Cutaneous Nerve Fibers Participate in the Progression of Psoriasis by Linking Epidermal Keratinocytes and Immunocytes

2021 ◽  
Author(s):  
Si-Qi Chen ◽  
Xue-Yan Chen ◽  
Ying-Zhe Cui ◽  
Bing-Xi Yan ◽  
Yuan Zhou ◽  
...  
Keyword(s):  
Immune Cells ◽  
Botulinum Toxin A ◽  
Sensory Nerve ◽  
Vital Role ◽  
Nerve Fibers ◽  
Cutaneous Nerve ◽  
Epidermal Keratinocytes ◽  
New Treatment ◽  
Peripheral Sensory ◽  
Psoriatic Lesions

Abstract Recent studies have illustrated that psoriatic lesions are innervated by dense sensory nerve fibers. Psoriatic plaques appeared to improve after central or peripheral nerve injury. Therefore, the nervous system may play a vital role in psoriasis. We aimed to clarify the expression of nerve fibers in psoriasis and their relationship with immune cells and keratinocytes, and to explore the effect of skin nerve impairment. Our results illustrated that nerve fibers in psoriatic lesions increased and were closely innervated around immune cells and keratinocytes. RNA-seq analysis showed that peripheral sensory nerve-related genes were disrupted in psoriasis. In spinal cord hemi-section mice, sensory impairment improved psoriasiform dermatitis and inhibited the abnormal proliferation of keratinocytes. Botulinum toxin A alleviated psoriasiform dermatitis by inhibiting the secretion of calcitonin gene-related peptide. Collectively, cutaneous nerve fibers participate in the progression of psoriasis by linking epidermal keratinocytes and immunocytes. Neurological intervention may be a new treatment strategy for psoriasis.

scholarly journals Botulinum Toxin-A Therapy in Pediatric Urology: Indications for the Neurogenic and Non-Neurogenic Neurogenic Bladder

2009 ◽  
Vol 9 ◽  
pp. 1300-1305 ◽  
Author(s):  
Lori Dyer ◽  
Israel Franco
Keyword(s):  
Botulinum Toxin ◽  
Neurogenic Bladder ◽  
Botulinum Toxin A ◽  
Sensory Nerve ◽  
Nerve Fibers ◽  
Review Article ◽  
Pediatric Urology ◽  
Urethral Sphincter ◽  
Toxin A

Although, the role of Botulinum Toxin-A in the treatment of the neurogenic and non-neurogenic neurogenic bladder is becoming more defined, this is the first review article to characterize the emerging role of Botulinum Toxin-A in the pediatric urologic population. Injection of Botulinum Toxin-A at the level of the bladder works by inhibiting uninhibited bladder contractions and, possibly, by blocking some of the sensory nerve fibers. In children with sphincter dyssynergy, injection at the level of the urethral sphincter works by inhibiting the involuntary guarding reflex and blocking dyssynergic voiding.

Intramucosal distribution and traveling of peripheral sensory nerve fibers in the larynx of cats

1986 ◽  
Vol 3 ◽  
pp. S99
Author(s):  
Yasumasa Tanaka ◽  
Yoshikazu Yoshida ◽  
Minoru Hirano ◽  
Masatoshi Morimoto ◽  
Takeshi Kanaseki
Keyword(s):  
Sensory Nerve ◽  
Nerve Fibers ◽  
Peripheral Sensory

scholarly journals Remote Photoplethysmography for Evaluation of Cutaneous Sensory Nerve Fiber Function

Sensors ◽  
2021 ◽  
Vol 21 (4) ◽  
pp. 1272
Author(s):  
Zbignevs Marcinkevics ◽  
Alise Aglinska ◽  
Uldis Rubins ◽  
Andris Grabovskis
Keyword(s):  
Nerve Fiber ◽  
Local Heating ◽  
Sensory Nerve ◽  
Diagnostic Techniques ◽  
Nerve Fibers ◽  
Cutaneous Nerve ◽  
Doppler Imaging ◽  
Remote Photoplethysmography ◽  
Sensory Nerve Fiber ◽  
Small Nerve

About 2% of the world’s population suffers from small nerve fiber dysfunction, neuropathy, which can result in severe pain. This condition is caused by damage to the small nerve fibers and its assessment is challenging, due to the lack of simple and objective diagnostic techniques. The present study aimed to develop a contactless photoplethysmography system using simple instrumentation, for objective and non-invasive assessment of small cutaneous sensory nerve fiber function. The approach is based on the use of contactless photoplethysmography for the characterization of skin flowmotions and topical heating evoked vasomotor responses. The feasibility of the technique was evaluated on volunteers (n = 14) using skin topical anesthesia, which is able to produce temporary alterations of cutaneous nerve fibers function. In the treated skin region in comparison to intact skin: neurogenic and endothelial component of flowmotions decreased by ~61% and 41%, the local heating evoked flare area decreased by ~44%, vasomotor response trend peak and nadir were substantially reduced. The results indicate for the potential of the remote photoplethysmography in the assessment of the cutaneous nerve fiber function. It is believed that in the future this technique could be used in the clinics as an affordable alternative to laser Doppler imaging technique.

scholarly journals Itch and Cough – Similar Role of Sensory Nerves in Their Pathogenesis

2020 ◽  
pp. S43-S54
Author(s):  
T. Pecova ◽  
I. Kocan ◽  
R. Vysehradsky ◽  
R. Pecova
Keyword(s):  
Sensory Nerve ◽  
Small Diameter ◽  
Nerve Fibers ◽  
Sensory Nerves ◽  
Upper Respiratory Tract ◽  
C Fibers ◽  
Afferent Nerves ◽  
Sensory Fibers ◽  
Peripheral Sensory

