Body mass index in relation to prostate specific antigen-related parameters
Abstract Purpose Limit previous studies were conducted to assess the association between body mass index (BMI) and series of prostate-specific antigen (PSA)-related parameters, which taken prostate volume (PV) and blood volume (BV) into consideration. The objective of this study was to assess the relationship between BMI and parameters of PSA concentrations in Chinese men. Methods A total of 86,930 men who had undergone annual medical examinations at the First Affiliated Hospital of Army Medical University between 1 January 2011 and 31 December 2018 were included. Partial Spearman correlation rank test was used to assess the relationship between BMI, PV, BV and PSA, and then estimated the correlation between BMI and series of PSA-related parameters. Results After adjustment for age, PV (correlation coefficient = 0.227, P-value < 0.001) was positively associated with PSA levels, but BMI (correlation coefficient = -0.057, P-value < 0.001) and BV (correlation coefficient = -0.041, P-value < 0.001) inversely correlated to PSA concentrations. Moreover, present study also indicated that BMI positively associated with PV and BV. Furthermore, present study identified that PSA mass (correlation coefficient = 0.001, P-value = 0.763) was not affected by obesity after adjustment for age in Chinese general men.Conclusion The results of this large-sample, hospital-based study in China indicated that a higher BMI might have a bigger PV and larger BV. BMI was negatively associated with PSA and PAS density, and no significantly association was detect between BMI and PSA mass.