scholarly journals A Possible Role of an Interaction of the Age at Common Childhood Infections and Selected Dietary Factors at Young Age, for the Risk of Multiple Sclerosis

2016 ◽  
Author(s):  
Klaus Lauer ◽  
Annette Wahl ◽  
Marcel Geilenkeuser
Keyword(s):  
Multiple Sclerosis ◽  
Linear Regression Analysis ◽  
Multiple Linear Regression Analysis ◽  
Dietary Factors ◽  
Young Age ◽  
Processed Meat ◽  
Additive Interaction ◽  
Regression Estimate ◽  
Childhood Infections ◽  
Increased Risk

An increased risk of multiple sclerosis (MS) had been found when individuals had consumed large amounts of processed meat and sausages at young age (Lauer, 2014). Furthermore it was found in many studies that MS patients had acquired a number of common childhood infections at higher ages than controls. Therefore, MS patients from an epidemiological long-term investigation in Germany and different hospital controls, were evaluated for a statistical interaction of these two factors. 324 MS patients and 242 hospital controls were inquired. The study focussed on age 0 - 16. Subjects were tested for additive interaction by multiple linear regression analysis (Knol et al., 2007). There was an additive interaction of the age at any common childhood infection with the consumption of scalded sausages (regression estimate = 0.1370; standard error = 0.0603; p = 0.0239). In contrast, no such interaction could be shown for: animal fats; smoked meat (e.g. ham and bacon); and cold - smoked German salami. Thus there was a synergy of the intake of scalded sausages (e.g. frankfurters, bolognas, etc.) and age at common childhood infections, for the later risk of MS.

Gene–environment interactions increase the risk of pediatric-onset multiple sclerosis associated with ozone pollution

2022 ◽  
pp. 135245852110699
Author(s):  
Amin Ziaei ◽  
Amy M Lavery ◽  
Xiaorong MA Shao ◽  
Cameron Adams ◽  
T Charles Casper ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Air Pollutant ◽  
Ozone Exposure ◽  
County Level ◽  
Ozone Pollution ◽  
Ozone Level ◽  
Additive Interaction ◽  
Gene Environment ◽  
Increased Risk ◽  
Pediatric Onset

Background: We previously reported a relationship between air pollutants and increased risk of pediatric-onset multiple sclerosis (POMS). Ozone is an air pollutant that may play a role in multiple sclerosis (MS) pathoetiology. CD86 is the only non-HLA gene associated with POMS for which expression on antigen-presenting cells (APCs) is changed in response to ozone exposure. Objectives: To examine the association between county-level ozone and POMS, and the interactions between ozone pollution, CD86, and HLA- DRB1*15, the strongest genetic variant associated with POMS. Methods: Cases and controls were enrolled in the Environmental and Genetic Risk Factors for Pediatric MS study of the US Network of Pediatric MS Centers. County-level-modeled ozone data were acquired from the CDC’s Environmental Tracking Network. Participants were assigned ozone values based on county of residence. Values were categorized into tertiles based on healthy controls. The association between ozone tertiles and having MS was assessed by logistic regression. Interactions between tertiles of ozone level and the GG genotype of the rs928264 (G/A) single nucleotide polymorphism (SNP) within CD86, and the presence of DRB1*15:01 ( DRB1*15) on odds of POMS were evaluated. Models were adjusted for age, sex, genetic ancestry, and mother’s education. Additive interaction was estimated using relative excess risk due to interaction (RERI) and attributable proportions (APs) of disease were calculated. Results: A total of 334 POMS cases and 565 controls contributed to the analyses. County-level ozone was associated with increased odds of POMS (odds ratio 2.47, 95% confidence interval (CI): 1.69–3.59 and 1.95, 95% CI: 1.32–2.88 for the upper two tertiles, respectively, compared with the lowest tertile). There was a significant additive interaction between high ozone tertiles and presence of DRB1*15, with a RERI of 2.21 (95% CI: 0.83–3.59) and an AP of 0.56 (95% CI: 0.33–0.79). Additive interaction between high ozone tertiles and the CD86 GG genotype was present, with a RERI of 1.60 (95% CI: 0.14–3.06) and an AP of 0.37 (95% CI: 0.001–0.75) compared to the lowest ozone tertile. AP results indicated that approximately half of the POMS risk in subjects can be attributed to the possible interaction between higher county-level ozone carrying either DRB1*15 or the CD86 GG genotype. Conclusions: In addition to the association between high county-level ozone and POMS, we report evidence for additive interactions between higher county-level ozone and DRB1*15 and the CD86 GG genotype. Identifying gene–environment interactions may provide mechanistic insight of biological processes at play in MS susceptibility. Our work suggests a possible role of APCs for county-level ozone-induced POMS risk.

