scholarly journals Effect of iodinated contrast media on thyroid: a brief review

2016 ◽  
Vol 6 (1) ◽  
pp. 12-15
Author(s):  
Şerife Mehlika Kuşkonmaz ◽  
Sema Yıldız
Keyword(s):  
Computed Tomography ◽  
Contrast Media ◽  
Contrast Agents ◽  
Clinical Evaluation ◽  
Thyroid Disease ◽  
Thyroid Dysfunction ◽  
Iodinated Contrast Media ◽  
Iodinated Contrast ◽  
Excess Iodide ◽  
Iodinated Contrast Agents

In parallel to the increased use of computed tomography, iodinated contrast agents are increasingly becoming a source of excess iodide. Iodinated contrast agents may induce thyroid dysfunction in exposed patients, especially in the presence of an underlying thyroid disease. Thus, an ordinary dose of the contrast used for the imaging, can induce hyper or hypothyroidism in a patient with subtle thyroid disease. This review will briefly discuss the physiology of iodine and the clinical evaluation of iodine induced thyroid dysfunction.

scholarly journals Thyroid dysfunction in preterm neonates exposed to iodine

2017 ◽  
Vol 45 (1) ◽  
Author(s):  
Fiona L.R. Williams ◽  
Jennifer Watson ◽  
Chris Day ◽  
Aung Soe ◽  
Sateesh K. Somisetty ◽  
...  
Keyword(s):  
Caesarean Section ◽  
Contrast Media ◽  
Preterm Infants ◽  
Breast Feeding ◽  
Thyroid Dysfunction ◽  
Exposed Group ◽  
Preterm Neonates ◽  
Iodinated Contrast Media ◽  
Iodinated Contrast ◽  
Blood Spot

AbstractBackground:Infants <32 weeks’ gestation should not be exposed to topical iodine and its avoidance is recommended during pregnancy and breast feeding. Exposure to contrast media and topical iodine is frequently used in many preterm neonates.Aim:To determine whether thyrotropin levels in preterm infants are affected by exposure to intrapartum/neonatal topical iodine and/or the use of iodinated contrast media.Design:Infants <32 weeks’ gestation were recruited. Maternal and neonatal exposures to iodinated contrast media and topical iodine were recorded; levels of thyrotropin and thyroxine were measured from blood-spot cards on postnatal days 7, 14, 28 and the equivalent of 36 weeks’ gestation.Results:One hundred and twenty-five infants were exposed to topical iodine/contrast media and 48 infants were unexposed. No infants were treated for hypothyroidism; three infants (exposed group) had transient hyperthyrotropinaemia. Mean thyrotropin levels were significantly higher on postnatal days 7, 14 and 28 in infants exposed to topical iodine prior to caesarean section compared to unexposed infants, a relationship which persisted after adjustment.Conclusions:In the context of this study, neonatal thyroid dysfunction was seen following exposure to iodine via caesarean section but not via exposure to contrast media.

scholarly journals Thyroid Dysfunction in Children Exposed to Iodinated Contrast Media

2016 ◽  
Vol 101 (6) ◽  
pp. 2366-2370 ◽  
Author(s):  
Meaghan L. Barr ◽  
Harvey K. Chiu ◽  
Ning Li ◽  
Michael W. Yeh ◽  
Connie M. Rhee ◽  
...  
Keyword(s):  
Contrast Media ◽  
Thyroid Dysfunction ◽  
Iodinated Contrast Media ◽  
Iodinated Contrast

scholarly journals Reduced iodinated contrast media for abdominal imaging by dual-layer spectral detector computed tomography for patients with kidney disease

2018 ◽  
Vol 13 (2) ◽  
pp. 437-443 ◽  
Author(s):  
Hirokazu Saito ◽  
Kana Noda ◽  
Koji Ogasawara ◽  
Shutaro Atsuji ◽  
Hiroko Takaoka ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Kidney Disease ◽  
Contrast Media ◽  
Abdominal Imaging ◽  
Iodinated Contrast Media ◽  
Iodinated Contrast

scholarly journals Iodinated contrast media

2021 ◽  
Vol 9 (1) ◽  
pp. 156-167
Author(s):  
Sami S. Alshowiman ◽  
Abdullah H Sahrah ◽  
Ayman K. Alswailem ◽  
Saud F. Alotaibi ◽  
Abdulaziz A. ALtowaijiri ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Contrast Media ◽  
Adverse Reactions ◽  
Iodinated Contrast Media ◽  
Radiographic Image ◽  
Complex Molecules ◽  
X Ray ◽  
Iodinated Contrast ◽  
Number Of Patients ◽  
Life Threatening

