SINTESIS, KARAKTERISASI DAN UJI AKTIVITAS SENYAWA KOMPLEKS Zn(II)-KATEKIN SEBAGAI INHIBITOR ENZIM LIPASE

ABSTRACT The study aims to synthesis, characterization and activity testing of Zn(II)-catechin as lipase inhibitor activity. The complex compound from synthesis result is characterized by its maximum wavelength, functional groups, metals and ligands bonds, and it’s melting point. This complex compound tested of Zn(II)-catechin as lipase inhibitor activity to p-NPP (para-nitrofenilpalmitat) substrate. The result shows that Zn(II)-catechin could be synthesized from Zn(II) ligans and metals with ratio ligands and metals mol is 1:1, that has maximum wavelength 454 nm, which contain Zn-O bond at 354,90 and 478,35 cm-1, and melting point of Zn(II)-catechin >250 oC. Zn(II)-catechin can inhibition 60,63% from concentration 50 µg/mL with mixed inhibition Keyword : Zn(II)-catechin, lipase, mixed inhibition ABSTRAK Penelitian ini bertujuan untuk melakukan sintesis, karakterisasi dan uji aktivitas senyawa kompleks Zn(II)-katekin terhadap aktivitas inhibitor enzim lipase. Senyawa kompleks hasil sintesis dikarakterisasi panjang gelombang maksimumnya, gugus fungsi serta ikatan logam dan ligannya, serta titik lelehnya. Senyawa kompleks diuji aktivitas inhibitor enzim lipase terhadap substrat p-NPP (paranitrofenilpalmitat). Hasil penelitian menunjukkan bahwa senyawa kompleks Zn(II)-katekin dapat disintesis dari ligan katekin dan logam Zn(II) dengan perbandingan mol ligan logam 1:1, mempunyai panjang gelombang maksimum 454 nm, mengandung ikatan Zn-O pada 354,90 dan 478,35 cm-1 dan titik leleh senyawa kompleks >250 oC. Senyawa kompleks Zn(II)-katekin pada konsentrasi 50µg/mL mempunyai daya inhinbisi sebesar 60,63% terhadap enzim lipase dengan jenis inhibisi campuran. Kata kunci : Zn(II)-katekin, lipase, inhibitor campuran

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In Vitro Pancreatic Lipase Inhibitor Activity of Mangifera foetida Leaves Extract

Jurnal Biodjati ◽

10.15575/biodjati.v6i1.10646 ◽

2021 ◽

Vol 6 (1) ◽

pp. 82-92

Author(s):

Oktira Roka Aji ◽

Riris Asyhar Hudaya ◽

Diah Asta Putri

Keyword(s):

Pancreatic Lipase ◽

Inhibitor Activity ◽

Lipase Inhibitor

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Determination of the functional groups and the melting point of iraqi asphaltenes

Petroleum Science and Technology ◽

10.1080/10916466.2018.1552970 ◽

2019 ◽

Vol 37 (4) ◽

pp. 486-491

Author(s):

Huda Mahmood Al-Attar

Keyword(s):

Melting Point ◽

Functional Groups

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The effect of type and concentration of acid on the characteristics of gelatine from bones of milkfish (Chanos chanos)

Food Research ◽

10.26656/fr.2017.5(4).690 ◽

2021 ◽

Vol 5 (4) ◽

pp. 404-409

Author(s):

S. Winarti ◽

U. Sarofa ◽

M.Y.R. Prihardi

Keyword(s):

Citric Acid ◽

Melting Point ◽

Functional Groups ◽

Raw Materials ◽

Total Body Weight ◽

Gel Strength ◽

Gel Point ◽

Spectra Analysis ◽

Two Factors ◽

Ft Ir

Gelatin is derived from the hydrolysis of the animal collagen contained in the bones and skin. Milkfish bones have the potential to be used as raw materials for gelatine production because it is estimated to be 15–20% of the total body weight of the fish. The extraction of gelatine from fish bones is a solution in utilizing the waste of the fish processing industry. Hydrolysis or soaking in an acidic solution against collagen is aimed to eliminate the salt of calcium and other minerals in the cartilage. This research was conducted to determine the influence of acid types and concentration on the milkfish bones gelatine production. This study used a completely randomized factorial design with two factors. The first factor was the type of acid (citric acid, acetic acid, and a mixture of citric and acetic acids), while the second factor was the concentration of acid (5%, 9%, and 13%). The data obtained were analysed using Analysis of Variance (ANOVA) and Duncan Multiple Range Test (DMRT) Advanced test. The results showed that the type and concentration of acid affected the yield, gel strength, viscosity, melting point, and gelling point. The best treatment in this study was extraction using a 9% concentration of citric acid to produce gelatine with a yield of 10.48%, gel strength 283.1 g bloom, viscosity 4.35 cP, melting point 60.1°C, gel point 16.9°C. Identification of gelatine functional groups was carried out on gelatine from the best treatment using FT-IR Spectrophotometer. From the results of FT-IR spectra analysis, it is known that the functional groups present in the sample are – OH, C-O, N-H, C-H, C-N, C=O which are the main functional groups of gelatine. This study showed that the type and concentration of acid affected the characteristics of milkfish bone gelatine

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Possibility of predicting the existence of a complex compound in the NaF-Na2SO4 system

Collection of Czechoslovak Chemical Communications ◽

10.1135/cccc19832437 ◽

1983 ◽

Vol 48 (9) ◽

pp. 2437-2445

Author(s):

