scholarly journals C-Reactive Protein Levels in Patients with Infectious Mononucleosis

2021 ◽  
Author(s):  
Alon Nevet ◽  
Maanit Shapira
Keyword(s):  
Differential Diagnosis ◽  
Electronic Medical Records ◽  
Infectious Mononucleosis ◽  
Medical Records ◽  
Bacterial Infections ◽  
C Reactive Protein ◽  
Protein Levels ◽  
Reactive Protein ◽  
Serologic Evidence ◽  
Host Characteristics

Abstract Background: Plasma level of C-reactive protein (CRP) is used as a biomarker of systemic inflammation. Differential distributions of CRP levels related to different pathogens aid clinicians in the differential diagnosis of patients.Objectives: To evaluate the distribution of CRP levels in patients with Infectious Mononucleosis (IMN) and its correlation with different pathogen and host characteristics.Methods: A retrospective study conducted on electronic medical records of patients diagnosed clinically and serologically with IMN in a public regional hospital during consecutive five years.Results: CRP levels were significantly elevated in patients hospitalized with clinical diagnosis of IMN and serologic evidence of EBV (average 6.8 md/dL) or CMV (average 6.3 md/dL). However, levels of CRP were not significantly correlated with plasma levels of liver enzymes. Conclusions: Although CRP levels may aid in the differential diagnosis of respiratory syndromes, its distribution in patients infected by hepatotrophic viruses is similar to that in bacterial infections.

C-reactive protein levels associated with COVID-19 outcomes in the United States

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Jacob Lentner ◽  
Taylor Adams ◽  
Valene Knutson ◽  
Sarah Zeien ◽  
Hassan Abbas ◽  
...  
Keyword(s):  
Electronic Medical Records ◽  
Patient Outcomes ◽  
Medical Records ◽  
The United States ◽  
Nasopharyngeal Swab ◽  
Swab Sample ◽  
C Reactive Protein ◽  
Protein Levels ◽  
Reactive Protein ◽  
Unit Increase

Abstract Context COVID-19 caused a worldwide pandemic, and there are still many uncertainties about the disease. C-reactive protein (CRP) levels could be utilized as a prognosticator for disease severity in COVID-19 patients. Objectives This study aims to determine whether CRP levels are correlated with COVID-19 patient outcomes and length of stay (LoS). Methods A retrospective cohort study was conducted utilizing data obtained between March and May 2020. Data were collected by abstracting past medical records through electronic medical records at 10 hospitals within CommonSpirit Health. Patients were included if they had a positive COVID-19 test from a nasopharyngeal swab sample, and if they were admitted and then discharged alive or had in-hospital mortality and were ≥18 years. A total of 541 patients had CRP levels measured and were included in this report. Patient outcome and LoS were the endpoints measured. Results The 541 patients had their CRP levels measured, as well as the demographic and clinical data required for analysis. While controlling for body mass index (BMI), number of comorbidities, and age, the first CRP was significantly predictive of mortality (p<0.001). The odds ratio for first CRP indicates that for each one-unit increase in CRP, the odds of death increased by 0.007. For LoS, the first CRP was a significant predictor (p<0.001), along with age (p=0.002). The number of comorbidities also predicted LoS (p=0.007), but BMI did not. The coefficient for the first CRP indicates that, for each one-unit increase in CRP, LoS increased 0.003 days. Conclusions The results indicate that there is a positive correlation between the CRP levels of COVID-19 patients and their respective outcomes with regard to death and LoS.

scholarly journals Az anti-Jo-1-pozitív antiszintetáz szindróma jellegzetességei gondozott betegeink alapján

2016 ◽  
Vol 157 (15) ◽  
pp. 575-583 ◽  
Author(s):  
Katalin Szabó ◽  
Melinda Nagy-Vincze ◽  
Levente Bodoki ◽  
Katalin Hodosi ◽  
Katalin Dankó ◽  
...  
Keyword(s):  
Medical Records ◽  
Clinical Laboratory ◽  
Clinical Symptoms ◽  
Clinical Phenotype ◽  
Demographic Data ◽  
Clinical Results ◽  
C Reactive Protein ◽  
Protein Levels ◽  
Reactive Protein ◽  
Worse Prognosis

Introduction: In idiopathic inflammatory myopathies, the presence of anti-Jo-1 antibody defines a distinct clinical phenotype (myositis, arthritis, interstitial lung disease, Raynaud’s phenomenon fever, mechanic’s hands), called antisynthetase syndrome. Aim: To determine the demographic data as well as clinical, laboratory and terapeutical features of anti-Jo1 positive patients, followed by the department of the authors. Method: The medical records of 49 consecutive anti-Jo1 patients were reviewed. Results: Demographic and clinical results were very similar to those published by other centers. Significant correlation was found between the anti-Jo-1 titer and the creatine kinase and C-reactive protein levels. Distinct laboratory results measured at the time of diagnosis of the disease (C-reactive protein, antigen A associated with Sjogren’s syndrome, positive rheumatoid factor), and the presence of certain clinical symptoms (fever, vasculitic skin) may indicate a worse prognosis within the antisyntetase positive patient group. Conclusion: In the cases above more agressive immunosuppressive therapy may be required. Orv. Hetil., 2016, 157(15), 575–583.

