scholarly journals Unusually high serum Ca 19-9 in a benign ovarian tumor

2016 ◽  
Author(s):  
Divya Pandey ◽  
Neha Pruthi ◽  
Sudha Salhan
Keyword(s):  
Tumor Markers ◽  
Ovarian Tumor ◽  
Tumor Staging ◽  
Abdominal Mass ◽  
Mucinous Cystadenoma ◽  
Total Abdominal Hysterectomy ◽  
High Serum ◽  
Ovarian Tumors ◽  
Mri Findings ◽  
Benign Ovarian Tumor

Introduction: Ovarian tumors have a varied spectrum of presentation. Tumors which look malignant clinico-biochemically can ultimately turn out to be benign. Tumor markers help in diagnosing various malignancies. Carbohydrate antigen 19-9 is one such marker seen to be elevated in some ovarian tumors. Case: A 55 year old, lean and thin postmenopausal female presented to Gynae OPD with abdominal mass, anorexia and weight loss developing over last 6 months. During workup, she was found to have unusually high Ca 19-9 along with MRI findings suggestive of ovarian tumor. Staging laparotomy followed by total abdominal hysterectomy with bilateral salpingoophorectomy was performed. Per operative findings were suggestive of benign nature of ovarian tumor of size 18× 20 cm. Patient was kept under follow up. Histopathology report showed benign mucinous cystadenoma. The serum levels of Ca19-9 returned to normal 8 weeks following surgery. This case report shows a rare and significant elevation of Ca19-9 levels with benign mucinous cystadenoma of the ovary, thus showing that women with unusually elevated tumor markers and even symptoms suggesting malignancy may actually harbour a benign disease. Conclusion: Unusually high Ca 19-9 may be associated with benign mucinous cystadenoma but thorough workup to rule out malignancy is a must in every case.

scholarly journals Metagenomic Analysis of Serum Microbe-Derived Extracellular Vesicles and Diagnostic Models to Differentiate Ovarian Cancer and Benign Ovarian Tumor

Cancers ◽  
2020 ◽  
Vol 12 (5) ◽  
pp. 1309 ◽  
Author(s):  
Se Ik Kim ◽  
Nayeon Kang ◽  
Sangseob Leem ◽  
Jinho Yang ◽  
HyunA Jo ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Extracellular Vesicles ◽  
Ovarian Tumor ◽  
Ovarian Tumors ◽  
Metagenomic Analysis ◽  
Serum Samples ◽  
Benign Ovarian Tumor ◽  
Diagnostic Models ◽  
Test Sets ◽  
Benign Ovarian Tumors

We aimed to develop a diagnostic model identifying ovarian cancer (OC) from benign ovarian tumors using metagenomic data from serum microbe-derived extracellular vesicles (EVs). We obtained serum samples from 166 patients with pathologically confirmed OC and 76 patients with benign ovarian tumors. For model construction and validation, samples were randomly divided into training and test sets in the ratio 2:1. Isolation of microbial EVs from serum samples of the patients and 16S rDNA amplicon sequencing were carried out. Metagenomic and clinicopathologic data-based OC diagnostic models were constructed in the training set and then validated in the test set. There were significant differences in the metagenomic profiles between the OC and benign ovarian tumor groups; specifically, genus Acinetobacter was significantly more abundant in the OC group. More importantly, Acinetobacter was the only common genus identified by seven different statistical analysis methods. Among the various metagenomic and clinicopathologic data-based OC diagnostic models, the model consisting of age, serum CA-125 levels, and relative abundance of Acinetobacter showed the best diagnostic performance with the area under the receiver operating characteristic curve of 0.898 and 0.846 in the training and test sets, respectively. Thus, our findings establish a metagenomic analysis of serum microbe-derived EVs as a potential tool for the diagnosis of OC.

