scholarly journals Morphology of the epoophoron in women with benign ovarian tumor

2011 ◽  
Vol 10 (2) ◽  
pp. 30-32
Author(s):  
L. I. Kokh ◽  
V. M. Perelmuter ◽  
A. V. Tardaskina ◽  
T. N. Dorosh
Keyword(s):  
Ovarian Tumor ◽  
Specific Area ◽  
Ovarian Tumors ◽  
Benign Ovarian Tumor ◽  
Inner Diameter ◽  
Benign Ovarian Tumors

We studied the epoophoron in women with benign ovarian tumor using morphological methods. It was established that the structure epoophoron in women with benign ovarian tumors, there are significant differences compared with controls. This manifests itself in reducing the number of tubules, increase in their specific area, outer and inner diameter, the height of the epithelium, the presence of secretions in the lumen.

scholarly journals Metagenomic Analysis of Serum Microbe-Derived Extracellular Vesicles and Diagnostic Models to Differentiate Ovarian Cancer and Benign Ovarian Tumor

Cancers ◽  
2020 ◽  
Vol 12 (5) ◽  
pp. 1309 ◽  
Author(s):  
Se Ik Kim ◽  
Nayeon Kang ◽  
Sangseob Leem ◽  
Jinho Yang ◽  
HyunA Jo ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Extracellular Vesicles ◽  
Ovarian Tumor ◽  
Ovarian Tumors ◽  
Metagenomic Analysis ◽  
Serum Samples ◽  
Benign Ovarian Tumor ◽  
Diagnostic Models ◽  
Test Sets ◽  
Benign Ovarian Tumors

We aimed to develop a diagnostic model identifying ovarian cancer (OC) from benign ovarian tumors using metagenomic data from serum microbe-derived extracellular vesicles (EVs). We obtained serum samples from 166 patients with pathologically confirmed OC and 76 patients with benign ovarian tumors. For model construction and validation, samples were randomly divided into training and test sets in the ratio 2:1. Isolation of microbial EVs from serum samples of the patients and 16S rDNA amplicon sequencing were carried out. Metagenomic and clinicopathologic data-based OC diagnostic models were constructed in the training set and then validated in the test set. There were significant differences in the metagenomic profiles between the OC and benign ovarian tumor groups; specifically, genus Acinetobacter was significantly more abundant in the OC group. More importantly, Acinetobacter was the only common genus identified by seven different statistical analysis methods. Among the various metagenomic and clinicopathologic data-based OC diagnostic models, the model consisting of age, serum CA-125 levels, and relative abundance of Acinetobacter showed the best diagnostic performance with the area under the receiver operating characteristic curve of 0.898 and 0.846 in the training and test sets, respectively. Thus, our findings establish a metagenomic analysis of serum microbe-derived EVs as a potential tool for the diagnosis of OC.

scholarly journals Telomerase Expression Increased the Risk of Borderline Ovarian Tumors

2016 ◽  
Author(s):  
Mila Maidarti
Keyword(s):  
Odds Ratio ◽  
Immunohistochemical Staining ◽  
Ovarian Tumor ◽  
Obstet Gynecol ◽  
Ovarian Tumors ◽  
Borderline Ovarian Tumor ◽  
Borderline Ovarian Tumors ◽  
Benign Ovarian Tumor ◽  
Benign Ovarian Tumors

Objective: To compare the expression of telomerase in benign ovarian tumors and borderline ovarian tumors. Methods: Thirteen samples of paraffin blocks of ovarian borderline tumors and benign ovarian tumors were taken from patients who underwent surgery from January 2006 to December 2011. In all samples, we performed immunohistochemical staining to the paraffin blocks. Semi quantitative determination of the expression of telomerase is done by an Anatomic Pathology specialist and Gynecologist, which already had the same perception about assessing the standardization sample. We used Fisher’s test to analyze the data. Results: There were significant relationship in the moderate expression of telomerase in the nucleus and cytoplasm between benign and borderline ovarian tumors, with an odds ratio of moderate telomerase expression in the cytoplasm and nucleus of 19.3 (95% CI: 1.4 - 943) and 26 (95% CI : 2.3 - 1211). This means that the risk of borderline ovarian tumors in the expression of moderate telomerase in the cytoplasm was 3.19 times compared to the negative expression, whereas in the nucleus it became 26-fold. There is no significant relationship among menopause, age, and telomerase expression in the nucleus and cytoplasm. Conclusion: There are significant differences in the expression of moderate strength telomerase in nucleus and cytoplasm between benign and borderline ovarian tumors. [Indones J Obstet Gynecol 2013; 37-1: 32-40] Keywords: benign ovarian tumor, borderline ovarian tumor, telomerase expression

scholarly journals Diagnostic extended usefulness of RMI: comparison of four risk of malignancy index in preoperative differentiation of borderline ovarian tumors and benign ovarian tumors

