scholarly journals Highly Protective Association of MMP-2-1306C/T Promoter Polymorphism With Asthma in a North Indian Population: A Pilot Study

2014 ◽  
Vol 6 (3) ◽  
pp. 234 ◽  
Author(s):  
Niti Birbian ◽  
Jagtar Singh ◽  
Surinder Kumar Jindal
2021 ◽  
Vol 12 (1) ◽  
pp. 13
Author(s):  
Swati Kapoor ◽  
AjitKumar Jaiswal ◽  
Girish Chaudhary ◽  
Abhimanyu Kochhar ◽  
JasmeetKaur Ryait ◽  
...  

2012 ◽  
Vol 42 (5) ◽  
pp. 151 ◽  
Author(s):  
Anika Daing ◽  
Sarvendra Vikram Singh ◽  
Charanjeet Singh Saimbi ◽  
Mohammad Akhlaq Khan ◽  
Srikanta Kumar Rath

2011 ◽  
Vol 72 (5) ◽  
pp. 436-439 ◽  
Author(s):  
Deepika Sharma ◽  
Archana Singh ◽  
Shubha Sagar Trivedi ◽  
Jayashree Bhattacharjee

Maturitas ◽  
2009 ◽  
Vol 62 (2) ◽  
pp. 166-170 ◽  
Author(s):  
Sangeeta Salhotra ◽  
Sarika Arora ◽  
Anubhuti ◽  
Sagar S. Trivedi ◽  
Jayashree Bhattacharjee

Lung ◽  
2014 ◽  
Vol 193 (1) ◽  
pp. 31-38 ◽  
Author(s):  
Shweta Sinha ◽  
Jagtar Singh ◽  
Surinder Kumar Jindal

2011 ◽  
Vol 31 (6) ◽  
pp. 353-359 ◽  
Author(s):  
Niti Birbian ◽  
Jagtar Singh ◽  
Surinder Kumar Jindal ◽  
Amit Joshi ◽  
Navneet Batra

Background:Asthma is the most prevalent disease in India according to the national survey conducted by NFHS 2 in 1998–399. Prostaglandin D2 (PGD2) is a bronchoconstriction inducing metabolite of arachidonic acid in the mast cells, which is produced on exposure to allergens and acts as a ligand for the Prostaglandin D2 Receptor (PTGDR). Polymorphisms in thePTGDRgene have been suggested to be involved in the mechanism of asthma.Objective:This is the first study conducted in India, investigating the role ofPTGDR−441C/Tpromoter polymorphism in asthma pathogenesis.Methods:A case-control study was performed with a total of 992 subjects, including 410 adult asthmatics and 582 healthy controls from regions of North India. ThePTGDR−441C/Tpolymorphism was genotyped by Tetra-Primer Amplification Refractory Mutation System Polymerase Chain Reaction (Tetra-Primer ARMS PCR).Results:Statistical analysis of the results between asthma cases and controls for thePTGDR−441C/Tpolymorphism showed Chi2(χ2) = 0.29, OR = 0.95, 95% CI (0.70–1.15) andp= 0.599. Neither the genotypic nor the allelic frequencies observed for thePTGDR−441C/Tpolymorphism, were significantly associated with asthma or asthma phenotypes.Conclusions:ThePTGDR−441C/Tpolymorphism is not associated with asthma or its phenotypes in the studied North Indian population.


Cytokine ◽  
2013 ◽  
Vol 61 (1) ◽  
pp. 188-193 ◽  
Author(s):  
Niti Birbian ◽  
Jagtar Singh ◽  
Surinder Kumar Jindal

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