The Coexistence Of Two Different Epithelial Ovarian Tumors: A Rare Case

2021 ◽  
Vol 17 ◽  
Author(s):  
Ömer Faruk Topaloğlu ◽  
Emine Uysal ◽  
Zeliha Esin Çelik ◽  
Çetin Çelik
Keyword(s):  
Ovarian Tumor ◽  
Cystic Lesion ◽  
Mucinous Cystadenoma ◽  
Serous Cystadenoma ◽  
Ovarian Tumors ◽  
Lumbar Region ◽  
Fluid Content ◽  
Tumor Subtypes ◽  
Epithelial Tumors ◽  
The Right

Background: Epithelial tumors are the most common subgroup and are seen in 60-70% of all ovarian tumors. Serous cystadenoma and mucinous cystadenoma are the most common benign epithelial tumors. Serous cystadenomas are ovarian tumors with the highest bilateral incidence. The coexistence of tumors with different histopathology in the ovaries is extremely rare and has only been reported in a few cases in the literature. We present a case of bilateral ovarian tumor that was diagnosed as serous and mucinous cystadenoma after laparoscopic surgery. Case report: A 45-year-old female patient was admitted to our center with swelling in the pelvic region and pain in the left lumbar region. US imaging showed a cystic lesion in the right adnexal area, 4x2cm in size, well-circumscribed, containing a few thin septa, and a low echo fluid content. A cystic lesion with 6x4cm sized multilocular, well-circumscribed, slightly high echo fluid content was observed in the left adnexal area. On CT, a complex cystic lesion measuring 6x4cm was observed in the left adnexal area, pushing the left ureter laterally and causing the hydroureter. In addition, a 4x2cm cystic lesion was observed in the right adnexal area and hydroureter was observed on the right side proximal to this lesion. Both lesions were removed by surgery. On histopathologic examination, the left-sided cystic lesion was diagnosed as mucinous cystadenoma, and the right-sided cystic lesion was diagnosed as serous cystadenoma. Conclusion: The coexistence of different ovarian tumor subtypes is rare. In this article, we presented a case in which serous and mucinous cystadenoma lesions were seen together for the fourth time in the literature, according to our knowledge.

scholarly journals Morphology of the epoophoron in women with benign ovarian tumor

2011 ◽  
Vol 10 (2) ◽  
pp. 30-32
Author(s):  
L. I. Kokh ◽  
V. M. Perelmuter ◽  
A. V. Tardaskina ◽  
T. N. Dorosh
Keyword(s):  
Ovarian Tumor ◽  
Specific Area ◽  
Ovarian Tumors ◽  
Benign Ovarian Tumor ◽  
Inner Diameter ◽  
Benign Ovarian Tumors

We studied the epoophoron in women with benign ovarian tumor using morphological methods. It was established that the structure epoophoron in women with benign ovarian tumors, there are significant differences compared with controls. This manifests itself in reducing the number of tubules, increase in their specific area, outer and inner diameter, the height of the epithelium, the presence of secretions in the lumen.

scholarly journals Serum Levels of S100A11 and MMP-9 in Patients with Epithelial Ovarian Cancer and Their Clinical Significance

2021 ◽  
Vol 2021 ◽  
pp. 1-5
Author(s):  
Wenjing Li ◽  
Zhumei Cui ◽  
Yan Kong ◽  
Xiangyu Liu ◽  
Xiangyu Wang
Keyword(s):  
Ovarian Cancer ◽  
Epithelial Ovarian Cancer ◽  
Clinical Significance ◽  
Ovarian Tumor ◽  
Tumor Staging ◽  
Serum Levels ◽  
Clinicopathological Characteristics ◽  
Chemotherapy Response ◽  
Healthy Women ◽  
Benign Ovarian Tumor

Objective. To investigate the serum levels of calgizzarin (S100A11) and matrix metalloproteinase-9 (MMP9) in patients with epithelial ovarian cancer (EOC) and determine their clinical significance. Methods. Serum levels of S100A11 and MMP9 were detected in patients with EOC, patients with benign ovarian tumor, and healthy women. The correlation between the two markers and clinicopathological characteristics of ovarian cancer was analysed. Results. The serum levels of S100A11 and MMP-9 in patients with EOC were higher than those in patients with benign ovarian tumor and in healthy women, and the expression levels of S100A11 and MMP-9 were positively correlated. S100A11 and MMP-9 were correlated with tumor staging, postoperative residual foci, ascites volume, serum CA125 level, chemotherapy response, and lymph node metastasis, while S100A11 and MMP-9 were not associated with the bilevel classification, histological type, age, and degree of differentiation. Conclusion. S100A11 and MMP-9 were both highly expressed in the serum of patients with EOC and were associated with cancer development, invasion, and metastasis. Therefore, they can be used as an important reference maker in the diagnosis and treatment of ovarian cancer.

