Quality of Life in Patients with Gluten Neuropathy; Case-Controlled Study

Background: Gluten neuropathy (GN) is defined as an otherwise idiopathic peripheral neuropathy in the presence of serological evidence of gluten sensitivity (positive antigliadin and/or transglutaminase or endomysium antibodies). We aimed to compare the quality of life (QoL) of GN patients with control subjects and to investigate the effect of a gluten free diet (GFD) on the QoL. Methods: All consecutive patients with GN attending a specialist neuropathy clinic were invited to participate. Overall Neuropathy Limitations Scale (ONLS) was used to assess the severity of neuropathy. The SF-36 questionnaire was used to measure participants’ QoL. A strict GFD was defined as effectively been able to eliminate all circulating gluten sensitivity-related antibodies whilst on the diet. Results: Fifty-three patients with GN and 53 age and gender matched controls were recruited. Compared to controls, GN showed significantly worse scores in physical functioning, role limitations due to physical health, energy/fatigue and general health subdomains of SF-36. After having adjusted for age, gender and disease severity, being on a strict GFD correlated with better SF-36 scores on the pain domain of the SF-36 (beta 0.317, p=0.019) and the overall health change domain of the SF-36 (beta 0.306, p=0.017). Conclusion: In GN physical dysfunctioning is the major determinant of poor QoL compared to controls. Routine checking for elimination of gluten sensitivity-related antibodies that results from a strict GFD should be encouraged as such elimination ameliorates the overall pain and health scores, indicating better QoL.

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Physical Activity and Quality of Life in Hemodialysis Patients and Healthy Controls: A Cross-Sectional Study

International Journal of Environmental Research and Public Health ◽

10.3390/ijerph18041978 ◽

2021 ◽

Vol 18 (4) ◽

pp. 1978

Author(s):

Tjaša Filipčič ◽

Špela Bogataj ◽

Jernej Pajek ◽

Maja Pajek

Keyword(s):

Quality Of Life ◽

Physical Activity ◽

Everyday Life ◽

Habitual Physical Activity ◽

Healthy Controls ◽

Age And Gender ◽

Comorbidity Score ◽

Sf 36 ◽

And Gender

Hemodialysis (HD) patients have lower functional abilities compared to healthy people, and this is associated with lower physical activity in everyday life. This may affect their quality of life, but research on this topic is limited. Therefore, the present study aimed to determine the relationship between habitual physical activity and quality of life in HD patients and healthy controls. Ninety-three HD patients and 140 controls participated in the study. Quality of life was assessed using a 36-item medical outcomes study short-form health survey (SF-36). Human Activity Profile (HAP) was used to assess habitual physical activity. The adjusted activity score (AAS) from HAP, age, gender, fat tissue index (FTI), lean tissue index (LTI), and Davies comorbidity score were analyzed as possible predictors of the Physical Component Summary (PCS) of the SF-36. Three sequential linear models were used to model PCS. In Model 1, PCS was regressed by gender and age; in Model 2 the LTI, FTI, and Davies comorbidity scores were added. Model 3 also included AAS. After controlling for age and gender (ModelHD 1: p = 0.056), LTI, FTI, and Davies comorbidity score effects (ModelHD 2: p = 0.181), the AAS accounted for 32% of the variation in PCS of HD patients (ModelHD 3: p < 0.001). Consequently, the PCS of HD patients would increase by 0.431 points if the AAS increased by one point. However, in healthy controls, AAS had a lower impact than in the HD sample (B = 0.359 vs. 0.431), while the corresponding effects of age and gender (ModelH 1: p < 0.001), LTI, FTI, and Davies comorbidity score (ModelH 2: p < 0.001) were adjusted for. The proportion of variation in PCS attributed to AAS was 14.9% (ModelH 3: p < 0.001). The current study results showed that physical activity in everyday life as measured by the HAP questionnaire is associated to a higher degree with the quality of life of HD patients than in healthy subjects. Routine physical activity programs are therefore highly justified, and the nephrology community should play a leading role in this effort.

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Quality of life in patients with Charcot-Marie-Tooth disease type 1A

Arquivos de Neuro-Psiquiatria ◽

10.1590/0004-282x20130045 ◽

2013 ◽

Vol 71 (6) ◽

pp. 392-396 ◽

Cited By ~ 2

Author(s):

Juliana B. Taniguchi ◽

Valeria M.C. Elui ◽

Flavia L. Osorio ◽

Jaime E.C. Hallak ◽

Jose A.S. Crippa ◽

...