ON THE ISSUE OF DIFFERENTIAL DIAGNOSIS OF BACTERIAL INFECTIONS AND PEDIATRIC MULTISYSTEM INFLAMMATORY SYNDROME DURING THE COVID-19 PANDEMIC

2021 ◽  
Vol 100 (6) ◽  
pp. 162-167
Author(s):  
L.N. Mazankova ◽  
◽  
O.V. Molochkova ◽  
O.В. Kovalev ◽  
O.V. Shamsheva ◽  
...  
Keyword(s):  
Differential Diagnosis ◽  
Systemic Inflammation ◽  
Inflammatory Reaction ◽  
Bacterial Infections ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Systemic Inflammatory Reaction ◽  
Comprehensive Examination ◽  
Severe Intoxication ◽  
Inflammatory Syndrome

During the COVID-19 pandemic, it is necessary to be wary of the development of pediatric multisystem inflammatory syndrome in children (PMIS) who have had a COVID-19 and had antibodies to the SARS-CoV-2 virus. The aim of this work is to describe two clinical cases in children with antibodies to SARS-CoV-2 against the background of yersiniosis in a 12-year-old child and salmonellosis in a 3-year-old child, which proceeded with a pronounced inflammatory reaction and required a differential diagnosis with multisystem inflammatory syndrome. These bacterial infections proceeded with severe intoxication and fever, had a polymorphic clinical picture with exanthema syndrome, conjunctivitis/scleritis, swelling of the palms/feet, diarrhea and toxic kidney damage, with a pronounced systemic inflammatory reaction – high leukocytosis with neutrophilia and lymphopenia, a significant increase in C-reactive protein, procalcitonin, hypercoagulability (increased fibrinogen, D-dimer). Etiotropic antibiotic therapy led to recovery in both cases. Conclusions: During the COVID-19 pandemic, if antibodies to the SARS-CoV-2 virus are detected in children in the presence of signs of systemic inflammation and corresponding symptoms, the alertness of doctors and a timely comprehensive examination are necessary to exclude bacterial infections, also characterized by signs of systemic inflammation, for the purpose of differential diagnosis of PMIS.

scholarly journals C-Reactive Protein Levels and its Association with Acute and Chronic Inflammatory Diseases- An Observational Study

2021 ◽  
Vol 04 (10) ◽  
Author(s):  
Aashish Bharti ◽  
Keyword(s):  
Bacterial Infections ◽  
Tissue Injury ◽  
Inflammatory Diseases ◽  
Serological Test ◽  
C Reactive Protein ◽  
Serum Samples ◽  
Blood Samples ◽  
Chronic Inflammatory Diseases ◽  
Protein Levels ◽  
Reactive Protein

Background: C-reactive protein is a nonspecific, acute-phase, inflammatory protein, whose expression is increased in response to tissue injury, inflammation and infection. The highest concentrations of CRP are found in an individual having some bacterial infections where CRP level increase up to 1,000-fold. The present study was undertaken to determine the C-reactive protein levels in clinically suspected OPD and IPD patient by Latex agglutination test (LAT). Material and Methods: Blood samples were collected from clinically suspected OPD and IPD patients with signs of inflammation in plain vacutainer tubes and received in Serology laboratory of Microbiology Department for CRP testing. All blood samples were screened by Qualitative CRP assay by using commercially available kit. Blood samples that were positive were further tested for CRP titre by semi-quantitative test using same kit (Beacon Diagnostics Pvt Ltd ). Results: A total of 450 serum samples were received for CRP testing during a period of six months. Higher CRP levels were obtained in patients with chronic inflammatory diseases (76%) and as compared to patients with acute inflammatory diseases (24%). Conclusion: CRP is an inexpensive and easily available serological test helpful in correlating severity and mortality of any disease. Early CRP testing can be a very helpful tool to improve the clinical outcomes of patients and decreased mortality.

scholarly journals Sex differences in an Italian pediatric population COVID-19 positive

2020 ◽  
Author(s):  
Elisabetta Straface ◽  
Isabella Tarissi De Jacobis ◽  
Rosa Vona ◽  
Camilla Cittadini ◽  
Alessandra Marchesi ◽  
...  
Keyword(s):  
Sex Differences ◽  
Electronic Medical Records ◽  
Medical Records ◽  
Pediatric Population ◽  
Gastrointestinal Symptoms ◽  
C Reactive Protein ◽  
Laboratory Findings ◽  
Reactive Protein ◽  
Males And Females ◽  
Positive Population

