scholarly journals Correlation between Red Blood Cell Distribution width, Neutrophil to Lymphocyte Ratio and Neutrophil to Platelet Ratio with 3-month Prognosis of Patients with Intracerebral Hemorrhage: A Retrospective Study

2022 ◽  
Author(s):  
Sheida Shaafi ◽  
Ehsan Bonakdari ◽  
Yalda Sadeghpour ◽  
Seyed Aria Nejadghaderi
Keyword(s):  
Prognostic Factor ◽  
Blood Cell ◽  
Intracerebral Hemorrhage ◽  
Red Blood Cell ◽  
Large Scale ◽  
Complete Blood Count ◽  
Cell Distribution ◽  
Distribution Width ◽  
Significant Difference ◽  
The Mean

Abstract Background: Red cell distribution width (RDW) is a parameter that indicates the heterogeneity of red blood cell size and could be as a prognostic factor in some diseases. Also, intracerebral hemorrhage (ICH) is considered a vascular event with a high mortality rate. Here, we aimed to examine the role of RDW, neutrophil to lymphocyte (NLR) and neutrophil to platelet ratios (NPR) in predicting the prognosis of patients with ICH.Methods: This is a retrospective cohort study which conducted on 140 patients with ICH admitted to the neurology ward and intensive care unit (ICU) in Imam Reza Hospital, Tabriz, Iran. Demographic data, National Institutes of Health Stroke Scale (NIHSS), and complete blood count (CBC) test parameters evaluated within 24 hours after hospitalization. These variables collected and re-evaluated three months later. Results: The mean age of the study population was 61.14 (±16) years and 51% were male. RDW had a significant positive correlation with hemoglobin concentration (r=0.3; p<0.001) and significant negative correlation with MCHC (r=-0.57; p<0.001) and neutrophil count (r=-0.235; p=0.006). Also, the mean NLR (p=0.05), neutrophil and platelet count (p=0.05), NIHSS (p=0.05), and RDW (p=0.01) had a significant difference between the deceased patients and those who partially recovered after 3 months. Moreover, the results of logistic regression showed variables including RDW (p=0.006) and NIHSS (p<0.001) levels were correlated significantly with mortality. Conclusion: RDW could be an appropriate prognostic factor and predictor in determining 3-months survival in ICH. Nevertheless, further large-scale prospective cohorts might be needed to evaluate the associations.

scholarly journals A Novel Parameter for Predicting Therapeutic Response in Iron Deficiency Anemia: Red Blood Cell Distribution Width

2019 ◽  
Vol 8 (3) ◽  
pp. 107-112
Author(s):  
Aslı Korur ◽  
Didar Yanardag Acik ◽  
Soner Solmaz ◽  
Cigdem Gereklioglu ◽  
Suheyl Asma ◽  
...  
Keyword(s):  
Blood Cell ◽  
Red Blood Cell ◽  
Blood Count ◽  
Complete Blood Count ◽  
Reticulocyte Count ◽  
Iron Therapy ◽  
Deficiency Anemia ◽  
Cell Distribution ◽  
Distribution Width ◽  
Red Blood Cell Distribution

Aim: Anemia is a public health problem worldwide. Cost effectiveness and efficient use of resources are vitally important. Red blood cell distribution width, which can be obtained from a standard complete blood count, is a measure of the variability in size of circulating erythrocytes. The present study was performed to investigate whether red blood cell distribution width can be used to predict response to iron therapy. Methods: This study was conducted in 50 patients admitted to hematology and family medicine clinics. Complete blood count and reticulocyte count were determined on day 5; complete blood count was examined 1 month after commencement of therapy. Results: Statistically significant differences were detected between hemoglobin levels and red blood cell distribution width values at the time of diagnosis and on day 5 and after 1 month of therapy. A significant positive correlation was found between the increase in red blood cell distribution width and the increase in hemoglobin. Conclusion: Red blood cell distribution width may be used in place of reticulocyte count to predict response to iron therapy. Red blood cell distribution width is the best biomarker for this purpose as a component of complete blood count, and therefore it may be accepted as superior to reticulocyte count.

scholarly journals Red Blood Cell Distribution Width: A Novel Predictive Indicator for Cardiovascular and Cerebrovascular Diseases

2017 ◽  
Vol 2017 ◽  
pp. 1-23 ◽  
Author(s):  
Ning Li ◽  
Heng Zhou ◽  
Qizhu Tang
Keyword(s):  
Blood Cell ◽  
Red Blood Cell ◽  
Complete Blood Count ◽  
Predictive Marker ◽  
Biochemical Parameter ◽  
Cerebrovascular Diseases ◽  
Deficiency Anemia ◽  
Cell Distribution ◽  
Distribution Width ◽  
Red Blood Cell Distribution

The red blood cell distribution width (RDW) obtained from a standard complete blood count (CBC) is a convenient and inexpensive biochemical parameter representing the variability in size of circulating erythrocytes. Over the past few decades, RDW with mean corpuscular volume (MCV) has been used to identify quite a few hematological system diseases including iron-deficiency anemia and bone marrow dysfunction. In recent years, many clinical studies have proved that the alterations of RDW levels may be associated with the incidence and prognosis in many cardiovascular and cerebrovascular diseases (CVDs). Therefore, early detection and intervention in time of these vascular diseases is critical for delaying their progression. RDW as a new predictive marker and an independent risk factor plays a significant role in assessing the severity and progression of CVDs. However, the mechanisms of the association between RDW and the prognosis of CVDs remain unclear. In this review, we will provide an overview of the representative literatures concerning hypothetical and potential epidemiological associations between RDW and CVDs and discuss the underlying mechanisms.

scholarly journals Red Blood Cell Distribution Width: Another Prognostic Factor for COVID-19?

