Exposures in the Indoor Environment and Prevalence of Allergic Conditions in the United States of America

Our study examines the association of the presence of mildew, cockroaches, and pets in homes as well as household dust allergens with the prevalence and/or severity of allergic diseases. No study has concurrently assessed home environment exposures in relation to allergic conditions in the general US population. Data from 5,409 participants from the 2005-2006 National Health and Nutrition Examination Survey living in their current homes for ≥1 year were analyzed. Multivariate logistic regression analyses between home exposures and allergic diseases prevalence and severity were performed. In adjusted analyses, mildew was associated with higher current asthma, allergies, and allergic rhinitis prevalence; endotoxin, with higher current asthma prevalence), and dust Canis familiaris (Can f) 1, with higher allergic rhinitis prevalence. However, presence of cockroaches and dust Dermatogoides farinae (Der f) 1 were associated respectively with lower current asthma and allergies prevalence. Presence of mildew, dust Der f1, Dermatogoides pteronyssinus (Der p) 1, Feline domesticus (Fel d) 1, and endotoxin were all associated with asthma and/or wheeze severity. Non-atopic asthma was more frequent with mildew and/or musty smell dust and higher dust Fel d1 concentration, while atopic asthma was more prevalent with higher Can f1and endotoxin concentrations in dust. This study confirms previous relationships and reports novel associations, generating hypotheses for future research.

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Asthma prevalence and associated factors among lebanese adults: the first national survey

BMC Pulmonary Medicine ◽

10.1186/s12890-021-01529-z ◽

2021 ◽

Vol 21 (1) ◽

Author(s):

Zeina Akiki ◽

Danielle Saadeh ◽

Rita Farah ◽

Souheil Hallit ◽

Hala Sacre ◽

...

Keyword(s):

Allergic Rhinitis ◽

Family History ◽

Respiratory Diseases ◽

Fruits And Vegetables ◽

Asthma Prevalence ◽

Cluster Sampling ◽

Cross Sectional ◽

Current Asthma ◽

Chronic Respiratory Diseases ◽

History Of

Abstract Background No national research has yet explored the prevalence of asthma among adults in Lebanon. This study aims to evaluate the prevalence of physician-diagnosed asthma and current asthma, and their determinants among Lebanese adults 16 years old or above. Methods A cross-sectional study was carried out using a multistage cluster sampling. The questionnaire used collected information on asthma, respiratory symptoms, and risk factors. Results The prevalence of physician-diagnosed asthma was 6.7% (95% CI 5–8.7%), and that of current asthma was 5% (95% CI 3.6–6.9%). Chronic symptoms such as cough, wheezing, and shortness of breath were worst at night. Factors positively associated with physician-diagnosed asthma were a secondary educational level (adjusted OR, aOR = 4.45), a family history of chronic respiratory diseases (aOR = 2.78), lung problems during childhood (15.9), and allergic rhinitis (4.19). Additionally, consuming fruits and vegetables less than once per week (3.36), a family history of chronic respiratory diseases (3.92), lung problems during childhood (9.43), and allergic rhinitis (8.12) were positively associated with current asthma. Conclusions The prevalence of asthma was within the range reported from surrounding countries. However, repeated cross-sectional studies are necessary to evaluate trends in asthma prevalence in the Lebanese population.

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Comparison of aeroallergen sensitisation patterns in the United States and Europe

Italian Journal of Medicine ◽

10.4081/itjm.2019.1189 ◽

2019 ◽

Vol 13 (4) ◽

pp. 225-233

Author(s):

Luca Conti ◽

Kelly Gatt ◽

Christopher Zammit ◽

Stephen Montefort ◽

David Bilocca

Keyword(s):

United States ◽

Complex Disease ◽

Immunoglobulin E ◽

Skin Prick Testing ◽

Symptom Control ◽

Allergic Diseases ◽

The United States ◽

Atopic Asthma ◽

Comprehensive Overview ◽

Asthma Phenotypes

The global prevalence of allergic diseases have increased considerably and are a major socio-economic burden. Asthma is a complex disease and understanding asthma phenotypes and endotypes could eventually lead to individualised management, and offer better symptom control and quality of life. In this review, we first summarise the pathogenesis of atopic asthma and delve into the assessment of sensitisation to aeroallergens through skin prick testing and serological testing with total and specific immunoglobulin E testing. We will then analyse the distribution of aeroallergen sensitisation patterns in the United States and Europe and its effect on the population. This review gives a comprehensive overview on atopy and it compares the prevalence and effect of atopy within various regions of both continents using data from large multicentre studies. We will conclude this review by discussing the efficacy of add-on treatments in the most prevalent severe asthma phenotypes and endotypes.

