scholarly journals Decreased ARID1A Expression Associates with Tumor Progression and Adverse Prognosis in Renal Cell Carcinoma

2021 ◽  
Author(s):  
Keerakarn Somsuan ◽  
Ratirath Samon ◽  
Paween Tangjitpisud ◽  
Siripat Aluksanasuwan ◽  
Yupa Srithongc ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Clear Cell ◽  
Surgical Removal ◽  
Web Tool ◽  
Lower Survival Rate ◽  
The Poor ◽  
Grade Ii ◽  
Data Commons

Abstract In this study, we aimed to evaluate association of ARID1A (AT-rich interacting domain-containing protein 1A) mutation and protein expression with clinicopathology and prognosis of renal cell carcinoma (RCC). Genomic Data Commons (GDC) showed ARID1A was one of the top-ten mutated genes found in kidney cancers and its mutations were found along its sequence. Interestingly, patients with ARID1A mutations had significantly lower survival rate (38%; n=68) comparing to the non-mutated cases (58%; n=192). The results from OSkirc web tool revealed that patients with low expression of ARID1A had significantly shorter overall survival and disease specific survival than those with high ARID1A expression. Immunohistochemistry revealed markedly decreased ARID1A expression in the RCC tissues (n=26), particularly in clear cell RCC (ccRCC) and chromophobe RCC (chRCC). Negative to weak ARID1A expression was significantly associated with ccRCC (grade II) and chRCC subtypes, presence of comorbidity, and low eGFR levels. Finally, ARID1A protein was undetectable in 3/11 cases with ccRCC (grade II) and 2/6 chRCC cases, all of which had metastasis 1−50 months after surgical removal. In conclusion, decreased ARID1A expression is associated with the poor prognosis and metastasis of RCC and thus may serve as the prognostic marker of RCC, particularly ccRCC and chRCC subtypes.

scholarly journals Histomorphological Study of Renal Tumours – A Single Centre Experience

2020 ◽  
Vol 7 (49) ◽  
pp. 2943-2947
Author(s):  
Vinay Kyasakkala Sannaboraiah ◽  
Sujatha Siddappa
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Clear Cell ◽  
Pathological Stage ◽  
Malignant Tumours ◽  
Renal Tumours ◽  
Common Grade ◽  
Grade Ii ◽  
Benign Tumours

BACKGROUND Renal tumours encompass a wide spectrum as distinct entities both in adults and in children. Renal cell carcinomas constitute majority of all renal neoplasms. Proper typing of renal tumours is not possible before surgery and histopathological examination. Accurate histopathological diagnosis and proper tumour typing is very important for early and proper surgical treatment. We wanted to study the various histomorphological patterns of renal tumours. METHODS We studied nephrectomy specimens with renal tumours received in the department of pathology from January 2018 to June 2020 (2 years 6 months, retrospective study). A total of 29 cases with renal tumours were included. Relevant Clinical details along with gross findings were recorded from the histopathology forms. Nephrectomy specimens were fixed overnight in 10 % formalin. Gross examination was done, representative tissue bits taken, routinely tissue processed, embedded and the sections were cut (4 – 5 microns). Haematoxylin and Eosin staining was done. Pathological diagnosis was done by two pathologists and arrived at a common consensus. RESULTS A total of 29 cases were included in our study. Of these 16 patients were male and 13 were female, with a male to female ratio of 1.2: 1. Most common age group affected was 5th decade. Mean age was 48 years. Out of 29 cases, 24 cases were malignant (82.75 %) and 5 cases were benign (17.24 %). Renal cell carcinoma (RCC) accounted for 18 cases out of 24 malignant tumours. Clear cell RCC was common subtype with 13 cases followed by 3 cases of chromophobe RCC and 2 cases of papillary RCC. In benign tumours, we had 4 cases of angiomyolipoma and 1 case of oncocytoma. Right sided kidney was affected with 17 cases (58.62 %) and left sided kidney 12 cases (41.7 %). Common tumour location was in upper pole. Pathological stage pT1 was seen in 9 cases followed pT2-5 cases, pT3-4 and pT4-2 cases. WHO / ISUP nuclear grading was noted. Grade II was seen in 11 cases followed by grade III seen in 4 cases. CONCLUSIONS Malignant renal tumours were most common than the benign tumours. Renal cell carcinoma was most common of the malignant tumours. Clear cell RCC was the most common subtype. Pathological stage pT1 was most common. Grade II was the most common grade. Proper histological typing, staging and grading are important for appropriate surgical treatment of renal tumours. KEYWORDS Renal Tumours, Renal Cell Carcinoma, Nephrectomy

