scholarly journals Exploring diagnostic performance of T2 mapping in diffuse glioma grading

2021 ◽  
Vol 11 (7) ◽  
pp. 2943-2954
Author(s):  
Weibin Gu ◽  
Shiyuan Fang ◽  
Xinyi Hou ◽  
Ding Ma ◽  
Shaowu Li
Keyword(s):  
Diagnostic Performance ◽  
T2 Mapping ◽  
Diffuse Glioma ◽  
Glioma Grading

Diagnostic performance of apparent diffusion coefficient parameters for glioma grading

2018 ◽  
Vol 139 (1) ◽  
pp. 61-68 ◽  
Author(s):  
Qun Wang ◽  
JiaShu Zhang ◽  
Xinghua Xu ◽  
XiaoLei Chen ◽  
BaiNan Xu
Keyword(s):  
Diffusion Coefficient ◽  
Apparent Diffusion Coefficient ◽  
Diagnostic Performance ◽  
Glioma Grading ◽  
Apparent Diffusion

scholarly journals Diagnostic value of magnetic resonance parametric mapping for non-invasive assessment of liver fibrosis in patients with primary sclerosing cholangitis

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Narine Mesropyan ◽  
Patrick Kupczyk ◽  
Guido M. Kukuk ◽  
Leona Dold ◽  
Tobias Weismueller ◽  
...  
Keyword(s):  
Liver Fibrosis ◽  
Primary Sclerosing Cholangitis ◽  
Sclerosing Cholangitis ◽  
Diagnostic Performance ◽  
T2 Mapping ◽  
Liver Stiffness ◽  
Significant Fibrosis ◽  
Non Invasive ◽  
Native T1 ◽  
Mapping Parameters

Abstract Background Primary sclerosing cholangitis (PSC) is a chronic cholestatic liver disease, characterized by bile duct inflammation and destruction, leading to biliary fibrosis and cirrhosis. The purpose of this study was to investigate the utility of T1 and T2 mapping parameters, including extracellular volume fraction (ECV) for non-invasive assessment of fibrosis severity in patients with PSC. Methods In this prospective study, patients with PSC diagnosis were consecutively enrolled from January 2019 to July 2020 and underwent liver MRI. Besides morphological sequences, MR elastography (MRE), and T1 and T2 mapping were performed. ECV was calculated from T1 relaxation times. The presence of significant fibrosis (≥ F2) was defined as MRE-derived liver stiffness ≥ 3.66 kPa and used as the reference standard, against which the diagnostic performance of MRI mapping parameters was tested. Student t test, ROC analysis and Pearson correlation were used for statistical analysis. Results 32 patients with PSC (age range 19–77 years) were analyzed. Both, hepatic native T1 (r = 0.66; P < 0.001) and ECV (r = 0.69; P < 0.001) correlated with MRE-derived liver stiffness. To diagnose significant fibrosis (≥ F2), ECV revealed a sensitivity of 84.2% (95% confidence interval (CI) 62.4–94.5%) and a specificity of 84.6% (CI 57.8–95.7%); hepatic native T1 revealed a sensitivity of 52.6% (CI 31.7–72.7%) and a specificity of 100.0% (CI 77.2–100.0%). Hepatic ECV (area under the curve (AUC) 0.858) and native T1 (AUC 0.711) had an equal or higher diagnostic performance for the assessment of significant fibrosis compared to serologic fibrosis scores (APRI (AUC 0.787), FIB-4 (AUC 0.588), AAR (0.570)). Conclusions Hepatic T1 and ECV can diagnose significant fibrosis in patients with PSC. Quantitative mapping has the potential to be a new non-invasive biomarker for liver fibrosis assessment and quantification in PSC patients.

scholarly journals Use of the new Lake Louise Criteria improves CMR detection of atypical forms of acute myocarditis

2020 ◽  
Author(s):  
Giulia Cundari ◽  
Nicola Galea ◽  
Gianluca De Rubeis ◽  
Andrea Frustaci ◽  
Francesco Cilia ◽  
...  
Keyword(s):  
Diagnostic Performance ◽  
T1 Mapping ◽  
Clinical Presentation ◽  
Acute Myocarditis ◽  
T2 Mapping ◽  
Cine Ssfp ◽  
Gadolinium Administration ◽  
Clinical Presentations ◽  
Atypical Clinical Presentation ◽  
Before And After

