scholarly journals Iodinated contrast media-induced hyperthyroidism

2020 ◽  
Vol 89 (2) ◽  
pp. e439
Author(s):  
Katarzyna Pelewicz ◽  
Piotr Miśkiewicz
Keyword(s):  
Contrast Media ◽  
Interventional Procedures ◽  
Thyroid Dysfunction ◽  
Iodine Intake ◽  
Prophylactic Therapy ◽  
Iodinated Contrast Media ◽  
Thyroid Status ◽  
Contrast Administration ◽  
Iodinated Contrast ◽  
Clinically Significant

Currently, iodinated contrast media (ICM) is widely used in radiology, therefore numerous patients are exposed to contrast administration during diagnostic and interventional procedures. ICM contains an amount of iodine well above the recommended dietary allowance, which can lead to thyroid dysfunction. Indeed, individuals that are highly susceptible to increased iodine intake are often patients with pre-existing thyroid disease. ICM-induced hyperthyroidism (IIH) is usually transient, however, it may present as clinically significant thyrotoxicosis. Although IIH has been investigated in multiple studies, there is still a lack of consensus regarding prophylactic therapy of IIH and no specific guidelines. This review aimed to summarise previous literature concerning the influence of ICM exposure on thyroid status and prophylactic therapy of IIH.

scholarly journals Thyroid dysfunction in preterm neonates exposed to iodine

2017 ◽  
Vol 45 (1) ◽  
Author(s):  
Fiona L.R. Williams ◽  
Jennifer Watson ◽  
Chris Day ◽  
Aung Soe ◽  
Sateesh K. Somisetty ◽  
...  
Keyword(s):  
Caesarean Section ◽  
Contrast Media ◽  
Preterm Infants ◽  
Breast Feeding ◽  
Thyroid Dysfunction ◽  
Exposed Group ◽  
Preterm Neonates ◽  
Iodinated Contrast Media ◽  
Iodinated Contrast ◽  
Blood Spot

AbstractBackground:Infants <32 weeks’ gestation should not be exposed to topical iodine and its avoidance is recommended during pregnancy and breast feeding. Exposure to contrast media and topical iodine is frequently used in many preterm neonates.Aim:To determine whether thyrotropin levels in preterm infants are affected by exposure to intrapartum/neonatal topical iodine and/or the use of iodinated contrast media.Design:Infants <32 weeks’ gestation were recruited. Maternal and neonatal exposures to iodinated contrast media and topical iodine were recorded; levels of thyrotropin and thyroxine were measured from blood-spot cards on postnatal days 7, 14, 28 and the equivalent of 36 weeks’ gestation.Results:One hundred and twenty-five infants were exposed to topical iodine/contrast media and 48 infants were unexposed. No infants were treated for hypothyroidism; three infants (exposed group) had transient hyperthyrotropinaemia. Mean thyrotropin levels were significantly higher on postnatal days 7, 14 and 28 in infants exposed to topical iodine prior to caesarean section compared to unexposed infants, a relationship which persisted after adjustment.Conclusions:In the context of this study, neonatal thyroid dysfunction was seen following exposure to iodine via caesarean section but not via exposure to contrast media.

scholarly journals Thyroid Dysfunction in Children Exposed to Iodinated Contrast Media

2016 ◽  
Vol 101 (6) ◽  
pp. 2366-2370 ◽  
Author(s):  
Meaghan L. Barr ◽  
Harvey K. Chiu ◽  
Ning Li ◽  
Michael W. Yeh ◽  
Connie M. Rhee ◽  
...  
Keyword(s):  
Contrast Media ◽  
Thyroid Dysfunction ◽  
Iodinated Contrast Media ◽  
Iodinated Contrast

Iodinated Contrast Media–Induced Thyroid Dysfunction in Euthyroid Nodular Goiter Patients

Thyroid ◽  
2016 ◽  
Vol 26 (8) ◽  
pp. 1030-1038 ◽  
Author(s):  
Edy Kornelius ◽  
Jeng-Yuan Chiou ◽  
Yi-Sun Yang ◽  
Shih-Chang Lo ◽  
Chiung-Huei Peng ◽  
...  
Keyword(s):  
Contrast Media ◽  
Thyroid Dysfunction ◽  
Nodular Goiter ◽  
Iodinated Contrast Media ◽  
Iodinated Contrast

scholarly journals Safety criteria for contrast administration in computed tomography cardiac angiography: perception of nursing

