scholarly journals Improved repeatability of subsolid nodule measurement in low-dose lung screening with monoenergetic images: a phantom study

2019 ◽  
Vol 9 (2) ◽  
pp. 171-179 ◽  
Author(s):  
Jihang Kim ◽  
Kyung Hee Lee ◽  
Junghoon Kim ◽  
Yoon Joo Shin ◽  
Kyung Won Lee
Keyword(s):  
Low Dose ◽  
Phantom Study ◽  
Lung Screening ◽  
Monoenergetic Images ◽  
Subsolid Nodule

scholarly journals Incidental renal tumours on low-dose CT lung cancer screening exams

2016 ◽  
Vol 24 (2) ◽  
pp. 104-109 ◽  
Author(s):  
Paul F Pinsky ◽  
Barbara Dunn ◽  
David Gierada ◽  
P Hrudaya Nath ◽  
Reginald Munden ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Lung Cancer ◽  
Renal Cancer ◽  
Low Dose ◽  
Lung Cancer Screening ◽  
National Lung Screening Trial ◽  
Renal Tumours ◽  
Chest X Ray ◽  
Low Dose Computed Tomography ◽  
Lung Screening

Introduction Renal cancer incidence has increased markedly in the United States in recent decades, largely due to incidentally detected tumours from computed tomography imaging. Here, we analyze the potential for low-dose computed tomography lung cancer screening to detect renal cancer. Methods The National Lung Screening Trial randomized subjects to three annual screens with either low-dose computed tomography or chest X-ray. Eligibility criteria included 30 + pack-years, current smoking or quit within 15 years, and age 55–74. Subjects were followed for seven years. Low-dose computed tomography screening forms collected information on lung cancer and non-lung cancer abnormalities, including abnormalities below the diaphragm. A reader study was performed on a sample of National Lung Screening Trial low-dose computed tomography images assessing presence of abnormalities below the diaphragms and abnormalities suspicious for renal cancer. Results There were 26,722 and 26,732 subjects enrolled in the low-dose computed tomography and chest X-ray arms, respectively, and there were 104 and 85 renal cancer cases diagnosed, respectively (relative risk = 1.22, 95% CI: 0.9–1.5). From 75,126 low-dose computed tomography screens, there were 46 renal cancer diagnoses within one year. Abnormalities below the diaphragm rates were 39.1% in screens with renal cancer versus 4.1% in screens without (P < 0.001). Cases with abnormalities below the diaphragms had shorter median time to diagnosis than those without (71 vs. 160 days, P = 0.004). In the reader study, 64% of renal cancer cases versus 13% of non-cases had abnormalities below the diaphragms; 55% of cases and 0.8% of non-cases had a finding suspicious for renal cancer (P < 0.001). Conclusion Low-dose computed tomography screens can potentially detect renal cancers. The benefits to harms tradeoff of incidental detection of renal tumours on low-dose computed tomography is unknown.

scholarly journals Yorkshire Lung Screening Trial (YLST): protocol for a randomised controlled trial to evaluate invitation to community-based low-dose CT screening for lung cancer versus usual care in a targeted population at risk

BMJ Open ◽  
2020 ◽  
Vol 10 (9) ◽  
pp. e037075 ◽  
Author(s):  
Philip AJ Crosbie ◽  
Rhian Gabe ◽  
Irene Simmonds ◽  
Martyn Kennedy ◽  
Suzanne Rogerson ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Usual Care ◽  
Low Dose ◽  
Task Force ◽  
Controlled Trial ◽  
Advisory Group ◽  
Eligibility Criteria ◽  
Link Type ◽  
Lung Screening ◽  
Screening Trial