scholarly journals Lysine-specific demethylase 2A gene expression in clear cell renal cell carcinoma and its clinical significance

2020 ◽  
Author(s):  
Jiannan Wang ◽  
Tan Li ◽  
Xiang Li ◽  
Yixia Zhang ◽  
Xuemei Wang
Keyword(s):  
Renal Cell Carcinoma ◽  
Survival Rate ◽  
Protein Expression ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Clear Cell ◽  
Clinicopathological Parameters ◽  
Cell Renal Cell Carcinoma ◽  
Lower Survival Rate ◽  
Lysine Specific Demethylase

Abstract BackgroundOur study aimed to explore the expression of lysine-specific demethylase 2A (KDM2A) in clear cell renal cell carcinoma (ccRCC) and its relationship with clinical features of ccRCC.MethodsA total of 50 patients with ccRCC were included. KDM2A expression was assessed by real-time PCR and immunohistochemistry (IHC). The correlations of KDM2A protein expression with clinicopathological parameters and survival rate were further verified.ResultsThe KDM2A mRNA expression was significantly higher in ccRCC tissues than para cancer samples (P<0.05). KDM2A protein was mainly expressed in the nucleus of tumor cells. Fifty (100%) of the ccRCC samples were immunopositive, 90% of which all showed high expression of KDM2A. Compared with para cancer tissues, ccRCC samples showed a larger proportion of high KDM2A expression in the overall and most stratified analysis (P<0.05). KDM2A protein expression was positively correlated with TNM stage (r = 0.307, P = 0.030), proteinuria (r = 0.385, P = 0.006), and urine erythrocyte (r = 0.307, P = 0.030). Moreover, Kaplan-Meier survival analysis revealed that higher expression of KDM2A in ccRCC patients was associated with lower survival rate (P = 0.004).ConclusionsOur findings provided the first evidence that KDM2A could be used as a promising diagnostic and prognostic biomarker in ccRCC patients.

638: Macroscopic Tumor Necrosis is a Prognostic Indicator for Non-Metastatic Clear Cell Renal Cell Carcinoma

2007 ◽  
Vol 177 (4S) ◽  
pp. 214-214
Author(s):  
Sung Kyu Hong ◽  
Byung Kyu Han ◽  
In Ho Chang ◽  
June Hyun Han ◽  
Ji Hyung Yu ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Tumor Necrosis ◽  
Clear Cell ◽  
Prognostic Indicator ◽  
Cell Renal Cell Carcinoma ◽  
Macroscopic Tumor

Rare localization of renal cell carcinoma metastases in the paranasal sinuses and breast: a case report

2019 ◽  
Vol 22 (6) ◽  
pp. 13-22
Author(s):  
E. V. Kryaneva ◽  
N. A. Rubtsova ◽  
A. V. Levshakova ◽  
A. I. Khalimon ◽  
A. V. Leontyev ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Paranasal Sinuses ◽  
Renal Cell ◽  
Clinical Case ◽  
Clear Cell ◽  
Malignant Tumors ◽  
Metastatic Potential ◽  
Cell Renal Cell Carcinoma ◽  
Metastatic Lesions

This article presents a clinical case demonsratinga high metastatic potential of clear cell renal cell carcinoma combined with atypical metastases to breast and paranasal sinuses. The prevalence of metastatic lesions to the breast and paranasal sinuses in various malignant tumors depending on their morphological forms is analyzed. The authors present an analysis of data published for the last 30 years. The optimal diagnostic algorithms to detect the progression of renal cell carcinoma and to evaluate the effectiveness of the treatment are considered.

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