scholarly journals Detection of Chloroalkanes by Surface-Enhanced Raman Spectroscopy in Microfluidic Chip

2018 ◽  
Author(s):  
Zdeněk Pilát ◽  
Martin Kizovský ◽  
Jan Ježek ◽  
Stanislav Krátký ◽  
Jaroslav Sobota ◽  
...  
Keyword(s):  
Raman Spectroscopy ◽  
Gold Surface ◽  
Surface Enhanced Raman Spectroscopy ◽  
Microfluidic System ◽  
Environmental Pollutant ◽  
Spectral Lines ◽  
Quantitative Detection ◽  
Sers Substrate ◽  
Surface Enhanced ◽  
Surface Enhanced Raman

Optofluidics, a research discipline combining optics with microfluidics, currently aspires to revolutionize the analysis of biological and chemical samples e.g. for medicine, pharmacology, or molecular biology. In order to detect low concentrations of analytes in water, we developed an optofluidic device containing a nanostructured substrate for surface enhanced Raman spectroscopy (SERS). The geometry of the gold surface allows localized plasmon oscillations to give rise to the SERS effect, in which the Raman spectral lines are intensified by the interaction of the plasmonic field with the electrons in the molecular bonds. The SERS substrate was enclosed in a microfluidic system, which allowed transport and precise mixing of the analyzed fluids, while preventing contamination or abrasion of the highly sensitive substrate. To illustrate its practical use, we employed the device for quantitative detection of persistent environmental pollutant 1,2,3-trichloropropane in water in submillimolar concentrations. The developed sensor allows fast and simple quantification of halogenated compounds and it will contribute towards the environmental monitoring and enzymology experiments with engineered haloalkane dehalogenase enzymes.

scholarly journals Detection of Chloroalkanes by Surface-Enhanced Raman Spectroscopy in Microfluidic Chips

Sensors ◽  
2018 ◽  
Vol 18 (10) ◽  
pp. 3212 ◽  
Author(s):  
Zdeněk Pilát ◽  
Martin Kizovský ◽  
Jan Ježek ◽  
Stanislav Krátký ◽  
Jaroslav Sobota ◽  
...  
Keyword(s):  
Raman Spectroscopy ◽  
Gold Surface ◽  
Surface Enhanced Raman Spectroscopy ◽  
Microfluidic System ◽  
Environmental Pollutant ◽  
Spectral Lines ◽  
Quantitative Detection ◽  
Sers Substrate ◽  
Surface Enhanced ◽  
Surface Enhanced Raman

Optofluidics, a research discipline combining optics with microfluidics, currently aspires to revolutionize the analysis of biological and chemical samples, e.g., for medicine, pharmacology, or molecular biology. In order to detect low concentrations of analytes in water, we have developed an optofluidic device containing a nanostructured substrate for surface enhanced Raman spectroscopy (SERS). The geometry of the gold surface allows localized plasmon oscillations to give rise to the SERS effect, in which the Raman spectral lines are intensified by the interaction of the plasmonic field with the electrons in the molecular bonds. The SERS substrate was enclosed in a microfluidic system, which allowed transport and precise mixing of the analyzed fluids, while preventing contamination or abrasion of the highly sensitive substrate. To illustrate its practical use, we employed the device for quantitative detection of persistent environmental pollutant 1,2,3-trichloropropane in water in submillimolar concentrations. The developed sensor allows fast and simple quantification of halogenated compounds and it will contribute towards the environmental monitoring and enzymology experiments with engineered haloalkane dehalogenase enzymes.

Multivariate Analysis Aided Surface-Enhanced Raman Spectroscopy (MVA-SERS) Multiplex Quantitative Detection of Trace Fentanyl in Illicit Drug Mixtures Using a Handheld Raman Spectrometer

2021 ◽  
pp. 000370282110329
Author(s):  
Ling Wang ◽  
Mario O. Vendrell-Dones ◽  
Chiara Deriu ◽  
Sevde Doğruer ◽  
Peter de B. Harrington ◽  
...  
Keyword(s):  
Raman Spectroscopy ◽  
Principal Component ◽  
Surface Enhanced Raman Spectroscopy ◽  
Quantitative Detection ◽  
Least Squares Regression ◽  
Surface Enhanced ◽  
Surface Enhanced Raman ◽  
Sers Detection ◽  
Current Screening

Recently there has been upsurge in reports that illicit seizures of cocaine and heroin have been adulterated with fentanyl. Surface-enhanced Raman spectroscopy (SERS) provides a useful alternative to current screening procedures that permits detection of trace levels of fentanyl in mixtures. Samples are solubilized and allowed to interact with aggregated colloidal nanostars to produce a rapid and sensitive assay. In this study, we present the quantitative determination of fentanyl in heroin and cocaine using SERS, using a point-and-shoot handheld Raman system. Our protocol is optimized to detect pure fentanyl down to 0.20 ± 0.06 ng/mL and can also distinguish pure cocaine and heroin at ng/mL levels. Multiplex analysis of mixtures is enabled by combining SERS detection with principal component analysis and super partial least squares regression discriminate analysis (SPLS-DA), which allow for the determination of fentanyl as low as 0.05% in simulated seized heroin and 0.10% in simulated seized cocaine samples.

