Examination Methods That are Effective in Diagnosing The Primary Origins Of Metastatic Bone Tumors of Unknown Primary Origin During The Initial Visit: A Retrospective Case Series

Abstract BackgroundThe occurrence of skeletal metastases of unknown primary origin (SMUP) is uncommon. To provide appropriate treatments for the primary and metastatic lesions, early diagnosis of the primary origin of SMUP is important. Therefore, this study aimed to assess the types of examination method effective in diagnosing the primary origin of SMUP and their order in terms of efficacy.MethodsWe retrospectively examined 63 patients with SMUP. The primary origin was examined via physical examination, blood test including tumor markers, chest radiography, thoracoabdominal computed tomography (CT) scan, positron emission tomography (PET)-CT scan, metastatic lesion biopsy, and other assessments. Examination methods considered effective for the diagnosis of the primary origin in a specific type of cancer were investigated.ResultsThe lung was the most common primary origin, followed by the lymph nodes, prostate, and breast. Meanwhile, biopsy (87.0%) was the most effective examination, followed by PET-CT scan (60.0%) and thoracoabdominal CT scan (38.6%). The first four steps; physical examination, blood tests, chest radiography, thoracoabdominal CT were effective in diagnosing the primary origin in 41 (65%) of 63 patients. Finally, four patients were diagnosed with SMUP.ConclusionsThe examination steps used in this study are effective in diagnosing the primary origin of SMUP during the initial visit. Blood tests are useful for hematological malignancy and prostate cancer. CT scan can be used to identify cancers in the lung, breast, and kidney, which are the common primary origins. Moreover, it is more useful than PET-CT scan from a comprehensive perspective.

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Cancer of unknown primary origin presented with rapid deterioration without significant symptoms, a case report

10.22541/au.163746165.53307237/v1 ◽

2021 ◽

Author(s):

Vahid Mansouri ◽

Samaneh Toutounchian ◽

Fatemeh Arabi ◽

Farid Kosari ◽

Sahar Tavakoli shiraji

Keyword(s):

Cardiac Arrest ◽

Case Report ◽

Cancer Of Unknown Primary ◽

Flank Pain ◽

Unknown Primary ◽

Rapid Deterioration ◽

Pet Ct ◽

Primary Origin ◽

Pet Ct Scan ◽

Unknown Primary Origin

A 34-year-old woman with flank pain was referred for suspicious lymphadenopathy. PET/CT scan revealed disseminated lesions without apparent primary origin. Although she did not complain of any symptoms, after rapid deterioration, she died of respiratory distress and cardiac arrest. Her strong beliefs contribute to symptoms tolerance and late diagnosis.

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EVALUATING THE ROLE OF FDG PET-CT SCAN AS A SOLE IMAGING MODALITY IN THE MANAGEMENT OF MUO NECK

10.36106/ijsr/3930114 ◽

2020 ◽

pp. 39-41

Author(s):

Krishnappa Krishnappa ◽

Krishna Prasad ◽

Shruti Satish ◽

Murali R Nadig

Keyword(s):

Ct Scan ◽

Predictive Value ◽

Fdg Pet ◽

Imaging Modality ◽

False Negative ◽

Unknown Primary ◽

Pet Ct ◽

Fdg Pet Ct ◽

Pet Ct Scan

Aim:to study the role of PET- CT SCAN as a single imaging modality in the diagnosis of MUO neck. methodology: retrospective study analysis of 51 cases of clinical unknown primary with cervical metastasis . RESULTS: FDG PET CT tracer uptake was detected in 24/51. true positive in 18 cases out of 24,false positive in 6 cases, false negative in 2 cases with sensitivity of 90%, specificity of 82%,positive predictive value of 75%,negative predictive value of 93% and accuracy of 84.91%. conclusion: FDG PET CT can be used as a sole imaging modality in the diagnosis of MUO neck.it is complimentary to endoscopy.

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Utility of Panendoscopy for the Detection of Unknown Primary Head and Neck Cancer in Patients with a Negative PET/CT Scan

Ear Nose & Throat Journal ◽

10.1177/014556131109000818 ◽

2011 ◽

Vol 90 (8) ◽

pp. E16-E20 ◽

Cited By ~ 18

Author(s):

Kavita M. Pattani ◽

Michael Goodier ◽

David Lilien ◽

Todd Kupferman ◽

Gloria Caldito ◽

...

Keyword(s):

Head And Neck Cancer ◽

Ct Scan ◽

Head And Neck ◽

Neck Cancer ◽

Unknown Primary ◽

Pet Ct ◽

Pet Ct Scan

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Cancer of unknown primary origin: Can FDG PET/CT have a role in detecting the site of primary?