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Ten-Year trends and prevalence of asthma, allergic rhinitis, and atopic dermatitis among the Korean population, 2008–2017

Clinical and Experimental Pediatrics ◽

10.3345/cep.2019.01291 ◽

2020 ◽

Vol 63 (7) ◽

pp. 278-283 ◽

Cited By ~ 12

Author(s):

Jihyun Ha ◽

Seung Won Lee ◽

Dong Keon Yon

Keyword(s):

Allergic Rhinitis ◽

Atopic Dermatitis ◽

Preschool Children ◽

Allergic Diseases ◽

The Elderly ◽

Korean Population ◽

School Age Children ◽

Asthma Prevalence ◽

School Age ◽

Cross Sectional Survey

Background: Major questions remain regarding the agestratified trends of allergic diseases and asthma in Korea.Purpose: To identify the estimated recent prevalence and 10- year trends in asthma, allergic rhinitis, and atopic dermatitis among the Korean population from 2008 to 2017.Methods: This nationwide cross-sectional survey (Korean National Health and Nutrition Examination Survey) over 10 years (2008–2017) examined representative samples of the Korean population (n=85,006) including 2,131 infants, 4,352 preschool children, 12,919 school-age children, 44,200 adults, and 21,404 elderly adults.Results: In the 2016 to 2017 population, the estimated prevalence of asthma was 0.9% in infants, 2.3% in preschool children, 4.1% in school-age children, 2.3% in adults, and 4.1% in the elderly. The estimated prevalence of allergic rhinitis was 9.0%, 20.2%, 27.6%, 17.1%, and 6.9%, respectively. The estimated prevalence of atopic dermatitis was 5.9%, 11.3%, 14.6%, 3.9%, and 1.6%, respectively. Ten-year trends revealed a significant decrease in asthma prevalence in infants, preschool children, and the elderly. and in atopic dermatitis prevalence in infants and preschool children (<i>P</i><0.05 for all trends). Furthermore, 10-year trends demonstrated a significant increase in allergic rhinitis prevalence in school-age children, adults, and the elderly, and in atopic dermatitis prevalence in school-age children and the elderly (<i>P</i><0.05 for all trends).Conclusion: These results improve our understanding of the age-stratified epidemiology of allergic diseases in Korea and suggest the need for the development of tailored and precise strategies to prevent allergic diseases in different age groups.

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Neuroinflammatory Gene Expression Pattern Is Similar between Allergic Rhinitis and Atopic Dermatitis but Distinct from Atopic Asthma

BioMed Research International ◽

10.1155/2020/7196981 ◽

2020 ◽

Vol 2020 ◽

pp. 1-10

Author(s):

Paulina Sobkowiak ◽

Wojciech Langwiński ◽

Joanna Nowakowska ◽

Irena Wojsyk-Banaszak ◽

Dawid Szczepankiewicz ◽

...

Keyword(s):

Gene Expression ◽

Allergic Rhinitis ◽

Atopic Dermatitis ◽

Expression Pattern ◽

Human Study ◽

Allergic Inflammation ◽

Allergic Diseases ◽

Atopic Asthma ◽

Control Group ◽

Altered Expression

Background and Aim. Neurogenic inflammation underlies the pathogenesis of allergic diseases. Interactions between neurons with the immune cells and structural cells (airway epithelium, nasal mucosa, skin keratinocytes) undergo altered regulation during chronic inflammation. Therefore, we hypothesized that the expression of neuroinflammatory genes may be altered allergic diseases, including atopic dermatitis and allergic rhinitis, and that, compared to atopic asthma, the expression pattern may be disease-specific in pediatric patients. Methods. In the study, we included 86 children diagnosed with atopic asthma (n=25), allergic rhinitis (n=20), and atopic dermatitis (n=20) and healthy control subjects (n=21) of Caucasian origin from the Polish population. The blood leukocyte expression of 31 genes involved in neuroinflammatory response (neurotrophins, their receptors, neuropeptides, and histamine signaling pathway) was analysed using TaqMan low-density arrays. The relative expression of selected proteins from plasma was done using TaqMan Protein Assays. Statistical analysis was done using Statistica. Results. Blood expression of 31 genes related to neuroimmune interactions showed significant increase in both allergic diseases, allergic rhinitis and atopic dermatitis, in comparison to the control group. We found 12 genes significantly increased in allergic rhinitis and 9 genes in which the expression was elevated in atopic dermatitis. Moreover, 9 genes with changed expression in atopic dermatitis overlapped with those in allergic rhinitis. Atopic asthma showed 5 genes with altered expression. The peripheral expression of neuroinflammatory genes in the human study was verified in target tissues (nasal epithelium and skin) in a rat model of allergic inflammation. Conclusions. A common pattern of neuroinflammatory gene expression between allergic rhinitis and atopic dermatitis may reflect similar changes in sensory nerve function during chronic allergic inflammation.