2021 ◽  
Author(s):  
Maria Lagadinou ◽  
Despoina Gkentzi ◽  
Markos N. Marangos ◽  
Fotini Paliogianni ◽  
Elena E. Solomou
Keyword(s):  
Prognostic Factor ◽  
Blood Cell ◽  
Red Blood Cell ◽  
Cell Distribution ◽  
Distribution Width ◽  
Red Blood Cell Distribution

scholarly journals ANALYSIS OF RED BLOOD CELL DISTRIBUTION WIDTH COEFFICIENT OF VARIATION ON STROKE PATIENT

2019 ◽  
Vol 25 (1) ◽  
pp. 11
Author(s):  
Kartika Paramita ◽  
Agus Alim Abdullah ◽  
Mansyur Arif
Keyword(s):  
Blood Cell ◽  
Patient Outcomes ◽  
Red Blood Cell ◽  
Hemorrhagic Stroke ◽  
Secondary Data ◽  
Cell Distribution ◽  
Cross Sectional ◽  
Distribution Width ◽  
Significant Difference ◽  
Red Blood Cell Distribution

 Stroke is a functional disorder attributed to acute focal or global brain injury by vascular cause and persists more than 24 hours. Stroke is divided into ischemic and hemorrhagic strokes. Red Blood Cell Distribution Width (RDW) is a measurement of erythrocyte volume variation in blood circulation. Increased RDW reflects the inflammation that plays a role in the development of atherosclerosis in stroke. This study aims to analyze differences in RDW-CV values in patients with stroke. The design was cross-sectional with a retrospective approach, secondary data from medical records of inpatients with stroke from January to December 2016 at the Dr. Wahidin Sudirohusodo Hospital. The study population consisted of 490 patients aged ≥ 18 years old. The Kruskal-Wallis, Mann-Whitney, and Anova one way tests were used to analyze differences in RDW-CV values in patients with ischemic and hemorrhagic stroke. Mann-Whitney test results showed no significant difference in RDW-CV values between groups of ischemic and hemorrhagic stroke (p 0.96). Kruskal-Wallis and Anova one way tests showed no significant difference in RDW-CV values between four groups of patient outcomes in ischemic and hemorrhagic stroke (p 0.13 and p 0.35 consecutively). There were no significant RDW-CV values between ischemic and hemorrhagic stroke. There was no significant difference between RDW-CV values of four groups of patient outcomes in ischemic and hemorrhagic stroke. RDW-CV values cannot be used to distinguish both ischemic and hemorrhagic stroke, including the prediction of stroke mortality

Red blood cell distribution width and mortality of spontaneous intracerebral hemorrhage patients

2020 ◽  
Vol 195 ◽  
pp. 106066
Author(s):  
Leonardo Lorente ◽  
María M. Martín ◽  
Agustín F. González-Rivero ◽  
Antonia Pérez-Cejas ◽  
Rafael Sabatel ◽  
...  
Keyword(s):  
Blood Cell ◽  
Intracerebral Hemorrhage ◽  
Red Blood Cell ◽  
Cell Distribution ◽  
Spontaneous Intracerebral Hemorrhage ◽  
Distribution Width ◽  
Red Blood Cell Distribution

scholarly journals Elevated Red Blood Cell Distribution Width as a Simple Prognostic Factor in Patients with Symptomatic Multiple Myeloma

2014 ◽  
Vol 2014 ◽  
pp. 1-8 ◽  
Author(s):  
Hyewon Lee ◽  
Sun-Young Kong ◽  
Ji Yeon Sohn ◽  
Hyoeun Shim ◽  
Hye Sun Youn ◽  
...  
Keyword(s):  
Multiple Myeloma ◽  
Prognostic Factor ◽  
Blood Cell ◽  
Red Blood Cell ◽  
Plasma Cells ◽  
Cell Distribution ◽  
Distribution Width ◽  
Poor Prognostic Factor ◽  
Inflammatory Biomarker ◽  
Red Blood Cell Distribution

