scholarly journals Prenatal and Perinatal Factors Associated with Pediatric Autism Spectrum Disorder in East China

2021 ◽  
Author(s):  
Yu Li ◽  
Lu Han ◽  
Ning Ding ◽  
Ziyi Zhang ◽  
Yuan Lin ◽  
...  
Keyword(s):  
Risk Factors ◽  
Autism Spectrum Disorder ◽  
Autism Spectrum ◽  
Spectrum Disorder ◽  
Typical Development ◽  
Perinatal Factors ◽  
Perinatal Risk Factors ◽  
Perinatal Risk ◽  
Prenatal Factors ◽  
History Of

Abstract Background Autism spectrum disorder (ASD) is a complex neurodevelopmental condition characterized by persistent challenges in social communication and interaction and restricted/repetitive patterns of behavior, interests or activities. An increasing number of studies have revealed that environmental exposure is a potential risk factor for ASD. The relationship between prenatal and perinatal risk factors and ASD has rarely been studied in large samples in China. Therefore, in this study, we compared children with ASD with typical developing (TD) children to assess the ASD-associated prenatal and perinatal risk factors and provide effective information for ASD prevention. Methods A case-control study of 709 children with autism spectrum disorder (ASD) and 709 gender-matched children with typical development was conducted to investigate the prenatal and perinatal risk factors of children with ASD compared with children with typical development ( TD). Through a self-developed general information questionnaire, the basic information (name, age, gender), prenatal factors (parents’ age at the child’s birth, parents’ education levels, use of assisted reproductive technology, history of miscarriage, gestational diabetes mellitus, gestational hypertension), and perinatal factors (delivery mode, full-term birth, parity, birth weight) of the children in the two groups were examined. Results The prenatal and perinatal factors of the groups were submitted to univariate analysis, the parent’s age at childbirth, education level, history of miscarriage, use of ART, pregnancy-induced hypertension, and GDM differed significantly between the two groups (P<0.05), and that among perinatal factors, infant parity and maturity also differed significantly between the two groups (P<0.05). These statistically significant factors were included in a binary logistic regression model. The results showed that the prenatal factors of young maternal age at the child’s birth (≤24 years vs 25-29 years, OR=2.408,95%CI:1.335~4.345), old paternal age at the childbirth(≥45years vs≤24years, OR=4.744, 95%CI:1.281~17.570 ), pregnancy induced hypertension (OR=6.178, 95%CI:2.311~16.517) and GDM(OR=0.220,95%CI:0.149~0.324), the perinatal factors of preterm birth(OR=4.434, 95%CI:2.872~6.846) and non-firstborn child(OR=1.387, 95%CI:1.029~1.869) are likely risk factors for ASD. Conclusion We show that some prenatal and perinatal factors are associated with a high prevalence of ASD in children.

A STUDY OF DEMOGRAPHIC AND RISK FACTORS OF CHILDREN WITH AUTISM SPECTRUM DISORDER

2021 ◽  
pp. 7-9
Author(s):  
Bobby Hmar ◽  
Suresh Chakravorty ◽  
Ammu Anil ◽  
Ripunjay Khatoniar
Keyword(s):  
Risk Factors ◽  
Autism Spectrum Disorder ◽  
Birth Order ◽  
Autism Spectrum ◽  
Spectrum Disorder ◽  
Perinatal Risk Factors ◽  
Perinatal Risk ◽  
Lower Segment Caesarean Section ◽  
Co Morbidity ◽  
History Of

Background of the study: Various risk factors have been reported in the development of Autism spectrum Disorder. The aim of our study is to explore the demographic and perinatal risk factors implicated in the development of ASD. A retrospective study was conducted with data of 49 children with ASD and found that total 71.3% of children were male 73.5% were in rst birth order. Out of 49 children 53.1% had history of Lower Segment Caesarean Section (LSCS). Indication of LSCS due to various obstetric or perinatal risk factors were reported in 17 cases. Three children had history of low birth weight with history of admission into Neonatal ICU. The study also explore the various co morbidity and found that ADHD (20.4%) was most common comorbidity followed by Mental retardation(18.4%), ADHD and MR(12.2%), seizure disorder and MR (8.2 %). This study found that male gender, rst birth order and perinatal risk factors are implicated in the development of Autism spectrum Disorder and majority of them have one or more another neuro developmental disorder as a comorbidity.

