Associations between glucokinase and glucokinase regulatory protein gene polymorphisms and clinical parameters in pregnant women

ABSTRAKTWstęp: Ciąża wiąże się ze zmianami w metabolizmie węglowodanów, które mogą wywierać wpływ na noworodka. Podstawowym macierzyńskim czynnikiem środowiskowym, który reguluje wzrost płodu, jest dostarczanie substratu do łożyska, a glukoza jest głównym substratem energetycznym do wzrostu wewnątrzmacicznego. Podstawowym źródłem glukozy są węglowodany z diety. Glukokinaza (GCK) jest enzymem odpowiedzialnym za regulację wychwytu i magazynowania glukozy. Białko regulatorowe glukinazy (GCKR) moduluje glukokinazę, która katalizuje wątrobową fosforylację glukozy, prowadząc do syntezy glikogenu i triacylogliceroli.Celem badania była ocena związku między polimorfizmami GCK rs1799884 i GCKR rs780094 a parametrami klinicznymi u kobiet w ciąży.Materiały i metody: Do badania włączono 207 kobiet w ciąży z prawidłowymi wartościami doustnego testu tolerancji glukozy (OGTT). Przeanalizowano związek między badanymi polimorfizmami a parametrami klinicznymi takimi jak: masa ciała przed ciążą, masa ciała przy porodzie, wzrost masy ciała w czasie ciąży, wskaźnik masy ciała (BMI) przed ciążą, BMI przy porodzie, wzrost BMI w trakcie ciąży, czas trwania ciąży, masa ciała noworodka, wynik w skali APGAR i stężenia glukozy dla OGTT.Wyniki i wnioski: Nie stwierdzono zależności istotnych statystycznie między polimorfizmami GCK rs1799884 i GCKR rs780094 a badanymi parametrami klinicznymi, z wyjątkiem wyższego wzrostu BMI podczas ciąży u kobiet z genotypem CC GCK rs1799884.

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Glucokinase Regulatory Protein Gene Polymorphism Affects Liver Fibrosis in Non-Alcoholic Fatty Liver Disease

PLoS ONE ◽

10.1371/journal.pone.0087523 ◽

2014 ◽

Vol 9 (2) ◽

pp. e87523 ◽

Cited By ~ 71

Author(s):

Salvatore Petta ◽

Luca Miele ◽

Elisabetta Bugianesi ◽

Calogero Cammà ◽

Chiara Rosso ◽

...

Keyword(s):

Liver Disease ◽

Liver Fibrosis ◽

Gene Polymorphism ◽

Fatty Liver ◽

Fatty Liver Disease ◽

Protein Gene ◽

Regulatory Protein ◽

Alcoholic Fatty Liver ◽

Glucokinase Regulatory Protein ◽

Alcoholic Fatty Liver Disease

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Association between glucokinase regulatory protein (GCKR) and apolipoprotein A5 (APOA5) gene polymorphisms and triacylglycerol concentrations in fasting, postprandial, and fenofibrate-treated states

American Journal of Clinical Nutrition ◽

10.3945/ajcn.2008.26363 ◽

2008 ◽

Vol 89 (1) ◽

pp. 391-399 ◽

Cited By ~ 37

Author(s):

Pablo Perez-Martinez ◽

Dolores Corella ◽

Jian Shen ◽

Donna K Arnett ◽

Nikos Yiannakouris ◽

...

Keyword(s):

Gene Polymorphisms ◽

Regulatory Protein ◽

Apolipoprotein A5 ◽

Glucokinase Regulatory Protein ◽

Apoa5 Gene

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Mutations in the glucokinase regulatory protein gene in 2p23 in obese French caucasians

Diabetologia ◽

10.1007/s00125-003-1083-y ◽

2003 ◽

Vol 46 (5) ◽

pp. 704-711 ◽

Cited By ~ 17

Author(s):

M. Veiga-da-Cunha ◽

J. Delplanque ◽

A. Gillain ◽

D. T. Bonthron ◽

P. Boutin ◽

...

Keyword(s):

Protein Gene ◽

Regulatory Protein ◽

Glucokinase Regulatory Protein

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Correction: Glucokinase Regulatory Protein Gene Polymorphism Affects Liver Fibrosis in Non-Alcoholic Fatty Liver Disease

PLoS ONE ◽

10.1371/journal.pone.0092497 ◽

2014 ◽

Vol 9 (3) ◽

pp. e92497

Author(s):

Keyword(s):

Liver Disease ◽

Liver Fibrosis ◽

Gene Polymorphism ◽

Fatty Liver ◽

Fatty Liver Disease ◽

Protein Gene ◽

Regulatory Protein ◽

Alcoholic Fatty Liver ◽

Glucokinase Regulatory Protein ◽

Alcoholic Fatty Liver Disease

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Association of rs780094 and rs1260326 glucokinase regulatory protein gene polymorphisms with dyslipidemia in a group of Serbian acute ischemic stroke patients

Archives of Biological Sciences ◽

10.2298/abs211126002b ◽

2022 ◽

pp. 2-2

Author(s):

Jelena Basic ◽

Vuk Milosevic ◽

Milica Zivanovic ◽

Jasen Kundalic ◽

Milena Despotovic ◽

...

Keyword(s):

Ischemic Stroke ◽

Acute Ischemic Stroke ◽

Lipid Profile ◽

Protein Gene ◽

Regulatory Protein ◽

Density Lipoprotein ◽

Coagulation Factor ◽

Lipoprotein Cholesterol ◽

Nucleotide Polymorphisms ◽

Glucokinase Regulatory Protein

Although genetic variations rs780094 and rs1260326 of the glucokinase regulatory protein gene (GCKR) could be associated with lipid profile imbalance, their influence on acute ischemic stroke (AIS) risk has not yet been established. The aim of this study was to investigate the influence of GCKR single nucleotide polymorphisms (SNPs) rs780094 and rs1260326 on lipid profile parameters in patients with AIS, and to evaluate the association of these SNPs with the risk of AIS. In a casecontrol study, a total of 148 subjects were screened for GCKR rs780094 and rs1260326 SNPs using the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. The lipid profile was determined based on serum total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C) and triacylglycerol (TG) concentrations. The frequencies of the minor rs780094T allele and the minor rs1260326T allele were significantly lower in AIS patients compared to controls. The rs780094TT genotype and the rs1260326TT genotype were associated with decreased risk of AIS compared to wildtype carriers. In conclusion, this is the first study implying that decreased risk of AIS in rs780094 and rs1260326 homozygous minor allele carriers is not caused by dyslipidemia, but possibly by the lack of coagulation factor glycosylation.

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