scholarly journals All-trans retinoic acid (ATRA) inhibits insufficient radiofrequency ablation (IRFA)-induced enrichment of tumor-initiating cells in hepatocellular carcinoma

2021 ◽  
Vol 33 (6) ◽  
pp. 694-707
Author(s):  
Song Wang ◽  
◽  
Jingtao Liu ◽  
Hao Wu ◽  
Anna Jiang ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Retinoic Acid ◽  
Radiofrequency Ablation ◽  
Tumor Initiating Cells ◽  
Trans Retinoic Acid ◽  
All Trans Retinoic Acid ◽  
Insufficient Radiofrequency Ablation

scholarly journals Effect of all-trans-retinoic acid and phorbol 12-myristate 13-acetate on the activity of human hepatocellular carcinoma cell-surface β-1,4-galactosyltransferase

1996 ◽  
Vol 320 (2) ◽  
pp. 623-625 ◽  
Author(s):  
Dapeng ZHOU ◽  
Songmin JIANG ◽  
Zhonghou SHEN ◽  
Jianxin GU
Keyword(s):  
Hepatocellular Carcinoma ◽  
Retinoic Acid ◽  
Cell Surface ◽  
Carcinoma Cell ◽  
Human Hepatocellular Carcinoma ◽  
Sugar Chain ◽  
Trans Retinoic Acid ◽  
All Trans Retinoic Acid ◽  
Human Hepatocellular Carcinoma Cell ◽  
Hepatocellular Carcinoma Cell

A human hepatocellular carcinoma cell line, SMMC-7721, was treated with all-trans-retinoic acid (RA) and phorbol 12-myristate 13-acetate (PMA) to induce its differentiation and proliferation respectively. A biantennary sugar chain fluorescently labelled with 2-aminopyridine (PA), GlcNAcβ1-2Manα1-6(GlcNAcβ1-2Manα1-3)Manβ1-4GlcNAcβ1-4GlcNAc-PA, was used to detect the activity of β-1,4-galactosyltransferase on the cell surface by HPLC. The results show that the activity of β-1,4-galactosyltransferase on the cell surface increases when the cell is treated with RA, but decreases when it is treated with PMA, whereas the activities of the whole cell remain stable during the treatments.

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