scholarly journals Amplitude of low-frequency fluctuations on Alzheimer’s disease with depression: evidence from resting-state fMRI

2020 ◽  
Vol 33 (4) ◽  
pp. e100147
Author(s):  
Yuzhu Mu ◽  
Yumei Li ◽  
Qi Zhang ◽  
Zhongxiang Ding ◽  
Mei Wang ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Resting State ◽  
Brain Activity ◽  
Inferior Frontal Gyrus ◽  
Low Frequency ◽  
Middle Frontal Gyrus ◽  
Left Inferior Frontal Gyrus ◽  
Superior Frontal Gyrus ◽  
Frequency Fluctuations ◽  
Left Middle

BackgroundThe prevalence of Alzheimer’s disease (AD) comorbid with depression is common. However, the mechanisms of AD with depression remain unclear.AimsTo investigate the regional alterations of brain activity of AD with depression in resting-state functional magnetic resonance imaging (rs-fMRI).Methods154 patients with AD who met the inclusion criteria were recruited from the Zhejiang Provincial People’s Hospital from October 2014 to October 2016. According to whether the core symptoms of depression were present, patients were divided into two groups, 22 patients with AD with depression (AD-D) and 52 patients with AD without depression (AD-nD). The amplitude of low frequency fluctuations (ALFF) was compared between two groups by performing independent-samples t-test.ResultsCompared with the AD-D group, increased ALFF values in the bilateral superior frontal gyrus, left middle frontal gyrus and left inferior frontal gyrus were observed in the AD-nD group. The brain activity in the AD-nD group in the bilateral superior frontal gyrus, left middle frontal gyrus and the left inferior frontal gyrus was higher than the AD-D group.ConclusionsResting-state brain functional alterations may be closely bound up with the pathophysiologic features of patients with AD with depressive symptoms.

scholarly journals Investigation of changes in the activity and function of dry eye-associated brain regions using the amplitude of low frequency fluctuations(ALFF)method

2022 ◽  
Author(s):  
Tie Sun ◽  
Hui-Ye Shu ◽  
Jie-Li Wu ◽  
Ting Su ◽  
Yu-Ji Liu ◽  
...  
Keyword(s):  
Dry Eye ◽  
Brain Activity ◽  
Pearson Correlation ◽  
Inferior Frontal Gyrus ◽  
Low Frequency ◽  
Brain Regions ◽  
Middle Frontal Gyrus ◽  
Brain Areas ◽  
Spontaneous Brain Activity ◽  
Frequency Fluctuations

Objective: The local characteristics of spontaneous brain activity in patients with dry eye (DE) and its relationship with clinical characteristics were evaluated using the amplitude of low-frequency fluctuations (ALFF) method. Methods: A total of 27 patients with DE (10 males and 17 females) and 28 healthy controls (HCs) (10 males and 18 females) were recruited, matched according to sex, age, weight, and height, classified into the DE and HC groups, and examined using functional magnetic resonance imaging scans. Spontaneous brain activity changes were recorded using ALFF technology. Data were recorded and plotted on the receiver operating characteristic curve, reflecting changes in activity in different brain areas. Finally, Pearson correlation analysis was used to calculate the potential relationship between spontaneous brain activity abnormalities in multiple brain regions and clinical features in patients with DE. GraphPad Prism 8 (GraphPad Software, Inc.) was used to analyze the linear correlation between the Hospital Anxiety and Depression Scale and ALFF value. Results: Compared with HCs, the ALFF values of patients with DE were decreased in the right middle frontal gyrus/right inferior orbitofrontal cortex, left triangle inferior frontal gyrus, left middle frontal gyrus, and right superior frontal gyrus. In contrast, the ALFF value of patients with DE was increased in the left calcarine. Conclusion: There are significant fluctuations in the ALFF value of specific brain regions in patients with DE versus HCs. This corroborates previous evidence showing that the symptoms of ocular surface damage in patients with DE are related to dysfunction in specific brain areas.

scholarly journals Altered patterns of fractional amplitude of low-frequency fluctuation and regional homogeneity in abstinent methamphetamine-dependent users