Modern principles of diagnosis and treatment of benign ovarian neoplasms in juveniles

2021 ◽  
Vol 20 (3) ◽  
pp. 100-116
Keyword(s):  
Tumor Markers ◽  
Ovarian Reserve ◽  
Ovarian Tumor ◽  
Clinical Situation ◽  
Ovarian Tumors ◽  
Benign Tumors ◽  
Age Related ◽  
Organ Sparing ◽  
Benign Ovarian Tumors ◽  
Management Tactics

This review is devoted to current issues of diagnosis and the choice of management tactics for juvenile girls with benign ovarian tumors. The updated data on age-related epidemiology, classification and terminology of true tumors and ovarian tumor-like formations are presented. Differential manifestation of benign tumors and ovarian tumor-like formations are described. The diagnostic value of genetic tumor markers is analyzed. The recommended management tactics for juvenile girls with benign ovarian tumors depending on the clinical situation are described. The results of the use of hormonal therapy in juveniles are presented. The importance of organ-sparing strategy to treat juvenile girls in order to preserve the ovarian reserve is indicated. Key words: girls, juvenile girls, true ovarian tumors, ovarian reserve, tumor markers, tumor-like ovarian formations, organ-sparing surgery, reproductive health

scholarly journals Expression levels of matrix metalloproteinases in ascites of patients with ovarian cancer and the relationship with pathological characteristics of ovarian cancer

2019 ◽  
Vol 6 (2) ◽  
pp. 12
Author(s):  
Shuna S ◽  
Ping L ◽  
Junfei W
Keyword(s):  
Ovarian Cancer ◽  
Matrix Metalloproteinase ◽  
Ovarian Tumor ◽  
Ovarian Tumors ◽  
Expression Levels ◽  
Benign Ovarian Tumor ◽  
Significant Difference ◽  
Malignant Ovarian Tumor ◽  
Serum Ca125 ◽  
The Difference

Objective: To explore the expression levels of matrix metalloproteinase-2 (MMP-2) and matrix metalloproteinase-9 (MMP-9) in ascites in ovarian tumor and provide a theoretical basis for the diagnosis and prognosis evaluation of ovarian cancer ascites.Methods: ELISA was used to detect the levels of MMP-2 and MMP-9 in ascites samples from 73 cases of patients with malignant ovarian tumor, and RIA was used to detect the expression level of CA125 in the serum in these patients.Results: The expression levels of MMP-2 and MMP-9 in ascites in malignant ovarian tumor were higher than those in ascites in benign ovarian tumor (t = 8.08, 10.39, p < .01), and the difference was of statistical significance. The expression levels of MMP-2 and MMP-9 in patients with stage III and IV malignant ovarian tumors were higher than those in patients with stage I and II malignant ovarian tumors, and the difference was statistically significant (t = 2.75, 2.75, p < .05). There was no statistically significant difference in the expression levels of MMP-2 and MMP-9 among the patients with different pathological types, different histological grades, lymph node metastasis or not, different ascites volumes and different residual lesions (p > .05). The sensitivities of detecting MMP-2 and MMP-9 in ascites were 76.0% and 88.0%, respectively, which were significantly higher than those of ascites cytological examinations (χ2 = 4.61, 12.74, p < .05), but in comparison with serum CA125, there was no statistically significant difference (p > .05). The specificities of detecting MMP-2 and MMP-9 in ascites were 78.3% and 82.6%, respectively, which were significantly lower than those of ascites cytological examinations (χ2 = 5.61, 4.38, p < .05), but in comparison with serum CA125, there was no statistically significant difference (χ2 = 1.64, 2.68, p < .05).Conclusions: The levels of MMP-2 and MMP-9 in ascites may be markers for the differential diagnosis of benign and malignant ovarian lesions, and they are related to the prognosis in patients with malignant ovarian tumors.