Waterpipe Tobacco Smoking and Other Multiple Sclerosis Environmental Risk Factors

2021 ◽  
Author(s):  
Nuha M. Alkhawajah ◽  
Salman Aljarallah ◽  
Laith Hussain-Alkhateeb ◽  
Mohammad Osama Almohaini ◽  
Taim A. Muayqil
Keyword(s):  
Risk Factors ◽  
Multiple Sclerosis ◽  
Tobacco Smoking ◽  
Case Control Study ◽  
Coffee Consumption ◽  
Case Control ◽  
Processed Meat ◽  
Increased Risk ◽  
Waterpipe Tobacco Smoking ◽  
Control Study

Abstract Introduction There are a number of well-established risk factors for multiple sclerosis (MS). Other factors however, showed conflicting or non-consistent results. Here we examine some factors that are unique to or more practiced in Saudi Arabia (SA) and the Arab region such as waterpipe tobacco smoking (WTS), face veiling, raw milk (RM), and camel milk (CM) consumption, tuberculosis (TB) infection in addition to other traditional factors. Methods This is a sex and age matched case-control study in which we used a structured questionnaire to examine the relation between a number of factors and exposures and the risk of MS. Three hundred MS patients and 601 controls were included. Data was analyzed across different statistical models using logistic regression adjusting for age, sex, marital status, duration of breastfeeding, age first joining school, coffee consumption, and face exposure. Results Cigarette smoking [OR = 1.79, (95% CI 1.01-3.17), P =0.047)], WTS [OR = 2.25, (95% CI 1.21-4.15), P =0.010)], and CM consumption [OR = 2.50, (95% CI 1.20-5.21), P =0.014)] increased the risk of MS. While performing hajj [OR = 0.47, (95% CI 0.34-0.67), P =0.001)], TB infection [OR = 0.29, (95% CI 0.11-0.78), P =0.015)], face veiling [OR = 0.32, (95% CI 0.23-0.47), P =0.001)] and coffee consumption [OR =0.67, (95% CI 0.49-0.89), P =0.008)], appeared to be associated with decreased risk. No association was found between fast food, processed meat, soft drinks, animal milk (other than camel) or RM consumption and the risk of MS. Conclusion The results of this case-control study confirm that different means of tobacco smoking are associated with increased risk of MS. It also sheds more light on the complex association between infections and MS.

scholarly journals Understanding Racial and Rural Disparities in the Relationship between Social Isolation and Social Technology Use

2021 ◽  
Vol 5 (Supplement_1) ◽  
pp. 933-933
Author(s):  
Kaileigh Byrne ◽  
Reza Ghaiumy Anaraky ◽  
Hannah Barfield ◽  
Summerlin Nickel
Keyword(s):  
Social Support ◽  
Older Adults ◽  
Social Isolation ◽  
Technology Use ◽  
Linear Regression Analysis ◽  
Negative Relationship ◽  
Multiple Linear Regression Analysis ◽  
Social Technology ◽  
Increased Risk ◽  
The Relationship

Abstract Social isolation is characterized by lack of social contacts and high degrees of loneliness. Feelings of loneliness and social isolation are linked to declines in cognitive functioning and increased risk of dementia. Previous research suggests that loneliness is more prevalent among Black and rural older adults compared to White and urban-dwelling older adults. Given these disparities, it is important to identify methods that reduce social isolation and loneliness among this population. Social technology, such as Facebook and Skype, is one possible way to connect with others. This study uses the Health and Retirement Study (HRS) dataset to examine racial and rural disparities in the relationship between social technology use and social isolation, loneliness, and social support among individuals age 50 and older. The overarching hypotheses are that (1) rural-dwelling older adults and older Blacks will report less social technology use compared to urban-dwelling and older White adults, and (2) there will be a negative relationship between loneliness and social technology use, and (3) a positive relationship between perceived positive social support and social technology use. Racial or rural disparities in these latter potential relationships are exploratory. Multiple linear regression analysis will be performed to assess these relationships. Preliminary correlational results indicate that, consistent with prior work, greater use of social technology was associated with higher social support (N=6,029; r=.29, p<.001). However, contrary to our hypothesis, greater self-reported loneliness was associated with greater social technology (r=.09, p<.001). Examination of potential racial and rural disparities in these relationships are currently underway.

scholarly journals Leptin receptor gene polymorphisms are associated with adiposity and metabolic alterations in Brazilian individuals

2013 ◽  
Vol 57 (9) ◽  
pp. 677-684 ◽  
Author(s):  
Raquel de Oliveira ◽  
Alvaro Cerda ◽  
Fabiana Dalla Vecchia Genvigir ◽  
Marcelo Ferraz Sampaio ◽  
Dikran Armaganijan ◽  
...  
Keyword(s):  
Waist Circumference ◽  
Gene Polymorphisms ◽  
Leptin Receptor ◽  
Receptor Gene ◽  
Linear Regression Analysis ◽  
Multiple Linear Regression Analysis ◽  
Leptin Resistance ◽  
Metabolic Markers ◽  
Increased Risk ◽  
Receptor Gene Polymorphisms