Abstract Background: Since December 2019 coronavirus disease (COVID-19) emerged in Wuhan and spread rapidly worldwide. Despite the high number of people affected, data on clinical features and prognostic factors in children and adolescents are limited. We propose a retrospective study aimed to evaluate clinical characteristics of children infected with SARS-CoV-2 in Italy, taking into account gender differences. Methods: A pediatric population admitted with COVID-19 to Bambino Gesù Children's Hospital of Rome (Italy) in the period from the end of February to May 2020 has been studied taking into account sex differences. Medical history, comorbidities, symptoms and laboratory findings were obtained from patients' electronic medical records. Results: In 41 patients (21 males and 20 females) we found that: i) fever and cough were the dominant symptoms, while gastrointestinal symptoms were rare; and ii) all ages of childhood were susceptible to COVID-19. Moreover, we found that females with COVID-19, although not significantly, were older than males and required more days of hospitalization (p = 0.01). Conversely, males had, although not significantly, higher values of C reactive protein and erythrocyte sedimentation rate than females. Conclusions: Based on the data listed above, sex differences were detected in an Italian pediatric COVID-19 positive population. Compared to the adults we found that COVID-19 infection in children is a non-severe inflammatory disease in both males and females. In any case, many detailed studies should be conducted.

scholarly journals Sex differences in an Italian pediatric population covid-19 positive

2021 ◽  
Author(s):  
Elisabetta Straface ◽  
Isabella Tarissi De Jacobis ◽  
Rosa Vona ◽  
Camilla Cittadini ◽  
Alessandra Marchesi ◽  
...  
Keyword(s):  
Electronic Medical Records ◽  
Medical Records ◽  
Pediatric Population ◽  
Gastrointestinal Symptoms ◽  
C Reactive Protein ◽  
Laboratory Findings ◽  
Reactive Protein ◽  
Erythrocyte Sedimentation ◽  
Males And Females ◽  
Number Of Males

Abstract Background: Since December 2019 coronavirus disease (COVID-19) emerged in Wuhan and spread rapidly worldwide. Despite the high number of people affected, data on clinical features and prognostic factors in children and adolescents are limited. We propose a retrospective study aimed to evaluate clinical characteristics of children infected with SARS-CoV-2 in Italy.Methods: A pediatric population admitted with COVID-19 to Bambino Gesù Children's Hospital of Rome (Italy) in the period from the end of February to May 2020 has been studied taking into account gender. Medical history, comorbidities, symptoms and laboratory findings were obtained from patients' electronic medical records. Results: In 41 patients (21 males and 20 females) we found that: i) fever and cough were the dominant symptoms, while gastrointestinal symptoms were rare; and ii) all ages of childhood were susceptible to COVID-19. Moreover, we found that females with COVID-19, were significantly (p = 0.04) older than males and required more days of hospitalization (p = 0.01). Moreover, compared to females, a greater number of males had high values of C reactive protein (3 males vs 1 female) and erythrocyte sedimentation rate (2 males vs 1 female).Conclusions: Compared to the adults we found that COVID-19 infection in children is a non-severe inflammatory disease in both males and females. In any case, many detailed studies should be conducted.

Suppression of elevations in serum C reactive protein levels by anti-IL-6 autoantibodies in two patients with severe bacterial infections

2013 ◽  
Vol 72 (6) ◽  
pp. 1100-1102 ◽  
Author(s):  
Toshihiro Nanki ◽  
Ikumi Onoue ◽  
Kenji Nagasaka ◽  
Aiko Takayasu ◽  
Masashi Ebisawa ◽  
...  
Keyword(s):  
Bacterial Infections ◽  
C Reactive Protein ◽  
Protein Levels ◽  
Reactive Protein

scholarly journals Semi-supervised estimation of covariance with application to phenome-wide association studies with electronic medical records data

2019 ◽  
Vol 29 (2) ◽  
pp. 455-465
Author(s):  
Stephanie F Chan ◽  
Boris P Hejblum ◽  
Abhishek Chakrabortty ◽  
Tianxi Cai
Keyword(s):  
Association Study ◽  
Medical Record ◽  
Electronic Medical Record ◽  
Electronic Medical Records ◽  
Medical Records ◽  
Surrogate Marker ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Discovery Research ◽  
Number Of Patients

Electronic medical records data are valuable resources for discovery research. They contain detailed phenotypic information on individual patients, opening opportunities for simultaneously studying multiple phenotypes. A useful tool for such simultaneous assessment is the phenome-wide association study, which relates a genomic or biological marker of interest to a wide spectrum of disease phenotypes, typically defined by the diagnostic billing codes. One challenge arises when the biomarker of interest is expensive to measure on the entire electronic medical record cohort. Performing phenome-wide association study based on supervised estimation using only subjects who have marker measurements may yield limited power. In this paper, we focus on the setting where the marker is measured on a small fraction of the patients while a few surrogate markers such as historical measurements of the biomarker are available on a large number of patients. We propose an efficient semi-supervised estimation procedure to estimate the covariance between the biomarker and the billing code, leveraging the surrogate marker information. We employ surrogate marker values to impute the missing outcome via a two-step semi-non-parametric approach and demonstrate that our proposed estimator is always more efficient than the supervised counterpart without requiring the imputation model to be correct. We illustrate the proposed procedure by assessing the association between the C-reactive protein and some inflammatory diseases with an electronic medical record study of inflammatory bowel disease performed with the Partners HealthCare electronic medical record database where C-reactive protein was only measured for a small fraction of the patients due to budget constraints.

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