In this study by way of encapsulation of reduced graphene oxide (rGO) into Ni-based metal-organic framework (Ni-MOFs) structure, the composite rGO@Ni-MOFs was first prepared. Then gold nanoparticles (AuNPs) decorated rGO@Ni-MOFs (rGO@Ni-MOFs/AuNPs) was obtained through the electrodeposition. The morphology and structure of rGO@Ni-MOFs/AuNPs were characterized by SEM, FTIR and XRD. The rGO@Ni-MOFs/AuNPs modified electrode was used for the detection of dopamine (DA). The combining the catalysis from Ni-MOFs and AuNPs with the conductivity of rGO endowed rGO@Ni-MOFs/AuNPs with synergetic high catalytic activity to the electrochemical oxidation of DA. The developed modified electrode had a good linear relationship with DA in the concentration range of 0.5 μM~120 μM, and the detection limit was 0.33 μM (S/N=3). Additionally, the potential interferents, electrode stability, reproducibility and practical applications were also studied and satisfactory results were obtained.