Rev Rene ◽  
2015 ◽  
Vol 16 (4) ◽  
pp. 504
Author(s):  
Laura Vargas Acauan ◽  
Maria Cristina Soares Rodrigues
Keyword(s):  
Computed Tomography ◽  
Contrast Media ◽  
Quality Care ◽  
Descriptive Study ◽  
Structured Interview ◽  
Qualitative Approach ◽  
Iodinated Contrast Media ◽  
Contrast Administration ◽  
Cardiac Angiography ◽  
Iodinated Contrast

To understand the perception of the nursing team about the safety criteria adopted in the use and administration of iodinated contrast media on computed tomography cardiac angiography. Methods: a descriptive study with a qualitative approach. The data were produced using the semi-structured interview with twelve participants from two diagnostic imaging centers. Results: two thematic categories emerged from the analysis: safe practices in the use and administration of iodinated contrast media and use of light technologies for safe care in the use of iodinated contrast media. Conclusion: it was surmised that safety criteria linked by light and hard technologies are used, but not standardized. To promote effective and quality care focused on patient safety, protocols and guidelines should be established to overcome possible barriers unsafe.

scholarly journals Effect of iodinated contrast media on thyroid: a brief review

2016 ◽  
Vol 6 (1) ◽  
pp. 12-15
Author(s):  
Şerife Mehlika Kuşkonmaz ◽  
Sema Yıldız
Keyword(s):  
Computed Tomography ◽  
Contrast Media ◽  
Contrast Agents ◽  
Clinical Evaluation ◽  
Thyroid Disease ◽  
Thyroid Dysfunction ◽  
Iodinated Contrast Media ◽  
Iodinated Contrast ◽  
Excess Iodide ◽  
Iodinated Contrast Agents

In parallel to the increased use of computed tomography, iodinated contrast agents are increasingly becoming a source of excess iodide. Iodinated contrast agents may induce thyroid dysfunction in exposed patients, especially in the presence of an underlying thyroid disease. Thus, an ordinary dose of the contrast used for the imaging, can induce hyper or hypothyroidism in a patient with subtle thyroid disease. This review will briefly discuss the physiology of iodine and the clinical evaluation of iodine induced thyroid dysfunction.

Iodine contrast prior to or during pregnancy and neonatal thyroid function: a systematic review

2021 ◽  
Vol 184 (1) ◽  
pp. 189-198 ◽  
Author(s):  
Nienke van Welie ◽  
Maite Portela ◽  
Kim Dreyer ◽  
Linda J Schoonmade ◽  
Madelon van Wely ◽  
...  
Keyword(s):  
Systematic Review ◽  
Contrast Media ◽  
Thyroid Function ◽  
Thyroid Dysfunction ◽  
Meta Analysis ◽  
Cochrane Library ◽  
Iodinated Contrast Media ◽  
Iodinated Contrast ◽  
Increased Risk ◽  
Neonatal Thyroid Function

Objective Thyroid dysfunction is a known side effect of iodinated contrast media. There is some evidence to suggest that iodinated contrast media administered to pregnant women may cause thyroid dysfunction not only in themselves but also in their offspring. Here, we systematically evaluated literature on the use of iodinated contrast media prior to or during pregnancy on the offspring’s thyroid function. Design Systematic review of published literature. Materials and methods Relevant studies were identified by PubMed, EMBASE and The Cochrane Library up to June 5, 2020. All study designs, reporting on the foetal or neonatal thyroid function after exposure to iodinated contrast media prior to or during pregnancy, were included. We undertook random effects meta-analysis and pooled the estimates as proportions with 95% CIs. Results We identified 402 articles, of which 26 were included. Six studies reported (n = 369) on exposure to iodinated contrast media prior to pregnancy by hysterosalpingography and 20 studies (n = 670) on exposure to these media during pregnancy by amniofetography, urography or CT. There was low to high risk of bias. The proportion of (transient) neonatal thyroid dysfunction was 0.0% (95% CI: 0.0–2.9% based on 3 studies) for hysterosalpingography, 2.25% (95% CI: 0.03–6.55% based on 2 studies) for amniofetography and 0.0% (95% CI: 0.0–0.02% based on 5 studies) for CT. There was a tendency towards an increased risk of thyroid dysfunction with higher amounts of contrast used. Conclusions Exposure to iodinated contrast media prior to or during pregnancy may increase the risk of thyroid dysfunction in offspring. We recommend keeping the amount of contrast used as low as possible.