Keyword(s):

Quality Of Life ◽

Short Form ◽

Control Group ◽

Life Questionnaire ◽

Charcot Marie Tooth ◽

Social And Emotional ◽

Charcot Marie Tooth Disease ◽

Sf 36 ◽

And Gender

We assessed the functional impairment in Charcot-Marie-Tooth resulting from 17p11.2-p12 duplication (CMT1A) patients using the Short-Form Health Survey (SF-36), which is a quality of life questionnaire. Twenty-five patients of both genders aged ≥10 years with a positive molecular diagnosis of CMT1A were selected. Age- and gender-matched Control Group (without family history of neuropathy), and the sociodemographic and professional conditions similar to the patients' group were selected to compare the SF-36 results between them. The results showed that the majority quality of life impairments in CMT1A patients occurred in the social and emotional domains. Functional capacity also tended to be significantly affected; other indicators of physical impairment were preserved. In conclusion, social and emotional aspects are mostly neglected in the assistance provided to CMT1A Brazilian patients, and they should be better understood in order to offer global health assistance with adequate quality of life as a result.

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The effect of postoperative early mobilization on healing process and quality of life following radical cystectomy and ileal conduit: A randomized prospective controlled trial

10.22541/au.161545934.45040085/v1 ◽

2021 ◽

Author(s):

Sevgi Peker ◽

Özgür Çakmak ◽

Talha Muezzinoglu ◽

Guven Aslan ◽

Hakan Baydur

Keyword(s):

Quality Of Life ◽

Radical Cystectomy ◽

Ileal Conduit ◽

Healing Process ◽

Intervention Group ◽

Early Mobilization ◽

Controlled Study ◽

Control Group ◽

Sf 36

Aim: This study was conducted to evaluate the effect of postoperative early mobilization in patients who underwent radical cystectomy (RC) and ileal conduit in terms of healing process and QOL. Methods: This multicenter prospective randomized controlled study was conducted with 40 patients who were randomly divided into two groups. The intervention group was mobilized within the first 16 hours postoperatively in accordance with the mobilization procedure which determined according to literature. Data were collected using the case report form, HADS and SF-36 QoL scale. Results: Postoperative hospitalization, duration of narcotic analgesic administration, first oral food intake, flatus, defecation and NG tube termination time were shorter in the intervention group. In the control group blood glucose and pulse values were higher after mobilization. SF-36 physical function, physical role difficulty and general perception of health were higher in intervention group at the postoperative first and third month (p <0.05). Conclusion: Our study showed that early mobilization contributed to the healing process positively and improved the quality of life in the patients who underwent radical cystectomy (RC) and ileal conduit surgery. Keywords: Early Mobilization, Radical Cystectomy, Ileal conduit, Quality of Life, Convalescence

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Quality of life, clinical outcomes and safety of early prophylactic levothyroxine administration in patients with Graves' hyperthyroidism undergoing radioiodine therapy: a randomized controlled study

Acta Endocrinologica ◽

10.1530/eje-15-1099 ◽

2016 ◽

Vol 174 (4) ◽

pp. 491-502 ◽

Cited By ~ 13

Author(s):

David Taïeb ◽

Claire Bournaud ◽

Marie-Claude Eberle ◽

Bogdan Catargi ◽

Claire Schvartz ◽

...

Keyword(s):

Quality Of Life ◽

Primary Endpoint ◽

Radioiodine Therapy ◽

Controlled Study ◽

Thyroid Function Tests ◽

Randomized Controlled ◽

Sf 36 ◽

Group A ◽

Group B

ObjectiveWhile radioiodine therapy is commonly used for treating Graves' disease, a prolonged and clinical hypothyroidism may result in disabling symptoms leading to deterioration of quality of life (QoL) of patients. Introducing levothyroxine (LT4) treatment in the early post-therapeutic period may be an interesting approach to limit this phenomenon.MethodsA multicenter, prospective, open-label randomized controlled trial enrolled 94 patients with Graves' hyperthyroidism randomly assigned to the experimental group (n=46) (group A: early prophylactic LT4treatment) or the control group (n=48) (group B: standard follow-up). The primary endpoint was the 6-month QoL. The secondary endpoints were other QoL scores such as Graves' ophthalmopathy (GO) outcomes, thyroid function tests and safety.ResultsThe primary endpoint at 6 months was achieved: the mental composite score (MCS) of Short Form 36 (SF-36) was significantly higher in group A compared to group B (P=0.009). Four other dimension scores of the SF-36 and four dimension scores of the thyroid-specific patient-reported outcome (ThyPRO) significantly differed between the two groups, indicating better QoL in group A. After adjustment for variables, the early LT4administration strategy was found as an independent factor for only two scores of SF-36: the MCS and the general health (GH) score. There were no differences in GO, final thyroid status and changes in the anti-TSH receptor antibodies (TRAbs) levels between the two groups. No adverse cardiovascular event was reported.ConclusionEarly LT4administration post-radioactive iodine (RAI) could represent a safe potential benefit for patients with regard to QoL. The optimal strategy taking into account administered RAI activities and LT4treatment dosage and timing remains to be determined.