2019 ◽  
Vol 12 (1) ◽  
Author(s):  
Shuang Zhang ◽  
Shan Yu ◽  
Wenying Hou ◽  
Xiaoying Li ◽  
Chunping Ning ◽  
...  
Keyword(s):  
Ovarian Tumor ◽  
Menopausal Status ◽  
Area Under The Curve ◽  
Ovarian Tumors ◽  
Borderline Ovarian Tumor ◽  
Cancer Antigen 125 ◽  
Borderline Ovarian Tumors ◽  
Risk Of Malignancy ◽  
Risk Of Malignancy Index ◽  
Benign Ovarian Tumors

Abstract Background This study aimed to examine the performance of the four risk of malignancy index (RMI) in discriminating borderline ovarian tumors (BOTs) and benign ovarian masses in daily clinical practice. Methods A total of 162 women with BOTs and 379 women with benign ovarian tumors diagnosed at the Second Affiliated Hospital of Harbin Medical University from January 2012 to December 2016 were enrolled in this retrospective study. Also, we classified these patients into serous borderline ovarian tumor (SBOT) and mucinous borderline ovarian tumor (MBOT) subgroup. Preoperative ultrasound findings, cancer antigen 125 (CA125) and menopausal status were reviewed. The area under the curve (AUC) of receiver operator characteristic curves (ROC) and performance indices of RMI I, RMI II, RMI III and RMI IV were calculated and compared for discrimination between benign ovarian tumors and BOTs. Results RMI I had the highest AUC (0.825, 95% CI: 0.790–0.856) among the four RMIs in BOTs group. Similar results were found in SBOT (0.839, 95% CI: 0.804–0.871) and MBOT (0.791, 95% CI: 0.749–0.829) subgroups. RMI I had the highest specificity among the BOTs group (87.6, 95% CI: 83.9–90.7%), SBOT (87.6, 95% CI: 83.9–90.7%) and MBOT group (87.6, 95% CI: 83.9–90.7%). RMI II scored the highest overall in terms of sensitivity among the BOTs group (69.75, 95% CI: 62.1–76.7%), SBOT (74.34, 95% CI: 65.3–82.1%) and MBOT (59.18, 95% CI: 44.2–73.0%) group. Conclusion Compared to other RMIs, RMI I was the best-performed method for differentiation of BOTs from benign ovarian tumors. At the same time, RMI I also performed best in the discrimination SBOT from benign ovarian tumors.

Obstetrics and Gynecology Residents Can Accurately Classify Benign Ovarian Tumors Using the International Ovarian Tumor Analysis Rules

2020 ◽  
Vol 39 (7) ◽  
pp. 1389-1393
Author(s):  
Jean Marie Vianney Sebajuri ◽  
Urania Magriples ◽  
Maria Small ◽  
Diomede Ntasumbumuyange ◽  
Stephen Rulisa ◽  
...  
Keyword(s):  
Ovarian Tumor ◽  
Ovarian Tumors ◽  
Obstetrics And Gynecology ◽  
Benign Ovarian Tumors

scholarly journals Overexpression of Notch3 and pS6 Is Associated with Poor Prognosis in Human Ovarian Epithelial Cancer

2016 ◽  
Vol 2016 ◽  
pp. 1-6 ◽  
Author(s):  
Zhaoxia Liu ◽  
Rongna Yun ◽  
Xiaolin Yu ◽  
Hui Hu ◽  
Genhua Huang ◽  
...  
Keyword(s):  
Tumor Angiogenesis ◽  
Ovarian Tumor ◽  
Clinical Stage ◽  
Epithelial Cancer ◽  
Ovarian Epithelial Cancer ◽  
Tumor Tissues ◽  
Potential Biomarker ◽  
Benign Ovarian Tumor ◽  
Benign Ovarian Tumors

Notch3 and pS6 play important roles in tumor angiogenesis. To assess the expression of Notch3 and pS6 in Chinese ovarian epithelial cancer patients, a ten-year follow-up study was performed in ovarian epithelial cancer tissues from 120 specimens of human ovarian epithelial cancer, 30 specimens from benign ovarian tumors, and 30 samples from healthy ovaries by immunohistochemistry. The results indicate that the expression of Notch3 and pS6 was higher in ovarian epithelial cancer than in normal ovary tissues and in benign ovarian tumor tissues (p<0.01). In tumor tissues, Notch3 expression and pS6 expression were negatively associated with age (p>0.05) but positively associated with clinical stage, pathological grading, histologic type, lymph node metastasis, and ascites (p<0.05orp<0.01). A follow-up survey of 64 patients with ovarian epithelial cancer showed that patients with high Notch3 and pS6 expression had a shorter survival time (p<0.01), in which the clinical stage (p<0.05) and Notch3 expression (p<0.01) played important roles. In conclusion, Notch3 and pS6 are significantly related to ovarian epithelial cancer development and prognosis, and their combination represents a potential biomarker and therapeutic target in ovarian tumor angiogenesis.