Association of Perinatal Risk Factors with Autism Spectrum Disorder

2017 ◽  
Vol 34 (03) ◽  
pp. 295-304 ◽  
Author(s):  
Michael Fassett ◽  
Morgan Peltier ◽  
Deborah Wing ◽  
Anny Xiang ◽  
Vicki Chiu ◽  
...  
Keyword(s):  
Risk Factors ◽  
Autism Spectrum Disorder ◽  
Autism Spectrum ◽  
Spectrum Disorder ◽  
Perinatal Risk Factors ◽  
Perinatal Risk

ASSOCIATION OF PERINATAL RISK FACTORS WITH AUTISM SPECTRUM DISORDER: A RETROSPECTIVE STUDY AT TERTIARY CARE CENTRE, MUMBAI

2021 ◽  
pp. 78-80
Author(s):  
Kondekar Alpana S ◽  
Sawant Vishal ◽  
Pendyala Chaitanya
Keyword(s):  
Risk Factors ◽  
Autism Spectrum Disorder ◽  
Risk Factor ◽  
Retrospective Study ◽  
Tertiary Care ◽  
Autism Spectrum ◽  
Spectrum Disorder ◽  
Perinatal Risk Factors ◽  
Perinatal Risk ◽  
Perinatal Risk Factor

Background: Autism spectrum disorder (ASD) is a complex neurodevelopmental condition, which is characterized by cognitive, behavioral, and social dysfunction. Their onset occurs in early childhood and during this period, there are various factors associated with autism risk. Hence,the present study was undertaken to determine the prevalence of various perinatal risk factors and its association with ASD in children. Methods: This was a retrospective study, included 200 cases of ASD over 5 years registered in pediatric neurodevelopment clinic at TN Medical College and BYL Nair Hospital, Mumbai. Study population divided in two groups- cases of ASD with perinatal risk factor and cases of ASD without perinatal risk factor. The prevalence of various perinatal risk factors in children with different grades of ASD calculated. Results: Based on ISAA score 149(74.5%) cases had mild autism and 51(25.5%) cases had moderate autism. The prevalence of various perinatal risk factors in children with different grades of ASD was found to be 79.5%(159/200). Pregnancy induced hypertension, bad obstetric history in mother were signicant risk factor for ASD. Lower segment caesarian section as mode of delivery was risk factor found to be associated more with mild form of autism, but statistically signicant association was found with vacuum delivery. We observed prematurity, low birth weight (LBW) and neonatal seizures as signicant risk factor, which may have contribution towards pathogenesis of ASD. Conclusion: The awareness between pediatrician and obstetrician about association of perinatal risk factors and ASD will denitely add to prevention and timely intervention of high risk patients.

scholarly journals Perinatal Risk Factors and Genu Valgum Conduce to the Onset of "Growing Pains" in Early Childhood

2016 ◽  
Author(s):  
Angelos Kaspiris ◽  
Efstathios Chronopoulos ◽  
Elias Vasiliadis
Keyword(s):  
Risk Factors ◽  
Corticosteroid Treatment ◽  
Genu Valgum ◽  
Perinatal Factors ◽  
Mineral Density ◽  
Perinatal Risk Factors ◽  
Perinatal Risk ◽  
Smoking During Pregnancy ◽  
Growing Pains ◽  
History Of

The most prevalent musculoskeletal disorder of childhood with unclear aetiology is Growing Pains (GPs). Anatomic deformities and factors that change bone turnover are implicated in GPs pathophysiology. Perinatal risk factors alter the bone metabolism affecting the bone mineral density and content. The aim of our study was to analyze the relationship between GPs, knock knees and perinatal factors. The examined population consisted of 276 children aged 3-7 years. Among them 10 pairs of dizygotic twins were evaluated. The data were collected by using a combination of semi-structured questionnaires, clinical examinations and medical charts of the children and the obstetric history of the mothers. 78 children presented GPs meeting Peterson&rsquo;s criteria. Genu valgum severity was a significant factor for GPs manifestation and for their increased frequency and intensity. Subsequently, perinatal factors regarding gestational age, Apgar score, head circumference (lower than 33cm) and birth length or weight (smaller than 50 cm and 3000gr, respectively) made a remarkable contribution to the development of GPs. Conversely, antenatal corticosteroid treatment, increased maternal age and maternal smoking during pregnancy were not predictive for the disorder. Our data are potentially supportive for the &ldquo;bone strength&rdquo; theory and for the contribution of anatomical disturbances in GPs appearance.