Milan Malinovský ◽

Jaroslava Vrbenská

Keyword(s):

Melting Point ◽

Binary System ◽

Experimental Determination ◽

Complex Compound ◽

Thermal Dissociation ◽

Experimental Studies ◽

Eutectic Point ◽

Melting Points ◽

Binary Phase Diagrams ◽

Thermodynamic Prediction

A method of thermodynamic prediction of the existence of a complex compound in the NaF-Na2SO4 binary system is described. On the basis of the knowledge of a part of liquids drawn in the vicinity of NaF melting point and coordinates of eutectic point, the conclusion was made that there exists the complex compound Na3FSO4 in the system. Its true and hypothetic melting points and the degree of its thermal dissociation were calculated. Further, the probable coordinates of a eutectic point in the Na3FSO4-Na2SO4 subsystem were found out. The calculated results were confronted with experimental determination; the agreement is very good. The method described can be useful for experimental studies of binary phase diagrams.

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Isolasi dan Identifikasi Senyawa Metabolit Sekunder Fraksi Metanol Batang Belajang Susu (Scindapsus pictus Hassk.)

Chemica: Jurnal Ilmiah Kimia dan Pendidikan Kimia ◽

10.35580/chemica.v21i1.14841 ◽

2020 ◽

Vol 21 (1) ◽

pp. 78

Author(s):

Nurul Amaliah ◽

Pince Salempa ◽

Muharram Muharram

Keyword(s):

Melting Point ◽

Secondary Metabolite ◽

Functional Groups ◽

Ftir Spectrum ◽

Wave Number ◽

Exploratory Research ◽

Methanol Fraction ◽

Infrared Spectrophotometer ◽

Stem Extract ◽

Spectrum Data

ABSTRAK Penelitian ini adalah penelitian eksplorasi yang bertujuan untuk mengisolasi senyawa metabolit sekunder dalam fraksi metanol batang belajang susu (S. pictus Hassk). Sampel penelitian diambil dari kecamatan Mambi, kabupaten Mamasa, Sulawesi Barat. Penelitian dilakukan melalui beberapa tahap yaitu ekstraksi (maserasi), fraksinasi, pemurnian, dan identifikasi. Isolat murni yang diperoleh dengan cara rekristalisasi berupa kristal berwarna putih berbentuk serbuk dengan titik leleh 250-252oC. Identifikasi dengan spektrofotometer inframerah memberikan serapan yang khas untuk gugus fungsi OH, CH2 dan CH3 gem dimetil, C-O, serta =C-H. Berdasarkan hasil uji golongan dan data spektrum FTIR maka disimpulkan bahwa senyawa yang diperoleh adalah senyawa golongan triterpenoid. Kata kunci: Belajang Susu, S. pictus Hassk dan Triterpenoid ABSTRACT This research is an exploratory research that aimed to isolating compounds of secondary metabolite methanol fraction of Belajang Susu (Scindapsus pictus Hassk) stem extract. The sample of this research is taken from Mambi sub-district, Mamasa district, West Sulawesi. The research was done through several stages: extraction (maceration), fractionation, purification and identification. The pure isolates obtained by recrystallization in form of the white crystals, powder crystals with melting point 250-252oC. Identification with an infrared spectrophotometer giving wave number of functional groups OH, CH2 and CH3 gem dimetyl, C-O, and =C-H. Based on the results of the group test and FTIR spectrum data it was concluded that the compounds obtained were triterpenoid group compounds. Keywords: Belajang Susu, S. pictus Hassk, and Triterpenoid

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Voids in Irradiated Tungsten and Molybdenum

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s0424820100062865 ◽

1969 ◽

Vol 27 ◽

pp. 190-191

Author(s):

Robert C. Rau ◽

Robert L. Ladd

Keyword(s):

Melting Point ◽

Fast Neutron ◽

Neutron Irradiation ◽

Elevated Temperatures ◽

Irradiation Temperature ◽

The Body ◽

Face Centered Cubic ◽

Body Centered Cubic ◽

Cubic Metals ◽

Face Centered

Recent studies have shown the presence of voids in several face-centered cubic metals after neutron irradiation at elevated temperatures. These voids were found when the irradiation temperature was above 0.3 Tm where Tm is the absolute melting point, and were ascribed to the agglomeration of lattice vacancies resulting from fast neutron generated displacement cascades. The present paper reports the existence of similar voids in the body-centered cubic metals tungsten and molybdenum.

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The observation of nano-voids in Au thin films

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s0424820100126627 ◽

1987 ◽

Vol 45 ◽

pp. 366-367

Author(s):

William Krakow

Keyword(s):

Thin Films ◽

Melting Point ◽

Present Author ◽

Stacking Faults ◽

Damage Threshold ◽

Ionic Species ◽

Rare Gases ◽

Chain Defects ◽

Vacancy Chains ◽

Au Thin Films

It has long been known that defects such as stacking faults and voids can be quenched from various alloyed metals heated to near their melting point. Today it is common practice to irradiate samples with various ionic species of rare gases which also form voids containing solidified phases of the same atomic species, e.g. ref. 3. Equivalently, electron irradiation has been used to produce damage events, e.g. ref. 4. Generally all of the above mentioned studies have relied on diffraction contrast to observe the defects produced down to a dimension of perhaps 10 to 20Å. Also all these studies have used ions or electrons which exceeded the damage threshold for knockon events. In the case of higher resolution studies the present author has identified vacancy and interstitial type chain defects in ion irradiated Si and was able to identify both di-interstitial and di-vacancy chains running through the foil.

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