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
An Xie ◽  
Qiuxia Wu ◽  
Winson Fu Zun Yang ◽  
Chang Qi ◽  
Yanhui Liao ◽  
...  
Keyword(s):  
Resting State ◽  
Brain Activity ◽  
Inferior Frontal Gyrus ◽  
Low Frequency ◽  
Regional Homogeneity ◽  
Anterior Cingulate ◽  
Frequency Fluctuation ◽  
Early Recovery ◽  
Left Inferior Frontal Gyrus ◽  
The Right

AbstractMethamphetamine (MA) could induce functional and structural brain alterations in dependent subjects. However, few studies have investigated resting-state activity in methamphetamine-dependent subjects (MADs). We aimed to investigate alterations of brain activity during resting-state in MADs using fractional amplitude of low-frequency fluctuation (fALFF) and regional homogeneity (ReHo). We analyzed fALFF and ReHo between MADs (n = 70) and healthy controls (HCs) (n = 84) and performed regression analysis using MA use variables. Compared to HCs, abstinent MADs showed increased fALFF and ReHo values in the bilateral striatum, decreased fALFF in the left inferior frontal gyrus, and decreased ReHo in the bilateral anterior cingulate cortex, sensorimotor cortex, and left precuneus. We also observed the fALFF values of bilateral striatum were positively correlated with the age of first MA use, and negatively correlated with the duration of MA use. The fALFF value of right striatum was also positively correlated with the duration of abstinence. The alterations of spontaneous cerebral activity in abstinent MADs may help us probe into the neurological pathophysiology underlying MA-related dysfunction and recovery. Since MADs with higher fALFF in the right striatum had shorter MA use and longer abstinence, the increased fALFF in the right striatum might implicate early recovery during abstinence.

scholarly journals Characteristics of Resting-State Functional Connectivity in Older Adults after the PICMOR Intervention Program: A Preliminary Report

2020 ◽  
Author(s):  
Hikaru Sugimoto ◽  
Toshikazu Kawagoe ◽  
Mihoko Otake-Matsuura
Keyword(s):  
Resting State ◽  
Verbal Fluency ◽  
Intervention Program ◽  
Inferior Frontal Gyrus ◽  
Middle Frontal Gyrus ◽  
Resting State Functional Connectivity ◽  
Post Intervention ◽  
Left Inferior Frontal Gyrus ◽  
Temporal Pole ◽  
Left Middle

Abstract Background: The present study aimed to provide a basis for future research examining neural mechanisms underlying the beneficial effect of an intervention program named Photo-Integrated Conversation Moderated by Robots (PICMOR) on verbal fluency in older adults, which was identified in our previous randomized controlled trial. In this preliminary report, we conducted an additional experiment after the intervention period using resting-state functional magnetic resonance imaging (rsfMRI). Specifically, we investigated the characteristics of resting-state functional connectivity (rsFC) of the intervention group (INT) by comparing with that of the control group (CONT). Methods: The rsfMRI data were acquired from 31 participants in INT and 30 participants in CONT after the intervention. In the analyses, two of the most important regions in verbal fluency, the left inferior and middle frontal gyri, were selected as seed regions, and the rsFCs were compared between INT and CONT. We also conducted regression analyses for rsFCs using the difference in individual scores of the phonemic verbal fluency test (PVFT) between the pre- and post-intervention periods (i.e., post- minus pre-intervention) as a dependent variable. Results: We found higher rsFC in INT than in CONT between the left inferior frontal gyrus and the temporal pole and middle frontal gyrus. The rsFC strength between the left inferior frontal gyrus and temporal pole positively correlated with an increased PVFT score between the pre- and post-intervention periods. In contrast, we found lower rsFC in INT than in CONT between the left middle frontal gyrus and the posterior cingulate cortex, precuneus, and postcentral gyrus. Conclusions: The present findings suggest that the beneficial intervention effect of PICMOR on verbal fluency is characterized by enhanced rsFC of the left inferior frontal gyrus with semantic and executive control-related regions and suppressed rsFC between the left middle frontal gyrus and default mode network. Although we cannot make any definitive conclusions because of a lack of rsfMRI data before the intervention, this pilot study successfully provides the candidates for rsFCs, reflecting the neural mechanisms underlying the beneficial intervention effect on verbal fluency.