scholarly journals Correlation of Sonographic Morphologic Index and CA-125 in Predicting the Nature of Ovarian Tumor

2019 ◽  
Vol 2 (3) ◽  
pp. 166-170
Author(s):  
Poonam Gusain ◽  
Suniti Joshi Rawal ◽  
Sharma Paudel
Keyword(s):  
Ovarian Tumor ◽  
Ovarian Tumors ◽  
University Teaching ◽  
Ca 125 ◽  
Fallopian Tubes ◽  
Female Reproductive System ◽  
Inclusion Criteria ◽  
Simple Method ◽  
Obstetrics And Gynaecology ◽  
Benign Ovarian Tumor

Introduction: Ovarian tumor is a group of diseases that originates in the ovaries or in the related areas of the fallopian tubes and the peritoneum. Ovarian cancer causes more deaths than any other cancer of the female reproductive system. This study was undertaken to evaluate the efficacy of Sonographic Morphology Index (MI) and CA-125 levels in predicting malignancy in patients with ovarian tumors. Methods: This study was conducted between April 2016 and April 2017 in the Department of Obstetrics and Gynaecology and Radiology of Tribhuvan University Teaching Hospital. During this period,106 women with ovarian tumors fulfilling inclusion criteria were taken into the study. CA-125 levels measured and MI scoring was done. The diagnosis made with MI score and CA-125 score were then compared with histopathology report. Results: Among the 106 studied cases (N=106), 88 (83.01%) had benign and 18 (16.98%) had malignant ovarian tumors. Negative Predictive Value (NPV) and sensitivity of CA-125 for ovarian tumor was 94.10% and 77.77 % respectively with accuracy of 73.58%. Sensitivity and NPV of MI score was 100% with accuracy of 84.9% in predicting nature of ovarian tumors. Pearsonscorrelation coefficient was 0.216 which showed a positive correlation between MI and CA-125 in predicting nature of ovarian tumors. Conclusion: The Sonographic MI system is an accurate and simple method to differentiate a malignant tumor from a benign ovarian tumor. The accuracy of the Sonographic MI system improved when the serum CA-125 level was also considered along.

scholarly journals Συμβολή στην ανίχνευση και μελέτη των ορολογικών καρκινικών δεικτών σε ασθενείς με καρκίνο κεφαλής ή τραχήλου

2007 ◽  
Author(s):  
Άννα Ελευθεριάδου
Keyword(s):  
Early Diagnosis ◽  
Tumor Markers ◽  
Tumor Staging ◽  
Performance Status ◽  
Serum Levels ◽  
High Serum ◽  
Response To Therapy ◽  
Early Diagnosis Of Cancer ◽  
Specificity And Sensitivity ◽  
Before And After

Objective. The identification of a reliable circulating tumor marker in squamous cell carcinoma of the head and neck (SCCHN) could assist in early diagnosis and monitoring response to therapy. The aim of this study was to investigate the effectiveness of the serum tumor markers Cyfra 21-1, TPA-M, SCCA and CEA. Study design. Serum levels of Cyfra 21-1, TPA-M, SCCA and CEA were measured in 136 patients with a histologically proven SCCHN before and after treatment and in 125 healthy subjects, as controls. We tried to evaluate the sensitivity and specificity of these tumor markers and to correlate their levels with tumor staging, grading or performance status. Immunohistochemical study of CK 8, 18 and 19 in a group of 44 patients suffering from SCC of Rhinopharynx was also performed. An effort was made to correlate IHC overexpression of CK19 with high serum levels of CYFRA 21-1. Results. The study showed that none of the above markers presented satisfactory specificity and sensitivity in early diagnosis. In comparison with the other markers. TPA-M was the most effective of all markers and indicated a positive correlation with the grade of differentiation and nodal status. It has been investigated a remarkable correlation between high levels of TPA-M and CYFRA 21-1 in advanced stages (III, IV) of cancer. No correlation was found between IHC of the three CKs, either between serum and tissue overexpression of CK19. Conclusions. All the tumor markers that were studied have significant limitations in the early diagnosis of cancer, but TPA-M and CYFRA 21-1 may have a role in monitoring the success of therapy and follow up of patients with SCCHN.

