving high-quality lung scan.

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