Modern principles of diagnosis and treatment of benign ovarian neoplasms in juveniles

2021 ◽  
Vol 20 (3) ◽  
pp. 100-116
Keyword(s):  
Tumor Markers ◽  
Ovarian Reserve ◽  
Ovarian Tumor ◽  
Clinical Situation ◽  
Ovarian Tumors ◽  
Benign Tumors ◽  
Age Related ◽  
Organ Sparing ◽  
Benign Ovarian Tumors ◽  
Management Tactics

This review is devoted to current issues of diagnosis and the choice of management tactics for juvenile girls with benign ovarian tumors. The updated data on age-related epidemiology, classification and terminology of true tumors and ovarian tumor-like formations are presented. Differential manifestation of benign tumors and ovarian tumor-like formations are described. The diagnostic value of genetic tumor markers is analyzed. The recommended management tactics for juvenile girls with benign ovarian tumors depending on the clinical situation are described. The results of the use of hormonal therapy in juveniles are presented. The importance of organ-sparing strategy to treat juvenile girls in order to preserve the ovarian reserve is indicated. Key words: girls, juvenile girls, true ovarian tumors, ovarian reserve, tumor markers, tumor-like ovarian formations, organ-sparing surgery, reproductive health

scholarly journals Expression levels of matrix metalloproteinases in ascites of patients with ovarian cancer and the relationship with pathological characteristics of ovarian cancer

2019 ◽  
Vol 6 (2) ◽  
pp. 12
Author(s):  
Shuna S ◽  
Ping L ◽  
Junfei W
Keyword(s):  
Ovarian Cancer ◽  
Matrix Metalloproteinase ◽  
Ovarian Tumor ◽  
Ovarian Tumors ◽  
Expression Levels ◽  
Benign Ovarian Tumor ◽  
Significant Difference ◽  
Malignant Ovarian Tumor ◽  
Serum Ca125 ◽  
The Difference

Objective: To explore the expression levels of matrix metalloproteinase-2 (MMP-2) and matrix metalloproteinase-9 (MMP-9) in ascites in ovarian tumor and provide a theoretical basis for the diagnosis and prognosis evaluation of ovarian cancer ascites.Methods: ELISA was used to detect the levels of MMP-2 and MMP-9 in ascites samples from 73 cases of patients with malignant ovarian tumor, and RIA was used to detect the expression level of CA125 in the serum in these patients.Results: The expression levels of MMP-2 and MMP-9 in ascites in malignant ovarian tumor were higher than those in ascites in benign ovarian tumor (t = 8.08, 10.39, p < .01), and the difference was of statistical significance. The expression levels of MMP-2 and MMP-9 in patients with stage III and IV malignant ovarian tumors were higher than those in patients with stage I and II malignant ovarian tumors, and the difference was statistically significant (t = 2.75, 2.75, p < .05). There was no statistically significant difference in the expression levels of MMP-2 and MMP-9 among the patients with different pathological types, different histological grades, lymph node metastasis or not, different ascites volumes and different residual lesions (p > .05). The sensitivities of detecting MMP-2 and MMP-9 in ascites were 76.0% and 88.0%, respectively, which were significantly higher than those of ascites cytological examinations (χ2 = 4.61, 12.74, p < .05), but in comparison with serum CA125, there was no statistically significant difference (p > .05). The specificities of detecting MMP-2 and MMP-9 in ascites were 78.3% and 82.6%, respectively, which were significantly lower than those of ascites cytological examinations (χ2 = 5.61, 4.38, p < .05), but in comparison with serum CA125, there was no statistically significant difference (χ2 = 1.64, 2.68, p < .05).Conclusions: The levels of MMP-2 and MMP-9 in ascites may be markers for the differential diagnosis of benign and malignant ovarian lesions, and they are related to the prognosis in patients with malignant ovarian tumors.

scholarly journals Correlation of Sonographic Morphologic Index and CA-125 in Predicting the Nature of Ovarian Tumor

2019 ◽  
Vol 2 (3) ◽  
pp. 166-170
Author(s):  
Poonam Gusain ◽  
Suniti Joshi Rawal ◽  
Sharma Paudel
Keyword(s):  
Ovarian Tumor ◽  
Ovarian Tumors ◽  
University Teaching ◽  
Ca 125 ◽  
Fallopian Tubes ◽  
Female Reproductive System ◽  
Inclusion Criteria ◽  
Simple Method ◽  
Obstetrics And Gynaecology ◽  
Benign Ovarian Tumor