scholarly journals Characteristics of Resting-State Functional Connectivity in Older Adults after the PICMOR Intervention Program: A Preliminary Report

2020 ◽  
Author(s):  
Hikaru Sugimoto ◽  
Toshikazu Kawagoe ◽  
Mihoko Otake-Matsuura
Keyword(s):  
Resting State ◽  
Verbal Fluency ◽  
Intervention Program ◽  
Inferior Frontal Gyrus ◽  
Middle Frontal Gyrus ◽  
Seed Region ◽  
Resting State Functional Connectivity ◽  
Post Intervention ◽  
Left Inferior Frontal Gyrus ◽  
Temporal Pole

Abstract Background: The present study aimed to provide a basis for future research examining the neural mechanisms that underlie the beneficial effect of an intervention program, Photo-Integrated Conversation Moderated by Robots (PICMOR), on verbal fluency in older adults as identified in our previous randomized controlled trial. In this preliminary report, we conducted an additional experiment using resting-state functional magnetic resonance imaging (rsfMRI) after the intervention period. Specifically, we investigated the resting-state functional connectivity (rsFC) characteristics of the intervention group (INT) compared to the control group (CONT). Methods: rsfMRI data were acquired from 31 and 30 participants in INT and CONT, respectively, after the intervention. In the analyses, two of the most important regions in verbal fluency, the left inferior and middle frontal gyri, were selected as seed regions, and the rsFCs were compared between groups. We also conducted regression analyses for rsFCs using the difference in individual phonemic verbal fluency task (PVFT) scores between the pre- and post-intervention periods (i.e., post- minus pre-intervention) as an independent variable. Results: We found higher rsFC in INT than in CONT between the left inferior frontal gyrus as a seed region and the temporal pole and middle frontal gyrus. The rsFC strength between the left inferior frontal gyrus and temporal pole positively correlated with an increased PVFT score between the pre- and post-intervention periods. In contrast, we found lower rsFC in INT than in CONT between the left middle frontal gyrus as a seed region and the posterior cingulate cortex, precuneus, and postcentral gyrus. Conclusions: Our findings suggest that the beneficial intervention effect of PICMOR on verbal fluency is characterized by enhanced rsFC of the left inferior frontal gyrus with semantic and executive control-related regions and suppressed rsFC between the left middle frontal gyrus and posterior cortical midline structures. No definitive conclusions can be made because of a lack of rsfMRI data before the intervention. However, this pilot study provides the candidates for rsFCs, reflecting the beneficial effects of PICMOR on the brain network involved in verbal fluency. Trial registration: The trial was retrospectively registered at the UMIN Clinical Trials Registry (UMIN000036667) (May 7th, 2019).

scholarly journals Abnormal Baseline Brain Activity in Patients with Pulsatile Tinnitus: A Resting-State fMRI Study

2014 ◽  
Vol 2014 ◽  
pp. 1-10 ◽  
Author(s):  
Lv Han ◽  
Liu Zhaohui ◽  
Yan Fei ◽  
Li Ting ◽  
Zhao Pengfei ◽  
...  
Keyword(s):  
Resting State ◽  
Structural Changes ◽  
Brain Activity ◽  
Inferior Frontal Gyrus ◽  
Low Frequency ◽  
Resting State Fmri ◽  
Pulsatile Tinnitus ◽  
Spontaneous Brain Activity ◽  
Fmri Study ◽  
The Brain