The Egyptian Journal of Radiology and Nuclear Medicine ◽

10.1016/j.ejrnm.2017.12.002 ◽

2018 ◽

Vol 49 (1) ◽

pp. 190-195

Author(s):

Ahmed Mohamed Wafaie ◽

Kareem Mohsen Moussa ◽

Eman Mahmoud Ebeid

Keyword(s):

Fdg Pet ◽

Cancer Of Unknown Primary ◽

Unknown Primary ◽

Pet Ct ◽

Primary Origin ◽

Fdg Pet Ct ◽

Unknown Primary Origin

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The role of whole body 18F-FDG PET/CT scan in patients with carcinoma of unknown primary

Journal of Clinical Oncology ◽

10.1200/jco.2009.27.15_suppl.e22051 ◽

2009 ◽

Vol 27 (15_suppl) ◽

pp. e22051-e22051

Author(s):

M. Hu ◽

J. Yu ◽

N. Liu ◽

L. Kong ◽

P. Zhang

Keyword(s):

Ct Scan ◽

Primary Tumor ◽

Fdg Pet ◽

Primary Site ◽

Unknown Primary ◽

Tumor Site ◽

Primary Tumor Site ◽

Pet Ct ◽

Fdg Pet Ct ◽

Pet Ct Scan

e22051 Background: Carcinoma of unknown primary (CUP) is a heterogeneous group of tumors and usually follows an aggressive biological and clinical behavior. Difficult challenges in oncology which the identification of the primary tumor and a complete disease staging could offer a more rational and efficient treatment in order to improve the survival time. Our aim was to evaluate the role of 18F-FDG PET/CT scan with two aspects: detection of the primary site, and estimation of tumor biological behavior which essential for the development of new, individual and targeted effective therapies. Methods: One hundred and seventeen patients presenting with histologically confirmed metastatic carcinoma (76 lymph nodes, 41 visceral biopsy proven) of unknown primary site were included in this retrospective study. The evaluations as follows had not revealed a primary site: detailed medical history, full physical and laboratory examinations, and diagnostic imaging methods. All patients underwent PET/CT. Results: In 42 (35.90%) patients, a primary tumor site which was confirmed by follow-up or surgery was showed by PET/CT. In 15 (12.82%) patients, the primary tumor site was suggested by PET/CT but not confirmed. In 60 (51.28%) patients, the primary tumor site was not localized modifying the stage of disease. In the other 17 (14.53%) patients, PET/CT scan identified further unexpected metastases. Overall, the following oncological treatment was influenced by the PET/CT scan, in a total of 38 (32.47%) patients. Between the adenocarcinoma and squamous cell carcinoma groups, no significant difference in SUVmax was found ( t=1.191, p = 0.244). A significantly higher SUVmax was found among patients with poorly or undifferentiated carcinoma compared with patients with well to moderately ( t=4.013, p<0.01) differentiation; In 42 patients with a confirmed primary tumor site, the SUVmax of Metastatic tumours have a closely relationship correlate with those of primary tumours, ( r=0.738, p<0.01). Furthermore, a significantly higher SUVmax was found among metastases compared with primary tumors ( t=3.470, p<0.01). Conclusions: Our data strongly support 18F-FDG PET/ CT imagings not only provide new insights in the diagnosis and staging of patients with CUP, but also evaluate biologic characters of tissue. 1 No significant financial relationships to disclose.

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Skeletal Metastasis of Unknown Primary Origin at the Initial Visit: A Retrospective Analysis of 286 Cases

PLoS ONE ◽

10.1371/journal.pone.0129428 ◽

2015 ◽

Vol 10 (6) ◽

pp. e0129428 ◽

Cited By ~ 18

Author(s):

Tatsuya Takagi ◽

Hirohisa Katagiri ◽

Yongji Kim ◽

Yoshiyuki Suehara ◽

Daisuke Kubota ◽

...

Keyword(s):

Retrospective Analysis ◽

Skeletal Metastasis ◽

Unknown Primary ◽

Initial Visit ◽

Primary Origin ◽

Unknown Primary Origin

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Positron emission tomography/computed tomography in patients with cancer of unknown primary origin

Acta chirurgica iugoslavica ◽

10.2298/aci0904159l ◽

2009 ◽

Vol 56 (4) ◽

pp. 159-164

Author(s):

S.M. Lucic ◽

M.A. Lucic ◽

A. Peter ◽

D. Jovanovic ◽

V. Vucaj-Cirilovic

Keyword(s):

Computed Tomography ◽

Positron Emission Tomography ◽

Cancer Of Unknown Primary ◽

Emission Tomography ◽

Unknown Primary ◽

Primary Cancer ◽

Positron Emission ◽

Pet Ct ◽

Primary Origin ◽

Unknown Primary Origin

Cancer of unknown primary origin is not an uncommon clinical state, usually accounting for 2%-7% of all cancer patients. Material and methods: Positron emission tomography and computed tomography (PET/CT) was performed in 17 patients with histologically proven metastatic tumors of unknown primary and negative or inconclusive conventional diagnostic procedures. Results: The study included 17 patients (8 male and 9 female) age from 42 to 76 years. PET / CT has pointed out the probable localization of primary tumors in 10 patients. According histological diagnosis of carcinoma of unknown origin, most common is adenocarcinoma (64.71%). Origin of the primary cancer was found in 72.73% patients with adenocarcinoma 66.67% of respondents with squamocelular carcinoma and 50% of respondents with low differentiated carcinoma. Location of primary cancer was not found in 41.18% of the respondents, including patients with mucinous adenocarcinoma and patients with melanoma. Conclusion: FDG PET/CT demonstrates very good whole-body imaging method in evaluation of patients with unknown primary carcinoma.

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