AbstractThe purpose of our study was to compare diagnostic performance of old and new Lake Louise Criteria (oLLC and nLLC) among different clinical presentations: infarct-like (IL), cardiomyopathic (CM) and arrhythmic (AR). 102 patients with clinical suspicion of acute myocarditis underwent cardiac magnetic resonance (CMR) on a 1.5 T scanner. Protocol included cine-SSFP, T2-weighted STIR, T2 mapping, early and late gadolinium enhancement and T1 mapping acquired before and after gadolinium administration. The degree of agreement has been calculated with Cohen’s K test. 42 patients also underwent endomyocardial biopsy (EMB). IL onset was present in 54/102 patients, CM in 28/102 and AR in 20/102. nLLC were positive in 58.3% of the patients, while oLLC in 37.9%, k = 0.57 (IC: 0.428–0.713). The degree of agreement between nLLC and oLLC was 0.49 (IC: 0.111–0.876) for AR onset (nLLC positive in 35% vs oLLC in 15%), 0.25 (IC: 0.035–0.459) for CM pattern (nLLC positive in 60.7% vs oLLC 17.9%) and 0.73 (IC: 0.543–0.912) for IL presentation (nLLC positive in 66.7% vs oLLC in 57.4%). Diagnostic accuracy was 75% for both nLLC and oLLC among IL onset, and 41.6% for oLLC vs 66.7% for nLLC, as regards CM clinical presentation. nLLC have improved diagnostic performance of CMR for the diagnosis of acute myocarditis, in particular for atypical clinical presentation.

scholarly journals Multiparametric Cardiovascular Magnetic Resonance in Acute Myocarditis: Comparison of 2009 and 2018 Lake Louise Criteria With Endomyocardial Biopsy Confirmation

2021 ◽  
Vol 8 ◽  
Author(s):  
Shuang Li ◽  
Xuejing Duan ◽  
Guangxun Feng ◽  
Arlene Sirajuddin ◽  
Gang Yin ◽  
...  
Keyword(s):  
Magnetic Resonance ◽  
Endomyocardial Biopsy ◽  
Diagnostic Performance ◽  
T1 Mapping ◽  
Acute Myocarditis ◽  
T2 Mapping ◽  
Relaxation Times ◽  
T2 Relaxation ◽  
3.0 T ◽  
Combined Parameters

Background: Cardiac magnetic resonance (CMR) has been shown to improve the diagnosis of myocarditis, but no systematic comparison of this technique is currently available. The purpose of this study was to compare the 2009 and 2018 Lake Louise Criteria (LLC) for the diagnosis of acute myocarditis using 3.0 T MRI with endomyocardial biopsy (EMB) as a reference and to provide the cutoff values for multiparametric CMR techniques.Methods: A total of 73 patients (32 ± 14 years, 71.2% men) with clinically suspected myocarditis undergoing EMB and CMR with 3.0 T were enrolled in the study. Patients were divided into two groups according to EMB results (EMB-positive and -negative groups). The CMR protocol consisted of cine-SSFP, T2 STIR, T2 mapping, early and late gadolinium enhancement (EGE, LGE), and pre- and post-contrast T1 mapping. Their potential diagnostic ability was assessed with receiver operating characteristic curves.Results: The myocardial T1 and T2 relaxation times were significantly higher in the EMB-positive group than in the EMB-negative group. Optimal cutoff values were 1,228 ms for T1 relaxation times and 58.5 ms for T2 relaxation times with sensitivities of 86.0 and 83.7% and specificities of 93.3 and 93.3%, respectively. The 2018 LLC had a better diagnostic performance than the 2009 LLC in terms of sensitivity, specificity, positive predictive value, and negative predictive value. T1 mapping + T2 mapping had the largest area under the curve (0.95) compared to other single or combined parameters (2018 LLC: 0.91; 2009 LLC: 0.76; T2 ratio: 0.71; EGEr: 0.67; LGE: 0.73; ). The diagnostic accuracy for the 2018 LLC was the highest (91.8%), followed by T1 mapping (89.0%) and T2 mapping (87.7%).Conclusion: Emerging technologies such as T1/ T2 mapping have significantly improved the diagnostic performance of CMR for the diagnosis of acute myocarditis. The 2018 LLC provided the overall best diagnostic performance in acute myocarditis compared to other single standard CMR parameters or combined parameters. There was no significant gain when 2018LLC is combined with the EGE sequence.