Numerous investigations studying the brain functional activity of the tinnitus patients have indicated that neurological changes are important findings of this kind of disease. However, the pulsatile tinnitus (PT) patients were excluded in previous studies because of the totally different mechanisms of the two subtype tinnitus. The aim of this study is to investigate whether altered baseline brain activity presents in patients with PT using resting-state functional magnetic resonance imaging (rs-fMRI) technique. The present study used unilateral PT patients (n=42) and age-, sex-, and education-matched normal control subjects (n=42) to investigate the changes in structural and amplitude of low-frequency (ALFF) of the brain. Also, we analyzed the relationships between these changes with clinical data of the PT patients. Compared with normal controls, PT patients did not show any structural changes. PT patients showed significant increased ALFF in the bilateral precuneus, and bilateral inferior frontal gyrus (IFG) and decreased ALFF in multiple occipital areas. Moreover, the increased THI score and PT duration was correlated with increased ALFF in precuneus and bilateral IFG. The abnormalities of spontaneous brain activity reflected by ALFF measurements in the absence of structural changes may provide insights into the neural reorganization in PT patients.

scholarly journals Altered Variability and Concordance of Dynamic Resting-State fMRI Indices in Patients With Attention Deficit Hyperactivity Disorder

2021 ◽  
Vol 15 ◽  
Author(s):  
Feiling Lou ◽  
Jiejie Tao ◽  
Ronghui Zhou ◽  
Shuangli Chen ◽  
Andan Qian ◽  
...  
Keyword(s):  
Attention Deficit Hyperactivity Disorder ◽  
Cognitive Control ◽  
Attention Deficit ◽  
Resting State ◽  
Brain Activity ◽  
Middle Frontal Gyrus ◽  
Clinical Test ◽  
Hyperactivity Disorder ◽  
Window Method ◽  
Left Middle

Objective: Attention deficit hyperactivity disorder (ADHD) is a commonly diagnosed neuropsychiatric disorder in children, which is characterized by inattention, hyperactivity and impulsivity. Using resting-state functional magnetic resonance imaging (R-fMRI), the alterations of static and dynamic characteristics of intrinsic brain activity have been identified in patients with ADHD. Yet, it remains unclear whether the concordance among indices of dynamic R-fMRI is altered in ADHD.Methods: R-fMRI scans obtained from 50 patients with ADHD and 28 healthy controls (HC) were used for the current study. We calculated the regional dynamic changes in brain activity indices using the sliding-window method and compared the differences in variability of these indices between ADHD patients and HCs. Further, the concordance among these dynamic indices was calculated and compared. Finally, the relationship between variability/concordance of these indices and ADHD-relevant clinical test scores was investigated.Results: Patients with ADHD showed decreased variability of dynamic amplitude of low-frequency fluctuation (dALFF) in the left middle frontal gyrus and increased one in right middle occipital gyrus, as compared with the HCs. Besides, ADHD patients showed decreased voxel-wise concordance in the left middle frontal gyrus. Further, lower voxel-wise concordance in ADHD’s left middle frontal gyrus was associated with more non-perseverative errors in Wisconsin Card Sorting Test, which reflects worse cognitive control.Conclusion: Our findings suggest that variability and concordance in dynamic brain activity may serve as biomarkers for the diagnosis of ADHD. Further, the decreased voxel-wise concordance is associated with deficit in cognitive control in ADHD patients.

scholarly journals Characteristics of Resting-State Functional Connectivity in Older Adults after the PICMOR Intervention Program: A Preliminary Report

2020 ◽  
Author(s):  
Hikaru Sugimoto ◽  
Toshikazu Kawagoe ◽  
Mihoko Otake-Matsuura
Keyword(s):  
Resting State ◽  
Verbal Fluency ◽  
Intervention Program ◽  
Inferior Frontal Gyrus ◽  
Middle Frontal Gyrus ◽  
Seed Region ◽  
Resting State Functional Connectivity ◽  
Post Intervention ◽  
Left Inferior Frontal Gyrus ◽  
Temporal Pole

