Electrofluidic circuits enable easy, straightforward monitoring of pressure within microfluidic channels for next-generation lab-on-a-chip systems.

SPIE Newsroom ◽  
2012 ◽  
Author(s):  
Yi-Chung Tung ◽  
Chueh-Yu Wu
Keyword(s):  
Lab On A Chip ◽  
Microfluidic Channels ◽  
Next Generation

Development of a platform for single cell genomics using convex lens-induced confinement

Lab on a Chip ◽  
2015 ◽  
Vol 15 (14) ◽  
pp. 3013-3020 ◽  
Author(s):  
Sara Mahshid ◽  
Mohammed Jalal Ahamed ◽  
Daniel Berard ◽  
Susan Amin ◽  
Robert Sladek ◽  
...  
Keyword(s):  
Single Cell ◽  
Base Pair ◽  
Single Cell Analysis ◽  
Lab On A Chip ◽  
Cell Analysis ◽  
Next Generation ◽  
Single Cell Genomics ◽  
Convex Lens ◽  
Genomic Dnas

We present a lab-on-a-chip for the next generation of single-cell genomics, performing full-cycle single-cell analysis by demonstrating mega-base pair genomic DNAs in nanochannels extracted in situ.

Particle Manipulation Inside a Grooved Microfluidic Channel

2009 ◽  
Author(s):  
Hsiu-hung Chen ◽  
Dayong Gao
Keyword(s):  
Rapid Prototyping ◽  
Microfluidic Device ◽  
Microfluidic Channel ◽  
Lab On A Chip ◽  
Cell Suspensions ◽  
Microfluidic Channels ◽  
Particle Manipulation ◽  
Post Processing ◽  
Processing Stage ◽  
Submicron Structures

The manipulation of particles and cells in micro-fluids, such as cell suspensions, is a fundamental task in Lab-on-a-Chip applications. According to their analysis purposes in either the pre- or post-processing stage, particles/cells flowing inside a microfluidic channel are handled by means of enriching, trapping, separating or sorting. In this study, we report the use of patterning flows produced by a series of grooved surfaces with different geometrical setups integrated into a microfluidic device, to continuously manipulate the flowing particles (5 to 20 μm in diameters) of comparable sizes to the depth of the channel in ways of: 1) concentrating, 2) focusing, and 3) potential separating. The device is fabricated using soft lithographic techniques and is composed of inlets, microfluidic channels, and outlets for loading, manipulating and retrieving cell suspensions, respectively. Such fabrication methods allow rapid prototyping of micron or submicron structures with multiple layers and replica molding on those fabricated features in a clear polymer. The particles are evenly distributed in the entrance of the microchannel and illustrate the enriching, focusing, or size-selective profiles after passing through the patterning grooves. We expect that the techniques of manipulating cell suspensions from this study can facilitate the development of cell-based devices on 1) the visualization of counting, 2) the visualization of sizing, and 3) the particle separating.

scholarly journals Crowd-sourced BioGames: managing the big data problem for next-generation lab-on-a-chip platforms

Lab on a Chip ◽  
2012 ◽  
Vol 12 (20) ◽  
pp. 4102 ◽  
Author(s):  
Sam Mavandadi ◽  
Stoyan Dimitrov ◽  
Steve Feng ◽  
Frank Yu ◽  
Richard Yu ◽  
...  
Keyword(s):  
Big Data ◽  
Lab On A Chip ◽  
Next Generation ◽  
Data Problem

scholarly journals Electro-actuated valves and self-vented channels enable programmable flow control and monitoring in capillary-driven microfluidics

2020 ◽  
Vol 6 (16) ◽  
pp. eaay8305 ◽  
Author(s):  
Yulieth Arango ◽  
Yuksel Temiz ◽  
Onur Gökçe ◽  
Emmanuel Delamarche
Keyword(s):  
Flow Control ◽  
High Throughput ◽  
Lab On A Chip ◽  
Microfluidic Channels ◽  
Electronic Feedback ◽  
Programmable Device ◽  
Assay Protocol

Microfluidics are essential for many lab-on-a-chip applications, but it is still challenging to implement a portable and programmable device that can perform an assay protocol autonomously when used by a person with minimal training. Here, we present a versatile concept toward this goal by realizing programmable liquid circuits where liquids in capillary-driven microfluidic channels can be controlled and monitored from a smartphone to perform various advanced tasks of liquid manipulation. We achieve this by combining electro-actuated valves (e-gates) with passive capillary valves and self-vented channels. We demonstrate the concept by implementing a 5-mm-diameter microfluidic clock, a chip to control four liquids using 100 e-gates with electronic feedback, and designs to deliver and merge multiple liquids sequentially or in parallel in any order and combination. This concept is scalable, compatible with high-throughput manufacturing, and can be adopted in many microfluidics-based assays that would benefit from precise and easy handling of liquids.