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Comorbid Migraine is Associated with a Negative Impact on Quality of Life in Patients with Major Depression

Cephalalgia ◽

10.1111/j.1468-2982.2005.00985.x ◽

2006 ◽

Vol 26 (1) ◽

pp. 26-32 ◽

Cited By ~ 29

Author(s):

C-I Hung ◽

C-Y Liu ◽

J-L Fuh ◽

Y-Y Juang ◽

S-J Wang

Keyword(s):

Quality Of Life ◽

Negative Impact ◽

Short Form ◽

Physical Symptom ◽

Sf 36 ◽

Related Quality ◽

Health Related ◽

And Gender ◽

The Impact

This study investigated the impact of migraine on health-related quality of life (HRQoL) among patients with major depressive disorder (MDD). We prospectively enrolled 151 consecutive psychiatric out-patients meeting DSM-IV criteria for MDD. Migraine and other headache types were diagnosed based on the International Classification of Headache Disorders, 2nd edition (2004). The Short Form-36 (SF-36) was administered as a generic instrument of HRQoL. Among 151 patients with MDD, migraine ( N = 73, 48.3%) was very common. Comorbidity of migraine predicted a significantly negative impact on all physical subscales and vitality but not on the other mental subscales of the SF-36 after controlling for depression, age and gender. The presence of migraine should be considered as an important physical symptom in clinic-based MDD samples. Simultaneous management of depression and severe headaches, especially migraine, might improve HRQoL in patients with MDD.

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Health related quality of life in children with migraine. A controlled study

Headache Medicine ◽

10.48208/headachemed.2013.10 ◽

2013 ◽

pp. 54-58

Author(s):

Mateus Lage Martins ◽

Rafael Corrêa Valério ◽

Tales José Corrêa de Almeida ◽

Vitor Rodrigues Laender ◽

Dilermando Fazito de Resende ◽

...

Keyword(s):

Quality Of Life ◽

Bodily Pain ◽

Controlled Study ◽

Health Related Quality ◽

Role Functioning ◽

Sf 36 ◽

Related Quality ◽

Health Related ◽

The Impact

Background: Headaches are prevalent in the pediatric population. Migraine significantly impacts the health-related quality of life (HRQoL) of sufferers. Objective: To measure the impact of migraine on the HRQoL of children, by applying the Brazilian version of the SF-36 in children with migraine and in controls. Methods: In this cross-sectional study, HRQoL was measured with the SF-36, and scores for the 8 domains of the test were contrasted comparing children (5 to 14 years) with and without migraine. Results: Sample consisted of 66 children (30 with migraine and 36 controls). Mean age was 10.9 years for migraine (Standard Deviation - SD = 3 years) and 10.4 for controls (SD = 3.1 years). Proportion of children with low HRQoL scores was significantly higher in the migraine group, relative to controls, for the 8 domains of the test: vitality, physical functioning, bodily pain, general health perceptions, physical role functioning, emotional role functioning, social role functioning, and mental health. Conclusion: Children with migraine are significantly impacted in their HRQoL, relative to children without migraine.

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Consequential Effect of Gluten-Free Diet on Health-Related Quality of Life in Celiac Populace-A Meta-Analysis

Current Research in Nutrition and Food Science Journal ◽

10.12944/crnfsj.8.3.29 ◽

2020 ◽

Vol 8 (3) ◽

pp. 1025-1036

Author(s):

Shivani Rustagi ◽

Saumya Choudhary ◽

Sheeba Khan ◽

Tanu Jain

Keyword(s):