Itch is the most common chief complaint in patients visiting dermatology clinics and is analogous to cough and also sneeze of the lower and upper respiratory tract, all three of which are host actions trying to clear noxious stimuli. The pathomechanisms of these symptoms are not completely determined. The itch can originate from a variety of etiologies. Itch originates following the activation of peripheral sensory nerve endings following damage or exposure to inflammatory mediators. More than one sensory nerve subtype is thought to subserve pruriceptive itch which includes both unmyelinated C-fibers and thinly myelinated Aδ nerve fibers. There are a lot of mediators capable of stimulating these afferent nerves leading to itch. Cough and itch pathways are mediated by small-diameter sensory fibers. These cough and itch sensory fibers release neuropeptides upon activation, which leads to inflammation of the nerves. The inflammation is involved in the development of chronic conditions of itch and cough. The aim of this review is to point out the role of sensory nerves in the pathogenesis of cough and itching. The common aspects of itch and cough could lead to new thoughts and perspectives in both fields.

scholarly journals Cutaneous Neuroimmune Interactions in Peripheral Neuropathic Pain States

2021 ◽  
Vol 12 ◽  
Author(s):  
Daniel B. Lowy ◽  
Preet G. S. Makker ◽  
Gila Moalem-Taylor
Keyword(s):  
Neuropathic Pain ◽  
Immune Cells ◽  
Sensory Nerve ◽  
Diabetic Polyneuropathy ◽  
Sensory Innervation ◽  
Skin Infections ◽  
Peripheral Neuropathic Pain ◽  
Emerging Therapies ◽  
Allergic Contact ◽  
Peripheral Sensory

Bidirectional interplay between the peripheral immune and nervous systems plays a crucial role in maintaining homeostasis and responding to noxious stimuli. This crosstalk is facilitated by a variety of cytokines, inflammatory mediators and neuropeptides. Dysregulation of this delicate physiological balance is implicated in the pathological mechanisms of various skin disorders and peripheral neuropathies. The skin is a highly complex biological structure within which peripheral sensory nerve terminals and immune cells colocalise. Herein, we provide an overview of the sensory innervation of the skin and immune cells resident to the skin. We discuss modulation of cutaneous immune response by sensory neurons and their mediators (e.g., nociceptor-derived neuropeptides), and sensory neuron regulation by cutaneous immune cells (e.g., nociceptor sensitization by immune-derived mediators). In particular, we discuss recent findings concerning neuroimmune communication in skin infections, psoriasis, allergic contact dermatitis and atopic dermatitis. We then summarize evidence of neuroimmune mechanisms in the skin in the context of peripheral neuropathic pain states, including chemotherapy-induced peripheral neuropathy, diabetic polyneuropathy, post-herpetic neuralgia, HIV-induced neuropathy, as well as entrapment and traumatic neuropathies. Finally, we highlight the future promise of emerging therapies associated with skin neuroimmune crosstalk in neuropathic pain.

Neurophysiological effect of 3-cm microwave radiation

1961 ◽  
Vol 200 (2) ◽  
pp. 192-194 ◽  
Author(s):  
Robert D. McAfee
Keyword(s):  
Microwave Irradiation ◽  
Subcutaneous Tissue ◽  
Sensory Nerve ◽  
Nerve Fibers ◽  
Whole Body ◽  
Nociceptive Response ◽  
Small Areas ◽  
Sensory Fibers ◽  
Peripheral Sensory ◽  
Stimulation Of

Neurophysiological effects from locally applied 3-cm microwave irradiation are demonstrated on decerebrate and anesthetized cats and shown to be the result of thermal stimulation of peripheral sensory nerve fibers. The penetrating characteristic of 3-cm radiation heats these fibers within the skin and subcutaneous tissue to 45° ± 2°C at which temperature a nociceptive response is elicited from the experimental animals. The irradiation is applied to small areas of skin or short sections of nerve trunks rich in sensory fibers and the nociceptive response obtained is quite different from the signs of a hyperthermal state seen during whole-body microwave irradiation.

scholarly journals 1006 Type 2 immune cells selectively interact with skin sensory nerve fibers in atopic dermatitis

2018 ◽  
Vol 138 (5) ◽  
pp. S171
Author(s):  
L. Oetjen ◽  
L. Yang ◽  
T. Whelan ◽  
S. Hamilton ◽  
P. Wang ◽  
...  
Keyword(s):  
Atopic Dermatitis ◽  
Immune Cells ◽  
Sensory Nerve ◽  
Nerve Fibers

scholarly journals Chinese Medicine in Diabetic Peripheral Neuropathy: Experimental Research on Nerve Repair and Regeneration

2012 ◽  
Vol 2012 ◽  
pp. 1-13 ◽  
Author(s):  
Yuanlin Piao ◽  
Xiaochun Liang
Keyword(s):  
Peripheral Neuropathy ◽  
Chinese Medicine ◽  
Diabetic Peripheral Neuropathy ◽  
Nerve Repair ◽  
Sensory Nerve ◽  
Nerve Fibers ◽  
Neurodegenerative Process ◽  
Recent Developments ◽  
Neurological Effects ◽  
Peripheral Sensory

Diabetic peripheral neuropathy (DPN) is one of the most common complications of chronic diabetes mellitus. Pathological characteristics of DPN include axonal atrophy, nerve demyelination, and delayed regeneration of peripheral sensory nerve fibers. The goal of treatment in DPN is not only to ameliorate neurological symptoms but also to slow or reverse the underlying neurodegenerative process. Schwann cells and neurotrophic factors play important roles in the repair and regeneration of peripheral nerves. The present paper reviews current studies and evidence regarding the neurological effects of traditional Chinese medicine, with an emphasis on recent developments in the area of nerve repair and regeneration in DPN.

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