scholarly journals Intelligent Shape-Morphing Micromachines

Research ◽  
2021 ◽  
Vol 2021 ◽  
pp. 1-16
Author(s):  
Qianying Chen ◽  
Pengyu Lv ◽  
Jianyong Huang ◽  
Tian-Yun Huang ◽  
Huiling Duan
Keyword(s):  
Precision Medicine ◽  
Smart Materials ◽  
Lab On A Chip ◽  
Dynamic Environments ◽  
Design Methods ◽  
Small Scale ◽  
Next Generation ◽  
Intelligent Machines ◽  
Shape Morphing ◽  
Shape Transformations

Intelligent machines are capable of switching shape configurations to adapt to changes in dynamic environments and thus have offered the potentials in many applications such as precision medicine, lab on a chip, and bioengineering. Even though the developments of smart materials and advanced micro/nanomanufacturing are flouring, how to achieve intelligent shape-morphing machines at micro/nanoscales is still significantly challenging due to the lack of design methods and strategies especially for small-scale shape transformations. This review is aimed at summarizing the principles and methods for the construction of intelligent shape-morphing micromachines by introducing the dimensions, modes, realization methods, and applications of shape-morphing micromachines. Meanwhile, this review highlights the advantages and challenges in shape transformations by comparing micromachines with the macroscale counterparts and presents the future outlines for the next generation of intelligent shape-morphing micromachines.

Nanotechnology-assisted microfluidic systems: from bench to bedside

Nanomedicine ◽  
2021 ◽  
Vol 16 (3) ◽  
pp. 237-258
Author(s):  
Navid Rabiee ◽  
Sepideh Ahmadi ◽  
Yousef Fatahi ◽  
Mohammad Rabiee ◽  
Mojtaba Bagherzadeh ◽  
...  
Keyword(s):  
Point Of Care ◽  
Lab On A Chip ◽  
Medical Applications ◽  
Next Generation ◽  
Wide Spread ◽  
Microfluidic Systems ◽  
Collective Attention ◽  
Increased Sensitivity ◽  
Organ On A Chip ◽  
Global Population

With significant advancements in research technologies, and an increasing global population, microfluidic and nanofluidic systems (such as point-of-care, lab-on-a-chip, organ-on-a-chip, etc) have started to revolutionize medicine. Devices that combine micron and nanotechnologies have increased sensitivity, precision and versatility for numerous medical applications. However, while there has been extensive research on microfluidic and nanofluidic systems, very few have experienced wide-spread commercialization which is puzzling and deserves our collective attention. For the above reasons, in this article, we review research advances that combine micro and nanotechnologies to create the next generation of nanomaterial-based microfluidic systems, the latest in their commercialization success and failure and highlight the value of these devices both in industry and in the laboratory.

scholarly journals Experimental Study on Microfluidic Mixing with Different Zigzag Angles

Micromachines ◽  
2019 ◽  
Vol 10 (9) ◽  
pp. 583 ◽  
Author(s):  
Chia-Hung Dylan Tsai ◽  
Xin-Yu Lin
Keyword(s):  
Reynolds Number ◽  
High Speed ◽  
Microfluidic Channel ◽  
Lab On A Chip ◽  
Flow Speed ◽  
Low Flow ◽  
Microfluidic Channels ◽  
Microfluidic Mixing ◽  
Mixing Performance ◽  
Speed Regime

This paper presents experimental investigations of passive mixing in a microfluidic channel with different zigzag angles. Zigzag channel is commonly used for microfluidic mixing because it does not need an additional control unit and can be easily implemented in a lab-on-a-chip system. In this work, microfluidic channels with six different zigzag angles, from θ = 0° to θ = 75°, are tested under ten different flow rates corresponding to Reynolds number from 0.309 to 309. Two colored liquids are mixed with the zigzag channels and mixing performance is evaluated based on the color of the pixels on the region of interest from captured images. According to the results, we found that the mixing performance is almost independent of the zigzag angle in the low-speed regime where its Reynolds number is less than 4. The mixing became very much depending on the zigzag angle in the high-speed regime where its Reynolds number is greater than 100. Microfluidic mixing is needed for Lab-on-a-chip applications in both low flow speed, such as medium perfusion for cell culture, and high flow speed, such as high-speed sensing on a point-of-care device. This work is aimed to provide practical information on zigzag mixing for chip design and applications.

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