scholarly journals Characteristics of Resting-State Functional Connectivity in Older Adults after the PICMOR Intervention Program: A Preliminary Report

2020 ◽  
Author(s):  
Hikaru Sugimoto ◽  
Toshikazu Kawagoe ◽  
Mihoko Otake-Matsuura
Keyword(s):  
Resting State ◽  
Verbal Fluency ◽  
Intervention Program ◽  
Inferior Frontal Gyrus ◽  
Middle Frontal Gyrus ◽  
Seed Region ◽  
Resting State Functional Connectivity ◽  
Post Intervention ◽  
Left Inferior Frontal Gyrus ◽  
Temporal Pole

Abstract Background: The present study aimed to provide a basis for future research examining the neural mechanisms that underlie the beneficial effect of an intervention program, Photo-Integrated Conversation Moderated by Robots (PICMOR), on verbal fluency in older adults as identified in our previous randomized controlled trial. In this preliminary report, we conducted an additional experiment using resting-state functional magnetic resonance imaging (rsfMRI) after the intervention period. Specifically, we investigated the resting-state functional connectivity (rsFC) characteristics of the intervention group (INT) compared to the control group (CONT). Methods: rsfMRI data were acquired from 31 and 30 participants in INT and CONT, respectively, after the intervention. In the analyses, two of the most important regions in verbal fluency, the left inferior and middle frontal gyri, were selected as seed regions, and the rsFCs were compared between groups. We also conducted regression analyses for rsFCs using the difference in individual phonemic verbal fluency task (PVFT) scores between the pre- and post-intervention periods (i.e., post- minus pre-intervention) as an independent variable. Results: We found higher rsFC in INT than in CONT between the left inferior frontal gyrus as a seed region and the temporal pole and middle frontal gyrus. The rsFC strength between the left inferior frontal gyrus and temporal pole positively correlated with an increased PVFT score between the pre- and post-intervention periods. In contrast, we found lower rsFC in INT than in CONT between the left middle frontal gyrus as a seed region and the posterior cingulate cortex, precuneus, and postcentral gyrus. Conclusions: Our findings suggest that the beneficial intervention effect of PICMOR on verbal fluency is characterized by enhanced rsFC of the left inferior frontal gyrus with semantic and executive control-related regions and suppressed rsFC between the left middle frontal gyrus and posterior cortical midline structures. No definitive conclusions can be made because of a lack of rsfMRI data before the intervention. However, this pilot study provides the candidates for rsFCs, reflecting the beneficial effects of PICMOR on the brain network involved in verbal fluency. Trial registration: The trial was retrospectively registered at the UMIN Clinical Trials Registry (UMIN000036667) (May 7th, 2019).

scholarly journals Characteristics of Resting-State Functional Connectivity in Older Adults after the PICMOR Intervention Program: A Preliminary Report

2020 ◽  
Author(s):  
Hikaru Sugimoto ◽  
Toshikazu Kawagoe ◽  
Mihoko Otake-Matsuura
Keyword(s):  
Resting State ◽  
Verbal Fluency ◽  
Intervention Program ◽  
Inferior Frontal Gyrus ◽  
Middle Frontal Gyrus ◽  
Seed Region ◽  
Resting State Functional Connectivity ◽  
Post Intervention ◽  
Left Inferior Frontal Gyrus ◽  
Temporal Pole

Abstract Background: The present study aimed to provide a basis for future research examining the neural mechanisms that underlie the beneficial effect of an intervention program, Photo-Integrated Conversation Moderated by Robots (PICMOR), on verbal fluency in older adults as identified in our previous randomized controlled trial. In this preliminary report, we conducted an additional experiment using resting-state functional magnetic resonance imaging (rsfMRI) after the intervention period. Specifically, we investigated the resting-state functional connectivity (rsFC) characteristics of the intervention group (INT) compared to the control group (CONT). Methods: rsfMRI data were acquired from 31 and 30 participants in INT and CONT, respectively, after the intervention. In the analyses, two of the most important regions in verbal fluency, the left inferior and middle frontal gyri, were selected as seed regions, and the rsFCs were compared between groups. We also conducted regression analyses for rsFCs using the difference in individual phonemic verbal fluency task (PVFT) scores between the pre- and post-intervention periods (i.e., post- minus pre-intervention) as an independent variable. Results: We found higher rsFC in INT than in CONT between the left inferior frontal gyrus as a seed region and the temporal pole and middle frontal gyrus. The rsFC strength between the left inferior frontal gyrus and temporal pole positively correlated with an increased PVFT score between the pre- and post-intervention periods. In contrast, we found lower rsFC in INT than in CONT between the left middle frontal gyrus as a seed region and the posterior cingulate cortex, precuneus, and postcentral gyrus. Conclusions: Our findings suggest that the beneficial intervention effect of PICMOR on verbal fluency is characterized by enhanced rsFC of the left inferior frontal gyrus with semantic and executive control-related regions and suppressed rsFC between the left middle frontal gyrus and posterior cortical midline structures. No definitive conclusions can be made because of a lack of rsfMRI data before the intervention. However, this pilot study provides the candidates for rsFCs, reflecting the beneficial effects of PICMOR on the brain network involved in verbal fluency. Trial registration: The trial was retrospectively registered at the UMIN Clinical Trials Registry (UMIN000036667) (May 7th, 2019).

