Performance of TGSE BLADE DWI in the diagnosis of cholesteatoma compared with RESOLVE DWI
Abstract Background: Based on the high resolution of soft tissue, MRI has gained increasing importance in the evaluation of cholesteatoma, especially diffusion-weighted imaging(DWI). The purpose of this study was to evaluate the role of 2D turbo gradient- and spin-echo (TGSE) diffusion-weighted (DW) pulse sequence with BLADE trajectory technique in the diagnosis of cholesteatoma at 3T and to qualitatively and quantitatively compare the image quality between the TGSE BLADE and RESOLVE methods.Method: A total of 42 patients (23 males, 19 females; age range, 7-65 years; mean, 40.1 years) with surgically confirmed cholesteatoma in the middle ear were enrolled in this study. All patients underwent DWI (both the prototype TGSE BLADE DWI sequence and RESOLVE DWI sequence) using a 3-T scanner with a 64-channel brain coil.Qualitative imaging parameters (imaging sharpness, geometric distortion, ghosting artifacts, and overall imaging quality) and quantitative imaging parameters (apparent diffusion coefficient [ADC], signal-to-noise ratio [SNR], contrast, and contrast-to-noise ratio [CNR] for the two diffusion acquisition techniques were assessed by two independent radiologists. Result: Comparison of the qualitative scores indicated that TGSE BLADE DWI produced less geometric distortion and ghosting artifacts (P<0.001) and higher image quality (P<0.001) than RESOLVE DWI. Comparison of the evaluated quantitative image parameters between TGSE and RESOLVE showed that TGSE BLADE DWI produced a significantly lower SNR (P<0.001) and higher parameter values (both contrast and CNR (P < 0.001)) than RESOLVE DWI.The ADC (P<0.001) measured by TGSE BLADE DWI (0.763×10-3 s/mm2) is significantly lower than that measured by RESOLVE DWI (0.928×10-3 s/mm2). Conclusion: Comparing with RESOLVE DWI, TGSE BLADE DWI can significantly improve the image quality of cholesteatoma by reducing magnetic sensitive artifacts, distortion, and blurring. TGSE BLADE DWI is more valuable for the diagnosis of small-sized (2mm) cholesteatoma lesions compare with RESOLVE DWI image. However, TGSE BLADE DWI also has some disadvantages: the whole image intensity is slightly low, so that the anatomical details of the air-bone interface are not well shown, which is the place to be improved in the future.