Quality Of Life ◽

Meta Analysis ◽

Gluten Free Diet ◽

Gluten Free ◽

Health Related Quality ◽

Component Score ◽

Sf 36 ◽

Related Quality ◽

Health Related

Globally, celiac disease (CD) affects around 1-2% of the population. Gluten elimination becomes the cornerstone treatment and is also being followed by non-celiac as a healthy dietary habit. However, there is lack of sustainable evidence to understand this view. Adherence to gluten-free diet (GFD) rendered a few to reduced quality of life. Hence, a meta-analysis has been performed to determine interaction of GFD and Health-related Quality of Life (HRQoL). NCBI/MEDLINE, PubMed, Cochrane Library, Google Scholar and Science Direct were combed from date of inception to October 30, 2018 for studies assessing the effect of GFD using validated questionnaires on HRQoL a) between healthy controls and celiac patients b) dietary adherence to GFD in celiac subjects. Random effect model was used for meta-analysis. Twenty-five studies comprising 5148 CD subjects fit in the inclusion criteria. GFD had moderate significant association with HRQoL, for PGWB odds ratio’s (OR) 0.613 [95% CI, 0.449-0.837], SF-36 Mental Component Score (MCS) 0.026 [95% CI, 0.011-0.060], Physical Component Score (PCS) 0.066 95% [CI, 0.032-0.138]. Partial adherence to GFD had lower quality of life when compared to strictly adherent patients for OR’s SF-36 MCS 5.080 [95% CI, 1.885- 13.692], PCS 3.204 [95% CI, 1.579- 6.503] and CDQoL 2.439 [95%CI (1.724- 3.450)]. The results implied moderate significant association between GFD and HRQoL and better compliance leads to favourable HRQoL.

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Effect of Age and Gender on Quality of Life in patients of Obstructive Jaundice

10.53350/pjmhs2115123150 ◽

2021 ◽

Vol 15 (12) ◽

pp. 3150-3151

Author(s):

Farhana Memon ◽

Ashfaque Ahmed ◽

Saima Sagheer ◽

Fariya Usmani ◽

Muhammad Naveed ◽

...

Keyword(s):

Quality Of Life ◽

Obstructive Jaundice ◽

Case Control Study ◽

Sampling Technique ◽

Age And Gender ◽

Sf 36 ◽

And Gender ◽

Effect Of Age ◽

Control Study

Aim: Effect of age and gender on quality of life in patients of obstructive jaundice. Methodology: This was a case control study conducted in OPD of General Surgery, Unit-1, Civil Hospital, Karachi. It is non-probability, consecutive sampling technique. The sample size was 195 subjects. 87 patients had an age between 18-60 years whereas 108 patients had >60 years of age. Either gender was included. QoL was measured by using SF-36 based on 8 domains. Data were analyzed through SPSS version-21 Results: Significant effect of age in obstructive jaundice patients on their QOL (p<0.01) where patients aged from 18 to 60 years had significantly higher SF-36 quality of life scores, both overall and in all eight individual domains than patients aged >60 years. Gender of the obstructive jaundice patients did not have a significant effect on their QOL, though the female patients had higher SF-36 quality of life scores, both overall and in all eight individual domains. Conclusion: Quality of life of obstructive jaundice patients were more improved with the age between 20-60 years than age >60 years, whereas gender had no significant impact on the quality of life. Keywords: Obstructive jaundice, age, gender, quality of life

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Influence of Family Therapy on Bullying Behaviour, Cortisol Secretion, Anger, and Quality of Life in Bullying Male Adolescents: A Randomized, Prospective, Controlled Study

The Canadian Journal of Psychiatry ◽

10.1177/070674370605100604 ◽

2006 ◽

Vol 51 (6) ◽

pp. 355-362 ◽

Cited By ~ 21

Author(s):

Marius K Nickel ◽

Moritz Muehlbacher ◽

Patrick Kaplan ◽

Jakub Krawczyk ◽

Wiebke Buschmann ◽

...

Keyword(s):

Quality Of Life ◽

Family Therapy ◽

Salivary Cortisol ◽

Cortisol Concentration ◽

Trait Anger ◽

Controlled Study ◽

Control Group ◽

Sf 36 ◽

Health Related

Objective: To determine the influence of brief strategic family therapy (BSFT) on salivary cortisol, anger, and health-related quality of life (QoL) in adolescent boys with bullying behaviour. Method: We selected a sample of 72 boys demonstrating bullying behaviour from the general population and treated 36 with BSFT for 12 weeks. The other 36 boys formed the control group. Primary outcome measures were salivary cortisol concentration 15 to 30 minutes after awakening and changes on the subscales of the State-Trait Anger Expression Inventory (STAXI) and the Health Survey (SF-36). Results: After 12 weeks' treatment, we observed a significant reduction in bullying behaviour in the BSFT group ( P = 0.017) and in the mean values (according to the intent-to-treat principle) for salivary cortisol concentration ( P < 0.001). The BSFT group also showed significantly greater change on the STAXI subscales State-Anger ( P < 0.001), Trait-Anger ( P < 0.001), Anger-Out ( P < 0.001), and Anger-Control ( P < 0.001). Treatment with BSFT also resulted in significant improvement on the SF-36 subscales for Vitality ( P < 0.001), Social Functioning ( P < 0.001), Role-Emotional ( P < 0.001), and Mental Health ( P < 0.001). Conclusions: BSFT effectively influenced bullying behaviour, salivary cortisol concentration, anger, and health-related QoL in adolescent bullying boys.

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