scholarly journals Characteristics of resting-state functional connectivity in older adults after the PICMOR intervention program: a preliminary report

2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Hikaru Sugimoto ◽  
Toshikazu Kawagoe ◽  
Mihoko Otake-Matsuura
Keyword(s):  
Resting State ◽  
Verbal Fluency ◽  
Intervention Program ◽  
Inferior Frontal Gyrus ◽  
Middle Frontal Gyrus ◽  
Seed Region ◽  
Resting State Functional Connectivity ◽  
Post Intervention ◽  
Left Inferior Frontal Gyrus ◽  
Temporal Pole

Abstract Background The present study aimed to provide a basis for future research examining the neural mechanisms that underlie the beneficial effect of an intervention program, Photo-Integrated Conversation Moderated by Robots (PICMOR), on verbal fluency in older adults as identified in our previous randomized controlled trial. In this preliminary report, we conducted an additional experiment using resting-state functional magnetic resonance imaging (rsfMRI) after the intervention period. Specifically, we investigated the resting-state functional connectivity (rsFC) characteristics of the intervention group (INT) compared to the control group (CONT). Methods rsfMRI data were acquired from 31 and 30 participants in INT and CONT, respectively, after the intervention. In the analyses, two of the most important regions in verbal fluency, the left inferior and middle frontal gyri, were selected as seed regions, and the rsFCs were compared between groups. We also conducted regression analyses for rsFCs using the difference in individual phonemic verbal fluency task (PVFT) scores between the pre- and post-intervention periods (i.e., post- minus pre-intervention) as an independent variable. Results We found higher rsFC in INT than in CONT between the left inferior frontal gyrus as a seed region and the temporal pole and middle frontal gyrus. The rsFC strength between the left inferior frontal gyrus and temporal pole positively correlated with an increased PVFT score between the pre- and post-intervention periods. In contrast, we found lower rsFC in INT than in CONT between the left middle frontal gyrus as a seed region and the posterior cingulate cortex, precuneus, and postcentral gyrus. Conclusions Our findings suggest that the beneficial intervention effect of PICMOR on verbal fluency is characterized by enhanced rsFC of the left inferior frontal gyrus with semantic and executive control-related regions and suppressed rsFC between the left middle frontal gyrus and posterior cortical midline structures. No definitive conclusions can be made because of a lack of rsfMRI data before the intervention. However, this pilot study provides the candidates for rsFCs, reflecting the beneficial effects of PICMOR on the brain network involved in verbal fluency. Trial registration The trial was retrospectively registered at the UMIN Clinical Trials Registry (UMIN000036667) (May 7th, 2019).

scholarly journals Characteristics of Resting-State Functional Connectivity in Older Adults after the PICMOR Intervention Program: A Preliminary Report

2020 ◽  
Author(s):  
Hikaru Sugimoto ◽  
Toshikazu Kawagoe ◽  
Mihoko Otake-Matsuura
Keyword(s):  
Resting State ◽  
Verbal Fluency ◽  
Intervention Program ◽  
Inferior Frontal Gyrus ◽  
Middle Frontal Gyrus ◽  
Resting State Functional Connectivity ◽  
Post Intervention ◽  
Left Inferior Frontal Gyrus ◽  
Temporal Pole ◽  
Left Middle

