scholarly journals MODEL MATEMATIKA KANKER NASOFARING DENGAN RADIOTERAPI

2021 ◽  
Vol 13 (2) ◽  
pp. 13
Author(s):  
Maulan Aziz Syafii ◽  
Yudi Ari Adi
Keyword(s):  

Karsinoma nasofaring merupakan keganasan pada kepala dan leher yang terletak di nasofaring. Penyakit ini ditandai oleh serangkaian fitur geografis, etiologis dan biologis yang unik yang berbeda dari kanker kepala dan leher lainnya. Lanskap molekuler kanker nasofaring ditentukan oleh serangkaian variasi epigenetik genetik dan familial dan somatik, yang sebagian besar kanker nasofaring bercampur dengan infeksi virus Epstein-Barr (EBV) laten menghasilkan fenotipe ganas. Ada beberapa cara untuk mengobati kanker nasofaring, salah satunya adalah radioterapi. Penelitian ini akan membentuk model matematis empat persamaan diferensial biasa dengan empat variabel. Analisis stabilitas dalam penelitian ini adalah mempelajari suatu sistem dengan tujuan untuk mengetahui bentuk kestabilan titik-titik kesetimbangan pada masing-masing komponen titik kesetimbangan dalam model, sehingga dapat diketahui kapan komponenn titik-titik ekuibrium dari populasi sel laten, populasi sel yang terinfeksi, populasi invasif karsinoma, dan konsentrasi Radioterapi mencapai titik penyembuhan. Hasil penelitian menunjukkan dua titik kesetimbangan yaitu titik kesetimbangan bebas penyakit dengan  dan titik ekuilibrium endemik untuk kanker nasofaring  dengan memberikan dosis tertentu.

Author(s):  
B. G. Uzman ◽  
M. M. Kasac ◽  
H. Saito ◽  
A. Krishan

In conjunction with the cultivation and transplantation of cells from human tumors by the Programs of Microbiology and Immunogenetics, virus surveillance by electron microscopy has been routinely employed. Of particular interest in this regard have been 3 cell lines cultured from lymph nodes or spleen of 2 patients with Hodgkin's disease and 1 patient with Letterer-Siwe's disease. Each of these cell lines when transplanted in Syrian hamster neonates conditioned with anti-lymphocyte serum grew as serially transplantable tumors; from such transplants of the 3 cell lines cell cultures were retrieved.Herpes type virus particles (Figs. 1, 2, 3) were found in the primary cultures of all three lines, in frozen thawed aliquots of same, and in cultures retrieved from their tumors growing by serial transplantation in hamsters. No virus was detected in sections of 25 of the serially transplanted tumors. However, in 10 such tumors there were repeated instances of tubular arrays in the cisternae of the endoplasmic reticulum (Fig. 4). On serologic examination the herpes virus was shown to be the Epstein-Barr virus.


Author(s):  
C. M. Payne ◽  
P. M. Tennican

In the normal peripheral circulation there exists a sub-population of lymphocytes which is ultrastructurally distinct. This lymphocyte is identified under the electron microscope by the presence of cytoplasmic microtubular-like inclusions called parallel tubular arrays (PTA) (Figure 1), and contains Fc-receptors for cytophilic antibody. In this study, lymphocytes containing PTA (PTA-lymphocytes) were quantitated from serial peripheral blood specimens obtained from two patients with Epstein -Barr Virus mononucleosis and two patients with cytomegalovirus mononucleosis. This data was then correlated with the clinical state of the patient.It was determined that both the percentage and absolute number of PTA- lymphocytes was highest during the acute phase of the illness. In follow-up specimens, three of the four patients' absolute lymphocyte count fell to within normal limits before the absolute PTA-lymphocyte count.In one patient who was followed for almost a year, the absolute PTA- lymphocyte count was consistently elevated (Figure 2). The estimation of absolute PTA-lymphocyte counts was determined to be valid after a morphometric analysis of the cellular areas occupied by PTA during the acute and convalescent phases of the disease revealed no statistical differences.


Author(s):  
R. Stephens ◽  
K. Traul ◽  
D. Woolf ◽  
P. Gaudreau

A number of antigens have been found associated with persistent EBV infections of lymphoblastoid cells. Identification and localization of these antigens were principally by immunofluorescence (IF) techniques using sera from patients with nasopharyngeal carcinoma (NPC), Burkitt lymphoma (BL), and infectious mononucleosis (IM). Our study was mainly with three of the EBV related antigens, a) virus capsid antigen (VCA), b) membrane antigen (MA), and c) early antigens (EA) using immunoperoxidase (IP) techniques with electron microscopy (EM) to elucidate the sites of reactivity with EBV and EBV infected cells.Prior to labeling with horseradish peroxidase (HRP), sera from NPC, IM, and BL cases were characterized for various reactivities by the indirect IF technique. Modifications of the direct IP procedure described by Shabo and the indirect IP procedure of Leduc were made to enhance penetration of the cells and preservation of antigen reactivity.


2000 ◽  
Vol 111 (1) ◽  
pp. 239-246 ◽  
Author(s):  
Kenny I. K. Lei ◽  
Lisa Y.S. Chan ◽  
Wing Y. Chan ◽  
Philip J. Johnson ◽  
Y. M. Dennis Lo

1996 ◽  
Vol 21 (2) ◽  
pp. 123-126
Author(s):  
U. BALDARI ◽  
A. ASCARI RACCAGNI ◽  
B. CELLI ◽  
M. GIOVANNA RIGHINI

Praxis ◽  
2006 ◽  
Vol 95 (14) ◽  
pp. 525-532
Author(s):  
Kolyvanos Naumann ◽  
Krayenbühl ◽  
Schulthess ◽  
Käser ◽  
Vetter

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