A Reproducible Surface-Enhanced Raman Spectroscopy Approach. Online SERS Measurements in a Segmented Microfluidic System

2007 ◽  
Vol 79 (4) ◽  
pp. 1542-1547 ◽  
Author(s):  
Katrin R. Strehle ◽  
Dana Cialla ◽  
Petra Rösch ◽  
Thomas Henkel ◽  
Michael Köhler ◽  
...  
Keyword(s):  
Raman Spectroscopy ◽  
Surface Enhanced Raman Spectroscopy ◽  
Microfluidic System ◽  
Surface Enhanced ◽  
Surface Enhanced Raman

scholarly journals Application of Doehlert Matrix for an Optimized Preparation of a Surface-Enhanced Raman Spectroscopy (SERS) Substrate Based on Silicon Nanowires for Ultrasensitive Detection of Rhodamine 6G

2019 ◽  
Vol 74 (2) ◽  
pp. 168-177 ◽  
Author(s):  
Awatef Ouhibi ◽  
Maroua Saadaoui ◽  
Nathalie Lorrain ◽  
Mohammed Guendouz ◽  
Noureddine Raouafi ◽  
...  
Keyword(s):  
Raman Spectroscopy ◽  
Silver Nitrate ◽  
Silicon Nanowires ◽  
Rhodamine 6G ◽  
Surface Enhanced Raman Spectroscopy ◽  
Influential Factor ◽  
Metallic Surface ◽  
Sers Substrate ◽  
Surface Enhanced ◽  
Surface Enhanced Raman

In this work, we combined a hierarchical nano-array effect of silicon nanowires (SiNWs) with a metallic surface of silver nanoparticles (AgNPs) to design a surface-enhanced Raman spectroscopy (SERS) scattering substrate for sensitive detection of Rhodamine 6G (R6G) which is a typical dye for fluorescence probes. The SiNWs were prepared by Metal-Assisted Chemical Etching (MACE) of n-Si (100) wafers. The Doehlert design methodology was used for planning the experiment and analyzing the experimental results. Thanks to this methodology, the R6G SERS response has been optimized by studying the effects of the silver nitrate concentration, silver nitrate and R6G immersion times and their interactions. The immersion time in R6G solution stands out as the most of influential factor on the SERS response.

scholarly journals Porous carbon nanowire array for surface-enhanced Raman spectroscopy

2020 ◽  
Vol 11 (1) ◽  
Author(s):  
Nan Chen ◽  
Ting-Hui Xiao ◽  
Zhenyi Luo ◽  
Yasutaka Kitahama ◽  
Kotaro Hiramatsu ◽  
...  
Keyword(s):  
Raman Spectroscopy ◽  
Porous Carbon ◽  
Hot Spots ◽  
Strong Dependence ◽  
Nanowire Array ◽  
Surface Enhanced Raman Spectroscopy ◽  
Localized Surface Plasmon ◽  
Sers Substrate ◽  
Surface Enhanced ◽  
Surface Enhanced Raman

Abstract Surface-enhanced Raman spectroscopy (SERS) is a powerful tool for vibrational spectroscopy as it provides several orders of magnitude higher sensitivity than inherently weak spontaneous Raman scattering by exciting localized surface plasmon resonance (LSPR) on metal substrates. However, SERS can be unreliable for biomedical use since it sacrifices reproducibility, uniformity, biocompatibility, and durability due to its strong dependence on “hot spots”, large photothermal heat generation, and easy oxidization. Here, we demonstrate the design, fabrication, and use of a metal-free (i.e., LSPR-free), topologically tailored nanostructure composed of porous carbon nanowires in an array as a SERS substrate to overcome all these problems. Specifically, it offers not only high signal enhancement (~106) due to its strong broadband charge-transfer resonance, but also extraordinarily high reproducibility due to the absence of hot spots, high durability due to no oxidization, and high compatibility to biomolecules due to its fluorescence quenching capability.

Surface-enhanced Raman spectroscopy (SERS) for detection of VX and HD in the gas phase using a hand-held Raman spectrometer

The Analyst ◽  
2020 ◽  
Vol 145 (19) ◽  
pp. 6334-6341 ◽  
Author(s):  
Vered Heleg-Shabtai ◽  
Hagai Sharabi ◽  
Amalia Zaltsman ◽  
Izhar Ron ◽  
Alexander Pevzner
Keyword(s):  
Raman Spectroscopy ◽  
Gas Phase ◽  
Surface Enhanced Raman Spectroscopy ◽  
Sers Substrate ◽  
Raman Spectrometer ◽  
Surface Enhanced ◽  
Surface Enhanced Raman

A sensitive surface-enhanced Raman spectroscopy (SERS) substrate was developed to enable hand-held Raman spectrometers to detect gas-phase VX and HD.

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