scholarly journals New Developments in Capillary Electrophoresis. Application of Capillary Electrophoresis to Quantitative Analysis and Characterization. Capillary electrophoretic study on the formation of inclusion complexes between .BETA.-cyclodextrin and 1- and 2-naphthalenesulfonates.

1997 ◽  
Vol 46 (6) ◽  
pp. 495-498 ◽  
Author(s):  
Sanyo HAMAI ◽  
Hiroshi WATANABE
Keyword(s):  
Capillary Electrophoresis ◽  
Quantitative Analysis ◽  
Inclusion Complexes ◽  
Electrophoretic Study ◽  
New Developments ◽  
Beta Cyclodextrin ◽  
Capillary Electrophoretic

scholarly journals Study of Cyclodextrin/Fluoroquinolone Inclusion Complexes by Capillary Electrophoresis

2013 ◽  
Vol 59 (2) ◽  
pp. 107-110 ◽  
Author(s):  
Blanka Székely-Szentmiklósi ◽  
B Tőkés
Keyword(s):  
Capillary Electrophoresis ◽  
Inclusion Complexes ◽  
Host Interactions ◽  
Beta Cyclodextrin ◽  
Experimental Parameters ◽  
Zone Electrophoresis ◽  
Capillary Zone ◽  
New Formulation ◽  
Hydroxypropyl Beta Cyclodextrin

AbstractIntroduction: In the present work we evaluated the complexation role of cyclodextrins toward fluoroquinolones in an attempt to assess their potential as new formulation additives for more efficient fluoroquinolone delivery and as selectors in capillary electrophoresis.Material and method: Guest-host interactions of two second generation quinolones, ciprofloxacin and norfloxacin with four cyclodextrins, beta-cyclodextrin (β-CD), gamma-cyclodextrin (γ-CD) and two beta-cyclodextrin derivatives, 2-hydroxypropyl beta-cyclodextrin (HP-β-CD) and randomly methylated beta-cyclodextrin (RAMEB), were tested by capillary electrophoresis in borate running buffer. Experimental parameters like buffer concentration, pH, organic modifier, voltage and cyclodextrin concentration have been varied for a better resolution.Results: In capillary zone electrophoresis ciprofloxacin and norfloxacin are migrating together, a difference in their migration times and thus separation occured by the addition of cyclodextrins.Conclusion: Our results suggest formation of inclusion complexes between fluoroquinolones and cyclodextrins. Differences in their affinity to host molecules resulted in separation of the two fluoroquinolones

scholarly journals Quantitative Analysis of Norfloxacin in β-Cyclodextrin Inclusion Complexes—Development and Validation of a Stability-indicating HPLC Method

2015 ◽  
Vol 31 (10) ◽  
pp. 1083-1089 ◽  
Author(s):  
Cassiana MENDES ◽  
Aline BUTTCHEVITZ ◽  
Jéssica Henriques KRUGER ◽  
Larissa Sakis BERNARDI ◽  
Paulo Renato OLIVEIRA ◽  
...  
Keyword(s):  
Quantitative Analysis ◽  
Inclusion Complexes ◽  
Hplc Method ◽  
Stability Indicating ◽  
Cyclodextrin Inclusion Complexes ◽  
Beta Cyclodextrin ◽  
Cyclodextrin Inclusion ◽  
Development And Validation

scholarly journals Host–Guest Inclusion Complexes of Essential Oils with Strong Antibacterial and Antifungal Features in Beta-Cyclodextrin for Solid-State Pharmaceutical Applications

2021 ◽  
Vol 11 (14) ◽  
pp. 6597
Author(s):  
Aldo Arrais ◽  
Marta Manzoni ◽  
Alessia Cattaneo ◽  
Valentina Gianotti ◽  
Nadia Massa ◽  
...  
Keyword(s):  
Solid State ◽  
Essential Oil ◽  
Essential Oils ◽  
Inclusion Complexes ◽  
Production Costs ◽  
Good Tolerance ◽  
Actual Application ◽  
Beta Cyclodextrin ◽  
Ft Ir ◽  
Antibacterial And Antifungal

Essential oils are widely recognized as natural alternatives to pharmaceutical antibacterial and antifungal agents. With respect to standard pharmaceutics, the advantages of essential oils are their (i) low production costs, (ii) lack of chemical and biochemical drawbacks that are intrinsic to the synthetic production process and (iii) good tolerance by humans. On the other hand, the liquid nature of essential oils poses concerns about their actual application in different therapeutic issues regarding their persistence and the ability to control or prolong drug release. In this study, two essential oils from oregano and winter savory showing antibacterial and antifungal features were complexed in a solid state with beta-cyclodextrin. Host–guest inclusion complexes were characterized using FT-IR spectroscopy, ESI-MS and GC-MS techniques. Manyfold terpenic and non-terpenic components of the oils could be observed and unambiguously identified as being included inside the carbohydrate hosts. Many of them provided a specific biocidal action. Indeed, essential oil host–guest inclusion products were tested against two Candida species and an S. aureus reference strain, showing that the oils effectively maintained their liquid performances. Solid-state tablets of the essential oil inclusion complexes embedded in polyvinylpyrrolidone could be obtained. These results pave the way for the solid-state application of essential oils in antibacterial and antifungal pharmaceutical treatments.

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