scholarly journals Disposable Optical Stretcher Fabricated by Micro Injection Moulding

2018 ◽  
Author(s):  
Gianluca Trotta ◽  
Rebeca Martínez Vázquez ◽  
Annalisa Volpe ◽  
Francesco Modica ◽  
Antonio Ancona ◽  
...  
Keyword(s):  
Capillary Tube ◽  
Lab On A Chip ◽  
Microfluidic Channels ◽  
Micro Injection Moulding ◽  
Electro Discharge Machining ◽  
Optical Stretcher ◽  
Real Mass ◽  
Manufacturing Technologies ◽  
Final Composition ◽  
Disposable Plastic

Micro Injection molding combined with the use of removable inserts is one of the most promising manufacturing process for microfluidic devices, such as Lab-on-a-chip, that have the potential to revolutionize the healthcare and diagnosis system. In this work we have designed, fabricated and tested a compact and disposable plastic optical stretcher. To produce the mould inserts, two micro manufacturing technologies have been used. Micro Electro Discharge machining was used to reproduce the inverse of the capillary tube connection characterized by high aspect ratio. Thanks to the high accuracy of femtosecond laser machining, instead, we manufactured insert with perfectly aligned microfluidic channels and fiber slots, facilitating the final composition of the optical manipulation device. The optical stretcher operation is tested using microbeads and red blood cells solutions. The prototype presented in this work demonstrates the feasibility of this approach that should guarantee a real mass production of ready-to-use- Lab-on-a-chip.

scholarly journals Disposable Optical Stretcher Fabricated by Microinjection Moulding

Micromachines ◽  
2018 ◽  
Vol 9 (8) ◽  
pp. 388 ◽  
Author(s):  
Gianluca Trotta ◽  
Rebeca Martínez Vázquez ◽  
Annalisa Volpe ◽  
Francesco Modica ◽  
Antonio Ancona ◽  
...  
Keyword(s):  
Capillary Tube ◽  
Microfluidic Channels ◽  
Lab On Chip ◽  
Femtosecond Laser Micromachining ◽  
Electro Discharge Machining ◽  
Optical Stretcher ◽  
Real Mass ◽  
On Chip ◽  
Manufacturing Technologies ◽  
Microinjection Moulding

Microinjection moulding combined with the use of removable inserts is one of the most promising manufacturing processes for microfluidic devices, such as lab-on-chip, that have the potential to revolutionize the healthcare and diagnosis systems. In this work, we have designed, fabricated and tested a compact and disposable plastic optical stretcher. To produce the mould inserts, two micro manufacturing technologies have been used. Micro electro discharge machining (µEDM) was used to reproduce the inverse of the capillary tube connection characterized by elevated aspect ratio. The high accuracy of femtosecond laser micromachining (FLM) was exploited to manufacture the insert with perfectly aligned microfluidic channels and fibre slots, facilitating the final composition of the optical manipulation device. The optical stretcher operation was tested using microbeads and red blood cells solutions. The prototype presented in this work demonstrates the feasibility of this approach, which should guarantee real mass production of ready-to-use lab-on-chip devices.

Particle Manipulation Inside a Grooved Microfluidic Channel

2009 ◽  
Author(s):  
Hsiu-hung Chen ◽  
Dayong Gao
Keyword(s):  
Rapid Prototyping ◽  
Microfluidic Device ◽  
Microfluidic Channel ◽  
Lab On A Chip ◽  
Cell Suspensions ◽  
Microfluidic Channels ◽  
Particle Manipulation ◽  
Post Processing ◽  
Processing Stage ◽  
Submicron Structures

The manipulation of particles and cells in micro-fluids, such as cell suspensions, is a fundamental task in Lab-on-a-Chip applications. According to their analysis purposes in either the pre- or post-processing stage, particles/cells flowing inside a microfluidic channel are handled by means of enriching, trapping, separating or sorting. In this study, we report the use of patterning flows produced by a series of grooved surfaces with different geometrical setups integrated into a microfluidic device, to continuously manipulate the flowing particles (5 to 20 μm in diameters) of comparable sizes to the depth of the channel in ways of: 1) concentrating, 2) focusing, and 3) potential separating. The device is fabricated using soft lithographic techniques and is composed of inlets, microfluidic channels, and outlets for loading, manipulating and retrieving cell suspensions, respectively. Such fabrication methods allow rapid prototyping of micron or submicron structures with multiple layers and replica molding on those fabricated features in a clear polymer. The particles are evenly distributed in the entrance of the microchannel and illustrate the enriching, focusing, or size-selective profiles after passing through the patterning grooves. We expect that the techniques of manipulating cell suspensions from this study can facilitate the development of cell-based devices on 1) the visualization of counting, 2) the visualization of sizing, and 3) the particle separating.

All-fiber 1-D optical stretcher for bio-cells implemented in a Lab-on-a-Chip

2013 ◽  
Author(s):  
Sungrae Lee ◽  
Yoon-Sung Bae ◽  
Pyo Jin Jeon ◽  
Seongil Im ◽  
Dug Young Kim ◽  
...  
Keyword(s):  
Lab On A Chip ◽  
Optical Stretcher

scholarly journals Electro-actuated valves and self-vented channels enable programmable flow control and monitoring in capillary-driven microfluidics

2020 ◽  
Vol 6 (16) ◽  
pp. eaay8305 ◽  
Author(s):  
Yulieth Arango ◽  
Yuksel Temiz ◽  
Onur Gökçe ◽  
Emmanuel Delamarche
Keyword(s):  
Flow Control ◽  
High Throughput ◽  
Lab On A Chip ◽  
Microfluidic Channels ◽  
Electronic Feedback ◽  
Programmable Device ◽  
Assay Protocol

