scholarly journals Association between SNCA Intron and genetic predisposition to sporadic Parkinson's disease: a meta-analysis based on 49576 individuals

2021 ◽  
Author(s):  
Peng Li ◽  
Zuqiang Fu ◽  
Lei Yan ◽  
Ming-yang Du ◽  
Wei-guoLiu
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Genetic Predisposition ◽  
Meta Analysis ◽  
Nucleotide Polymorphisms ◽  
High Risk Populations ◽  
Sporadic Parkinson’S Disease ◽  
Intron Region ◽  
Racial Factors ◽  
Intronic Snps

Abstract Background The aetiology of Parkinson's disease (PD) is indistinct, but previous studies of different ethnicities have shown that genetic variations in synuclein alpha (SNCA) have an essential character in the risk of PD. The relation between SNCA intronic single nucleotide polymorphisms (SNPs) and the risk of PD is unclear. Based on the general population and five ethnic groups, this article managed a meta-analysis about the connection of SNCA intronic SNPs with the PD genetic predisposition. Methods This study was implemented according to the 24-step guideline, with strict criteria. The analysis was performed using Stata 16.0 software. Five genetic models were used to analyze the strength of the association, which was quantified by OR value and 95% CI. Results We included 15433 cases and 34143 controls from 31 articles. 6 SNPs in the intron region were screened, and 5 SNPs were statistically significant. Three variants augmented the PD susceptibility (rs2736990, rs3822086, and rs3857059), and two SNPs decreased the risk (rs356186 and rs7684318). Subgroup analysis showed that rs2736990 and rs3822086 carriers added the PD genetic predisposition in the East Asian group. European and Latin group carrying rs3857059 and rs2736990 is the high-risk populations of PD. Conclusions This study finally found 5 SNCA intronic SNPs related to the risk of PD. And racial factors should not be ignored.

scholarly journals Analysis ofLRRK2,SNCA,andITGA8Gene Variants with Sporadic Parkinson’s Disease Susceptibility in Chinese Han Population

2016 ◽  
Vol 2016 ◽  
pp. 1-6 ◽  
Author(s):  
Jie Fang ◽  
Kehui Yi ◽  
Mingwei Guo ◽  
Xingkai An ◽  
Hongli Qu ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Chinese Han Population ◽  
Genotype Frequency ◽  
Nucleotide Polymorphisms ◽  
Chinese Han ◽  
Han Population ◽  
Age Related ◽  
Sporadic Parkinson’S Disease ◽  
Genetic And Environmental Factors

Background. Parkinson’s disease (PD) is an age-related neurodegenerative disease affected by multiple genetic and environmental factors. We performed a case-control study on candidate gene to scrutinize whether genetic variants inLRRK2,SNCA, andITGA8genes could be associated with sporadic PD in Chinese Han population.Methods. Five single-nucleotide polymorphisms (SNPs) ofLRRK2(rs1491942),SNCA(rs2301134, rs2301135, and rs356221), andITGA8(rs7077361) were selected and genotyped among 583 unrelated PD patients and 558 healthy controls.Results. Rs1491942 ofLRRK2gene had a significantly higher genotype frequency (P=3.543E-09) and allelic G/C frequencies (P=2.601E-10) in PD patients than controls. Rs2301135 ofSNCAgene also showed an obvious difference in genotype frequency (P=4.394E-07) and allelic G/C frequencies (P=9.116E-13) between PD patients and controls. SNPs rs2301134 and rs356221 ofSNCAgene and rs7077361 ofITGA8gene lacked the significant association with the susceptibility of PD in Chinese Han population.Conclusions. Our study firstly expresses that rs1491942 ofLRRK2and rs2301135 ofSNCAgene are substantially associated with sporadic Parkinson’s disease in Chinese Han population.

scholarly journals Sporadic Parkinson’s Disease Potential Risk Loci Identified in Han Ancestry of Chinese Mainland

2021 ◽  
Vol 12 ◽  
Author(s):  
Bo Wang ◽  
Xin Liu ◽  
Shengyuan Xu ◽  
Zheng Liu ◽  
Yu Zhu ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Genome Wide Association Study ◽  
Chinese Mainland ◽  
Biological Information ◽  
Nucleotide Polymorphisms ◽  
Genome Wide ◽  
Increased Risk ◽  
Sporadic Parkinson’S Disease ◽  
The Relationship

