scholarly journals The First Determination of the Plasmid-Mediated Quinolone Resistance Determinants qnrA and qnrB from the Sudan

2019 ◽  
Vol 8 (03) ◽  
pp. 1612-1618
Author(s):  
I.A. Malik ◽  
K.M. Elhag
Keyword(s):  
Quinolone Resistance ◽  
Resistance Determinants

First description of NDM-1-, KPC-2-, VIM-2- and IMP-4-producing Klebsiella pneumoniae strains in a single Chinese teaching hospital

2014 ◽  
Vol 143 (2) ◽  
pp. 376-384 ◽  
Author(s):  
Y. LIU ◽  
L.-G. WAN ◽  
Q. DENG ◽  
X.-W. CAO ◽  
Y. YU ◽  
...  
Keyword(s):  
16S Rrna ◽  
Klebsiella Pneumoniae ◽  
Teaching Hospital ◽  
Multidrug Resistant ◽  
The Other ◽  
Quinolone Resistance ◽  
Resistance Determinants ◽  
Carbapenem Resistant ◽  
Extended Spectrum ◽  
Chinese Teaching

SUMMARYA total of 180 non-duplicate carbapenem-resistant Klebsiella pneumoniae isolates were recovered from patients hospitalized between December 2010 and January 2012 at a Chinese hospital. Eight KPC-2, four NDM-1, one VIM-2, and five KPC-2 plus IMP-4 producers were identified and all were multidrug resistant due to the presence of other resistance determinants, including extended-spectrum β-lactamases (CTX-M-15, SHV-12), 16S rRNA methylases (armA, rmtB) and plasmid-mediated quinolone-resistance determinants (qnrA, B, S, aac(6′)-Ib-cr). Nine K. pneumoniae clones (Kpn-A1/ST395, Kpn-A3/ST11, Kpn-A2/ST134, Kpn-B/ST263, Kpn-C/ST37, Kpn-D/ST39, Kpn-E/ST1151, Kpn-F/ST890, Kpn-G/ST1153) were identified. blaKPC-2 was located on transferable ~65 kb IncL/M (ST395, ST11, ST134, ST39) and ~100 kb IncA/C (ST37, ST1153, ST890) plasmids, respectively. On the other hand, blaNDM-1 was associated with a ~70 kb IncA/C plasmid (ST263). However, non-typable plasmids of ~40 kb containing blaVIM-2 were detected in the ST1151 clone. This work reports the first co-occurrence of four diverse types of carbapenemase of K. pneumoniae clones from a single hospital in China. IncA/C, IncL/M, and other successful plasmids may be important for the dissemination of carbapenemases, producing a complex epidemiological picture.

Occurrence of Plasmid-Mediated Quinolone Resistance Determinants andrmtBGene inSalmonella entericaSerovar Enteritidis and Typhimurium Isolated from Food-Animal Products in Tunisia

2013 ◽  
Vol 10 (9) ◽  
pp. 813-819 ◽  
Author(s):  
Nazek Al-Gallas ◽  
Mohamed Salah Abbassi ◽  
Becher Gharbi ◽  
Molka Manai ◽  
Mohamed N. Ben Fayala ◽  
...  
Keyword(s):  
Quinolone Resistance ◽  
Animal Products ◽  
Resistance Determinants ◽  
Food Animal

scholarly journals Prevalence of plasmid-mediated quinolone resistance determinants among oxyiminocephalosporin-resistant Enterobacteriaceae in Argentina

2013 ◽  
Vol 108 (7) ◽  
pp. 924-927 ◽  
Author(s):  
Giovanna Rincon Cruz ◽  
Marcela Radice ◽  
Samantha Sennati ◽  
Lucia Pallecchi ◽  
Gian María Rossolini ◽  
...  
Keyword(s):  
Quinolone Resistance ◽  
Resistance Determinants

scholarly journals Plasmid-mediated quinolone resistance determinants in Enterobacteriaceae from urine clinical samples

2018 ◽  
pp. 1-11 ◽  
Author(s):  
Orsolya Szabó ◽  
Dániel Gulyás ◽  
Nikolett Szabó ◽  
Katalin Kristóf ◽  
Béla Kocsis ◽  
...  
Keyword(s):  
Quinolone Resistance ◽  
Clinical Samples ◽  
Resistance Determinants

High Prevalence of Plasmid-Mediated Quinolone Resistance Determinants Among Serotype K1 Hypervirulent Klebsiella pneumoniae Isolates in China

2019 ◽  
Vol 25 (5) ◽  
pp. 681-689 ◽  
Author(s):  
Yang Liu ◽  
Fang-ling Du ◽  
Tian-xin Xiang ◽  
La-Gen Wan ◽  
Dan-dan Wei ◽  
...  
Keyword(s):  
Klebsiella Pneumoniae ◽  
Quinolone Resistance ◽  
Resistance Determinants ◽  
High Prevalence

scholarly journals Complete Nucleotide Sequence of pK245, a 98-Kilobase Plasmid Conferring Quinolone Resistance and Extended-Spectrum-β-Lactamase Activity in a Clinical Klebsiella pneumoniae Isolate

2006 ◽  
Vol 50 (11) ◽  
pp. 3861-3866 ◽  
Author(s):  
Ying-Tsong Chen ◽  
Hung-Yu Shu ◽  
Ling-Hui Li ◽  
Tsai-Lien Liao ◽  
Keh-Ming Wu ◽  
...  
Keyword(s):  
Antimicrobial Resistance ◽  
Klebsiella Pneumoniae ◽  
Shigella Flexneri ◽  
Quinolone Resistance ◽  
Gene Encoding ◽  
Modification System ◽  
Resistance Determinants ◽  
Restriction Modification System ◽  
Extended Spectrum ◽  
Sequence Elements

ABSTRACT A plasmid containing the qnrS quinolone resistance determinant and the gene encoding the SHV-2 β-lactamase has been discovered from a clinical Klebsiella pneumoniae strain isolated in Taiwan. The complete 98-kb sequence of this plasmid, designated pK245, was determined by using a whole-genome shotgun approach. Transfer of pK245 conferred low-level resistance to fluoroquinolones in electroporant Escherichia coli epi300. The sequence of the immediate region surrounding qnrS in pK245 is nearly identical (>99% identity) to those of pAH0376 from Shigella flexneri and pINF5 from Salmonella enterica serovar Infantis, the two other qnrS-carrying plasmids reported to date, indicating a potential common origin. Other genes conferring resistance to aminoglycosides (aacC2, strA, and strB), chloramphenicol (catA2), sulfonamides (sul2), tetracycline (tetD), and trimethoprim (dfrA14) were also detected in pK245. The dfrA14 gene is carried on a class I integron. Several features of this plasmid, including three separate regions containing putative replicons, a partitioning-control system, and a type II restriction modification system, suggest that it may be able to replicate and adapt in a variety of hosts. Although no critical conjugative genes were detected, multiple insertion sequence elements were found scattered throughout pK245, and these may facilitate the dissemination of the antimicrobial resistance determinants. We conclude that pK245 is a chimera which acquired its multiple antimicrobial resistance determinants horizontally from different sources. The identification of pK245 plasmid expands the repertoire of the coexistence of quinolone and extended-spectrum-β-lactam resistance determinants in plasmids carried by various species of the family Enterobacteriaceae in different countries.

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