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Trends in adult current asthma prevalence and contributing risk factors in the United States by state: 2000–2009

BMC Public Health ◽

10.1186/1471-2458-13-1156 ◽

2013 ◽

Vol 13 (1) ◽

Cited By ~ 28

Author(s):

Xingyou Zhang ◽

Teresa Morrison-Carpenter ◽

James B Holt ◽

David B Callahan

Keyword(s):

United States ◽

Risk Factors ◽

The United States ◽

Asthma Prevalence ◽

Current Asthma

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Incidence and Survival Outcomes in Patients with Lung Neuroendocrine Neoplasms in the United States

Cancers ◽

10.3390/cancers13081753 ◽

2021 ◽

Vol 13 (8) ◽

pp. 1753

Author(s):

Shrunjal Shah ◽

Rohit Gosain ◽

Adrienne Groman ◽

Rahul Gosain ◽

Arvind Dasari ◽

...

Keyword(s):

Population Data ◽

Large Cell ◽

The United States ◽

Population Based ◽

Future Research ◽

Neuroendocrine Neoplasms ◽

Typical Carcinoid ◽

Adjusted Incidence Rate ◽

Future Research Directions ◽

Adjusted Incidence

Background: The incidence and prevalence of neuroendocrine neoplasms (NENs) are rapidly rising. Epidemiologic trends have been reported for common NENs, but specific data for lung NENs are lacking. Methods: We conducted a retrospective analysis utilizing the Surveillance, Epidemiology, and End Results (SEER) database. Associated population data were utilized to report the annual age-adjusted incidence and overall survival (OS) trends. Trends for large-cell neuroendocrine carcinoma (LCNEC) and atypical carcinoid (AC) were reported from 2000–2015, while those for typical carcinoid (TC) and small cell lung cancer (SCLC) were reported from 1988–2015. Results: We examined a total of 124,969 lung NENs [103,890—SCLC; 3303—LCNEC; 8146—TC; 656—AC; 8974—Other]. The age-adjusted incidence rate revealed a decline in SCLC from 8.6 in 1988 to 5.3 in 2015 per 100,000; while other NENs showed an increase: TC increased from 0.57 in 1988 to 0.77 in 2015, AC increased from 0.17 in 2001 to 0.22 in 2015, and LCNEC increased from 0.16 in 2000 to 0.41 in 2015. The 5-year OS rate among SCLC, LCNEC, AC, and TC patients was 5%, 17%, 64%, and 84%, respectively. On multivariable analyses, OS and disease-specific survival (DSS) varied significantly by stage, sex, histological type, insurance type, marital status, and race, with a better survival noted in earlier stages, females, married, insured, Hispanic and other races, and urban population. Similarly, TC and AC had better survival compared to SCLC and LCNEC. Conclusion: The incidence of lung NENs is rising, possibly in part because of advanced radiological techniques. However, the incidence of SCLCs is waning, likely because of declining smoking habits. Such population-based studies are essential for resource allocation and to prioritize future research directions.

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Modern methods of allergen-specific immunotherapy in allergic rhinitis treatment

Kazan medical journal ◽

10.17750/kmj2016-288 ◽

2016 ◽

Vol 97 (2) ◽

pp. 288-294

Author(s):

N M Rakhmatullina ◽

Yu V Pastushenko ◽

O R Trofimova ◽

N A Sibgatullina ◽

D G Akhmedzyanova ◽

...