scholarly journals A Review: Radiographic Iodinated Contrast Media-Induced Thyroid Dysfunction

2015 ◽  
Vol 100 (2) ◽  
pp. 376-383 ◽  
Author(s):  
Sun Y. Lee ◽  
Connie M. Rhee ◽  
Angela M. Leung ◽  
Lewis E. Braverman ◽  
Gregory A. Brent ◽  
...  
Keyword(s):  
Contrast Media ◽  
Thyroid Dysfunction ◽  
Iodinated Contrast Media ◽  
Iodinated Contrast

scholarly journals Iodinated Contrast Media Increased the Risk of Thyroid Dysfunction: A 6-Year Retrospective Cohort Study

2015 ◽  
Vol 100 (9) ◽  
pp. 3372-3379 ◽  
Author(s):  
Edy Kornelius ◽  
Jeng-Yuan Chiou ◽  
Yi-Sun Yang ◽  
Chiung-Huei Peng ◽  
Yung-Rung Lai ◽  
...  
Keyword(s):  
Cohort Study ◽  
Contrast Media ◽  
Retrospective Cohort Study ◽  
Retrospective Cohort ◽  
Thyroid Dysfunction ◽  
Iodinated Contrast Media ◽  
Iodinated Contrast

scholarly journals Prevention of Iodinated Contrast Media-Induced Hyperthyroidism in Patients with Euthyroid Goiter

2021 ◽  
pp. 1-8
Author(s):  
Katarzyna Pelewicz ◽  
Rafał Wolny ◽  
Tomasz Bednarczuk ◽  
Piotr Miśkiewicz
Keyword(s):  
Contrast Media ◽  
Prophylactic Treatment ◽  
Sodium Perchlorate ◽  
Thyroid Volume ◽  
Thyroid Stimulating Hormone ◽  
Prophylactic Therapy ◽  
Iodinated Contrast Media ◽  
Severe Condition ◽  
Hormone Levels ◽  
Iodinated Contrast

<b><i>Introduction:</i></b> Iodinated contrast media (ICM)-induced hyperthyroidism is an underestimated, potentially severe condition; however, its prevention has not been sufficiently investigated. The aim of this study was to evaluate the influence of ICM on thyroid status, the advantages of prophylactic therapy for iodine-induced hyperthyroidism (IIH) in patients with euthyroid goiter and cardiovascular comorbidities, and the association between the incidence of IIH and thyroid volume. <b><i>Methods:</i></b> Thirty-six euthyroid patients undergoing procedures involving ICM administration were divided into 2 groups: the first group (<i>n</i> = 13) received prophylactic treatment with thiamazole or thiamazole combined with sodium perchlorate during ICM exposure; the second group (<i>n</i> = 23) did not receive prophylaxis. Thyroid-stimulating hormone levels were evaluated before and after ICM, and thyroid hormone levels were assessed after ICM at different points in time. The morphology of the thyroid was evaluated by ultrasonography. <b><i>Results:</i></b> Twenty-one patients (58%) developed hyperthyroidism after ICM. Hyperthyroidism was observed more frequently in the group without prophylactic treatment than in the group with prophylaxis (65 vs. 15%, respectively; <i>p</i> = 0.006). No cases of overt hyperthyroidism were observed in the group receiving thiamazole with sodium perchlorate. IIH persisted for a median time of 52.5 days. Larger thyroid volume was associated with a significantly higher occurrence of ICM-induced hyperthyroidism (<i>p</i> = 0.04). <b><i>Conclusions:</i></b> Patients with euthyroid goiter receiving ICM are at risk of developing hyperthyroidism. The occurrence of hyperthyroidism after ICM in euthyroid patients with goiter is higher in those with larger thyroid volume. The frequency of ICM-induced hyperthyroidism in euthyroid patients with goiter is lower in those receiving prophylactic therapy with thiamazole in monotherapy or in combination with sodium perchlorate than in those not receiving prophylactic treatment.

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