OBJECTIVE: The aim of the study was to investigate whether adiposity and metabolic markers, such as leptin, glucose, and lipids, are influenced by leptin (LEP) and leptin receptor (LEPR) gene polymorphisms in a sample of our population. SUBJECTS AND METHODS: A group of 326 individuals of Caucasian-European descent, aged 30 to 80 years, 87 men and 239 women, 148 obese and 178 non-obese, was randomly selected at two clinical hospitals in the city of Sao Paulo, Brazil. All individuals declared their ethnic group as white during the initial interview. Anthropometric measurements, body mass index (BMI), and fat mass were evaluated. Blood samples were drawn for DNA extraction and measurements of leptin, soluble leptin receptor, glucose, and lipids. LEP -2548G>A and LEPR Lys109Arg (c.326A>G), Gln233Arg (c.668A>G) and Lys656Asn (c.1968G>C) polymorphisms were detected by PCR-RFLP. RESULTS: Increased leptin and serum lipids, and LEPR Arg223Arg (GG genotype) were associated with higher risk for obesity (p < 0.05), while reduced risk was found in LEPR Arg109Arg (GG genotype) carriers (OR: 0.38, 95%CI: 0.19-0.77, p = 0.007). Multiple linear regression analysis showed a relationship between LEPR 223Arg, increased waist circumference, and leptinemia (p < 0.05), while LEPR 109Arg was associated with high total cholesterol and triglycerides (p < 0.05). LEPR haplotype 3 (AGG: 109Lys/233Arg/656Lys) carriers have increased risk for obesity (OR: 2.56, 95% CI: 1.19-5.49, p = 0.017). Moreover, this haplotype was associated with increased BMI, waist circumference, and leptinemia (p < 0.05). CONCLUSIONS: LEPR polymorphisms are associated with obesity, hyperleptinemia, and atherogenic lipid profile, suggesting their potential role for leptin resistance and cardiovascular risk. Moreover, LEPR haplotype 3 confers susceptibility to adiposity and hyperleptinemia in our population.

Shift work at young age is associated with increased risk for multiple sclerosis

2011 ◽  
Vol 70 (5) ◽  
pp. 733-741 ◽  
Author(s):  
Anna Karin Hedström ◽  
Torbjörn Åkerstedt ◽  
Jan Hillert ◽  
Tomas Olsson ◽  
Lars Alfredsson
Keyword(s):  
Multiple Sclerosis ◽  
Shift Work ◽  
Young Age ◽  
Increased Risk

Shift work at young age is associated with increased risk of multiple sclerosis in a Danish population

2016 ◽  
Vol 9 ◽  
pp. 104-109 ◽  
Author(s):  
S. Gustavsen ◽  
H.B. Søndergaard ◽  
D.B. Oturai ◽  
B. Laursen ◽  
J.H. Laursen ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Shift Work ◽  
Young Age ◽  
Danish Population ◽  
Increased Risk

scholarly journals Diet and colorectal cancer in UK Biobank: a prospective study

2019 ◽  
Vol 49 (1) ◽  
pp. 246-258 ◽  
Author(s):  
Kathryn E Bradbury ◽  
Neil Murphy ◽  
Timothy J Key
Keyword(s):  
Colorectal Cancer ◽  
Cox Regression ◽  
Dietary Factors ◽  
Processed Meat ◽  
Dietary Intakes ◽  
Uk Biobank ◽  
Breakfast Cereals ◽  
Increased Risk ◽  
Red And Processed Meat

Abstract Background Most of the previous studies on diet and colorectal cancer were based on diets consumed during the 1990s. Methods We used Cox-regression models to estimate adjusted hazard ratios for colorectal cancer by dietary factors in the UK Biobank study. Men and women aged 40–69 years at recruitment (2006–10) reported their diet on a short food-frequency questionnaire (n = 475 581). Dietary intakes were re-measured in a large sub-sample (n = 175 402) who completed an online 24-hour dietary assessment during follow-up. Trends in risk across the baseline categories were calculated by assigning re-measured intakes to allow for measurement error and changes in intake over time. Results During an average of 5.7 years of follow-up, 2609 cases of colorectal cancer occurred. Participants who reported consuming an average of 76 g/day of red and processed meat compared with 21 g/day had a 20% [95% confidence interval (CI): 4–37] higher risk of colorectal cancer. Participants in the highest fifth of intake of fibre from bread and breakfast cereals had a 14% (95% CI: 2–24) lower risk of colorectal cancer. Alcohol was associated with an 8% (95% CI: 4–12) higher risk per 10 g/day higher intake. Fish, poultry, cheese, fruit, vegetables, tea and coffee were not associated with colorectal-cancer risk. Conclusions Consumption of red and processed meat at an average level of 76 g/d that meets the current UK government recommendation (≤90 g/day) was associated with an increased risk of colorectal cancer. Alcohol was also associated with an increased risk of colorectal cancer, whereas fibre from bread and breakfast cereals was associated with a reduced risk.

O06-5 Shift work at young age is associated with increased risk for multiple sclerosis

2016 ◽  
Author(s):  
Lars Alfredsson ◽  
Anna-Karin Hedström ◽  
Torbjörn Åkerstedt ◽  
Jan Hillert ◽  
Tomas Olsson
Keyword(s):  
Multiple Sclerosis ◽  
Shift Work ◽  
Young Age ◽  
Increased Risk
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