Keyword(s):

Allergic Rhinitis ◽

Allergic Disease ◽

Specific Immunotherapy ◽

Immunological Response ◽

Allergic Diseases ◽

Repeated Administration ◽

Pathological Process ◽

Atopic Asthma ◽

Allergen Specific Immunotherapy ◽

Modern Methods

The article presents the modern methods of allergen-specific immunotherapy in patients with allergic rhinitis. Allergen-specific immunotherapy - a method of treating allergic diseases, involves reducing the organism’s sensitivity to the allergen effects by repeated administration of allergen extract, starting with the minimum dose. Given the allergic rhinitis high prevalence, as well as its tendency to increase, strong interest in effective methods of its treatment is fully justified. Over the last 20 years, it has become clear that asthma and rhinitis are two types of manifestations of a single pathological process in the airways. It has been proven that allergic disease clinical features may change over time. In addition, patients with allergy are prone to multivalent sensitization. Currently none of the drugs used to relieve allergic rhinitis symptoms can not change the organism’s response to an allergen. Allergen-specific immunotherapy can reduce allergic disease symptoms severity, reduces the need in drugs use, decreases the chance of additional sensitization to other allergens, prevents the asthma development. This therapy has become one of the most widely used effective methods of atopic diseases treatment: seasonal and perennial rhinoconjunctivitis, atopic asthma. Allergen-specific immunotherapy can lead to a change in the immunological response to the relevant allergens in early stages, acting through regulatory cells. Current studies are aimed, on the one hand, at reducing the therapeutic allergovaccines ability to cause allergic reactions, on the other - to maintain or enhance their immunogenic properties. Achieving this goal is possible by changing the route of administration and delivery of therapeutic allergens (non-injection methods of allergen-specific immunotherapy), and using a variety of allergens modification techniques.

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Montelukast Use and Patterns of Ambulatory Care among Asian versus Non-Asian Adult Patients with Asthma and/or Allergic Rhinitis in the United States

Journal of Health Economics and Outcomes Research ◽

10.36469/9835 ◽

2015 ◽

Vol 3 (2) ◽

pp. 194-213

Author(s):

Joseph Vasey ◽

Shalini Bagga ◽

Huan Huang ◽

Tongsheng Wang ◽

David Thompson

Keyword(s):

United States ◽

Allergic Rhinitis ◽

Combination Therapy ◽

Ambulatory Care ◽

Persistent Asthma ◽

The United States ◽

Future Research ◽

Therapy Regimen ◽

Asian Patients ◽

Significant Difference

Background: Asthma and allergic rhinitis (AR) are inflammatory conditions that are similar in pathophysiology. Mild-to-moderate persistent asthma has been widely treated with inhaled corticosteroids, while allergic rhinitis is commonly treated with antihistamines, nasal corticosteroids, anticholinergics, and other allergy specific medications. The introduction of montelukast, a leukotriene receptor antagonist, has opened a treatment pathway that is common to both conditions. Previous real world studies of montelukast (Singulair®) relative to other medications have not investigated the role of race in the management of asthma and AR, specifically as relates to differences among Asian versus non-Asian patients. Objective: To contrast montelukast use and patterns of ambulatory care for adult Asian versus non-Asian patients in the United States with asthma and/or AR. Methods: Data for adult asthma and AR patients were extracted from a national electronic medical records database for the years 2006-2014. Patients were classified into condition cohort (Asthma-Only, AR-Only, Asthma & AR), and treatment condition (monotherapy or combination therapy, with or without montelukast for Asthma and Asthma & AR cohorts, usual care with or without montelukast for AR-Only) and stratified by race (Asian vs. non-Asian). Results: Overall patterns of use of montelukast were similar for Asian and non-Asian patients, but Asians were more likely to receive it as part of a combination therapy regimen. Changes in treatment regimen followed similar patterns for both groups. Asian patients with both asthma and AR were found to have lower service utilization rates if their therapy included montelukast, whereas for non-Asians there was no significant difference between regimens with or without montelukast. Conclusion: Differences in montelukast use and outcomes of care exist between Asian and non-Asian patients in the United States. Future research should explore the reasons for these differences and whether they can be replicated in non-US settings.

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Prevalence of allergic diseases among teenagers 13–14 years old in Tyumen city

Allergology and Immunology in Pediatrics ◽

10.53529/2500-1175-2021-3-35-39 ◽

2021 ◽

pp. 35-39

Author(s):

Kseniya Pavlovna Kuzmicheva ◽

Elena Igorevna Malinina ◽

Olga Aleksandrovna Rychkova ◽

Luiza Viktorovna Klimina ◽

Arina Evgenevna Rodionova ◽

...