Abstract Background: The present study aimed to provide a basis for future research examining neural mechanisms underlying the beneficial effect of an intervention program named Photo-Integrated Conversation Moderated by Robots (PICMOR) on verbal fluency in older adults, which was identified in our previous randomized controlled trial. In this preliminary report, we conducted an additional experiment after the intervention period using resting-state functional magnetic resonance imaging (rsfMRI). Specifically, we investigated the characteristics of resting-state functional connectivity (rsFC) of the intervention group (INT) by comparing with that of the control group (CONT). Methods: The rsfMRI data were acquired from 31 participants in INT and 30 participants in CONT after the intervention. In the analyses, two of the most important regions in verbal fluency, the left inferior and middle frontal gyri, were selected as seed regions, and the rsFCs were compared between INT and CONT. We also conducted regression analyses for rsFCs using the difference in individual scores of the phonemic verbal fluency test (PVFT) between the pre- and post-intervention periods (i.e., post- minus pre-intervention) as a dependent variable. Results: We found higher rsFC in INT than in CONT between the left inferior frontal gyrus and the temporal pole and middle frontal gyrus. The rsFC strength between the left inferior frontal gyrus and temporal pole positively correlated with an increased PVFT score between the pre- and post-intervention periods. In contrast, we found lower rsFC in INT than in CONT between the left middle frontal gyrus and the posterior cingulate cortex, precuneus, and postcentral gyrus. Conclusions: The present findings suggest that the beneficial intervention effect of PICMOR on verbal fluency is characterized by enhanced rsFC of the left inferior frontal gyrus with semantic and executive control-related regions and suppressed rsFC between the left middle frontal gyrus and default mode network. Although we cannot make any definitive conclusions because of a lack of rsfMRI data before the intervention, this pilot study successfully provides the candidates for rsFCs, reflecting the neural mechanisms underlying the beneficial intervention effect on verbal fluency.

scholarly journals Characteristics of Resting-State Functional Connectivity in Older Adults after the PICMOR Intervention Program: A Preliminary Report

2019 ◽  
Author(s):  
Hikaru Sugimoto ◽  
Toshikazu Kawagoe ◽  
Mihoko Otake-Matsuura
Keyword(s):  
Older Adults ◽  
Resting State ◽  
Verbal Fluency ◽  
Preliminary Report ◽  
Intervention Program ◽  
Intervention Period ◽  
Resting State Functional Connectivity ◽  
Temporal Pole ◽  
Phonemic Verbal Fluency ◽  
Fluency Test

Abstract Background: The present study aimed to provide a basis for future research examining neural mechanisms underlying the beneficial effect of an intervention program named Photo-Integrated Conversation Moderated by Robots (PICMOR) on verbal fluency in older adults, which was identified in our previous study. In this preliminary report, we conducted an additional experiment using resting-state functional magnetic resonance imaging (rsfMRI) and investigated the characteristics of resting-state functional connectivity (rsFC) of participants in the intervention group (INT) by comparing with that of participants in the control group (CONT).Methods: The rsfMRI data were acquired from 31 participants in INT and 30 participants in CONT after the randomized control trial. These data were analyzed by a seed-based approach, in which the left inferior and middle frontal gyrus (IFG/MFG) were selected as seed regions and the rsFCs with them were compared between INT and CONT. To interpret the group difference in the rsFCs, we also conducted regression analyses using individual scores of the phonemic verbal fluency test, which were collected before and after the intervention.Results: We found higher rsFC in INT than in CONT between the left IFG and the temporal pole and MFG. The rsFC strength between the left IFG and temporal pole positively correlated with an increased score in the phonemic verbal fluency test through the intervention period. In contrast, we found lower rsFC in INT than in CONT between the left MFG and the posterior cingulate cortex, precuneus, and postcentral gyrus.Conclusions: Along with our previous findings that greater enhancement of the phonemic verbal fluency score through the intervention period was observed in INT than in CONT, the present findings suggest that the beneficial intervention effect is characterized by enhanced rsFC of the left IFG with semantic and executive control-related regions and suppressed rsFC between the left MFG and default mode network.Trial registration: The trial was retrospectively registered at the UMIN Clinical Trials Registry (UMIN000036667) (Date of registration: 7th May, 2019).

scholarly journals Amplitude of low-frequency fluctuations on Alzheimer’s disease with depression: evidence from resting-state fMRI

2020 ◽  
Vol 33 (4) ◽  
pp. e100147
Author(s):  
Yuzhu Mu ◽  
Yumei Li ◽  
Qi Zhang ◽  
Zhongxiang Ding ◽  
Mei Wang ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Resting State ◽  
Brain Activity ◽  
Inferior Frontal Gyrus ◽  
Low Frequency ◽  
Middle Frontal Gyrus ◽  
Left Inferior Frontal Gyrus ◽  
Superior Frontal Gyrus ◽  
Frequency Fluctuations ◽  
Left Middle

