scholarly journals Chinese Medicine in Diabetic Peripheral Neuropathy: Experimental Research on Nerve Repair and Regeneration

2012 ◽  
Vol 2012 ◽  
pp. 1-13 ◽  
Author(s):  
Yuanlin Piao ◽  
Xiaochun Liang
Keyword(s):  
Peripheral Neuropathy ◽  
Chinese Medicine ◽  
Diabetic Peripheral Neuropathy ◽  
Nerve Repair ◽  
Sensory Nerve ◽  
Nerve Fibers ◽  
Neurodegenerative Process ◽  
Recent Developments ◽  
Neurological Effects ◽  
Peripheral Sensory

Diabetic peripheral neuropathy (DPN) is one of the most common complications of chronic diabetes mellitus. Pathological characteristics of DPN include axonal atrophy, nerve demyelination, and delayed regeneration of peripheral sensory nerve fibers. The goal of treatment in DPN is not only to ameliorate neurological symptoms but also to slow or reverse the underlying neurodegenerative process. Schwann cells and neurotrophic factors play important roles in the repair and regeneration of peripheral nerves. The present paper reviews current studies and evidence regarding the neurological effects of traditional Chinese medicine, with an emphasis on recent developments in the area of nerve repair and regeneration in DPN.

scholarly journals Clinical Effect of Integrated Traditional Chinese and Western Medicine on Diabetic Peripheral Neuropathy

2021 ◽  
Vol 5 (6) ◽  
pp. 122-124
Author(s):  
Hao Peng ◽  
Yuhong Duan
Keyword(s):  
Peripheral Neuropathy ◽  
Chinese Medicine ◽  
Treatment Effect ◽  
Western Medicine ◽  
Diabetic Peripheral Neuropathy ◽  
Clinical Effect ◽  
Nerve Repair ◽  
Effective Rate ◽  
Control Group ◽  
Observation Group

Objective: Patients with diabetic peripheral neuropathy were treated with integrated traditional Chinese and western medicine, and the final results were observed. Methods: 70 patients with such symptoms were randomly divided into two groups. The number of people is the same, and the treatment methods are different. The control group uses western medicine, while the observation group uses traditional Chinese medicine to evaluate the treatment effect. Results: After treatment, the effective rate of the observation group was (P < 0.05), indicating that the treatment effect was significantly better. Conclusion: Patients with clinical diabetic peripheral neuropathy treated with routine nutrition and nerve repair, and with Chinese medicine, the effect is more satisfactory, and the effect is positive, so as to promote the optimization of their health.

scholarly journals PENGARUH AKUPUNKTUR JIN’S 3 NEEDLE TERHADAP PENURUNAN INTENSITAS NYERI DIABETIC NEUROPATHY PERIFER

2020 ◽  
Vol 4 (1) ◽  
pp. 46-51
Author(s):  
Leny Candra Kurniawan ◽  
Ikhwan Abdullah
Keyword(s):  
Peripheral Neuropathy ◽  
Side Effects ◽  
Diabetic Neuropathy ◽  
Diabetic Peripheral Neuropathy ◽  
Nerve Fibers ◽  
Significance Level ◽  
Peripheral Diabetic Neuropathy ◽  
Study Population ◽  
Sugar Levels ◽  
Needle Acupuncture

Diabetic Peripheral Neuropathy is a type of nerve damagethat occurs due to diabetes. High blood sugar levels in thelong term can cause damage to nerve fibers throughout thebody, such as legs, feet, blood circulation, heart, digestivesystem, and urinary tract. Diabetic Peripheral Neuropathy isa serious complication of diabetes that often causes pain inthe limbs. Pain management Diabetic Peripheral Neuropathyis usually by administering pain medication for a long periodof time. These medicines will have side effects. The use ofacupuncture as an alternative to help reduce the intensity ofpain in peripheral diabetic neuropathy has proven to beeffective and relatively without side effects. The advantage ofacupuncture therapy is that it has relatively no side effects.The general aim of this study is to reduce the intensity of painin peripheral neuropathy. The research design usesquantitative methods. The study population was all patientswith peripheral neuropathy who visited the Harmoni HealthyClinic in March-May 2019. The sampling method used wasaccidental sampling. The benefits of this study provide analternative for DM sufferers to reduce the intensity ofneuropathic pain naturally with acupuncture without fear.side effects. From the results of this study it is known thatthere is an influence of Jin’s Three Needle acupuncture inreducing the intensity of pain in Peripheral Neuropathy.Calculations using statistical SPSS 21 with paired sample ttest obtained significant results (0.00) from the value of α(0.05), then H1 is accepted. So with a significance level of5%, it can be concluded that Jin's Three Needle acupuncturecan reduce the intensity of pain in diabetic peripheralneuropathy

scholarly journals Prevention of HIV-1 TAT Protein-Induced Peripheral Neuropathy and Mitochondrial Disruption by the Antimuscarinic Pirenzepine

