scholarly journals THE INTERLEUKIN-6- 174 G/C AND 572 G/C PROMOTER POLYMORPHISM ASSOCIATED WITH HIGH RISK OF ORAL PRE CANCER AND CANCER IN NORTH INDIAN POPULATION

2016 ◽  
Vol 8 ◽  
pp. 13-24
Author(s):  
Shalini Gupta ◽  
Kumud Nigam ◽  
M.L.B. Bhatt ◽  
Abbas Ali Mahdi
Keyword(s):  
High Risk ◽  
Interleukin 6 ◽  
Indian Population ◽  
Promoter Polymorphism ◽  
North Indian Population

Association between −174 G/C Promoter Polymorphism of the Interleukin-6 Gene and Progression of Prostate Cancer in North Indian Population

2008 ◽  
Vol 27 (9) ◽  
pp. 505-510 ◽  
Author(s):  
Pravin Kesarwani ◽  
Dinesh Kumar Ahirwar ◽  
Anil Mandhani ◽  
Rama Devi Mittal
Keyword(s):  
Prostate Cancer ◽  
Interleukin 6 ◽  
Indian Population ◽  
Promoter Polymorphism ◽  
North Indian Population

High risk association of IL-4 VNTR polymorphism with asthma in a North Indian population

Cytokine ◽  
2014 ◽  
Vol 66 (1) ◽  
pp. 87-94 ◽  
Author(s):  
Niti Birbian ◽  
Jagtar Singh ◽  
Surinder Kumar Jindal ◽  
Ranbir Chander Sobti
Keyword(s):  
High Risk ◽  
Indian Population ◽  
North Indian Population ◽  
Vntr Polymorphism ◽  
Risk Association

scholarly journals No Association ofPTGDR−441C/TPolymorphism with Asthma in a North Indian Population

2011 ◽  
Vol 31 (6) ◽  
pp. 353-359 ◽  
Author(s):  
Niti Birbian ◽  
Jagtar Singh ◽  
Surinder Kumar Jindal ◽  
Amit Joshi ◽  
Navneet Batra
Keyword(s):  
Indian Population ◽  
D2 Receptor ◽  
Promoter Polymorphism ◽  
North India ◽  
Amplification Refractory Mutation System ◽  
Prostaglandin D2 ◽  
North Indian Population ◽  
Mutation System ◽  
Prevalent Disease

Background:Asthma is the most prevalent disease in India according to the national survey conducted by NFHS 2 in 1998–399. Prostaglandin D2 (PGD2) is a bronchoconstriction inducing metabolite of arachidonic acid in the mast cells, which is produced on exposure to allergens and acts as a ligand for the Prostaglandin D2 Receptor (PTGDR). Polymorphisms in thePTGDRgene have been suggested to be involved in the mechanism of asthma.Objective:This is the first study conducted in India, investigating the role ofPTGDR−441C/Tpromoter polymorphism in asthma pathogenesis.Methods:A case-control study was performed with a total of 992 subjects, including 410 adult asthmatics and 582 healthy controls from regions of North India. ThePTGDR−441C/Tpolymorphism was genotyped by Tetra-Primer Amplification Refractory Mutation System Polymerase Chain Reaction (Tetra-Primer ARMS PCR).Results:Statistical analysis of the results between asthma cases and controls for thePTGDR−441C/Tpolymorphism showed Chi2(χ2) = 0.29, OR = 0.95, 95% CI (0.70–1.15) andp= 0.599. Neither the genotypic nor the allelic frequencies observed for thePTGDR−441C/Tpolymorphism, were significantly associated with asthma or asthma phenotypes.Conclusions:ThePTGDR−441C/Tpolymorphism is not associated with asthma or its phenotypes in the studied North Indian population.

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