IntroductionLung cancer is the world’s leading cause of cancer death. Low-dose computed tomography (LDCT) screening reduced lung cancer mortality by 20% in the US National Lung Screening Trial. Here, we present the Yorkshire Lung Screening Trial (YLST), which will address key questions of relevance for screening implementation.Methods and analysisUsing a single-consent Zelen’s design, ever-smokers aged 55–80 years registered with a general practice in Leeds will be randomised (1:1) to invitation to a telephone-based risk-assessment for a Lung Health Check or to usual care. The anticipated number randomised by household is 62 980 individuals. Responders at high risk will be invited for LDCT scanning for lung cancer on a mobile van in the community. There will be two rounds of screening at an interval of 2 years. Primary objectives are (1) measure participation rates, (2) compare the performance of PLCOM2012 (threshold ≥1.51%), Liverpool Lung Project (V.2) (threshold ≥5%) and US Preventive Services Task Force eligibility criteria for screening population selection and (3) assess lung cancer outcomes in the intervention and usual care arms. Secondary evaluations include health economics, quality of life, smoking rates according to intervention arm, screening programme performance with ancillary biomarker and smoking cessation studies.Ethics and disseminationThe study has been approved by the Greater Manchester West research ethics committee (18-NW-0012) and the Health Research Authority following review by the Confidentiality Advisory Group. The results will be disseminated through publication in peer-reviewed scientific journals, presentation at conferences and on the YLST website.Trial registration numbersISRCTN42704678 and NCT03750110.

Image Quality Measured From Ultra-Low Dose Chest Computed Tomography Examination Protocols Using 6 Different Iterative Reconstructions From 4 Vendors, a Phantom Study

2020 ◽  
Vol 44 (1) ◽  
pp. 95-101 ◽  
Author(s):  
Mercy Afadzi ◽  
Kristian Fosså ◽  
Hilde Kjernlie Andersen ◽  
Trond Mogens Aaløkken ◽  
Anne Catrine T. Martinsen
Keyword(s):  
Computed Tomography ◽  
Image Quality ◽  
Low Dose ◽  
Phantom Study ◽  
Chest Computed Tomography

Ultra-low-dose lung screening CT with model-based iterative reconstruction: an assessment of image quality and lesion conspicuity

2017 ◽  
Vol 59 (5) ◽  
pp. 553-559 ◽  
Author(s):  
Yun Hye Ju ◽  
Geewon Lee ◽  
Ji Won Lee ◽  
Seung Baek Hong ◽  
Young Ju Suh ◽  
...  
Keyword(s):  
Image Quality ◽  
Radiation Dose ◽  
Iterative Reconstruction ◽  
Low Dose ◽  
Image Noise ◽  
Low Dose Ct ◽  
Group 5 ◽  
Lung Screening ◽  
Lesion Conspicuity ◽  
Group 1

Background Reducing radiation dose inevitably increases image noise, and thus, it is important in low-dose computed tomography (CT) to maintain image quality and lesion detection performance. Purpose To assess image quality and lesion conspicuity of ultra-low-dose CT with model-based iterative reconstruction (MBIR) and to determine a suitable protocol for lung screening CT. Material and Methods A total of 120 heavy smokers underwent lung screening CT and were randomly and equally assigned to one of five groups: group 1 = 120 kVp, 25 mAs, with FBP reconstruction; group 2 = 120 kVp, 10 mAs, with MBIR; group 3 = 100 kVp, 15 mAs, with MBIR; group 4 = 100 kVp, 10 mAs, with MBIR; and group 5 = 100 kVp, 5 mAs, with MBIR. Two radiologists evaluated intergroup differences with respect to radiation dose, image noise, image quality, and lesion conspicuity using the Kruskal–Wallis test and the Chi-square test. Results Effective doses were 61–87% lower in groups 2–5 than in group 1. Image noises in groups 1 and 5 were significantly higher than in the other groups ( P < 0.001). Overall image quality was best in group 1, but diagnostic acceptability of overall image qualities in groups 1–3 was not significantly different (all P values > 0.05). Lesion conspicuities were similar in groups 1–4, but were significantly poorer in group 5. Conclusion Lung screening CT with MBIR obtained at 100 kVp and 15 mAs enables a ∼60% reduction in radiation dose versus low-dose CT, while maintaining image quality and lesion conspicuity.