Contrast media are the materials utilized in radiology to improve the visualization of certain body structures subjected to analysis in a medical image. Contrast media are, then, diagnostic drugs because they increase the visibility of organs and tissues and allow the identification of details that otherwise could not be observed. With the introduction of multidetector computed tomography the number of patients undergoing contrast studies has grown exponentially in recent years. In computed tomography the formation of the radiographic image is obtained with the use of contrast media containing iodine atoms, exploiting the different attenuation that the X-ray beam presents in crossing the anatomical districts. The Iodinated Contrast Media (ICM) are a category of numerous substances formed by even complex molecules that vary considerably in their properties, uses and toxic effects. Even though iodinated contrast agents have a good safety profile, it is necessary to understand that some patients can have severe, life-threatening allergic reactions because of the side effects of the chemicals. This paper describes the clinical pharmacology, use and adverse reactions of intravenous iodinated contrast media used in computerized tomography, offering all doctors, even non-radiologists, the opportunity for rapid updating.

scholarly journals Hypersensitivity reactions to iodinated contrast media

2019 ◽  
Vol 16 (3) ◽  
pp. 85-91
Author(s):  
L G Khludova ◽  
T N Myasnikova ◽  
V V Smirnov ◽  
T V Latysheva ◽  
M R Khaitov
Keyword(s):  
Contrast Media ◽  
Contrast Agents ◽  
Previous History ◽  
Skin Tests ◽  
Public Health Issue ◽  
Hypersensitivity Reactions ◽  
Iodinated Contrast Media ◽  
Iodinated Contrast ◽  
Alternative Agent ◽  
History Of

Hypersensitivity reactions to iodinated contrast media are a pressing public health issue. Lack of understanding of pathogenetic mechanisms of such reactions leads to unjustified refuse of diagnostic and therapeutic procedures using iodinated contrast agents. Reactions of hypersensitivity to other iodine-containing medications are not a contraindication for use of contrast agents. Skin allergy tests are only performed in the patients who had a history of allergic reactions to iodinated contrast media. Usually it is possible to determine an alternative agent by means of skin tests. Premedication before a contrast-enhanced radiological examination has to be indicated to all patients with previous history of allergic disease.

The presence of iodinated contrast agents amplifies DNA radiation damage in computed tomography

2011 ◽  
Vol 6 (6) ◽  
pp. 507-513 ◽  
Author(s):  
Caroline Pathe ◽  
Katharina Eble ◽  
Daniel Schmitz-Beuting ◽  
Boris Keil ◽  
Bjoern Kaestner ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Contrast Agents ◽  
Radiation Damage ◽  
Iodinated Contrast ◽  
Iodinated Contrast Agents

scholarly journals Contrast Media: Are There Differences in Nephrotoxicity among Contrast Media?

2014 ◽  
Vol 2014 ◽  
pp. 1-8 ◽  
Author(s):  
Richard Solomon
Keyword(s):  
Clinical Trials ◽  
Contrast Media ◽  
Contrast Agents ◽  
Filtration Rate ◽  
Randomized Clinical Trials ◽  
The Past ◽  
Iodinated Contrast ◽  
Using Data ◽  
The Relationship ◽  
Iodinated Contrast Agents

Iodinated contrast agents are usually classified based upon their osmolality—high, low, and isosmolar. Iodinated contrast agents are also nephrotoxic in some but not all patients resulting in loss of glomerular filtration rate. Over the past 30 years, nephrotoxicity has been linked to osmolality although the precise mechanism underlying such a link has been elusive. Improvements in our understanding of the pathogenesis of nephrotoxicity and prospective randomized clinical trials have attempted to further explore the relationship between osmolality and nephrotoxicity. In this review, the basis for our current understanding that there are little if any differences in nephrotoxic potential between low and isosmolar contrast media will be detailed using data from clinical studies.

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