scholarly journals Synthesis of NiO-CNTs nanocomposite for modification of glassy carbon electrode and Application for Electrochemical determination of fentanyl as an opioid analgesic drug

2021 ◽  
pp. ArticleID:211137
Author(s):  
Hao Ding ◽  
Keyword(s):  
Glassy Carbon Electrode ◽  
Glassy Carbon ◽  
Opioid Analgesic ◽  
Electrochemical Determination ◽  
Carbon Electrode ◽  
Analgesic Drug

scholarly journals ELECTROCHEMICAL DETERMINATION OF KETOROLAC - A NON-OPIOID ANALGESIC AT GLASSY CARBON ELECTRODE

2019 ◽  
pp. 199-204
Author(s):  
ROHINI M HANABARATTI ◽  
JAYANT I GOWDA ◽  
SURESH M TUWAR
Keyword(s):  
Glassy Carbon Electrode ◽  
Glassy Carbon ◽  
Low Cost ◽  
Opioid Analgesic ◽  
Oxidation Mechanism ◽  
Differential Pulse ◽  
Electrochemical Determination ◽  
Carbon Electrode ◽  
Peak Current

Objectives: The study has been carried to investigate the electro-oxidation mechanism and to develop a selective and sensitive method for determination of ketorolac (KTL), a non-opioid analgesic drug,.Methods: A simple electro analytical method was used for the determination of ketorolac (KTL) using glassy carbon electrode by cyclic and differential pulse voltammetric techniques (DPV). The effect of various experimental parameters such as accumulation time, pH, scan rate, on the voltammetric responses of KTL was evaluated.Results: In the optimized conditions, variation of peak current with respect to concentration was studied and the calibration curve of the peak current vs. KTL concentration was drawn with a linear range of 10- 350 μM with an excellent detection limit of 8.08×10-8 M. This method was successfully tested for the determination of KTL in pharmaceuticals and human urine samples.Conclusion: From the results, it was observed that, the selected method is rapid, sensitive and low cost.

scholarly journals Electrochemical determination of ascorbic acid at p-phenylenediamine film-holes modified glassy carbon electrode

2015 ◽  
Vol 80 (9) ◽  
pp. 1161-1175 ◽  
Author(s):  
Bikila Olana ◽  
Shimeles Kitte ◽  
Tesfaye Soreta
Keyword(s):  
Ascorbic Acid ◽  
Detection Limit ◽  
Glassy Carbon Electrode ◽  
Modified Electrode ◽  
Glassy Carbon ◽  
Linear Response ◽  
Modified Electrodes ◽  
Electrochemical Determination ◽  
Carbon Electrode

In this work the determination of ascorbic acid (AA) at glassy carbon electrode (GCE) modified with a perforated film produced by reduction of diazonium generated in situ from p-phenylenediamine (PD) is reported. Holes were intentionally created in the modifier film by stripping a pre-deposited gold nanoparticles. The modified electrodes were electrochemically characterized by common redox probes: hydroquinone, ferrocyanide and hexamineruthenium(III). The cyclic voltammetric and amperometric response of AA using the modified electrodes was compared with that of bare GCE. The bare GCE showed a linear response to AA in the concentration range of 5 mM to 45 mM with detection limit of 1.656 mM and the modified GCE showed a linear response to AA in the concentration range of 5 ?M to 45 ?M with detection limit of 0.123 ?M. The effect of potential intereferents on amperometric signal of AA at the modified GCE was examined and found to be minimal. The inter-electrode reproducibility, stability, and accuracy were determined. The modified electrode showed excellent inter-electrode reproducibility, accuracy and stability. The modified electrode reported is a promising candidate for use in electroanalysis of AA.

Sign in / Sign up

Export Citation Format

Share Document