SU-FF-I-139: Low Dose Breast CT with Photon Counting Detectors: A Phantom Study

2009 ◽  
Vol 36 (6Part5) ◽  
pp. 2467-2467
Author(s):  
H Le ◽  
J Ducote ◽  
M Klopfer ◽  
S Molloi
Keyword(s):  
Low Dose ◽  
Photon Counting ◽  
Phantom Study ◽  
Breast Ct ◽  
Photon Counting Detectors

Evaluation of a new low-dose biplanar system to assess lower-limb alignment in 3D: a phantom study

2012 ◽  
Vol 41 (10) ◽  
pp. 1287-1293 ◽  
Author(s):  
Philippe Thelen ◽  
Cyrille Delin ◽  
Dominique Folinais ◽  
Catherine Radier
Keyword(s):  
Lower Limb ◽  
Low Dose ◽  
Phantom Study ◽  
Limb Alignment ◽  
Lower Limb Alignment

Effectiveness of mobile computerized tomographic (CT) lung scanning unit for early diagnosis of lung cancer in under-served populations.

2019 ◽  
Vol 37 (15_suppl) ◽  
pp. 6567-6567
Author(s):  
Derek Raghavan ◽  
Darcy L Doege ◽  
Mellisa S Wheeler ◽  
John D Doty ◽  
James Oliver ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cancer Screening ◽  
Low Dose ◽  
Lung Cancer Screening ◽  
The United States ◽  
Lung Cancers ◽  
Low Dose Ct ◽  
Screening Unit ◽  
Lung Screening ◽  
Lung Scanning

6567 Background: The National Lung Screening Trial (NLST) demonstrated that screening high-risk patients with low-dose CT (LDCT) of the chest reduces lung cancer mortality compared to screening with chest x-ray. Uninsured and Medicaid patients lack access to this hospital-based screening test due to geographic isolation/socio-economic factors. We hypothesized that a mobile screening unit would improve access and confer benefits demonstrated by the NLST to this under-served group, which is most at risk of lung cancer deaths. Methods: In collaboration with Samsung Inc, we inserted a BodyTom portable 32 slide low-dose CT scanner into a 35-foot coach, reinforced to avoid equipment damage, to function as a mobile lung scanning unit. The unit includes a waiting area, high speed wireless internet connection for rapid image transfer, and electronic tablets to deliver smoking cessation and health education programs and shared decision-making video aids. It has been certified as a lung cancer screening Center of Excellence by Lung Cancer Alliance. We employed the LUNG RADS approach to lesion classification, yielding high sensitivity and specificity in assessment. All films were reviewed by a central panel of oncologists, pulmonologists and radiologists. The protocol was approved by Chesapeake IRB, which oversees all LCI cancer trials. Interim analysis at this time was approved by the Oversight Committee. Results: We screened 470 under-served smokers between 4/2017-1/2019; M:F 1.1:1, mean age 61 years (range 55-64), with average pack year history of 45.7 (30-150) (25% African-American; 3% Hispanic; 65% rural; 100% uninsured, under-insured or Medicaid - NC Medicaid does not cover lung cancer screening). Patients over the age of 64 years were excluded as they are covered by Medicare for lung cancer screening. We found at initial screen 35 subjects with LUNG RADS 4 lesions, 49 subjects with LUNG RADS 3 lesions, 10 lung cancers (2.1%), including 4 at stage I-II. 4 non-lung cancers were identified and treated. Other incidental non-oncologic findings are the subject of another presentation. Conclusions: In this small sample using the first mobile low dose CT lung screening unit in the United States, the initial cancer detection rate is comparable to that reported in the NLST but with marked improvement of screening rates in underserved groups and with better anticipated outcomes at lower cost than if they had first presented with metastatic disease.

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