BackgroundThe prevalence of Alzheimer’s disease (AD) comorbid with depression is common. However, the mechanisms of AD with depression remain unclear.AimsTo investigate the regional alterations of brain activity of AD with depression in resting-state functional magnetic resonance imaging (rs-fMRI).Methods154 patients with AD who met the inclusion criteria were recruited from the Zhejiang Provincial People’s Hospital from October 2014 to October 2016. According to whether the core symptoms of depression were present, patients were divided into two groups, 22 patients with AD with depression (AD-D) and 52 patients with AD without depression (AD-nD). The amplitude of low frequency fluctuations (ALFF) was compared between two groups by performing independent-samples t-test.ResultsCompared with the AD-D group, increased ALFF values in the bilateral superior frontal gyrus, left middle frontal gyrus and left inferior frontal gyrus were observed in the AD-nD group. The brain activity in the AD-nD group in the bilateral superior frontal gyrus, left middle frontal gyrus and the left inferior frontal gyrus was higher than the AD-D group.ConclusionsResting-state brain functional alterations may be closely bound up with the pathophysiologic features of patients with AD with depressive symptoms.

Magnetoencephalography Resting-State Correlates of Executive and Language Components of Verbal Fluency

2021 ◽  
Author(s):  
Victor Oswald ◽  
Younes Zerouali ◽  
Aubrée Boulet-Craig ◽  
Maja Krajinovic ◽  
Caroline Laverdière ◽  
...  
Keyword(s):  
Resting State ◽  
Verbal Fluency ◽  
Right Hemisphere ◽  
Spectral Power ◽  
Inferior Frontal Gyrus ◽  
Factor Loading ◽  
Language Abilities ◽  
Verbal Test ◽  
Eyes Open ◽  
The Right

Abstract Verbal fluency (VF) is a heterogeneous test that requires executive functions as well as language abilities. The purpose of this study was to elucidate the specificity of the resting state MEG correlates of the executive and language components. To this end, we administered a VFtest, another verbal test (Vocabulary), and another executive test (Trail Making Test), and we recorded 5-min eyes-open resting-state MEG data in 28 healthy participants. We used source-reconstructed spectral power estimates to compute correlation/anticorrelation MEG clusters with the performance at each test, as well as with the advantage in performance between tests, across individuals using cluster-level statisticsin the standard frequency bands. By obtaining conjunction clusters between verbal fluency scores and factor loading obtained for verbal fluency and each of the two other tests, we showed a core of slow clusters (delta to beta) localized in the right hemisphere, in adjacent parts of the premotor, pre-central and post-central cortex in the mid-lateral regions related to executive monitoring. We also found slow parietal clusters bilaterally and a cluster in the gamma 2 and 3 bandsin the left inferior frontal gyrus likely associated with phonological processinginvolved in verbal fluency.

scholarly journals Think Hard or Think Smart: Network Reconfigurations After Divergent Thinking Associate With Creativity Performance

2020 ◽  
Vol 14 ◽  
Author(s):  
Hong-Yi Wu ◽  
Bo-Cheng Kuo ◽  
Chih-Mao Huang ◽  
Pei-Jung Tsai ◽  
Ai-Ling Hsu ◽  
...  
Keyword(s):  
Resting State ◽  
Divergent Thinking ◽  
Inferior Frontal Gyrus ◽  
Dynamic Reconfiguration ◽  
Angular Gyrus ◽  
Resting State Functional Connectivity ◽  
Creative Achievement ◽  
Before And After ◽  
Network Organizations ◽  
Creative Group

Evidence suggests divergent thinking is the cognitive basis of creative thoughts. Neuroimaging literature using resting-state functional connectivity (RSFC) has revealed network reorganizations during divergent thinking. Recent studies have revealed the changes of network organizations when performing creativity tasks, but such brain reconfigurations may be prolonged after task and be modulated by the trait of creativity. To investigate the dynamic reconfiguration, 40 young participants were recruited to perform consecutive Alternative Uses Tasks (AUTs) for divergent thinking and two resting-state scans (before and after AUT) were used for mapping the brain reorganizations after AUT. We split participants into high- and low-creative groups based on creative achievement questionnaire (CAQ) and targeted on reconfigurations of the two brain networks: (1) default-mode network (DMN) and (2) the network seeded at the left inferior frontal gyrus (IFG) because the between-group difference of AUT-induced brain activation located at the left IFG. The changes of post-AUT RSFCs (DMN and IFGN) indicated the prolonged effect of divergent thinking. More specifically, the alterations of RSFCIFG−AG and RSFCIFG−IPL (AG: angular gyrus, IPG: inferior parietal lobule) in the high-creative group had positive relationship with their AUT performances (originality and fluency), but not found in the low-creative group. Furthermore, the RSFC changes of DMN did not present significant relationships with AUT performances. The findings not only confirmed the possibility of brain dynamic reconfiguration following divergent thinking, but also suggested the distinct IFGN reconfiguration between individuals with different creativity levels.