Introduction: Ovarian tumor is a group of diseases that originates in the ovaries or in the related areas of the fallopian tubes and the peritoneum. Ovarian cancer causes more deaths than any other cancer of the female reproductive system. This study was undertaken to evaluate the efficacy of Sonographic Morphology Index (MI) and CA-125 levels in predicting malignancy in patients with ovarian tumors. Methods: This study was conducted between April 2016 and April 2017 in the Department of Obstetrics and Gynaecology and Radiology of Tribhuvan University Teaching Hospital. During this period,106 women with ovarian tumors fulfilling inclusion criteria were taken into the study. CA-125 levels measured and MI scoring was done. The diagnosis made with MI score and CA-125 score were then compared with histopathology report. Results: Among the 106 studied cases (N=106), 88 (83.01%) had benign and 18 (16.98%) had malignant ovarian tumors. Negative Predictive Value (NPV) and sensitivity of CA-125 for ovarian tumor was 94.10% and 77.77 % respectively with accuracy of 73.58%. Sensitivity and NPV of MI score was 100% with accuracy of 84.9% in predicting nature of ovarian tumors. Pearsonscorrelation coefficient was 0.216 which showed a positive correlation between MI and CA-125 in predicting nature of ovarian tumors. Conclusion: The Sonographic MI system is an accurate and simple method to differentiate a malignant tumor from a benign ovarian tumor. The accuracy of the Sonographic MI system improved when the serum CA-125 level was also considered along.

scholarly journals Unusually high serum Ca 19-9 in a benign ovarian tumor

2016 ◽  
Author(s):  
Divya Pandey ◽  
Neha Pruthi ◽  
Sudha Salhan
Keyword(s):  
Tumor Markers ◽  
Ovarian Tumor ◽  
Tumor Staging ◽  
Abdominal Mass ◽  
Mucinous Cystadenoma ◽  
Total Abdominal Hysterectomy ◽  
High Serum ◽  
Ovarian Tumors ◽  
Mri Findings ◽  
Benign Ovarian Tumor

Introduction: Ovarian tumors have a varied spectrum of presentation. Tumors which look malignant clinico-biochemically can ultimately turn out to be benign. Tumor markers help in diagnosing various malignancies. Carbohydrate antigen 19-9 is one such marker seen to be elevated in some ovarian tumors. Case: A 55 year old, lean and thin postmenopausal female presented to Gynae OPD with abdominal mass, anorexia and weight loss developing over last 6 months. During workup, she was found to have unusually high Ca 19-9 along with MRI findings suggestive of ovarian tumor. Staging laparotomy followed by total abdominal hysterectomy with bilateral salpingoophorectomy was performed. Per operative findings were suggestive of benign nature of ovarian tumor of size 18× 20 cm. Patient was kept under follow up. Histopathology report showed benign mucinous cystadenoma. The serum levels of Ca19-9 returned to normal 8 weeks following surgery. This case report shows a rare and significant elevation of Ca19-9 levels with benign mucinous cystadenoma of the ovary, thus showing that women with unusually elevated tumor markers and even symptoms suggesting malignancy may actually harbour a benign disease. Conclusion: Unusually high Ca 19-9 may be associated with benign mucinous cystadenoma but thorough workup to rule out malignancy is a must in every case.

scholarly journals HE4 has a High Diagnostic Value to Detect Epithelial Ovarian Cancer

2016 ◽  
Author(s):  
Bismarck J. Laihad
Keyword(s):  
Ovarian Tumor ◽  
Histopathological Examination ◽  
Diagnostic Value ◽  
Ovarian Tumors ◽  
Diagnostic Study ◽  
Serum Concentrations ◽  
Serum Samples ◽  
Cross Sectional ◽  
Benign Ovarian Tumor ◽  
Tissue Specimens

Objective: To find out the diagnostic value of CA125 and HE4 as a tumor marker, and also RMI and ROMA as a malignancy predictor in patients with ovarian tumors. Methods: This study was a diagnostic study using cross-sectional design.This study was performed in Jakarta from November 2010 to May 2011. One hundred and twenty eight serum samples of patients diagnosed with ovarian tumors were collected before undergoing surgery in Dr. Cipto Mangunkusumo General Hospital. The CA125 and HE4 levels were then examined. The histopathological examination of tissue specimens were performed in Department of Pathology Anatomy in RSCM. For statistical analysis, we used a 2x2 table to produce ROC-AUC curve. Results: The median value of HE4 and CA125 serum concentrations was higher and more significant on patients with ovarian malignancy than patients with benign ovarian tumor (p

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