Abstract Background: The present study aimed to provide a basis for future research examining the neural mechanisms that underlie the beneficial effect of an intervention program, Photo-Integrated Conversation Moderated by Robots (PICMOR), on verbal fluency in older adults as identified in our previous randomized controlled trial. In this preliminary report, we conducted an additional experiment using resting-state functional magnetic resonance imaging (rsfMRI) after the intervention period. Specifically, we investigated the resting-state functional connectivity (rsFC) characteristics of the intervention group (INT) compared to the control group (CONT). Methods: rsfMRI data were acquired from 31 and 30 participants in INT and CONT, respectively, after the intervention. In the analyses, two of the most important regions in verbal fluency, the left inferior and middle frontal gyri, were selected as seed regions, and the rsFCs were compared between groups. We also conducted regression analyses for rsFCs using the difference in individual phonemic verbal fluency task (PVFT) scores between the pre- and post-intervention periods (i.e., post- minus pre-intervention) as an independent variable. Results: We found higher rsFC in INT than in CONT between the left inferior frontal gyrus as a seed region and the temporal pole and middle frontal gyrus. The rsFC strength between the left inferior frontal gyrus and temporal pole positively correlated with an increased PVFT score between the pre- and post-intervention periods. In contrast, we found lower rsFC in INT than in CONT between the left middle frontal gyrus as a seed region and the posterior cingulate cortex, precuneus, and postcentral gyrus. Conclusions: Our findings suggest that the beneficial intervention effect of PICMOR on verbal fluency is characterized by enhanced rsFC of the left inferior frontal gyrus with semantic and executive control-related regions and suppressed rsFC between the left middle frontal gyrus and posterior cortical midline structures. No definitive conclusions can be made because of a lack of rsfMRI data before the intervention. However, this pilot study provides the candidates for rsFCs, reflecting the beneficial effects of PICMOR on the brain network involved in verbal fluency. Trial registration: The trial was retrospectively registered at the UMIN Clinical Trials Registry (UMIN000036667) (May 7th, 2019).

scholarly journals Characteristics of resting-state functional connectivity in older adults after the PICMOR intervention program: a preliminary report

2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Hikaru Sugimoto ◽  
Toshikazu Kawagoe ◽  
Mihoko Otake-Matsuura
Keyword(s):  
Resting State ◽  
Verbal Fluency ◽  
Intervention Program ◽  
Inferior Frontal Gyrus ◽  
Middle Frontal Gyrus ◽  
Seed Region ◽  
Resting State Functional Connectivity ◽  
Post Intervention ◽  
Left Inferior Frontal Gyrus ◽  
Temporal Pole

Abstract Background The present study aimed to provide a basis for future research examining the neural mechanisms that underlie the beneficial effect of an intervention program, Photo-Integrated Conversation Moderated by Robots (PICMOR), on verbal fluency in older adults as identified in our previous randomized controlled trial. In this preliminary report, we conducted an additional experiment using resting-state functional magnetic resonance imaging (rsfMRI) after the intervention period. Specifically, we investigated the resting-state functional connectivity (rsFC) characteristics of the intervention group (INT) compared to the control group (CONT). Methods rsfMRI data were acquired from 31 and 30 participants in INT and CONT, respectively, after the intervention. In the analyses, two of the most important regions in verbal fluency, the left inferior and middle frontal gyri, were selected as seed regions, and the rsFCs were compared between groups. We also conducted regression analyses for rsFCs using the difference in individual phonemic verbal fluency task (PVFT) scores between the pre- and post-intervention periods (i.e., post- minus pre-intervention) as an independent variable. Results We found higher rsFC in INT than in CONT between the left inferior frontal gyrus as a seed region and the temporal pole and middle frontal gyrus. The rsFC strength between the left inferior frontal gyrus and temporal pole positively correlated with an increased PVFT score between the pre- and post-intervention periods. In contrast, we found lower rsFC in INT than in CONT between the left middle frontal gyrus as a seed region and the posterior cingulate cortex, precuneus, and postcentral gyrus. Conclusions Our findings suggest that the beneficial intervention effect of PICMOR on verbal fluency is characterized by enhanced rsFC of the left inferior frontal gyrus with semantic and executive control-related regions and suppressed rsFC between the left middle frontal gyrus and posterior cortical midline structures. No definitive conclusions can be made because of a lack of rsfMRI data before the intervention. However, this pilot study provides the candidates for rsFCs, reflecting the beneficial effects of PICMOR on the brain network involved in verbal fluency. Trial registration The trial was retrospectively registered at the UMIN Clinical Trials Registry (UMIN000036667) (May 7th, 2019).

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