Body Mass Index and Breast Cancer Risks Among Igbo Women in Imo and Abia States, Nigeria: A Case Control Study

Background: The association between body mass index (BMI) and breast cancer risk has been well recognized. The purpose of this study was to determine the association of BMI with breast cancer risks among women of Igbo origin in Imo and Abia states in South Eastern Nigeria. Methods: The study was conducted at three different locations: Abia State University Teaching Hospital Aba, Abia State; Federal Medical Centre, Owerri, Imo State; and the Maranatha Specialist Mission Hospital, Aba, Abia State. This was a prospective hospital-based case control study. Data were collected on socio-demographic characteristics and anthropometric measures using a structured questionnaire. Collected data were imported to SPSS version 23 for analysis. In all, 681 patients participated in the study of which 347 were cases and 334 were controls. The T-test was used to assess statistical differences of height, weight, and BMI in the studied groups. Logistic regressions were used to calculate the multivariate odds ratio (OR) using 95% confidence interval (CI) with significant level set at p>0.05. Results: Higher BMI is associated with increased risk of breast cancer. There was a significant statistical difference between the height of cases and controls in both pre-and post-menopausal women. The mean value of height was 161.14± 7.1cm among cases compared to controls which was 161.39 cm (p<0.05). The mean weight among cases was 66.34 ± 11.8kg compared to controls at 65.45 ± 9.2kg (p<0.05); the mean BMI was 25.6± 4.8kg/m2 among cases compared to controls 25.1± 4.6 kg/m2 (p<0.05). Conclusion and Implications For Translation: Primary prevention measures are important to modestly curtail the increasing burden of obesity and high BMI. By controlling the weight, through physical activities, changes in diet and modestly alcohol intake will reduce the risk of breast cancer. Key words: • Breast Cancer • Imo State • Abia State • South East Nigeria • Body Mass Index • Nigeria Copyright © 2019 Oyamienlen et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Influence of body mass index on breast cancer risk related dietary patterns among women in Northern Tanzania: a case-control study

Das Gesundheitswesen ◽

10.1055/s-0031-1283501 ◽

2011 ◽

Vol 73 (08/09) ◽

Author(s):

I Jordan ◽

A Hebestreit ◽

B Swai ◽

M Krawinkel

Keyword(s):

Breast Cancer ◽

Body Mass Index ◽

Breast Cancer Risk ◽

Cancer Risk ◽

Body Mass ◽

Dietary Patterns ◽

Case Control Study ◽

Case Control ◽

Northern Tanzania ◽

Control Study

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Comparing and assessing the reported penetrance of cancer susceptibility genes for breast cancer.

Journal of Clinical Oncology ◽

10.1200/jco.2020.38.15_suppl.1520 ◽

2020 ◽

Vol 38 (15_suppl) ◽

pp. 1520-1520

Author(s):

Kanhua Yin ◽

Danielle Braun ◽

Ankur Tiwari ◽

Jin Wang ◽

Preeti Singh ◽

...

Keyword(s):

Breast Cancer ◽

General Population ◽

Case Control Study ◽

Cancer Susceptibility ◽

Susceptibility Genes ◽

Case Control ◽

Cancer Risks ◽

Cancer Susceptibility Genes ◽

Increased Risk ◽

Control Study

1520 Background: It is critical for oncologists to be aware of unbiased and interpretable cancer risks (i.e., penetrance) in carriers with germline pathogenic variants in cancer susceptibility genes. However, relevant literature is large and varies significantly in study design, patient ascertainment, and types of risk estimates reported. This heterogeneity can cause inconsistent conclusions between studies and create barriers for clinicians to understand and apply them in practice. To further understand the current literature, we assessed penetrance studies associated with non-BRCA breast cancer susceptibility genes based on study design and ascertainment adjustment. Methods: We used a validated natural language processing-based abstract classifier to identify all penetrance studies regarding eleven genes: ATM, BARD1, CDH1, CHEK2, NBN, NF1, PALB2, PTEN, RECQL, STK11, and TP53. Relevant studies were then manually annotated as “with ascertainment adjustment” if a study was based on: (1) a general population; (2) a pedigree analysis or a family-based study with appropriate ascertainment adjustment; or (3) a hospital-based study or a panel testing analysis with well-matched cases and controls. Results: A total of 49 penetrance studies were identified, with a median of nine studies for each gene (range: 4-16). The case-control study was the dominant study type, accounting for over 80% in five genes, 50% in two genes, and 18% to 43% in the other four genes. The proportion of studies with ascertainment adjustment was generally low (mean: 33%) and varied widely between different genes (7% to 80%). Contradictory breast cancer risks (no increased risk vs. significantly increased risk) were found in eight genes (73%) (Table). The most common ascertainment bias identified was a case-control study with cases (patients) who had a strong family history but using general population controls. Conclusions: Ascertainment bias is common in penetrance studies, but few studies adjust for it appropriately. Clinicians should be aware of this issue, and new methods are warranted to select unbiased risk estimates, synthesize them, and provide the accurate general-population penetrance. [Table: see text]

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