T2* mapping combined with conventional T2-weighted image for prostate cancer detection at 3.0T MRI: a multi-observer study

2016 ◽  
Vol 58 (1) ◽  
pp. 114-120 ◽  
Author(s):  
Lian-Ming Wu ◽  
Qiu-Ying Yao ◽  
Jiong Zhu ◽  
Qing Lu ◽  
Si-Teng Suo ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Diagnostic Performance ◽  
T2 Mapping ◽  
Area Under The Curve ◽  
Mapping Data ◽  
Body Regions ◽  
Experience Levels ◽  
Primary Determinant ◽  
Magnetic Resonance Imaging Mri ◽  
Age Range

Background T2* relaxation is a primary determinant of image contrast with Gradient echo (GRE) sequences, and it has been widely used across body regions. Purpose To compare the diagnostic performance of T2* mapping in combination with T2-weighted (T2W) imaging to T2W imaging alone for prostate cancer (PCa) detection. Material and Methods The study included 31 patients (mean age, 62 ± 3 years; age range, 45–78 years) who underwent magnetic resonance imaging (MRI) at 3.0T and histological examination. Three observers with varying experience levels reviewed T2W imaging alone, T2* mapping alone, and T2W imaging combined with T2* mapping. A five-point scale was used to assess the probability of PCa in each segment on MR images. Statistical analysis was performed using Z tests after adjusting for data clustering. Results The area under the curve (AUC) of T2W imaging and T2* mapping data (observer 1, 0.93; observer 2, 0.90; observer 3, 0.77) was higher than T2W imaging (observer 1, 0.84; observer 2, 0.79; observer 3, 0.69) for all observers ( P < 0.01 in all comparisons). The AUC of T2W imaging and T2* mapping data was higher for observers 1 and 2 than for observer 3 ( P < 0.01). The sensitivity and specificity of T2W imaging and T2* mapping data (observer 1, 95%, 85%; observer 2, 90%, 83%; and observer 3, 82%, 63%, respectively) was higher than T2W imaging (observer 1, 78%, 79%; observer 2, 76%, 72%; observer 3, 74%, 51%, respectively) for all observers ( P < 0.01 for observer 1; P < 0.01 for observers 2 and 3). Conclusion The addition of T2* mapping to T2W imaging improved the diagnostic performance of MRI in PCa detection.

scholarly journals Diagnostic Performance of Unenhanced Electrocardiogram-gated Cardiac CT for Myocardial Edema Using Cardiac T2 Mapping as a Reference Standard

2021 ◽  
Author(s):  
Takafumi Emoto ◽  
Masafumi Kidoh ◽  
Seitaro Oda ◽  
Daisuke Sakabe ◽  
Kosuke Morita ◽  
...  
Keyword(s):  
Diagnostic Performance ◽  
Large Scale ◽  
Tissue Characterization ◽  
Cardiac Ct ◽  
Volume Fraction ◽  
T2 Mapping ◽  
Characteristic Curve ◽  
Extracellular Volume ◽  
Myocardial Edema ◽  
Reference Standard

Abstract Purpose To assess the diagnostic performance of unenhanced electrocardiogram (ECG)-gated cardiac CT for myocardial edema, using T2 mapping as the reference standard. Methods This study included 34 patients (23 men; age 64.7 ± 14.6 years) who underwent cardiac CT and MRI. On the unenhanced ECG-gated cardiac CT images, regions of interest (ROIs) were drawn on the septal myocardium. Using T2 mapping as the reference standard, the diagnostic performance of unenhanced cardiac CT for myocardial edema was evaluated by using the area under the receiver operating characteristic curve (AUC) with sensitivity and specificity. Results Mean CT values moderately correlated with mean T2 values (Rho = -0.41; P < 0.05). Mean CT values provided a sensitivity of 63.2% and a specificity of 93.3% for detecting myocardial edema, with a cut-off value of ≤ 45.0 HU (AUC = 0.77; P < 0.01). Inter-observer reproducibility in measuring mean CT values was excellent (ICC = 0.93; [95% CI: 0.86, 0.96]). Conclusion This is the first clinical study to assess the diagnostic performance of unenhanced ECG-gated cardiac CT for myocardial edema, using T2 mapping as the reference standard. Our study suggested that the CT value of myocardium in unenhanced ECG-gated cardiac CT may be an optional parameter in addition to late iodine enhancement and extracellular volume fraction for myocardial tissue characterization, but further prospective, large-scale clinical studies are needed.

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