scholarly journals ATOPIC DERMATITIS IN CHILDREN: PREAND PERINATAL RISK FACTORS

2012 ◽  
Vol 9 (2) ◽  
pp. 19-22
Author(s):  
E B Belan ◽  
L K Gavrikov ◽  
A S Kasyanova ◽  
N A Khlynova ◽  
T L Sadchikova ◽  
...  
Keyword(s):  
Risk Factors ◽  
Atopic Dermatitis ◽  
Early Age ◽  
Perinatal Factors ◽  
Perinatal Risk Factors ◽  
Perinatal Risk ◽  
Pregnancy Failure ◽  
Pregnancy And Delivery ◽  
Medical Reports ◽  
History Of

Background. To study the influence of some pre- and perinatal factors on risk of atopic dermatitis development in children up to 3 years old. Materials and methods. 460 newborns and children histories up to 3 years old as well as pregnancy and delivery medical reports of their mothers have been analyzed. The data were estimated differentially depending on presence or absence of atopic dermatitis in 3 years old children. Results. The most significant perinatal risk factors for development of atopic dermatitis were: family history of atopy in mother (OR 3,99 [95% CI 2,38; 6,72]), gestosis, fetoplacentary insufficiency (OR 1,65 [95% CI 1,08; 2,54]), threat of interruption of pregnancy failure (OR 1,82 [95% CI 1,21; 2,74]), fed by a milk formulas (OR 1,70 [95% CI 1,13; 2,56]), cytomegalovirus (OR 1,56 [95% CI 1,02; 2,41])and ureaplasma infection in anamnesis (OR 1,77 [95% CI 1,10; 2,78]), and antibiotics (macrolids) intake during pregnancy. Conclusions. The influence of some pre- and perinatal risk factors of atopic dermatitis in children of early age has been demonstrated.

scholarly journals Autism spectrum disorder screening in children aged 16-30 months using the Modified Checklist for Autism in Toddlers-Revised (M-CHAT-R)

2021 ◽  
Vol 61 (5) ◽  
pp. 247-52
Author(s):  
Clarissa Josephine Aditya ◽  
Jenni Kim Dahliana ◽  
Ariani Dewi Widodo ◽  
Rini Sekartini
Keyword(s):  
Risk Factors ◽  
Autism Spectrum Disorder ◽  
High Risk ◽  
Neurodevelopmental Disorder ◽  
Significant Risk ◽  
Autism Spectrum ◽  
Male Gender ◽  
Spectrum Disorder ◽  
Screening Tools ◽  
History Of

Background Autism spectrum disorder (ASD) is a complex neurodevelopmental disorder with a global prevalence of 7.6 in 1,000 children. The Modified Checklist for Autism in Toddlers - Revised (M-CHAT-R) is one of many screening tools for ASD. It is fast, easy to use, and has been translated and validated in the Indonesian language. Objective To determine the prevalence of ASD in Indonesia and its risk factors. Methods A cross-sectional study was conducted from March to October 2020. In the first protocol (March to July 2020), 219 children aged 16-30 months from 20 hospital walk-in clinics in five districts of Jakarta were included. Subjects’ parents filled out the M-CHAT-R questionnaire during their visit. A series of questions were asked to provide information about probable risk factors associated with ASD: gender, family history of ASD, preterm birth, low birth weight (LBW), and history of seizures. The second protocol (August to October 2020) was completed by parents via an online form, where 746 children aged 16-30 months were enrolled. Therefore, a total of 965 subjects were eligible for statistical analysis. Results Of 965 subjects, 56.58% were males. Subjects’ mean of age was 22.59 (SD 4.15) months. M-CHAT-R screening showed that 34 (3.52%) subjects were at high risk of developing ASD. Only male gender was significantly associated with ASD. Conclusion We screened for ASD in healthy 16-30-month-old Indonesian children. The rate of high-risk M-CHAT-R score was 3.52%. Male gender was a significant risk factor for high-risk M-CHAT-R results.

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