Recent investigations demonstrated that genetic factors might play an important role in sporadic Parkinson’s disease (sPD). To clarify the specific loci susceptibility to sPD, we analyze the relationship between 30 candidate single nucleotide polymorphisms (SNPs) and sPD in the population of Han ancestry from Chinese mainland (HACM) by using genome-wide association study, sequenom massARRAY, DNA sequence, and biological information analysis. Results showed that the subjects carrying the T allele of rs863108 and rs28499371 exhibited a decreased risk for sPD. The subjects carrying the T allele of rs80315856 exhibited an increased risk for sPD. The A/T genotype of rs863108 and the C/T genotype of rs28499371 were a potential increased risk for sPD, and the G/T genotype of rs80315856 and T/T genotype of rs2270568 were a potential decreased risk for sPD. The minor allele frequency (MAF) of rs80315856 and rs2270568 was higher in sPD. The T allele of rs80315856 and rs2270568 might be a risk locus for sPD. Our data suggested that the alteration of these SNPs might play some roles through changing/affecting LINC01524/LOC105372666, DMRT2/SMARCA2, PLEKHN1, and FLJ23172/FNDC3B genes in the pathogenesis of sPD.

Genetic Predisposition to Parkinson’s Disease and Cancer

2014 ◽  
Vol 14 (3) ◽  
pp. 310-321 ◽  
Author(s):  
Zhiming Li ◽  
Qing Lin ◽  
Qilin Ma ◽  
Congxia Lu ◽  
Chi-Meng Tzeng
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Genetic Predisposition

scholarly journals Fibroblast Growth Factor 20 Gene Polymorphism in Parkinson’s Disease in Asian Population: A Meta-Analysis

Genes ◽  
2021 ◽  
Vol 12 (5) ◽  
pp. 674
Author(s):  
Han-Lin Chiang ◽  
Yih-Ru Wu ◽  
Yi-Chun Chen ◽  
Hon-Chung Fung ◽  
Chiung-Mei Chen
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Meta Analysis ◽  
Lewy Bodies ◽  
Asian Population ◽  
Protective Role ◽  
Lewy Neurites ◽  
Chinese Populations ◽  
Study Results

Parkinson’s disease (PD) is a neurodegenerative disease with the pathological hallmark of Lewy bodies and Lewy neurites composed of α-synuclein. The SNP rs591323 is one of the risk loci located near the FGF20 gene that has been implicated in PD. The variation of FGF20 in the 3′ untranslated region was shown to increase α-synuclein expression. We examined the association of rs591323 with the risk of PD in a Taiwanese population and conducted a meta-analysis, including our study and two other studies from China, to further confirm the role of this SNP in Taiwanese/Chinese populations. A total of 586 patients with PD and 586 health controls (HCs) were included in our study. We found that the minor allele (A) and the AA + GA genotype under the dominant model are significantly less frequent in PD than in controls. The meta-analysis consisted of 1950 patients with PD and 2073 healthy controls from three studies. There was significant association between rs591323 and the risk of PD in the additive (Z = −3.96; p < 0.0001) and the dominant models (Z = −4.01; p < 0.0001). Our study results and the meta-analysis support the possible protective role of the rs591323 A allele in PD in Taiwanese/Chinese populations.

Effects of music-based movement therapy on motor function, balance, gait, mental health, and quality of life for patients with Parkinson’s disease: A systematic review and meta-analysis

2021 ◽  
pp. 026921552199052
Author(s):  
Zonglei Zhou ◽  
Ruzhen Zhou ◽  
Wen Wei ◽  
Rongsheng Luan ◽  
Kunpeng Li
Keyword(s):  
Quality Of Life ◽  
Mental Health ◽  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Motor Function ◽  
Meta Analysis ◽  
Freezing Of Gait ◽  
Movement Therapy ◽  
Walking Velocity

Objective: To conduct a systematic review evaluating the effects of music-based movement therapy on motor function, balance, gait, mental health, and quality of life among individuals with Parkinson’s disease. Data sources: A systematic search of PubMed, Embase, Cochrane Library, Web of Science, PsycINFO, CINAHL, and Physiotherapy Evidence Database was carried out to identify eligible papers published up to December 10, 2020. Review methods: Literature selection, data extraction, and methodological quality assessment were independently performed by two investigators. Publication bias was determined by funnel plot and Egger’s regression test. “Trim and fill” analysis was performed to adjust any potential publication bias. Results: Seventeen studies involving 598 participants were included in this meta-analysis. Music-based movement therapy significantly improved motor function (Unified Parkinson’s Disease Rating Scale motor subscale, MD = −5.44, P = 0.002; Timed Up and Go Test, MD = −1.02, P = 0.001), balance (Berg Balance Scale, MD = 2.02, P < 0.001; Mini-Balance Evaluation Systems Test, MD = 2.95, P = 0.001), freezing of gait (MD = −2.35, P = 0.039), walking velocity (MD = 0.18, P < 0.001), and mental health (SMD = −0.38, P = 0.003). However, no significant effects were observed on gait cadence, stride length, and quality of life. Conclusion: The findings of this study show that music-based movement therapy is an effective treatment approach for improving motor function, balance, freezing of gait, walking velocity, and mental health for patients with Parkinson’s disease.

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