2021 ◽  
Vol 12 ◽  
Author(s):  
May Madi Han ◽  
Katie E. Frizzi ◽  
Ronald J. Ellis ◽  
Nigel A. Calcutt ◽  
Jerel Adam Fields
Keyword(s):  
Peripheral Neuropathy ◽  
Transgenic Mouse ◽  
Sensory Nerve ◽  
Nerve Fibers ◽  
Daily Injection ◽  
Tat Protein ◽  
Hiv Tat ◽  
Associated Proteins ◽  
Mitochondrial Disruption ◽  
Large Motor

HIV-associated distal sensory polyneuropathy (HIV-DSP) affects about one third of people with HIV and is characterized by distal degeneration of axons. The pathogenesis of HIV-DSP is not known and there is currently no FDA-approved treatment. HIV trans-activator of transcription (TAT) is associated with mitochondrial dysfunction and neurotoxicity in the brain and may play a role in the pathogenesis of HIV-DSP. In the present study, we measured indices of peripheral neuropathy in the doxycycline (DOX)-inducible HIV-TAT (iTAT) transgenic mouse and investigated the therapeutic efficacy of a selective muscarinic subtype-1 receptor (M1R) antagonist, pirenzepine (PZ). PZ was selected as we have previously shown that it prevents and/or reverses indices of peripheral neuropathy in multiple disease models. DOX alone induced weight loss, tactile allodynia and paw thermal hypoalgesia in normal C57Bl/6J mice. Conduction velocity of large motor fibers, density of small sensory nerve fibers in the cornea and expression of mitochondria-associated proteins in sciatic nerve were unaffected by DOX in normal mice, whereas these parameters were disrupted when DOX was given to iTAT mice to induce TAT expression. Daily injection of PZ (10 mg/kg s.c.) prevented all of the disorders associated with TAT expression. These studies demonstrate that TAT expression disrupts mitochondria and induces indices of sensory and motor peripheral neuropathy and that M1R antagonism may be a viable treatment for HIV-DSP. However, some indices of neuropathy in the DOX-inducible TAT transgenic mouse model can be ascribed to DOX treatment rather than TAT expression and data obtained from animal models in which gene expression is modified by DOX should be accompanied by appropriate controls and treated with due caution.

scholarly journals Intraepidermal Nerve Fiber Analysis in Human Patients and Animal Models of Peripheral Neuropathy: A Comparative Review

2019 ◽  
Vol 48 (1) ◽  
pp. 59-70 ◽  
Author(s):  
Lisa M. Mangus ◽  
Deepa B. Rao ◽  
Gigi J. Ebenezer
Keyword(s):  
Peripheral Neuropathy ◽  
Animal Models ◽  
Skin Biopsy ◽  
Nerve Fiber ◽  
Sensory Nerve ◽  
Nerve Fibers ◽  
Fiber Analysis ◽  
Comparative Review ◽  
Nerve Fiber Analysis ◽  
Intraepidermal Nerve Fiber

Analysis of intraepidermal nerve fibers (IENFs) in skin biopsy samples has become a standard clinical tool for diagnosing peripheral neuropathies in human patients. Compared to sural nerve biopsy, skin biopsy is safer, less invasive, and can be performed repeatedly to facilitate longitudinal assessment. Intraepidermal nerve fiber analysis is also more sensitive than conventional nerve histology or electrophysiological tests for detecting damage to small-diameter sensory nerve fibers. The techniques used for IENF analysis in humans have been adapted for large and small animal models and successfully used in studies of diabetic neuropathy, chemotherapy-induced peripheral neuropathy, HIV-associated sensory neuropathy, among others. Although IENF analysis has yet to become a routine end point in nonclinical safety testing, it has the potential to serve as a highly relevant indicator of sensory nerve fiber status in neurotoxicity studies, as well as development of neuroprotective and neuroregenerative therapies. Recently, there is also interest in the evaluation of IENF via skin biopsy as a biomarker of small fiber neuropathy in the regulatory setting. This article provides an overview of the anatomic and pathophysiologic principles behind IENF analysis, its use as a diagnostic tool in humans, and applications in animal models with focus on comparative methodology and considerations for study design.

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