scholarly journals Telomerase Expression Increased the Risk of Borderline Ovarian Tumors

2016 ◽  
Author(s):  
Mila Maidarti
Keyword(s):  
Odds Ratio ◽  
Immunohistochemical Staining ◽  
Ovarian Tumor ◽  
Obstet Gynecol ◽  
Ovarian Tumors ◽  
Borderline Ovarian Tumor ◽  
Borderline Ovarian Tumors ◽  
Benign Ovarian Tumor ◽  
Benign Ovarian Tumors

Objective: To compare the expression of telomerase in benign ovarian tumors and borderline ovarian tumors. Methods: Thirteen samples of paraffin blocks of ovarian borderline tumors and benign ovarian tumors were taken from patients who underwent surgery from January 2006 to December 2011. In all samples, we performed immunohistochemical staining to the paraffin blocks. Semi quantitative determination of the expression of telomerase is done by an Anatomic Pathology specialist and Gynecologist, which already had the same perception about assessing the standardization sample. We used Fisher’s test to analyze the data. Results: There were significant relationship in the moderate expression of telomerase in the nucleus and cytoplasm between benign and borderline ovarian tumors, with an odds ratio of moderate telomerase expression in the cytoplasm and nucleus of 19.3 (95% CI: 1.4 - 943) and 26 (95% CI : 2.3 - 1211). This means that the risk of borderline ovarian tumors in the expression of moderate telomerase in the cytoplasm was 3.19 times compared to the negative expression, whereas in the nucleus it became 26-fold. There is no significant relationship among menopause, age, and telomerase expression in the nucleus and cytoplasm. Conclusion: There are significant differences in the expression of moderate strength telomerase in nucleus and cytoplasm between benign and borderline ovarian tumors. [Indones J Obstet Gynecol 2013; 37-1: 32-40] Keywords: benign ovarian tumor, borderline ovarian tumor, telomerase expression

scholarly journals Ovarian Mucinous Cystadenoma Presenting as Pseudo-Meigs Syndrome

2012 ◽  
Vol 13 (2) ◽  
pp. 216-218
Author(s):  
Gazi Khan Md Shahiduzzaman ◽  
Poritosh Kumar Chowdhury ◽  
Bishnupada Paik ◽  
Sankar Proshad Biswas ◽  
Rafiqul Islam
Keyword(s):  
Postmenopausal Woman ◽  
Pleural Effusion ◽  
Ovarian Tumor ◽  
Mucinous Cystadenoma ◽  
Pelvic Mass ◽  
Exploratory Laparotomy ◽  
Shortness Of Breath ◽  
Lower Abdomen ◽  
Ovarian Fibroma ◽  
Benign Ovarian Tumor

Meigs syndrome is defined as the co-existence of benign ovarian tumor with ascites and hydrothorax that resolves after resection of tumor. The ovarian tumor in Meigs syndrome is fibroma. On the contrary, Pseudo- Meigs syndrome is characterized by the co-existence of hydrothorax, ascites and ovarian tumor either benign or malignant other than ovarian fibroma. The case herein concerns a 70 year old postmenopausal woman presented with the complaints of progressive shortness of breath on exertion and progressive swelling of lower abdomen. Her clinical and radiological examination revealed a massive right sided pleural effusion, mild ascites and a large heterogeneous pelvic mass with solid and cystic components, suggestive of left ovarian tumor. The patient underwent an exploratory laparotomy with excision of tumor, right ovary and whole of the uterus. The tumor was diagnosed histologically as an ovarian mucinous ystadenoma. Postoperative resolution of hydrothorax and ascites confirmed the diagnosis of Pseudo-Meigs syndrome. DOI: http://dx.doi.org/10.3329/jom.v13i2.12760 J Medicine 2012; 13 : 216-218

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