scholarly journals Resting-state functional connectivity, cortical GABA and neuroactive steroids in peripartum and peripartum depressed women: a functional magnetic imaging and resonance study

2018 ◽  
Author(s):  
Kristina M. Deligiannidis ◽  
Christina L. Fales ◽  
Aimee R. Kroll-Desrosiers ◽  
Scott A. Shaffer ◽  
Vanessa Villamarin ◽  
...  
Keyword(s):  
Functional Connectivity ◽  
Resting State ◽  
Neuroactive Steroids ◽  
Anterior Cingulate ◽  
Resonance Spectroscopy ◽  
Resting State Functional Connectivity ◽  
Magnetic Imaging ◽  
Temporal Pole ◽  
The Right ◽  
The Relationship

ABSTRACTPostpartum depression (PPD) is associated with abnormalities in resting-state functional connectivity (RSFC) but the underlying neurochemistry is unclear. We hypothesized that peripartum GABAergic neuroactive steroids (NAS) are related to cortical GABA concentrations and RSFC in PPD as compared to healthy comparison women (HCW). To test this, we measured RSFC with fMRI and GABA+/Creatine (Cr) concentrations with proton magnetic resonance spectroscopy (1H MRS) in the pregenual anterior cingulate (pgACC) and occipital cortices (OCC) and quantified peripartum plasma NAS. We examined between-group differences in RSFC and the relationship between cortical GABA+/Cr concentrations with RSFC. We investigated the relationship between NAS, RSFC and cortical GABA+/Cr concentrations. Within the default mode network (DMN) an area of the dorsomedial prefrontal cortex (DMPFC) had greater connectivity with the rest of the DMN in PPD (peak voxel: MNI coordinates (2, 58, 32), p=0.002) and was correlated to depression scores (peak HAM-D17 voxel: MNI coordinates (0, 60, 34), p=0.008). pgACC GABA+/Cr correlated positively with DMPFC RSFC in a region spanning the right anterior/posterior insula and right temporal pole (r=+0.661, p=0.000). OCC GABA+/Cr correlated positively with regions spanning both amygdalae (right amygdala: r=+0.522, p=0.000; left amygdala: r=+0.651, p=0.000) as well as superior parietal areas. Plasma allopregnanolone was higher in PPD (p=0.03) and positively correlated with intra DMPFC connectivity (r=+0.548, p=0.000) but not GABA+/Cr. These results provide initial evidence that PPD is associated with altered DMN connectivity; cortical GABA+/Cr concentrations are associated with postpartum RSFC and allopregnanolone is associated with postpartum intra-DMPFC connectivity.

scholarly journals Effects of tDCS on Sound Duration in Patients with Apraxia of Speech in Primary Progressive Aphasia

2021 ◽  
Author(s):  
Charalambos Themistocleous ◽  
Kimberly Webster ◽  
Kyrana Tsapkini
Keyword(s):  
Speech Therapy ◽  
Inferior Frontal Gyrus ◽  
Primary Progressive Aphasia ◽  
Preliminary Evidence ◽  
Apraxia Of Speech ◽  
Post Intervention ◽  
Left Inferior Frontal Gyrus ◽  
Primary Progressive ◽  
Speech Fluency ◽  
Sound Duration

Transcranial direct current stimulation (tDCS) over the left Inferior Frontal Gyrus (IFG) was found to improve apraxia of speech (AOS) in post-stroke aphasia, speech fluency in adults who stutter, naming and spelling in primary progressive (PPA). This paper aims to determine whether tDCS over the left IFG coupled with AOS therapy improves speech fluency in patients with PPA more than sham. Eight patients with non-fluent PPA with AOS symptoms received either active or sham tDCS, along with speech therapy for 15 weekday sessions. Speech therapy consisted of repetition of increasing syllable-length words. Evaluations took place before, immediately after, and two months post-intervention. Words were segmented into vowels and consonants and the duration of each vowel and consonant was measured. Segmental duration was significantly shorter after tDCS than sham for both consonants and vowels. tDCS gains generalized to untrained words. The effects of tDCS sustained over two months post-treatment in trained words. Taken together, these results demonstrate that the tDCS over the left IFG facilitates speech production by reducing segmental duration. The results provide preliminary evidence that tDCS can maximize efficacy of speech therapy in non-fluent PPA with AOS.

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