scholarly journals Direct Demonstration of Viable Staphylococcus aureus Biofilms in an Infected Total Joint Arthroplasty

2008 ◽  
Vol 90 (8) ◽  
pp. 1751-1758 ◽  
Author(s):  
Paul Stoodley ◽  
Laura Nistico ◽  
Sandra Johnson ◽  
Leslie-Ann Lasko ◽  
Mark Baratz ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Total Joint Arthroplasty ◽  
Joint Arthroplasty ◽  
Direct Demonstration

scholarly journals The bactericidal effect of vancomycin is not altered by tranexamic acid, adrenalin, dexamethasone, or lidocaine in vitro

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Christiane Schwerdt ◽  
Eric Röhner ◽  
Sabrina Böhle ◽  
Benjamin Jacob ◽  
Georg Matziolis
Keyword(s):  
Staphylococcus Aureus ◽  
Tranexamic Acid ◽  
Total Joint Arthroplasty ◽  
Staphylococcus Epidermidis ◽  
Joint Infection ◽  
Bactericidal Effect ◽  
Joint Arthroplasty ◽  
Zone Of Inhibition ◽  
Agar Diffusion Test

AbstractOne of the most challenging complications of total knee arthroplasty (TKA) is periprosthetic joint infection (PJI). There is growing evidence of a good anti-infective effect of intrawound vancomycin powder in total joint arthroplasty. At the same time, various different locally applied substances have become popular in total joint arthroplasty. The objective of this study was therefore to investigate a possible inhibition of the bactericidal effect of vancomycin by tranexamic acid, adrenalin, lidocaine, or dexamethasone. The bactericidal effect of vancomycin was quantified using the established method of the agar diffusion test. The plates were incubated with Staphylococcus aureus or Staphylococcus epidermidis and four wells were stamped out. The wells were filled with vancomycin alone, the tested substance alone or a mixture of the two. The fourth well remained empty as a control. The plates were incubated overnight at 37 °C and the zone of inhibition in each field was measured on the next day. All tests were run three times for each pathogen and mean values and standard deviations of the measurements were calculated. Differences between the substances were tested using the t-test at a level of significance of 0.05. The bacterial growth was homogeneous on all plates. The baseline value for the zone of inhibition of vancomycin was on average 6.2 ± 0.4 mm for Staphylococcus aureus and 12 ± 0.3 mm for Staphylococcus epidermidis. In all other substances, no inhibition was detected around the well. The combination of vancomycin and each other substance did not show any different result compared to vancomycin alone. The bactericidal effect of vancomycin on staphylococci is not altered by tranexamic acid, adrenalin, dexamethasone, or lidocaine in vitro.

The Cost-Effectiveness of Preoperative Staphylococcus aureus Screening and Decolonization in Total Joint Arthroplasty

2018 ◽  
Vol 33 (7) ◽  
pp. S191-S195 ◽  
Author(s):  
Yehuda E. Kerbel ◽  
Anisha R. Sunkerneni ◽  
Gregory J. Kirchner ◽  
John P. Prodromo ◽  
Vincent M. Moretti
Keyword(s):  
Staphylococcus Aureus ◽  
Cost Effectiveness ◽  
Total Joint Arthroplasty ◽  
Joint Arthroplasty ◽  
The Cost

scholarly journals Can nasal Staphylococcus aureus screening and decolonization prior to elective total joint arthroplasty reduce surgical site and prosthesis-related infections? A systematic review and meta-analysis

2020 ◽  
Vol 15 (1) ◽  
Author(s):  
Xingyang Zhu ◽  
Xiaobo Sun ◽  
Yuqing Zeng ◽  
Wenjun Feng ◽  
Jie Li ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Total Joint Arthroplasty ◽  
Meta Analysis ◽  
Bacterial Species ◽  
Surgical Site Infections ◽  
Joint Arthroplasty ◽  
Cochrane Library ◽  
Superficial Infection ◽  
Joint Infections ◽  
The Impact

Abstract Background Nasal Staphylococcus aureus (S. aureus) screening and decolonization has been widely used to reduce surgical site infections (SSIs) prior to total knee and hip arthroplasty (TKA and THA). However, it remains considerably controversial. The aim of this study was to ascertain whether this scheme could reduce SSIs and periprosthetic joint infections (PJIs) following elective primary total joint arthroplasty (TJA). Methods A systematic search was performed in MEDLINE, Embase, and the Cochrane Library until October, 2019. Outcomes of interest included SSI, PJI, superficial infection, and different bacterial species that caused infections. Data from eligible studies were then extracted and synthesized. Pooled odds ratios (OR) and 95% confidence intervals (CIs) were calculated. We also performed additional analyses to evaluate whether there were differences in postoperative SSIs caused by S. aureus or other bacteria. Results Nine studies were included in our meta-analysis. The pooled data elucidated that nasal S. aureus screening and decolonization dramatically mitigated the risk of SSI, PJI, and superficial infection compared to nondecolonization group. The analysis of bacterial species causing infection also showed that the S. aureus infections postoperative were significantly decreased in the decolonization group. However, there was no statistical difference in the SSI caused by other bacteria between the two groups. Conclusion S. aureus screening and decolonization prior to elective primary THA and TKA could significantly decrease the risk of SSI and PJI. However, more robust studies are needed to further evaluate the impact of S. aureus screening and decolonization on infection risk after TJA.

Cost-Effectiveness of Staphylococcus aureus Decolonization Strategies in High-Risk Total Joint Arthroplasty Patients

2017 ◽  
Vol 32 (9) ◽  
pp. S91-S96 ◽  
Author(s):  
Devin M. Williams ◽  
Andy O. Miller ◽  
Michael W. Henry ◽  
Geoffrey H. Westrich ◽  
Hassan M.K. Ghomrawi
Keyword(s):  
Staphylococcus Aureus ◽  
Cost Effectiveness ◽  
High Risk ◽  
Total Joint Arthroplasty ◽  
Joint Arthroplasty
Sign in / Sign up

Export Citation Format

Share Document