Microfluidics are essential for many lab-on-a-chip applications, but it is still challenging to implement a portable and programmable device that can perform an assay protocol autonomously when used by a person with minimal training. Here, we present a versatile concept toward this goal by realizing programmable liquid circuits where liquids in capillary-driven microfluidic channels can be controlled and monitored from a smartphone to perform various advanced tasks of liquid manipulation. We achieve this by combining electro-actuated valves (e-gates) with passive capillary valves and self-vented channels. We demonstrate the concept by implementing a 5-mm-diameter microfluidic clock, a chip to control four liquids using 100 e-gates with electronic feedback, and designs to deliver and merge multiple liquids sequentially or in parallel in any order and combination. This concept is scalable, compatible with high-throughput manufacturing, and can be adopted in many microfluidics-based assays that would benefit from precise and easy handling of liquids.

Funkenerosive Mikrobohrungen mit der Plug & Play Sonodrive300/Improved process for microstructuring of components – EDM micro-drilling with the Plug & Play Sonodrive300

2020 ◽  
Vol 110 (11-12) ◽  
pp. 784-786
Author(s):  
Stefan Kunz ◽  
Antonia Winkler
Keyword(s):  
Removal Rate ◽  
Resource Efficiency ◽  
Manufacturing Processes ◽  
High Reproducibility ◽  
Eine Hohe ◽  
Electro Discharge Machining ◽  
Micro Drilling ◽  
Manufacturing Methods ◽  
Manufacturing Technologies

Die steigende Komplexität von Produkten und Fertigungsprozessen fordert von den Fertigungsverfahren gesteigerte Präzision und Geometrievielfalt, eine hohe Reproduktionsfähigkeit sowie kürzere Prozesszeiten. Gleichzeitig steigen der Anteil der Automatisierung und der Trend zur Miniaturisierung. Auch für die Mikrostrukturierung gilt es wirtschaftliche Fertigungsverfahren einzusetzen. Ebenso spielen Kosten- und Ressourceneffizienz in diesem Zusammenhang eine wichtige Rolle. Funkenerosion, ein seit vielen Jahren etabliertes Strukturierungsverfahren, eignet sich aufgrund von einigen Technologievorteilen hervorragend zur Mikrostrukturierung von Bauteilen, gehört jedoch wegen der niedrigen Abtragsrate im Vergleich zu anderen Fertigungstechnologien zu den eher langsamen Verfahren. The increasing complexity of products and manufacturing processes demands increased precision and geometric diversity, high reproducibility and shorter process times from manufacturing methods. At the same time, the proportion of automation and the trend towards miniaturization are increasing. Economical manufacturing methods need to be used for microstructuring as well. Cost and resource efficiency also play an important role in this context. Electro discharge machining (EDM), a structuring process that has been established for many years, is excellently suited for microstructuring components due to a number of technological advantages, but is one of the rather slow processes due to its low removal rate compared to other manufacturing technologies.

scholarly journals Feature Characterization of Microfluidic Channels Created Using Direct Laser Ablation

2007 ◽  
Vol 15 (2) ◽  
pp. 32-35
Author(s):  
John Little ◽  
Dan Borah
Keyword(s):  
Laser Ablation ◽  
Large Scale ◽  
Industrial Applications ◽  
Microfluidic Channels ◽  
Direct Laser ◽  
Large Scale Integration ◽  
Manufacturing Technologies ◽  
Scale Integration ◽  
Micrometer Scale

Microfluidic devices, with their ability to manipulate and analyze nanoliter volumes of chemicals and other fluids, have attracted great interest across a broad range of research and industrial applications. Corporate and academic laboratories around the world are deeply engaged in developing manufacturing technologies for these devices, hoping to create the same kind of benefits and value that accrued from the miniaturization and large scale integration of electronic devices. The flexibility and programmability of direct laser ablation make it attractive as a fabrication technology, but many other aspects of its performance remain to be understood and characterized. Advanced confocal microscopy, which provides fast, high-resolution, threedimensional visualization and measurement of micrometer scale structure, is ideally suited to this characterization task.

scholarly journals Experimental Study on Microfluidic Mixing with Different Zigzag Angles

Micromachines ◽  
2019 ◽  
Vol 10 (9) ◽  
pp. 583 ◽  
Author(s):  
Chia-Hung Dylan Tsai ◽  
Xin-Yu Lin
Keyword(s):  
Reynolds Number ◽  
High Speed ◽  
Microfluidic Channel ◽  
Lab On A Chip ◽  
Flow Speed ◽  
Low Flow ◽  
Microfluidic Channels ◽  
Microfluidic Mixing ◽  
Mixing Performance ◽  
Speed Regime

This paper presents experimental investigations of passive mixing in a microfluidic channel with different zigzag angles. Zigzag channel is commonly used for microfluidic mixing because it does not need an additional control unit and can be easily implemented in a lab-on-a-chip system. In this work, microfluidic channels with six different zigzag angles, from θ = 0° to θ = 75°, are tested under ten different flow rates corresponding to Reynolds number from 0.309 to 309. Two colored liquids are mixed with the zigzag channels and mixing performance is evaluated based on the color of the pixels on the region of interest from captured images. According to the results, we found that the mixing performance is almost independent of the zigzag angle in the low-speed regime where its Reynolds number is less than 4. The mixing became very much depending on the zigzag angle in the high-speed regime where its Reynolds number is greater than 100. Microfluidic mixing is needed for Lab-on-a-chip applications in both low flow speed, such as medium perfusion for cell culture, and high flow speed, such as high-speed sensing on a point-of-care device. This work is aimed to provide practical information on zigzag mixing for chip design and applications.

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