Keyword(s):

Allergic Rhinitis ◽

Atopic Dermatitis ◽

Environmental Factors ◽

Bronchial Asthma ◽

Clinical Symptoms ◽

Negative Impact ◽

Allergic Diseases ◽

Epidemiological Surveillance ◽

Current Asthma ◽

The City

Introduction. The prevalence of bronchial asthma and other allergic diseases, in particular atopic dermatitis and allergic rhinitis, nowadays can be estimated by global population studies, such as the International Study of Asthma and Allergy in Childhood (ISAAC), and the Global Asthma Network (GAN). There are some difficulties in epidemiological surveillance, diagnosis, treatment and prevention of these nosologies in most of the countries, especially in developing countries with low availability of medical care. Thanks to the GAN program, therapeutic recommendations were made to reduce the global burden of allergic pathology. Purpose of the study. To study the prevalence of clinical symptoms of allergic diseases in children 13–14 years old in the city of Tyumen, as well as highlight the main risk factors that contribute to the disease development. Materials and methods. This cross-sectional study was carried out in 2019 as part of the Global Asthma Network (GAN) project among adolescents 13–14 years of age in the city of Tyumen. The respondents filled out standardized Russified questionnaires, which contained 48 questions concerning the symptoms of allergic diseases and environmental factors. According to the results of the analysis of 3007 questionnaires, it was found that asthma-like symptoms were ever observed in 19,2% of participants, current asthma-like symptoms were noted in 8,5% of respondents, 5,1% of adolescents had medical-verified bronchial asthma. The prevalence of lingering allergic rhinitis and current allergic rhinoconjunctivitis was 28,9% and 12,2% respectively, while only 5,4% of respondents had a verified diagnosis of allergic rhinitis. A quarter of the respondents had symptoms of atopic dermatitis at some point (25,6%), only 4,5% had symptoms of current atopic dermatitis, 3,8% had been diagnosed with atopic dermatitis. The negative impact of heavy freight traffic in the city of Tyumen, as well as the use of paracetamol, revealed the increase in the prevalence of allergic diseases. Conclusion. As a result of data analysis, it was found that the prevalence of current asthma-like symptoms, symptoms of atopic dermatitis and allergic rhinitis significantly exceed the numbers of official statistics. Often, adolescents with symptoms of an allergic disease do not have a correct diagnosis, which is confirmed by a low percentage of positive answers regarding the verification of the diagnosis by a doctor. Among children 13–14 years old in the city of Tyumen there is a high percentage of the prevalence of symptoms of allergic rhinitis, which is probably associated with climatic, geographical and environmental factors.

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Comparative analysis of skin prick test with immunoblotting of different manufacturers in the context of determining the sensitization to birch allergen in patients with respiratory allergic diseases

OTORHINOLARYNGOLOGY 2-3(2) 2019 - OTORHINOLARYNGOLOGY ◽

10.37219/2528-8253-2019-6-20 ◽

2020 ◽

pp. 20-27

Author(s):

Artemii Bogomolov

Keyword(s):

Allergic Rhinitis ◽

Systematic Error ◽

Skin Testing ◽

Allergic Diseases ◽

Specific Ige ◽

Test Method ◽

Atopic Asthma ◽

Western Blots

The aim of the study was to evaluate the diagnostic parameters of various methods for determining birch allergen sensitization in patients with respiratory allergic diseases – allergic rhinitis and bronchial asthma. Materials and methods: During the study, 88 patients with allergic rhinitis and/or atopic asthma were examined with three different methods of specific allergic diagnosis (in vivo and in vitro) according to the recommendations of the ethics committee of the Pirogov Vinnitsa National Medical University, all of which were out of acute. Inclusion criteria were a diagnosis of allergic rhinitis (both intermittent and persistent) and/or atopic asthma. The pre-test was conducted according to the classic test method according to the normative documents with commercial allergen extracts. Western blots for the determination of IgE levels were performed using RIDA AllergyScreen test systems (R-Biopharm AG, Darmstadt, Germany) and Euroline (Euroimmun). Results and discussion: Systematic error of measurement results of immunoblot of different manufacturers is equal to 2.27 ku/l, which indicates the presence of a systematic difference. The distribution graph corresponds to the type of absolute systematic error graphs. The standard deviation of the difference was 11.28, which is significantly compared to the values themselves. Thus, the results of the two systems for the determination of specific IgE for birch allergen by the Rida AllergyScreen and Euroline methods are not well matched due to systematic divergence of indicators. There is a good agreement between the results of skin testing with birch allergens and the detection of specific IgE by the Rida AllergyScreen test, and between the results of skin testing with birch allergen and the detection of specific IgE by the Euroline method, there is a moderate agreement between the results.

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