Red blood cell distribution width (RDW) is a parameter reported in complete blood cell count tests, and has been reported as an inflammatory biomarker. Multiple myeloma (MM) is known to be associated with inflammatory microenvironments. However, the importance of RDW has been seldom studied in MM. For this study, 146 symptomatic myeloma patients with available RDW at diagnosis were retrospectively reviewed, and their characteristics were compared between two groups, those with high (>14.5%) and normal (≤14.5%) RDW. RDW was correlated to hemoglobin, MM stage,β2-microglobulin, M-protein, bone marrow plasma cells, and cellularity (P<0.001). During induction, overall response rates of the two groups were similar (P=0.195); however, complete response rate was higher in the normal-RDW group than it was in the high-RDW group (P=0.005). With a median follow-up of 47 months, the normal-RDW group showed better progression-free survival (PFS) (24.2 versus 17.0 months,P=0.029) compared to the high-RDW group. Overall survival was not different according to the RDW level (P=0.236). In multivariate analysis, elevated RDW at diagnosis was a poor prognostic factor for PFS (HR 3.21, 95% CI 1.24–8.32) after adjustment with other myeloma-related prognostic factors. RDW would be a simple and immediately available biomarker of symptomatic MM, reflecting the systemic inflammation.

scholarly journals Increased red blood cell distribution width in patients with plaque psoriasis

2020 ◽  
Author(s):  
Davide Geat
Keyword(s):  
Blood Cell ◽  
Disease Severity ◽  
Red Blood Cell ◽  
Plaque Psoriasis ◽  
Linear Regression Analysis ◽  
Psoriatic Patient ◽  
Cell Distribution ◽  
Distribution Width ◽  
Significant Difference ◽  
Red Blood Cell Distribution

Background: Red blood cell distribution width (RDW) is frequently increased in inflammatory disorders and the magnitude of its elevation correlates with disease severity. This study was hence aimed to explore RDW values in patients with psoriasis. Methods: The study population consisted of 366 adult patients with mild to severe plaque psoriasis and 366 age- and sex-matched healthy blood donor controls. For each psoriatic patient demographic, clinical and laboratory data were regularly collected. Results: RDW and MCV were significantly higher in psoriatic patients compared to controls (13.95 vs. 13.40% and 90.4 vs. 89 fL; both p<0.01). In order to assess whether RDW elevations were related to psoriasis severity, we divided our psoriatic patient population into two groups based on a PASI cut-off of 10. No significant differences were observed between the two groups (i.e. PASI > 10 and ≤ 10) in terms of RDW (p=0.36). Adopting different PASI cut-offs (i.e.  3, 5, 7, 12) did also not result in statistically significant differences (p= 0.93, 0.48, 0.22, 0.42, respectively). In linear regression analysis, no significant correlation was also found between RDW and PASI or CRP, nor with age, gender or the psoriasis comorbidities listed in Table I. Furthermore, no significant difference of RDW values was noted between psoriatic patients with and without PsA (p = 0.27). Conclusions: The results of this study confirm that RDW is elevated in psoriatic patients, though the magnitude of its increase did not appear to be associated with disease severity.

scholarly journals Correlation of Albumin Serum Levels as Inflammation Marker with Red Blood Cell Distribution Width Value in Regular Hemodialysis Patients at H. Adam Malik General Hospital Medan

2021 ◽  
Vol 8 (7) ◽  
pp. 369-374
Author(s):  
Soraya Mourina Hutasuhut ◽  
Alwi Thamrin Nasution ◽  
M. Feldy Gazaly Nasution
Keyword(s):  
Blood Cell ◽  
Serum Albumin ◽  
General Hospital ◽  
Red Blood Cell ◽  
Serum Levels ◽  
Cell Distribution ◽  
Distribution Width ◽  
The Mean ◽  
Red Blood Cell Distribution ◽  
Regular Hemodialysis

Background: One of the modalities of renal replacement therapy in chronic kidney disease (CKD) is hemodialysis (HD). The role of inflammation in HD patients by uremic toxins and dialysis can be assessed by the marker of serum albumin. This inflammation also causes dysregulation of the hormone erythropoietin which results in increased variability or heterogeneity of red blood cell distribution width (RDW). Previous studies have revealed an association between RDW and albumin levels in regular HD patients which leads to increased patient morbidity and mortality. This study aims to determine the relationship between albumin serum levels and RDW as a marker of inflammation in regular HD patients. Method: This was a cross sectional study design, conducted in June to August 2020 at the HD unit of Haji Adam Malik General Hospital in Medan. Twenty subjects were included. Data were analyzed using Pearson correlation test and T-test to find the correlation between albumin serum levels and RDW, and other variables. Results: Of the 20 subjects taken based on consecutive sampling, the majority was male, 13 people (65%), mean age was 50.30 ± 12.57 years with the most comorbid type 2 diabetes mellitus for 14 people (70%). The mean serum albumin level was 3.2 ± 0.65 mg/dl. The mean RDW value was 15.93 ± 1.87%. This study showed that there was a significant relationship between serum albumin levels and RDW values ​​(r = - 0.687; p = 0.001). RDW values ​​were also significantly associated with hemoglobin levels (r = 0.497; p = 0.026) and creatinine (r= 0.519; p= 0.019). Conclusion: Albumin, hemoglobin, and creatinine levels were significantly associated with RDW values ​​in regular HD patients. Keywords: inflammation, albumin, regular hemodialysis, RDW.

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